Chiropractic Mechanisms

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Chiropractic Mechanisms in everyday practice. PLEASE NOTE PHONE NUMBER IS NO LONGER VALID

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Chiropractic Mechanisms

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  106. 106. S ub lux a tio n: A M o d ifia b le D is-E a se R isk F a cto r C o p yr i g h t 1 9 9 9 D r . An d r e w S . B o n c i R is k F ac to r D e fin e d : F ac to rs in th e e n v iro n m e n t, o r c h e m ic al , p s yc h o lo g ic al, o r p h ys io lo g ic al, th at are th o u g h t to p re d is p o s e an in d iv id u al to th e d e v e lo p m e n t o f a d is e as e . S in c e s u b lu x atio n p re d is p o s e s an in d iv id u al to d is e as e , th e n it c an b e th o u g h t o f as a ris k fac to r fo r d is e as e . N e uro g e nic Infla m m a tio n: C a us e s infiltra tio n tha t drive s e nd-o rg a n tra ns fo rm a tio n thro u g h m a c ro pha g e a c tiva tio n. S ym pa the tic -L ym ph N o de D e ne rva tio n: C a us e s im m une dys re g ula tio n w ith s ys te m s w ide influe nc e s . R e m o vi n g t he s u b l uxati o n t hr o ug h c hi r o p r ac ti c ad ju s t m e n ts r e d u c e s th e p o t e n t i al fo r d i s - e as e . Th i s o c c u r s w h e n i n fl am m at o r y fl u i d s p r o d u c e d b y m e c h an i c al d i s t o r t i o n ar e fl u s h e d o u t o f th e i n t e r ve r t e b r al fo r am e n t h u s r e d u c i n g n e u r o g e n i c i n fl am m at i o n an d r e m o vi n g th e fo r c e s d r i vi n g l ym p h n o d e d e n e r vati o n . Th e r e fo r e , adju s ti n g s u b l u xati o n an d n o r m al i zi n g fu n c t i o n r e d u c e s t h e p o t e n ti al fo r d i s -e as e . P r im a r y Pr e ve ntion: Se c ond a r y Pr e ve ntion T e r tia r y Pr e ve ntion C o n c e r n e d w i t h p r e ve n t i n g In vo l ve s e ar l y d i ag n o s i s an d Is i m p o r t an t i n l i m i t i n g t h e th e d e ve l o pm e n t o f d i s e as e i n p r o m p t t h e r ap y t o s h o r t e n t h e d e g r e e o f d i s ab i l i t y an d a s u s c e p t i b l e o r p o t e n ti al l y d u r ati o n o f i l l n e s s , i t s s e ve r i t y p r o m o ti n g r e h ab i l i t ati o n i n s u s c e p ti b l e p o p ul at i o n . an d l i m i t i ts s e q u e l ae . c h r o n i c an d i r r e ve r s i bl e Ad ju s t i n g s u b l u xati o n s D e t e c t i n g an d ad ju s t i n g d i s e as e s . A d ju s t i n g p r e ve n t s t h e d e ve l o p m e n t o f s u b l uxati o n s r e m o ve s a p o t e n t s u b l u xat i o n h e l p s t o p r e ve n t d i s e as e . r i s k fac t o r fo r d i s e as e . p r o g r e s s i ve d i s ab i l i ti e s . © 1998, 1999 Dr. Andrew S. Bonci, All Rights Reserved. 11
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  122. 122. T he C hiro p ra ctic A d justm ent: T he B est P reventio n C o p yr i g h t 1 9 9 9 D r . Andr e w S. B o nc i V erteb ral S u b lu xa tio n P r im a r y Pr e ve ntion: c a us e s infla m m a to ry fluids to build up C o nc e r ne d w i th pr e ve nti n g a ro und the s pina l ne rve s . T his the de ve l o pm e nt o f di s e as e i n ins tig a te s pa tho phys io lo g ic a lte ra tio n a s us c e pti b l e o r p o te n ti al l y s us c e pti b l e po pul ati o n. s uc h a s ne uro g e nic infla m m a tio n a nd Adjus ti ng s ubl uxati o n s lym ph no de de ne rva tio n. S uc h p r e ve nts the de