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Citric acid cycle
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Citric acid cycle

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Citric acid cycle Citric acid cycle Presentation Transcript

  • Citric Acid Cycle
  • Gylcolysis Electron Transport and Oxidative phosphorylation TCA Cycle
  • Entry into the TCA Cycle
  •  Only step in TCA cycle that involves the formation of a C-C bond
  • Isocitrate Dehydrogenase
  •  -Ketoglutarate Dehydrogenase
  • Succinyl-CoA Synthetase
  • Fumarase
  • Malate Dehydrogenase
  •  Acetyl-CoA + 3 NAD+ + Q + GDP + Pi +2 H20  HSCoA + 3NADH + QH2 + GTP + 2 CO2 + 2 H+  Isocitrate Dehydrogenase 1 NADH=2.5 ATP  a-ketoglutarate dehydrogenase ATP 1 NADH=2.5  Succinyl-CoA synthetase 1 GTP=1 ATP  Sunccinate dehydrogenase  Malate Dehydrogenase ATP  Total of 10 ATPs gained from oxidation of 1 Acetyl-CoA 1 QH2=1.5 ATP 1 NADH=2.5
  • Regulation of TCA Cycle
  • Protein/amino acid Catabolites feed Into the TCA Cycle
  • Fats breakdown and feed into the TCA Cycle
  • TCA Cycle provides intermediates for many biosynthetic processes
  • The "filling up" reactions • PEP carboxylase - converts PEP to oxaloacetate • Pyruvate carboxylase - converts pyruvate to oxaloacetate • Malic enzyme converts pyruvate into malate
  • Following the carbons through the TCA cycle