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Role of vit e & se in mastitis

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  • 1. ROLE OF VIT-E & Se IN MASTITIS SAURAV PAUL FINAL YEAR RANCHI VETERINARY COLLEGE RANCHI, JHARKHAND “ E- care Se “ National Essay Competition , 2008, (Winner presentation East zone )
  • 2. Introduction
    • The theory that bovine nutrition and resistance to mastitis are interrelated and has been demonstrated by a number of different models.
    • Se and vitamin E are integral components of the host defenses against infectious diseases.
    • The concerted efforts of nutritionists, immunologists and veterinarians to define optimum dietary concentrations of Se and vitamin E have led to an universal improvement in bovine mammary health and milk quality.
  • 3. Contd…
    • Dietary supplementation of mammals with vitamin E and Se is important to maintain host defense mechanisms, including
      • antibody production,
      • cell proliferation,
      • cytokine production,
      • prostaglandin metabolism,
      • neutrophil function.
  • 4. FUNCTIONS OF VIT-E & Se IN MASTITIS
    • AS ANTIOXIDANT
    • INCREASES INTRACELLULAR KILLING OF BACTERIA
  • 5.
  • 6.
  • 7.
    • Respiratory burst
    • Superoxide and hydrogen peroxide
    • Free Radicals (highly unstable) VIT-E & Se
    • Acts on Polyunsaturated Fatty Acids of healthy cells.
    • Leads to Cellular damage
    Mechanism:-
  • 8. VITAMIN- E
    • A Fat soluble Vitamin
    • Chemically alcohol – Tocopherol
    • 8 different types , alpha tocopherol is most active
    • Antioxidant & Scavenger of Free Radicals
    • Prevents the damage of cell membrane from lipid peroxidation
  • 9. Selenium
    • A Trace element
    • Mainly helpful as Se containing enzyme GLUTATHION PEROXIDASE (GSH-Px)
    • Antioxidant
    • Converts hydrogen peroxide into water & lipid hydroperoxide to the corresponding alcohol
  • 10. FACTS
    • Vitamin E supplementation of diets increased intracellular kill of Staphylococcus aureus and E. coli by bovine blood neutrophils but had no effect on phagocytic index.
    • Neutrophils collected from cows fed Se-supplemented diets have increased intracellular killing of bacteria, enhanced viability and reduced extracellular hydrogenperoxide concentration compared with neutrophils harvested from milk of cows fed Se-deficient diets.
  • 11.
    • PMN intracellular killing of E.coli ( Hogan et al., JDS 1990 )
  • 12. Reduction in mastitis incidence ( Ohio State Research)
  • 13. IMPORTANT POINTS
    • Incidence and prevalence of mastitis was reduced by vitamin E/Se supplementation, especially heifers when given 21 days prepartum.
    • Vitamin E appears to be especially important beginning at 7-10 days before calving through 3-5 days after calving.
    • Cows supplemented with both vitamin E and Se had shorter rates and duration of clinical signs
    • Cows with serum vitamin E concentrations < 3.0 µg/ml were 9.4 times more likely to have mastitis.
  • 14. Obviously, vitamin E/Se plays an important, if not well defined role in the overall nutrition of cattle. Much of this will depend on age, stage of production, stress levels and so on. It is important for the producer to understand what he needs to be shooting for in his given situation.
  • 15. There is Rs 6000 crores economic losses in india during year 2002 out of which Rs 4300 crores due to subclinical mastitis and Rs 1700 crores due to clinical, thus in context of above all conditions the role of vit E / Se is inevitable in mastitis.
  • 16. References
    • Atroshi, F., J. Tyopponen, S. Sankari, R. Kangasniemi and J. Parantainen. 1986. Possible roles of vitamin E and glutathione metabolism in bovine mastitis. Int. J. Vitam. Nutr. Res. 57:37.
    • Baboir, B.M. 1984. The respiratory burst of phagocytes. J. Clin. Invest. 73:599.
    • Boxer, L.A., J.M. Oliver, S.P. Speilberg, J.M. Allen and J.D. Schulman. 1979. Protection of granulocytes by vitamin E in glutathione synthetase deficiency. New England J. Med. 301:901.
    • Blood,veterinary medicine,9th edition
    • Heinzerling, R.H., R.P. Tenderdy, L.L. Wick and D.C. Lueker. 1974. Vitamin E protects mice against Diplococcus pneumoniae type I infection. Infect. Immun. 10:1292.
  • 17. References
    • Hogan, J.S., K.L. Smith, W.P. Weiss, D.A. Todhunter and W.L. Shockey. 1990. Relationships among vitamin E, selenium, and bovine blood neutrophils. J. Dairy Sci. 73:2372.
    • Hogan, J.S., W.P. Weiss, D.A. Todhunter, K.L. Smith and P.S. Schoenberger. 1992. Bovine neutrophil responses to parenteral vitamin E. J. Dairy Sci. 75:399.
    • Hogan, J.S., W.P. Weiss, K.L. Smith, D.A. Todhunter, P.S. Schoenberger and S.N. Williams. 1993. Vitamin E as adjuvant in an Escherichia coli J5 vaccine. J. Dairy Sci. 76:401.
    • Hogan, J.S., W.P. Weiss, K.L. Smith, L.M. Sordillo and S.N. Williams. 1996. Milk and plasma a-tocopherol responses during clinical Escherchia coli mastitis. J. Dairy Sci. 79:71.
  • 18. THANKS

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