Prolactin

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Prolactin

  1. 1. HAPPY NEW YEAR 2014
  2. 2. PROLACTIN Dr. Laxmikanta Say
  3. 3. General Characteristics Synonym – Lactogenic or Mamotrophic hormone  Synthesis – Acidophilic cells of Ant. Pituitary. Polypeptide – 198 amino acids  MW – 25,000  Half Life – 20 Min.  Normal Serum Level  - Female – 6-50 ng/ml plasma - Male – 6-25 ng/ml plasma
  4. 4. CONTROL OF SECRETION INCREASED SECRETION  Sleep  Exercise & stresses  Pregnancy - 250 ng/ml  Nursing & breast stimulation  Primary hypothyroidism  Dopamine antagonist  Secretion of pituitary stalk DECREASED SECRETION  PIF  Dopamine  Dopamine agonists  Serotonin antagonist
  5. 5. ACTIONS OF PROLACTIN  During Pregnancy - milk production  Immediately following Pregnancy - stimulates galactosyltransferase activity - low FSH & LH - antireproductive & antigonadal - Lactational Amenorrhoea.
  6. 6. LACTATIONAL AMENORRHOEA Stoppage of menstrual periods  Temporary sterility  Inhibitory actions of Prolactin on Gonadotrophins – FSH & LH  Duration  Women who don not nurse – 6 weeks  Women who nurse regularly  – 25-30 weeks (6 months)
  7. 7. HYPERPROLACTINEMIA  Decreased FSH & LH  Elevated Serum Prolactin Females - Galactorrhoea, infertility & amenorrhoea.  Chiari-Frommel Syndrome – Persistence of lactation  & amenorrhoea  Males – Hypogonadism - Decreased spermatogenesis - Loss of Libido - Impotence

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