Definiens Tissue Studio Advanced Digital Pathology Image Analysis Solution

Definiens Tissue Studio™
The Most Advanced Digital Pathology Image Analysis Solution

Definiens Tissue Studio™ overview
Enables simple, fast, and accurate ROI detection via the new Definiens Composer Technology™
Provides multi-parametric quantitationon a cell-by-cell basis
Handles heterogeneous tissue samples
Works with whole slides and TMAs
Handles images acquired from any source
Operates as a dedicated workstation or as a client server application

Definiens Composer Technology™
What is it?
Definiens Composer Technology™ was developed to enable the user to easily teach the system how to identify regions of interest (ROIs).
How does it work?
Simply load up to 4 representative images, and use the “paintbrush tool” on a few representative ROIs in your images. Then click the “Learn” button.
How does this differ from other approaches?
Training the system with 4 representative images ensures a robust image analysis solution without over fitting.
Combines machine learning, pattern recognition and auto adaptive analysis algorithms based on Definiens eCognitionNetwork Language ™.
Definiens Tissue Studio™ is faster and more flexible.

ROI Detection and Cell by Cell Analysis across and within selected ROIs
Definiens Tissue Studio™ Workflow

Load training images

Define image analysis solution

Load up to four different images:Detect tissue / Background / Segment images

Definiens Composer Technology™:“Paint” on a few representative ROIs

Definiens Composer Technology™:After painting a few ROIs, click the “Learn” button

Definiens Composer Technology™:Computer has now been “trained”

Definiens Composer Technology™:Merge “Object Primitives”

Second Definiens Composer step:Re-classify Islets into “tumor” and “normal”

Select ROIs in tumor islets

ROIs at 20xParameters can be adjusted and previewed here

Detect nuclei

Batch Process:Analyze selected images

Export multi-parametric quantitative features

List of supported instruments
Hamamatsu: Nanozoomer
Zeiss: Mirax
Aperio: Scanscope
Applied Imaging: Ariol
TissueGnostics
Bacus WebSlide
DMetrix
Generic (tif, jpg, etc.)

Summary
Deeper insights
Quantifies nuclear, membrane and cytoplasmic biomarkers on a cell-by-cell basis
Supports all standard IHC tissue stains (blue, brown and red), H&E and IF
Analyzes all slides and TMA images from all major image acquisition devices
Faster results
Identifies regions of interest automatically
Operates through a simple, intuitive user interface
Offers unlimited throughput with parallel batch processing
Better decisions
Delivers accurate and reproducible results
Enables multiparametric investigations to identify underlying correlations
Supports translational research through rapid iterative investigation of biomarkers

Questions Contact:
Daniel R. Nicolson
Director, Global Accounts
484-678-9090
dnicolson@definiens.com

Definiens Tissue Studio Advanced Digital Pathology Image Analysis Solution

by drnicolson on Aug 31, 2009

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