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Glucocorticoid

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  • 1. ANATOMY CUT SECTION HISTOLOGY
  • 2. Blood supply of adrenal gland IPA SSRA MSRA A O RT A ISRA RA
  • 3. CLASSIFICATION OF STEROID HORMONES
  • 4. CLASSIFICATION OF STEROID HORMONES
  • 5. STEROID HORMONES
  • 6. SYNTHESIS
  • 7. SYNTHESIS OF GLUCOCORTICOID CHOLESTEROL Cholesterol Desmolase PREGNENOLONE 17α Hydroxylase 3β HSD PROGESTERONE 21β Hydroxylase 11-DEOXY CORTICOSTERONE 11β Hydroxylase CORTICOSTERONE 17α Hydroxylase 17 HYDROXY PREGNENOLONE 3β HSD 17 HYDROXY PROGESTERONE 21β Hydroxylase 11 DEOXY CORTISOL 11β Hydroxylase CORTISOL
  • 8. Summary of synthesis
  • 9. SECRETION Hormone Synonym Avg plasma concentration (μg/dl) Avg amount secreted (mg/24hr) Cortisol Compound F Hydrocortisone 13.5 10 Corticosterone Compound B 0.4 3
  • 10. TRANSPORTATION ACTH
  • 11. Metabolism and Excretion
  • 12. CONTROL OF SECRETION
  • 13. CONTROL OF SECRETION
  • 14. DIURNAL VARIATION
  • 15. MECHANISM OF ACTION 1.Genomic action 2.Non genomic action
  • 16. ACTION PHYSIOLOGICAL 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. Carbohydrate metabolism Protein metabolism Fat metabolism Permissive action ACTH secretion Vascular reactivity Nervous system Water metabolism Blood cells and lymphatic organ Resistance to stress Bone GIT Others PHARMACOLOGICAL  Anti inflammatory and antiallergic