Citric acid cycle

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Citric acid cycle

  1. 1. Citric Acid Cycle
  2. 2. Gylcolysis Electron Transport and Oxidative phosphorylation TCA Cycle
  3. 3. Entry into the TCA Cycle
  4. 4.  Only step in TCA cycle that involves the formation of a C-C bond
  5. 5. Isocitrate Dehydrogenase
  6. 6.  -Ketoglutarate Dehydrogenase
  7. 7. Succinyl-CoA Synthetase
  8. 8. Fumarase
  9. 9. Malate Dehydrogenase
  10. 10.  Acetyl-CoA + 3 NAD+ + Q + GDP + Pi +2 H20  HSCoA + 3NADH + QH2 + GTP + 2 CO2 + 2 H+  Isocitrate Dehydrogenase 1 NADH=2.5 ATP  a-ketoglutarate dehydrogenase ATP 1 NADH=2.5  Succinyl-CoA synthetase 1 GTP=1 ATP  Sunccinate dehydrogenase  Malate Dehydrogenase ATP  Total of 10 ATPs gained from oxidation of 1 Acetyl-CoA 1 QH2=1.5 ATP 1 NADH=2.5
  11. 11. Regulation of TCA Cycle
  12. 12. Protein/amino acid Catabolites feed Into the TCA Cycle
  13. 13. Fats breakdown and feed into the TCA Cycle
  14. 14. TCA Cycle provides intermediates for many biosynthetic processes
  15. 15. The "filling up" reactions • PEP carboxylase - converts PEP to oxaloacetate • Pyruvate carboxylase - converts pyruvate to oxaloacetate • Malic enzyme converts pyruvate into malate
  16. 16. Following the carbons through the TCA cycle

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