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Pattern Of Cancer In Adolescent And Young Adults In INDIA: With A Note On Bone Cancer Doctor Kalyani MDM.D.(Path), FICP, FIAMS, MNAMS. Professor of Pathology Sri Devaraj Urs Medical College Sri Devaraj Urs Academy Of Higher Education And Research (Deemed to be university) Kolar. Karnataka. India. Dr.Kalyani R. MD 1
Dr.Kalyani R. MD The following is the talk presented at an International conference organized by EPS Global Medical Development form on 18th April 2011 at Yangzhou, China 2
The Present Study is Undertaken at Sri R.L Jalappa Hospital and Research Institute Kolar INDIA Dr.Kalyani R. MD 3
The Present Study is Supported with a Mission… Mission of Sri Devaraj Urs Medical college shall strive to be an Institution of excellence in the field of Medical Education with continued improvement of systems and process. To serve the poor in and around Kolar India… Dr.Kalyani R. MD 4
These cancer are more likely related to genetic predisposition and specific health behavior & life style among young people exposing themselves to new causative agent before the old do and also the short period of exposure between the beginning of life and cancer diagnosis.
The shift of non-epithelial cancers in children to epithelial cancers in older adults occurs through several years in AYA age group.
Introduction Dr.Kalyani R. MD 8
Epidemiology helps to track Hence Epidemiological study helps to know the incidence, age / gender / site distribution & the probable risk factors responsible for cancer. Dr.Kalyani R. MD 9
Delay in diagnosis especially of bone & brain cancers in which professional delay is always longer than patient symptoms delayed
Poor outcome is because of mix of tumor types seen in this age group, having different biology of cancer, high risk prognostic cytogenetic features, more resistant form of cancer, low clinical trial participation and treatment not yet fully adopted to the tumor biology and is not tailored for cancers of AYA 8.
In our study no follow-up of cases was done to comment on prognosis.
Trends and pattern of cancers in AYA define risk factors.
In the present study incidence is high (26.6%) with female preponderance (in all age groups).
Predominance of epithelial cancers than non-epithelial cancers was seen in both gender at early age compared to other studies which can be correlated to lifestyle & dietary habits of the people.
This study provide leads for further etiological research and identify cancers that have the greatest impact in these age groups.
This epidemiologic study helps to take-up cancer preventive measures and screening programmes in early detection of cancer.
Dr.Kalyani R. MD 34
References Nanda Kumar A, Gupta PC, Gangadhar P, Visweshwara R.N. Development of an atlas of cancer in India : First all India Report : 2001-2002. National Cancer Registery programme (ICMR), Bangalore, India. 2004. Cancer in adolescents & young adults, Department of health sciences, California. Yalukder MH, Jabeen S, Shaheen S, Islam MJ, Haque M. Pattern of cancers in young adults at National Institute of Cancer research and hospital (NICRH), Bangladesh. Mymensingh Med J, 2007 ; 16 (2) : 528-33. Cancer incidence in young adults special topic from Canadian cancer statistics 2002. More young adults being diagnosed with cancer – First Canadian research in this area Canadian cancer statics 2002 by Canadian cancer society. Xiachengwu Wu, Frank D Groves, Collenc Mclanghlin et al. Cancer incidence patterns among adolescents and young adults in the united states. Cancer causes and control 2005 ; 16 : 309 -320. Archie Blefer, Aaron Viny, Ronald Barr, Cancer in 15 to 29 years olds by primary site. The oncologist 2006 ; 11 (6) : 590 – 601. Conrad V Fernandez, Ronald D Barr. Adolescents and young adults with cancer : An orphane. Paediatric Child Health 2006 ; 11 (2) 103 – 106. Ramandeep s, Robert D Alston, Tim OB Eden, et al. Cancer at ages 15-29 years: The contrasting incidence in India and England. Pediate Blood Cancer @ 2010 Wiley-Liss.Inc. Dr.Kalyani R. MD 35
ACKNOWLEDGMENT I thank Honorable Vice-Chancellor Prof. S. Chandrasekhar Shetty, Sri Devaraj Urs Academy Of Higher Education And Research (Deemed to be university) for the constant encouragement. I thank Dr. M. L. Harendra Kumar, Prof & HOD, Dept. of Pathology, Dr. Subhahish Das, co-author, my colleague staffs and technical staffs for constant support. I thank Dr. T. V. Rao, Prof of Microbiology for formatting this presentation. This work is published in Asian Pacific Journal of cancer Prevention 2010;11:655-659. Dr.Kalyani R. MD 36