How do drugs work?
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How do drugs work?

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Science Week 2013 Activity

Science Week 2013 Activity
Centre Cultural de Martorell
Integrated Plan for Foreign Languages
Institut Pompeu Fabra

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How do drugs work? How do drugs work? Presentation Transcript

  • How do drugs work? Dr. Francisco Pérez García Departament de Farmacologia
  • Donat el caràcter i la finalitat exclusivament docent i eminentment il·lustrativa de les explicacions a classe d'aquesta presentació, l’autor s’acull a l’article 32 de la Llei de Propietat Intel·lectual vigent respecte de l'ús parcial d'obres alienes com ara imatges, gràfics o altre material contingudes en les diferents diapositives
  • The term pharmacology comes from the Greek words: •pharmakon - drug or medicine •logos - the truth about or a rational discussion
  • A synthesis of several biomedical sciences…. Pharmacology …but unique in its own right
  • Pharmacologists Study Science at Every Level
  • (2α,4α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-13-{[(2R,3S)- 3-(benzoylamino)2-hydroxy-3-phenylpropanoyl]oxy}- 1,7-dihydroxy-9-oxo-5,20-epoxytax11-en-2-yl benzoate = TAXOL A LITTLE BIT OF CHEMISTRY AND A LITTLE BIT OF BOTANY
  • FROM AMINOACIDS TO PROTEIN DRUG RECEPTORS
  • RELATIONSHIP BETWEEN PROTEIN STRUCTURE AND FUNCTION Function relies on interactions with other molecules Binding of molecules to proteins is reversible LOCK AND KEY THEORY Ligand = molecule bound reversibly by a protein Binding site = site on protein where ligand binds HIV protease + drug inhibitor
  • Kd = Kon/Koff = [D][R]/[DR] Ka = 1/Kd = Koff/Kon = [DR]/[D][R]
  • Induced fit model vs lock and key model
  • ACKNOWLEGMENTS The project «Contemporary Sciences and Research» (2012-2014) belongs to the Integrated Plan for Foreign Languages of Departament Of Education, Government of Catalonia More info at www.formaciovirtual.com/cs and www.tecnologies.net 52