Riboflavin ( B2) MUHAMMAD MUSTANSAR

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Riboflavin ( B2) MUHAMMAD MUSTANSAR

  1. 1. 1
  2. 2. B2RIBOFLAVIN•
  3. 3. 3Riboflavin (B2)It is also called as beauty vitamin. it is yellowish green fluorescent compoundsoluble in water.The word riboflavin is derived from 2 sourcesribose – means many ribose sugar found inseveral vitaminsflavin – yellow. It is widely involved in oxidation-reductionreaction.
  4. 4. Structure & function
  5. 5. 8Sources• Plant : Rice Bajra Pulses- soybeans Vegetables – spinachcauliflower brinjal• Animals:- liver of sheep eggs Mutton Prawn milk
  6. 6. 9
  7. 7. 10Absorption & excretionIt is readily absorbed from intestinal tractIt is carried to tissue of the body &incorporated into the cell enzymes.It is stored in liver, kidney & heart.Excretion – urine & sweat
  8. 8. BIOCHEMICAL FUNCTIONS OFRIBOFLAVIN:A- Biochemical role of FMN as a coenzyme1. FMN as a part of redox potential2. FMN is a coenzyme for L-amino acidoxidases:
  9. 9. 3. FMN being a part of Cut. C reductase4. FMN also accepts 2H+from NADH+H+5. FMN is a coenzyme for Warburg’s yellowenzyme [a component of respiratorychain]
  10. 10. B- FAD is a coenzyme for the followingenzyme:Like FMN, FAD is also is a part ofmitochondrial respiratory chain
  11. 11. 1. D-aminoacid oxidases: The enzymescatalyze reaction similar to L-aminoacidoxidases but with FAD as coenzyme.2. Aldehyde oxidase3. Acyl-CoA dehydrogenase of the βoxidation of fatty acids
  12. 12. 4. Succinate dehydrogenase, an enzyme ofcitric acids cycle and converts succinateto fumarate in mitochondria5. Xanthine oxidase present in milk, smallintestine, kidney converts purine bases touric acid
  13. 13. 6. Glucose oxidase prepared from fungi7. Glycine oxidase which oxidativedeaminates glycine to glyoxylic acid andammonia
  14. 14. Riboflavin-B2Involved in energy metabolism; part of twoco- enzymes,FMN and FADParticipate in citric acid cycle and betaoxidation and electron transportRemove ammonia during deamination ofsome amino- acids
  15. 15. 19Daily requirementMen – 1.5mgwomen – 1.2 mgPregnancy and lactation – 2 to 2.3 mg .Children – 1.3mg.
  16. 16. 20FunctionsIt is essential for normal growth.Metabolism – It is involved in the metabolismof carbohydrates, fat & proteins.Digestion – it helps in digestionNervous system – it helps in properfunctioning of Nervous system
  17. 17. RIBOFALVIN IMPORTANCE
  18. 18. 22DeficiencyOcular changes-it consists of corneal vasodilatation,superficial & interstitial keratitis.Skin & nails –it may also result in dull or oily hair. Oilyskin, premature wrinkle on face.
  19. 19. 23Deficiencysore throatcheliosisglossitisseborrheic dermatitisanemia
  20. 20. SYMPTOMS OF RIBOFLAVINDEFICIENCY• Stomatitis• Anemia• Swollen and dark tongue• Angular chelosis: cracks in corners ofmouth and lips
  21. 21. 26• Chapping &fissuring of lipsCHEILOSISGLOSSITIS• Inflammmed• Red beefy tongue
  22. 22. 28SEBORRHEIC DERMATITIS Red, scaly, itchy rashesseen on• scalp• sides of nose• eyebrows• eyelids• skin behind ears, middle ofchest
  23. 23. 29Oral manifestationTongue:- in severe cases the tongue becomesglazed & smooth due to complete atrophy ofthe papillae.Lips:- becomes red & shiny because ofdesquamation of epithelium.
  24. 24. 30ManagementRiboflavin 25,000 to 50,000 mcg is givendaily in divided doses.
  25. 25. VITAMIN B2 (Riboflavin)SOURCES: Yeast Whole grain Dry beans and pea Green vegetablesRDA: 1.5-1.8 mg/day in adultsFUNCTIONS:In two active forms FMN and FAD serves as coenzyme in various reactionsDEFICIENCY Cheilosis-fissuring at angle of the mouth Glossitis-tongue smooth and purplish Seborrhagic Dermatitis:scaly,greasy,desquamation Eyes: corneal vascularizationChronic alcoholics are susceptible to deficiencies.

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