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prostaglandinsPG leukotrienesLT thromboxinesTX

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  • Pathways of arachidonic acid (AA) release and metabolism.
  • Transcript

    • 1. P ROSTAGLANDINS PGL EUKOTRIENES LTTHROMBOXINE TXDR MUSTANSAR
    • 2. INTRODUCTION Eicosanoids (20 carbons) are found in the animal kingdom and a variety of plants. The eicosanoids are oxygenation products of acid arachidonic (AA) polyunsaturated fatty acid. Acid arachidonic is released from membrane by phospholipase A2 (PLA2).
    • 3. PROSTAGLANDINS & LEUKOTRIENES  Localhormones - very active,many functions..  Autacoids from 20 C PUFA Prostaglandins Prostacyclin Thromboxanes Leukotrienes
    • 4. FUNCTIONS Inflammation Smooth muscle tone Blood coagulation Reproduction GI secretion
    • 5. .SYNTHES . PHOSPHOLI PIDSIS PHOSPHOLIPASE A2 ARACHIDO NIC ACID CYCLOOXYGENASE 5 LIPOOXYGENASE LT PG G2 A4 LT PG LT C4ISOMERASE H2 THROMBOXANE SYNTHASE B4 LT D4 PGE2 PROSTACYCLINE SYNTHASE PG THROMBOX D2 ANE A2 PG PG F2 I2
    • 6. Pathways of arachidonic acid (AA) releaseand metabolism.
    • 7. . PHOSPHO LIPIDS STEROIDS PHOSPHOLIPASE A2 NSAIDS ARACHIDO ZILEUTON NIC ACID CYCLOOXYGENASE 5 LIPOOXYGENASE LT A4 PG G2 PGH2 LT C4 LT B4 LT D4 PGE2 THROMB ,PG D2 OXANE A2 ,PG F2 PG I2
    • 8. BIOSYNTHESIS OFPROSTAGLANDINS Enzyme is Cyclo oxygenase(COX) COX 1-constitutive. COX 2-inducible NSAIDS- Nonselective COX inhibitors. COXIBS - Selective COX inhibitors Aspirin- Irreversible inhibition of COX Other NSAIDS- Reversible inhibition
    • 9. ACTIONSInflammation Most important mediators.. Synthesised as per need. NSAIDS
    • 10. ACTIONS –SMOOTH MUSCLESBlood vessels Pg E2, Prostacycline - vasodilatation Thromboxane A2 – constriction
    • 11. Prostaglandins
    • 12. ACTIONS :SMOOTH MUSCLEBronchus PgE2 •BRONCHO DILATION PgI2 PgF2α •CONSTRICT TXA2 ION LT
    • 13. UTERUSBoth uterus &cervix Cervical Initiation ripening of Labour •PgE2 •PgE1 •PgF2
    • 14. ACTIONS GIT MUCUS HCO3- ACIDNatural ulcer protectants..NSAIDS..
    • 15.  GIT CrampsMotilit Secretio y n Diarrho ea
    • 16. RENALPgE2,Prostacyclin -protective.. PgE2,Pg I2 RENAL DIRECT ON VASODILATA TUBULES TION RBF DIURESIS NATRIURESIS
    • 17. COAGULATION TXA PLATEL AGGREGATIO ETS N 2 (-) ENDOTHELPgI2 IUM AGGREGATIO N
    • 18. . Pulmonary vessels- vasodilatation CNS- EYE-↓IOT Neurotransmit ter
    • 19. Clinical Application Female Reproductive Organ Male Reproductive System Inflammation & Immunity Gastrointestinal Tract Respiratory System Musculo skeletal Cardiovascular Glaucoma Kidney Cancer
    • 20. Preparations &Uses
    • 21. Prostagln PreparationPREPARATIONSdinPgE₁ Misoprostol , Alprostadil,Latanopros tPgE₂ Rioprostil , Enprostil DinoprostonePgF₂α Prostin15Methyl Carboprost / Prostodin
    • 22. USES1.ObstetricsTherapeutic abortion PgE1/MISOPRO STOLCervical ripening PgE₁/PgE2Severe Post partum hge 15METHYL PgF2 im/PgE1 Rectal
    • 23. 2.Peptic ulcer PgE1/Misoprostol PgE2/Enprostil,Rioprostil,Arbaprostil3.Glaucoma : PgE1 / Latanoprost4-PDA PgE1/Alprostadil5-Primary pulmonary hypertention : PgI ₂
    • 24. SUMMARY OF USESUse PreparationAbortion PgE1Cervical PgE1 / E2ripeningPeptic ulcer PgE1Glaucoma PgE1- LatanoprostPPH PgI2
    • 25. ADRVomiting,Diarrhoea,Abdo minal crampsUterine crampsBronchospasm
    • 26. LEUKOTRIENES
    • 27. PHOSPHOLIPIDS ARACHIDONIC ACIDCYCLOOXYGE LIPOOXYGEN NASE ASE Zileuton LEUKOTRI ENES LEUKOTRIE Monteleuk NEPROSTAGLANDINS astZafirleu RECEPTOR kast Chromoglyc MAS ate T Nedochromi CEL l L