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Riboflavin ( B2) MUHAMMAD MUSTANSAR
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Riboflavin ( B2) MUHAMMAD MUSTANSAR

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Riboflavin ( B2) MUHAMMAD MUSTANSAR Riboflavin ( B2) MUHAMMAD MUSTANSAR Presentation Transcript

  • 1
  • B2RIBOFLAVIN•
  • 3Riboflavin (B2)It is also called as beauty vitamin. it is yellowish green fluorescent compoundsoluble in water.The word riboflavin is derived from 2 sourcesribose – means many ribose sugar found inseveral vitaminsflavin – yellow. It is widely involved in oxidation-reductionreaction.
  • Structure & function
  • 8Sources• Plant : Rice Bajra Pulses- soybeans Vegetables – spinachcauliflower brinjal• Animals:- liver of sheep eggs Mutton Prawn milk
  • 9
  • 10Absorption & excretionIt is readily absorbed from intestinal tractIt is carried to tissue of the body &incorporated into the cell enzymes.It is stored in liver, kidney & heart.Excretion – urine & sweat
  • BIOCHEMICAL FUNCTIONS OFRIBOFLAVIN:A- Biochemical role of FMN as a coenzyme1. FMN as a part of redox potential2. FMN is a coenzyme for L-amino acidoxidases:
  • 3. FMN being a part of Cut. C reductase4. FMN also accepts 2H+from NADH+H+5. FMN is a coenzyme for Warburg’s yellowenzyme [a component of respiratorychain]
  • B- FAD is a coenzyme for the followingenzyme:Like FMN, FAD is also is a part ofmitochondrial respiratory chain
  • 1. D-aminoacid oxidases: The enzymescatalyze reaction similar to L-aminoacidoxidases but with FAD as coenzyme.2. Aldehyde oxidase3. Acyl-CoA dehydrogenase of the βoxidation of fatty acids
  • 4. Succinate dehydrogenase, an enzyme ofcitric acids cycle and converts succinateto fumarate in mitochondria5. Xanthine oxidase present in milk, smallintestine, kidney converts purine bases touric acid
  • 6. Glucose oxidase prepared from fungi7. Glycine oxidase which oxidativedeaminates glycine to glyoxylic acid andammonia
  • Riboflavin-B2Involved in energy metabolism; part of twoco- enzymes,FMN and FADParticipate in citric acid cycle and betaoxidation and electron transportRemove ammonia during deamination ofsome amino- acids
  • 19Daily requirementMen – 1.5mgwomen – 1.2 mgPregnancy and lactation – 2 to 2.3 mg .Children – 1.3mg.
  • 20FunctionsIt is essential for normal growth.Metabolism – It is involved in the metabolismof carbohydrates, fat & proteins.Digestion – it helps in digestionNervous system – it helps in properfunctioning of Nervous system
  • RIBOFALVIN IMPORTANCE
  • 22DeficiencyOcular changes-it consists of corneal vasodilatation,superficial & interstitial keratitis.Skin & nails –it may also result in dull or oily hair. Oilyskin, premature wrinkle on face.
  • 23Deficiencysore throatcheliosisglossitisseborrheic dermatitisanemia
  • SYMPTOMS OF RIBOFLAVINDEFICIENCY• Stomatitis• Anemia• Swollen and dark tongue• Angular chelosis: cracks in corners ofmouth and lips
  • 26• Chapping &fissuring of lipsCHEILOSISGLOSSITIS• Inflammmed• Red beefy tongue
  • 28SEBORRHEIC DERMATITIS Red, scaly, itchy rashesseen on• scalp• sides of nose• eyebrows• eyelids• skin behind ears, middle ofchest
  • 29Oral manifestationTongue:- in severe cases the tongue becomesglazed & smooth due to complete atrophy ofthe papillae.Lips:- becomes red & shiny because ofdesquamation of epithelium.
  • 30ManagementRiboflavin 25,000 to 50,000 mcg is givendaily in divided doses.
  • VITAMIN B2 (Riboflavin)SOURCES: Yeast Whole grain Dry beans and pea Green vegetablesRDA: 1.5-1.8 mg/day in adultsFUNCTIONS:In two active forms FMN and FAD serves as coenzyme in various reactionsDEFICIENCY Cheilosis-fissuring at angle of the mouth Glossitis-tongue smooth and purplish Seborrhagic Dermatitis:scaly,greasy,desquamation Eyes: corneal vascularizationChronic alcoholics are susceptible to deficiencies.