Beta oxidation

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Beta oxidation

  1. 1. Fatty acid Catabolism (b-oxidation)
  2. 2. Import of acyl-CoA into mitochondria
  3. 3. b-oxidation
  4. 4. b-oxidation • B-oxidation of palmitate (C16:0) yields 106 molecules of ATP • C 16:0-CoA + 7 FAD + 7 NAD+ + 7 H20 + 7 CoA  8 acetyl-CoA + 7 FADH2 + 7 NADH + 7 H+
  5. 5. 2.5 ATPs per NADH = 17.5 1.5 ATPs per FADH2 = 10.5 10 ATPs per acetyl-CoA = 80 Total = 108 ATPs • 2 ATP equivalents (ATP AMP + PPi, PPi  2 Pi) consumed during activation of palmitate to acylCoA • Net yield = 106 ATPs
  6. 6. Acyl-CoA Dehydrogenase
  7. 7. X
  8. 8. b-oxidation of odd chain fatty acids
  9. 9. b-oxidation of unsaturated fatty acids
  10. 10. b-oxidation of fatty acids with even numbered double bonds
  11. 11. Formation of ketone bodies
  12. 12. Re-utilization of ketone bodies
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