ve l o pm e nt o f c ha ng e s a lte r pro pe r bo dy d i s e as e . func tio ns w hic h e nha nc e s the lik e liho o d o f dis e a s e . Se c ond a r y P r e ve ntion In vo l ve s e ar l y di ag no s i s and pr o m pt the r ap y to s ho r te n the dur ati o n o f i l l ne s s , i ts s e ve r i ty and l i m i t i ts se q ue l ae . D e te c ti n g and ad jus ti ng s ubl uxati o ns r e m o ve s a po te nt A d ju stin g r i s k fac to r fo r di s e as e . a nd re m o ving s ubluxa tio ns flus he s o ut the infla m m o g e ns w hic h irrita te a nd a lte r s pina l ne rve func tio n. T his w ill T e r tia r y Pr e ve ntion a tte nua te ne uro g e nic infla m m a tio n Is i m po r tant i n l i m i ti ng the a nd a llo w fo r the re ne rva tio n o f lym ph d e g r e e o f d i s abi l i ty and no de s . O nc e this is a c c o m plis he d, p r o m o ti ng r e hab i l i tati o n i n no rm a l func tio n is re turne d a nd c h r o ni c and i r r e ve r s i bl e dis e a s e c a n be pre ve nte d. d i s e as e s . Adjus ti ng s ub l uxati o n he l ps to p r e ve nt p r o g r e s s i ve di abi l i ti e s . © 1998, 1999 Dr. Andrew S. Bonci, All Rights Reserved. 13
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  276. 276. 5 S teps of S u blu xation In flam m ation C o p yr i g h t 1 9 9 9 , D r . An d r e w S . B o n c i S te p 4 : Im m une Infiltra tio n S te p 1 : M e c ha nic a l D is to rtio n D i ve r g e n t s t r e s s e s ap p l i e d t o p e r i fo r am i n al s o ft ti s s u e s l i b e r at e s p r o i n fl am m ato r y l i p i d s . S te p 2 : B io c he m ic a l T ra nsduc tio n Im m u n e i n fi l t r at i o n m ag n i fi e s an d P L A2 c o n c e n tr ate s t h e i n fl am m ato r y s o u p w h i c h e xac e r b ate s th e affe c ts . In fl am m o g e n s h ave b e e n s h o w n to P G E2 p r o vo k e d e m ye l i n at i o n an d p o te n t i ati o n o f e p h ap ti c ac t i o n p o te n t i al s . L TB 4 S te p 5 : C yto k ine P ro duc tio n S te p 3 : A c tio n P o te ntia l F a c ilita tio n C yto k i n e i n fi l tr ate i s k n o w n t o p r o vo k e g e n e e xp r e s s i o n an d p r o fo u n d ti s s u e al t e r at i o n s . © 1998, 1999 Dr. Andrew S. Bonci, All Rights Reserved. 28
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  292. 292. Biochem ical T ransduction of Mechanical Mem brane Stresses © 1998 Dr. Andre w S. Bonci #1: M e chanical she ar force s distort the fluid mosaic of the phospholipid bilaye r PL A2 /C a+ + #2: The me chanically distorte d me mbrane allows calcium ions to e nte r the ce ll's inte rior whe re it activ ate s e nzyme s. The se activ ate d e nzyme s initiate the arachidonic acid cascade with the ultimate production of prostaglandins and le ukotrie ne s, Arachidonic Acid s e 5-L na ip o e xy yg ge lo ox na c se Cy A lg Prostaglandins og n Leukotrienes en ic A u c t io ge In d nt une Im m Neurogenic Inflammation
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  317. 317. T h e In fla m m a to ry -F a cilita tin g L esio n © 1 9 9 8 , D r. A nd re w S . B o nci PGE2 S ens ory-E ffector R es p ons e: An ti dr o m i c r e l e as e o f Substan c e -P an d C al c i to n i n G e n e -R e l ate d P e p ti d e dr i ve s N e u r o g e n i c In fl am m ati o n In te rv e rte b ral F o ram e n M otor R es p on s e: L o w e r e d thr e s h o l d o n s o m ati c an d au to n o m i c m o to r ne r ve s fac i l i tate s s o m ati c m us c l e s p as m s , s ym p ath e ti c and par as ym p athe ti c e ffe r e nt r e s po ns e s . Inte rle ukins
