Beta oxidation
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Beta oxidation

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    Beta oxidation Beta oxidation Presentation Transcript

    • Fatty acid Catabolism (b-oxidation)
    • Import of acyl-CoA into mitochondria
    • b-oxidation
    • b-oxidation • B-oxidation of palmitate (C16:0) yields 106 molecules of ATP • C 16:0-CoA + 7 FAD + 7 NAD+ + 7 H20 + 7 CoA  8 acetyl-CoA + 7 FADH2 + 7 NADH + 7 H+
    • 2.5 ATPs per NADH = 17.5 1.5 ATPs per FADH2 = 10.5 10 ATPs per acetyl-CoA = 80 Total = 108 ATPs • 2 ATP equivalents (ATP AMP + PPi, PPi  2 Pi) consumed during activation of palmitate to acylCoA • Net yield = 106 ATPs
    • Acyl-CoA Dehydrogenase
    • X
    • b-oxidation of odd chain fatty acids
    • b-oxidation of unsaturated fatty acids
    • b-oxidation of fatty acids with even numbered double bonds
    • Formation of ketone bodies
    • Re-utilization of ketone bodies