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Clearsprings summit june 2010

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3 Hour lecture given to a group at Clearsprings Health Center on the science behind detoxification. This covers many of the physiological mechanisms of toxicokinetics via connective tissue …

3 Hour lecture given to a group at Clearsprings Health Center on the science behind detoxification. This covers many of the physiological mechanisms of toxicokinetics via connective tissue structures.

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  • 1. Toxico-Dynamics: Connection to Modern Health Dr. Michael Broeg www.clearspringshealth.com Dr. Andrew Bonci www.drbonci.com © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 2. “To gain knowledge, add something each day. To gain wisdom, remove something each day.” ~ Lao Tzu ~ © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 3. By removing bodily toxins, The Broeg Detox Method restores the body to its original wisdom. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 4. A Prolific Problem  Over the last 100 years, biological systems years have been exposed to toxicological agents at an alarming rate. rate  These toxicological agents are numerous and diverse. diverse  These toxicological agents carry teratogenic and mutagenic potential.  These exposures stress our bodies' abilities to maintain homeostasis. homeostasis © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 5. Synthetic Chemical Production in the United States © 2009 Dr. Michael Broeg. All Rights Reserved. Paukla-Baille Hamilton, M.D.,PhD. Toxic Overload, p.17
  • 6. The Broeg Thesis  Connective Tissue structures connect the outer limits of the body to the inner limits of the human genome.  They act as:  Biological Filters  Biological Semiconductors © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 7. The Broeg Thesis  Consumption of and exposure to toxicants will:  “clog” the filters  “distort” the semiconductors  This will alter the body's perception of itself and its environment. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 8. Homeostatic Distress  While connective tissues remain under toxic bombardment, bombardment the organism is under homeostatic distress.  Homeostasis is maintained, but at great metabolic and physiological costs to the organism. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 9. Homeostatic Breakdown  After years of toxic insult and its metabolic costs to maintain homeostasis, the homeostasis organism begins to lose physiologic ground and the organism manifests disease. disease © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 10. Biomagnification ● Biomagnification is the bioaccumulation of a substance up the food chain by transfer of residues of the substance in smaller organisms that are food for larger organisms in the chain. http://toxics.usgs.gov/definitions/biomagnification.html © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 11. “Indeed, we are all so contaminated that if we were cannibals our meat would be banned from human consumption.” consumption Paula Baillie-Hamilton, MD Oxford-educated Physician Leading Expert on Toxins in Food © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 12. Connective Tissue  Connective tissues encompass the major structural constituents of the body.  Traditionally, they function in support, support defense, transport, defense transport storage, and repair. storage repair • The hallmark of connective tissue: matrix & ground substance Gartner and Hiatt. Color Atlas of Histology 5th ed. pp. 51-56 © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 13. Feeling the Matrix • Matter • Mater • Madre • Mother • Womb © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 14. Basic Conceptualization • The connective tissue forms the basic framework onto which every structure and function of the body is contextualized. contextualized • The term we use for this is “matrix”. matrix © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 15. Connective Tissue • Connective tissues function in slowing down the flow of extracellular fluid and resisting compression, thus permitting more time for the exchange of materials by the cells and retarding the spread of toxic materials. Gartner and Hiatt. Color Atlas of Histology 5th ed. pp. 51-56 © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 16. Defining Cellular Components  Fibroblasts  Macrophages  Mast Cells Gartner and Hiatt. Color Atlas of Histology 5th ed. pp. 51-56 © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 17. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 18. “Communication” Tissue  Connective tissues are increasingly being viewed as sources of piezoelectric impulses and as semiconductors in a vast “communications” communications network . © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 19. Semiconductor Pathophysiology  A damaged or otherwise debris filled or intoxicated matrix will alter normal semiconductor physiology. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 20. TOXICOKINETICS © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 21. Nuclear Matrix Compartment Intracellular Mat rix Compartment Extr acellular Matrix Compartmen t © 2009, 2010 Dr. Michael Broeg. All Right Reserved. Vascular Matrix Com partment Physico-Anatomical Compartments