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  477. 477. N e u r o g en ic In flam m atio n S im p lified © 1 9 9 7 , 1 9 9 8 A ndre w S . B o nc i, B A , D C , D A A P M D R G Irrita tio n A xo n R e fle x re s u lts in b o th o rth o d ro m ic T h e o rth o d ro m ic im p u ls e is N o c ic e ptive , A N D an tid ro m ic im p u ls e re fle x iv e ly c o n v e rte d in to an O rtho dro m ic Input p ro p ag atio n a n tid ro m ic im p u ls e at th e le v e l o f th e a x o n a n d w ith o u t s p in al c o rd as s is tan c e To S p i nal Cord m ic O rt h o d ro Im p u ls e R e le a s e o f S ubs ta nc e -P C a lc ito nin G e ne R e la te d O rth o d ro m ic P e ptide fro m fre e ne rve I m p u ls e e nding A n ti d r o m ic I m p u ls e An unders tanding of neurogenic inflam m ation is integral to the prac tic e of m odern c hiroprac tic . Irritation to the D RG by m ec hanic al or c hem ic al m eans c an res ult in an antidrom ic im puls e being propagated to the peripheral free nerve ending along T is s ue M a s t C e ll the axon. T his antidrom ic im puls e propagation runs c ontrary to the c las s ic al unders tanding of how s ens ory nerves c onduc t S ti m u l ati o n w i th r e s u l tan t their im puls es , i.e., peripheral to c entral. W hen the antidrom ic im puls e is s trong enough the free nerve ending releas es the tw o r e l e as e o f h i s tam i n e , pow erful im m une induc tion tac hykinins s ubs tanc e-P and c alc itonin gene related peptide. T hes e tac hykinins direc tly influenc e h e p ar i n an d p r o te as e s tis s ue m as t c ells to degranulate and c aus e blood ves s els to dilate. In addition to irritation to the D RG , the s ens ory axons engage in w hat has been term ed the axon reflex. In this reflex, a s ingle nerve axon and its m any term inal arborizations are involved. Here an orthodrom ic im puls e is quic kly rerouted out the adjac ent arborizations antidrom ic ally w ith s ubs equent releas e of tac hykinins .
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  489. 489. 5 S teps of N eu rogen ic In flam m ation C o pyr i g ht 1 9 9 9 , D r . Andr e w S. B o nc i St e p 1 : N e ur o pe pt i d e In duc t i o n St e p 4 : M ac r o p hag e Ac ti vat i o n is t ax e mo Ch S te p 3 : M as t C e l l St i m ul at i o n F r e e R ad i c al s C yt o ki ne s P r o te as e s P P T m -R N A Va so - 1 di la + NK tio SP n St e p 2 : Se ns o r y- E ffe c t o r P r o pag at i o n St e p 5 : E nd- O r g an Al t e r at i o ns © 1998, 1999 Dr. Andrew S. Bonci, All Rights Reserved. 50
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  551. 551. N eu ro g en ic C h ro n ic In fla m m a tio n © 1 9 9 8 , D r. A ndre w S . B o nc i R e le a se of Substa nc e -P P GE 2 low e rs ne urona l A c tiva te s M a c ropha ge s thre shold for stim ula tion TIS SU E IN J U R Y F IB R O SIS T o xic O xygen M etab o lites G row th Factors (PD G F, FG F, T G F-B) P ro teas es Fibro genic C ytokines Neutro p hil C hemo tac tic F acto rs C o agulatio n F ac to rs A ngiogenesis Factors (FG F ) A.A. M etab o lites Rem odeling C ollagenases Nitric O xid e R e fe re n ce s : Hartung HP , W olters K, T oyka KV. S ubs tanc e P : binding properties and s tudies on c ellular res ponses in guinea pig m ac rophages . J Im m unol 1986; 136(10):3856-63. Robbins P athologic Basis of Dis ease. 5th ed p. 77.
