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NuSomnea: Urinary biomarker for diagnosis of pediatric sleep apnea

by on Feb 08, 2013

  • 399 views

Revolutionary diagnosis & management of OSA while eliminating the need for overnight sleep tests.Uromarker™ test assays urinary peptide biomarkers in first morning void, providing comparable or ...

Revolutionary diagnosis & management of OSA while eliminating the need for overnight sleep tests.Uromarker™ test assays urinary peptide biomarkers in first morning void, providing comparable or greater accuracy than PSG.Prospective, controlled trial demonstrated 100% sensitivity & 96.5% specificity for OSA diagnosis.Significant advantages over PSG make it ideal disease management tool to monitor therapy effectiveness (via recurring tests) & improve outcomes.Solves problems for diagnosis of burgeoning pediatric OSA.NuSomnea co-founder is CLIA-certified lab, providing rapid refinement, validation and commercialization of test.US & PCT patents protect methods and kits, including certain proteomic biomarkers, for diagnosing OSA.
Significant prevalence of OSA in US children – 3% (~2.3 million)Obstructive sleep apnea in children is associated with Serious neurocognitive and cardiovascular morbidity
Systemic inflammation Increased health care useOSA is hard to differentiate from snoring without PSGPrimary snoring affects between 20%-30% of children
Significant diagnostic challenges:Expensive to test all snorers,Physician exam only 30-50% accurate,PSG is particularly difficult to successfully execute in children - not reliable or accurate ,Cost for pediatric PSG higher than adult, yet reimbursed reimbursement rate is the same ,Cost of misdiagnosis is also high,Home sleep tests not approved for children
OSA masked as ADHD
ADHD affects 7% of children; 50% of those have undiagnosed OSA¹
Behavioral problems & hyperactivity can be caused by sleep fragmentation or deprivation in children with OSA
Increased ADHD diagnosis has resulted in overuse of stimulant drugs
Treatment of OSA can resolve symptoms
Tonsillectomy and adenoidectomy not always successful
Increasing numbers of children have residual sleep apnea despite this T&A surgery.²
Increase in pediatric obesity translates into increase OSA
Obese children are increasingly recognized as a high-risk group for the presence of sleep-disordered breathing and for peri-operative complications. ³
In 2008, more than one third of children and adolescents were overweight or obese.⁴

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NuSomnea: Urinary biomarker for diagnosis of pediatric sleep apnea NuSomnea: Urinary biomarker for diagnosis of pediatric sleep apnea Presentation Transcript