CholelithiasisPresence of stones in thegallbladder is referred to as cholelithiasis(from the Greekchol- (bile) +lith- (stone) +iasis- (process).
CHOLELITHIASIS (GALLSTONES)Epidemiology• Gallstones afflict 10% to 20% of adultpopulations in developed countries.• It is estimated that more than 20 million personsin the United States have gallstones, totaling some25 to 50 tons in weight!Over 95% of biliary tract disease isattributable tocholelithiasis (gallstones).
TYPES OF GALLSTONES1.Cholesterol stones20%2.Pigment stones5%3.Mixed stones75%
The risk factors mostcommonly associated with the development ofcholesterol stones are:1. Age and Sex.2. Environmental Factors.3. Acquired Disorders.4. Hereditary Factors.
Cholesterol gallstone formation involves foursimultaneous conditions:(1) The bile must be supersaturated withcholesterol;(2) hypomotility of the gallbladder promotesnucleation;(3) cholesterol nucleation in the bile isaccelerated;(4) hypersecretion of mucus in the gallbladdertraps the nucleated crystals, leading to theiraggregation into stones.Accretion within the gallbladder mucous layer.
The four contributing factors for cholelithiasis: supersaturation, gallbladderhypomotility, crystal nucleation, and accretion within the gallbladder mucous layer.Amicelleis anaggregate ofsurfactantmoleculesdispersed inaliquidcolloid12 34