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General Anaesthetics - drdhriti

General Anaesthetics - drdhriti



A Power point presentation on General anaesthetics suitable for UG MBBS level students

A Power point presentation on General anaesthetics suitable for UG MBBS level students



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  • KWI- essence.
  • LOW solubility in blood= fast induction and recovery HIGH solubility in blood= slower induction and recovery.
  • Lower anesthetic solubility  in blood results in the "blood" compartment becoming saturated with the drug following fewer gas molecules transferred from the lungs into the blood.   Once the "blood" compartment is saturated with anesthetic, additional anesthetic molecules are readily transferred to other compartments, the most important one of which is the brain.
  • Imagine two cups of warm water: into one you put a spoon of sugar and into the other a spoon of sand. Which will be in higher concentration in the bottom of the cup? The sand is insoluble, the sugar dissolves, so very little reaches the bottom. For bottom of cup read brain. The blood:gas partition coefficient is the ratio of the concentrations of anesthetic gas in the blood and gas phases at equilibrium. In general, the blood:gas partition coefficient represents the capacity of the blood or a specific tissue to absorb the anesthetic. A higher blood:gas partition coefficient (e.g., 2.0 equals a 2% blood concentration and a 1% lung concentration at equilibrium) shows greater affinity for the blood. An anesthetic that has a blood concentration of 3% and a lung concentration of 6% at equilibrium would have a partition coefficient of 0.5, showing a greater affinity for the gas phase. The blood/gas partition coefficient describes how the gas will partition itself between the two phases after equilibrium has been reached. Isoflurane for example has a blood/gas partition coefficient of 1.4. This means that if the gas is in equilibrium the concentration in blood will be 1.4 times higher than the concentration in the alveoli. A higher blood gas partition coefficient means a higher uptake of the gas into the blood and therefore a slower induction time. It takes longer until the equilibrium with the brain partial pressure of the gas is reached Agents with low blood solubility require few molecules to dissolve into the blood to raise the partial pressure to equilibrium.
  • This agent was used previously, but not now. It is faster acting substitute of Halothane. The features include -
  • These drugs are used as inducing agents and given via iv route. Produces loss of consciousness in one arm-brain circulation time (11 secs). These are not used for maintenance for the reasons – 1. Administration of multiple doses by i.v. injection or a continuous i.v. infusion can result in drug accumulation and delays in recovery from anesthesia. 2. The higher cost of i.v. therapy compared with the cost of inhaled therapy also is a consideration. 3. The lack of a means for continuously measuring the depth of anesthesia the most important reason for avoiding the use of i.v. anesthetics for anesthesia maintenance.

General Anaesthetics - drdhriti General Anaesthetics - drdhriti Presentation Transcript