MDs are their best guinea pigs… “Do unto yourself before doing unto others” 16th century – Santorio Santorio (Padua, Italy) weighed himself (and his food and drink) daily for 30 years, identifying ‘insensible perspiration’ 1929 – Dr. Werner Fossmannn inserted a thin tube into a vein in his arm and slid it into his heart (shared 1956 Nobel prize)-inspires modern era of cardiology) 1939 - Gerhard Domagk (1939 Nobel prize) discovers sulfa drugs and later injects himself with sterilized extracts of human cancers in search of cancer vaccines Lawrence K Altman, MD, Who Goes First? The Story of Self-Experimentation in Medicine. NY Times article, 2006. Myth dispelled: after pledging to be a guinea pig researching the mosquito/yellow fever connection, Walter Reed reniged. One team member died another barely survived.