  • 22. Toxicant Load  Toxicants require transport proteins and other intermediary binding proteins for solubility.  They must compete for these transport and binding proteins with other biological agents such as:  Hormones  Lipids  Ions  Medications © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 23. Toxicant Load  A toxicant may exert its toxic load by either:  Displacing Biologically Active Agents from Transport and Binding Proteins.  Being Displaced from Transport and Binding Proteins by other Biologically Active Agents. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 24. Movement Through Compartments  Toxicants, like other biological agents, effectively leap-frog from compartment to compartment by grabbing and releasing protein matrix structures until dynamic equilibrium is established. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 25. Vascular Matrix © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 26. Extracellular matrix © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 27. Intracellular Matrix © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 28. Nuclear Matrix © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 29. Nuclear Matrix Proteins  There is an intricate network of non-nucleotide fibers that act as a scaffolding for chromatin.  This nuclear protein scaffold forms what is called the nuclear matrix. matrix  These and other epigenetic mechanisms are toxicant targets. targets Genome Biol. 2008 Jan 22;9(1):201. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 30. Loop Domains  NMP or Matrix Attachment Regions (MARs) organize chromatin strands into Loop Domains.  Loop Domains are regions of DNA code that are active. active  Other regions of non- looped DNA code Hum Mol Genet. 2009 Feb 15;18(4):645-54. are dormant sequences. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 31. Nuclear Protein Matrix Damage  Toxic insult and damage to NMP, S/MARs results in loss of epigenetically prescribed loop domains.  Loss of loop domains alters the “differentiated” cell characteristics seen in normal cells. Handb Exp Pharmacol. 2008;(186):67-103. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 32. Matrix as a Garbage Filter © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 33. Blocked Filter The alterations seen throughout the ECM and other matrix systems effectively act to slow the flow of nutrient delivery to parenchymal cells while blocking the outflow of toxic products. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 34. Macrophage Response  Macrophages respond to xenobiotic substances in the ECM with the release of Cytokines and Reactive Oxygen Species such as:  Superoxides  Singlet oxygens  Peroxides Methods Mol Biol. 2010;598:75-94. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 35. Alteration to Ground Substance  The internal milieu becomes filled with a variety of matrix altering substances which include:  Biotransformed xenobiotic substances  Oxidized matrix proteins and GAGs  Cellular debris  Proinflammatory cytokines © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 36. Compartmental Nutrient Depletion  During Compartmental Dysregulation, nutrients are reallocated across compartmental barriers in an effort to maintain homeostasis. homeostasis  This occurs in an effort to detoxify and repair damage.  There is an increased need for:  Inorganic Cofactors  Organic Coenzymes  Exogenous Antioxidants © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 37. High Nutritional Demand  Compartmental Dysregulation and attempts to detoxify and normalize compartmental function places a high demand on nutritional resources.  As metabolic demand rises, so does the compartmental demand for micronutrients.  Remember, vitamins and minerals activate enzyme systems. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 38. Compartmental Nutrient Depletion  As nutrient resources are strained in any given matrix compartment, nutrients are siphoned from surrounding compartments.  This leads to partial metabolism of xenobiotics and the build-up of many precursor metabolites. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 39. Consequences  Connective tissues become:  Burdened with Toxins  Damaged and Dysregulated  Nutrient Depleted © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 40. Adding Insult to Injury  In an attempt to “do the right thing” by many well intentioned individuals and health practitioners prescribe synthetic vitamins, devitalized “foods” and fasting regimes. regimes  The fractionated vitamins and devitalized foods only serve to magnify compartmental nutrient deficiencies with the further build up of toxins.  Fasting fails to provide the necessary nutrients that drive the enzyme systems for optimal detoxification, repair, and rebuilding of tissues. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 41.  The Broeg Detox Method follows a simple formula of:  Tissue Matrix Cleansing  Repairing Damaged Tissues  Restoring Functional Balance  Regaining Vitality and Clarity © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 42. Importance of Detoxification  The fact is that tough diseases cannot heal until the body has unloaded its burden of stockpiled, disease- causing chemicals. chemicals Sherry Rogers, MD. Detoxify or Die. 2002. p. 179. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 43. Tissue Matrix Cleansing  Cleansing the tissue matrix compartments of pharmaceuticals, toxicants and other bioaccumulated xenobiotics is the first step toward health. health  Cleansing requires:  Elimination of novel toxic insult  Extraction of old toxicants © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 44. Unload Xenobiotic Debris  The first and perhaps most important step in detoxification is to abandon ALL toxic insult. insult © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 45. Eliminating Novel Toxic Insult Participants will A partial list follows: systematically  OTC Medications eliminate the  Illicit Drugs addition of novel toxicants that would  Devitalized Foods delay the outflow of  Processed Foods old xenobiotics that have  Plastics accumulated over  Smoking time.  Alcohol © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 46. Outflow of Old Xenobiotics  As toxicants are no longer being pushed into the system and toward the nucleus, they will begin to flow away from the nuclear compartment and towards the organs of excretion. excretion J Toxicol Environ Health A. 2009;72(2):88-93. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 47. Extraction of Old Toxicants  The outer compartments reduce their burden of toxicants first, by first moving their toxicants through the organs of elimination: elimination  Skin  Liver and Kidney  Lungs and Colon © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 48. Extraction of Old Toxicants  Inner compartments, by the process of diffusion, pass their diffusion toxicants to the more superficial compartments and ultimately through the organs of elimination. elimination © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 49. Xenobiotic Extraction Extensive clinical experience has demonstrated that xenobiotic compounds can be withdrawn from the matrix compartments by enhancing perfusion. Perfusion is enhanced by the following:  Dry sauna diaphoresis  Niacin induced vasodilation © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 50. Dry Sauna Diaphoresis  Dry heat sauna enhances the detoxification experience through the  Q10 Temperature Effect  Formation of Heat Shock Proteins  Tissue Toxicant Mobilization © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 51. Q10 (Temperature Coefficient)  Increasing the heat energy of xenobiotics enhances their kinetic energy. energy  This loosens them R is the rate from their T is the temperature in Celsius compartmental matrix degrees or kelvins. components. J Physiol. 2007 Nov 15;585(Pt 1):263-77. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 52. Role of Sauna Induced HSPs  Dry sauna induced HSPs serve two roles during tissue detoxification:  Parenchymal tissue conservation  Immune mediated matrix purification © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 53. Tissue Toxicant Mobilization  The introduction of heat enhances the rate of tissue metabolism which mobilizes tissue embedded toxicants. toxicants Crit Care Med. 2009 Oct;37(10 Suppl):S384-90. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 54. Toxicant Transport  Once tissue embedded toxicants are loosened and mobilized from their matrix constraints, constraints they must be transported to the organs of excretion for removal. J Toxicol Environ Health A. 2009;72(2):88-93. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 55. Passing the Toxic Baton  During the detoxification process, toxicants are passed like a baton in a relay race from the deep nuclear compartment to the vascular compartment where it is carried to the detoxifying epithelium of the skin, lungs, kidneys and bowel. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 56. Enhancing Toxicant Transport  Toxicant removal is enhanced by opening up the irrigation channels and providing a clear, unobstructed path for elimination.  This is facilitated through the vasodilating effects of niacin. niacin Annu Rev Pharmacol Toxicol. 2008;48:79-106. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 57. The Broeg Detox Synergy The dry sauna produces a synergistic effect with the niacin that enhances xenobiotic removal from deep within the matrix compartments. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 58. Hepatic Xenobiosis  Many of the mobilized tissue toxicants are filtered through the liver where they undergo Phase I and II detoxification reactions. J Environ Sci Health B. 2009 Aug;44(6):553-63. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 59. Reversal of Symptoms and Signs  As toxicants are withdrawn from tissues, symptoms and signs of previous “illnesses” present themselves in what is often referred to as the “healing crisis” or “Hering's Law of Cure.” Constantine Hering. Materia Medica. 1888. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 60. Repairing Tissue Damage  Repairing tissue damage is another key component to the Broeg Method that is often overlooked by other programs. programs  We accomplish this with:  Whole food diet  Non-fractionated dietary supplements © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 61. Whole Food Diet  A whole food diet is imperative in the repair of the damaged connective tissues during the detoxification process.  The detoxification process is metabolically expensive. Curr Drug Metab. 2002 Oct;3(5):481-90. Expert Opin Drug Metab Toxicol. 2010 Jan 29. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 62. The Broeg Eating Plan ● Participants are encouraged to eat at a level lower on the food chain to avoid high concentrations of bioaccumulants. bioaccumulants © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 63. Fractionated Vitamins  Laboratory manufactured vitamins are incomplete sets of metabolic cofactors.  Fractionated vitamin consumption produces loss of optimal cofactor- enzyme ratios. Brian Clement. Supplements Exposed. 2010. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 64. “Three-hundred-thousand years of evolution trumps anything that scientists have created or can create in a laboratory.” Andrew S. Bonci, BA, DC © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 65. Restoring Functional Balance  The Broeg Detox Method fosters healthy neuroendocrine immune function.  This is accomplished with light phase exercises as a compliment to connective tissue drainage and repair. repair © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 66. Light Phase Exercise  Light phase exercise helps to re-establish the neurological integrity that is often distorted by synaptic toxicants. toxicants Hum Exp Toxicol. 2007 Apr;26(4):339-46. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 67. ECM Microstreaming  The rhythmic movements of exercise facilitate ground substance circulation and subsequent emptying of the ECM of xenobiotic build-up. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 68. The Spin Cycle  A detoxification program without the proper exercise initiative, is like washing your dirty clothes without the benefit of the spin cycle. cycle © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 69. Nornalized Semiconduction  With the rebuilt, restructured and normalized matrix structures, vicinal water can reestablish its liquid crystal structure and restore proper organism- wide, electrostatic communications. communications Pischinger. The Extracellular matrix and Ground Regulation. 2007. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 70. Health Restored  With a properly functioning matrix structure, efficient exchange of molecular precursors, removal of waste and global electrostatic communication, communication health is restored to the organism. © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 71. Regaining Mental Clarity  Detoxification is like wiping a mirror clean to better see one's own reflection.  Detoxification let's one see deeply into one's own being.  Detoxification lifts the veil of illusion and restores our natural state of clarity. clarity © 2009, 2010 Dr. Michael Broeg. All Right Reserved.
  • 72. Clearsprings Your Bridge to Wellness © 2009, 2010 Dr. Michael Broeg. All Right Reserved.