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  706. 706. Su b lu xatio n -N o cic ep tio n an d Im m u n o su pp re ssio n Copyright 1999, Dr. Andrew S . Bonc i 2 Hypoth alam ic C R H, th rou gh portal circu lation , trigg e rs th e re le ase of A C TH from th e an te rior pitu itary glan d. t ion ACT lu x a H 1 S u b c e pt io n i No c A dre na l C o rte x Nocice ption , as ce n din g in th e 3 pale os pin aoth alam ic tract, trigg e rs th e C o rtis o l h ypoth alam ic-pitu itary axis . R e le a s e C R H is re le as e d in th e pitu itary portal s y s te m . I n cre as e d s e ru m cortis ol h as im m u n os u pre s s ive e ffe cts . O f particu lar in te re st is s u ppre s s ion of ge n e tran scription of in te rce llu lar adh e s ion m ole cu le s (I C A Ms ) an d s e le ctin s . 4 IC AM S uppre s s io n D u rin g in flam m ation le u k ocy te s an d th e blood ve s s e l e n doth e lial ce lls e x pre s s adh e s ion m ole cu le s (I C A M s an d s e le ctin s ). Th e s e I C A Ms are n e ce s s ary to allow th e le u k ocyte s to adh e re to th e ve ss e l e n doth e liu m du rin g diape de s is . C ortisol s u ppre s s e s adh e s ion m ole cu le s th e re by tra ppin g th e le u k ocy te s in th e circu latory sys te m . Th is e ffe ctive ly s u ppre s s e s im m u n e fu n ction . A c c o rding to pre va iling c hiro pra c tic think ing , s pina l a djus tm e nts a re de sig ne d to re m o ve the ve rte bra l no c ic e ptive s o urc e . T his , in turn, m itig a te s the a s c e nding pro to pa thic s tim ula tio n to the hypo tha la m o -pituita ry-a dre na l a xis tha t drive s the im m uno s upre s s ive c ha ng e s . S pina l a djustm e nts he lp to re turn the e ndo c rine s ys te m ba c k into o ptim a l te ns io n, thus w ithdra w ing the im m uno suppre s s ive influe nc e s , no rm a lizing func tio n a nd s uppo rting a re turn to he a lth. © 1998, 1999 Dr. Andrew S. Bonci, All Rights Reserved. 73
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  788. 788. S ub lux a tio n Infla m m a tio n-Im m une-C N S C o nnectio n C o p yr i g h t 1 9 9 9 D r . An d r e w S . B o n c i Con s titu tion al S ym p tom s of S u b lu x ation S u b lu x a tio n c a u s e s im m u n e in filtra te s to b u ild u p in th e s u b lu x a te d jo in ts . P G E 2 h a s a h a lf-life o f a p p ro x im a te ly 3 0 s e c o n d s a n d its g re a te s t e ffe c ts lo c a lly in th e jo in t. I L -1 h a s a h a lf-life o f a p p ro x im a te ly 3 0 m in u te s a n d a c ts b o th lo c a lly a n d s ys te m ic a lly. uk in -1 B e h av io rs e r le C las s ic In t S ic k A d ju s tin g a s u b lu x a te d jo in t PG a llo w s th e in fla m m o g e n s to b e E2 flu s h e d o u t o f th e jo in t. I L -1 e s c a p e s th e jo in t in la rg e S o m no le nc e q u a n titie s , e n te rs th e b lo o d s tre a m a n d is d is s e m in a te d to -1 th e b ra in . O n c e in th e b ra in , P yre xia IL I L -1 a lte rs b ra in fu n c tio n w h ic h g iv e s ris e to th e s ic k A no re xia b e h a v io rs : s o m n o le n c e , p yre x ia a n d a n o re x ia . T h is e x p la in s w h y s u b lu x a tio n m a k e s s o m e in d iv id u a ls fe e l S u b lu x ation In flam m ation ill a ll o v e r. © 1998, 1999 Dr. Andrew S. Bonci, All Rights Reserved. 81
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