Polysaccharides

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Polysaccharides

  1. 1. Carbohydrates: oligo- and polysaccharides
  2. 2. Glycosidic Linkage
  3. 3. Disaccharides maltose (a-D-glucosyl-(1->4)-b-D-glucopyranose)
  4. 4. cellobiose (b-D-glucosyl-(1->4)-b-D-glucopyranose)
  5. 5. Lactose (b-D-galactosyl-(1->4)-b-D-glucopyranose)
  6. 6. sucrose (a-D-glucosyl-(1->2)-b-D-fructofuranose)
  7. 7. Higher Oligosaccharides
  8. 8. Oligosaccharide groups are incorporated in to many drug structures
  9. 9. Polysaccharides
  10. 10. Amylose and Amylopectin
  11. 11. Iodine binding to starch
  12. 12. glycogen
  13. 13. Dextrans
  14. 14. Cellulose
  15. 15. Cellulose vs Amylose Amylose Cellulose Glucose units rotated 180o relative to next residue
  16. 16. Cellulose
  17. 17. Chitin
  18. 18. Chitin vs Cellulose
  19. 19. Glycoproteins
  20. 20. O-linked Glycoproteins
  21. 21. Blood ABO Antigens • Structure of the ABO blood group carbohydrates, R represents the linkage to protein in the secreted forms, sphingolipid in the cell-surface bound form • open square = GlcNAc, open diamond = galactose, filled square = fucose, filled diamond = GalNAc, filled diamond = sialic acid (NANA)
  22. 22. N-linked Glycoproteins

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