• Like
Upcoming SlideShare
Loading in...5


Uploaded on


  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Be the first to comment
    Be the first to like this
No Downloads


Total Views
On Slideshare
From Embeds
Number of Embeds



Embeds 0

No embeds

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

    No notes for slide


  • 1. GUTPLUS
  • 2. GUTGUT FLORAFLORA CarbohydrateCarbohydrate fermentation andfermentation and absorptionabsorption PreventPrevent pathogenicpathogenic microbialmicrobial growthgrowth ImmunityImmunity MetabolicMetabolic functionfunction Main Functions of GUT FLORA
  • 3. Antibiotic Induced Diarrhoea Antibiotics depletes normal Body's Lactobacilli Alteration of colonic Microflora Colonisation by Pathogens Release of Toxins Colonic mucosal injury and inflammation Diarrhoea Diarrhoea: It is a condition in which a sufferer has frequent watery loose stool more than three times a day.
  • 4. GI Infections
  • 5. Irritable Bowel Syndrome A functional Bowel disorder in which abdominal pain is associated with the defecation or change in bowel habit.
  • 6. Post Surgical Prophylaxis • Post: After • Surgical: Related to surgery. • Prophylaxis: Treatment given to prevent the disease before it occurs.
  • 7. Probiotics • Pro : For & Bio : Life • Live microorganisms thought to be healthy for the host. • Criteria for bacteria to be included as a Probiotic - Survives the stomach acid and bile - Non-pathogenic and non-toxic - Must be of human origin and should be able to survive in the intestinal ecosystem. - Adheres to the intestinal lining
  • 8.  Production of inhibitory substances like bacteriocins, acidophylins  Reduction of pH  Blocking of adhesion sites  Degradation of toxin receptors  Competition for nutrients MOA of Probiotics
  • 9. Lactobacillus rhamnosus  Great ability to adhere to human mucosa cells  Found in human intestinal microflora Add two points
  • 10. Bifidobacterium longum  One of the most important residents in the human gastrointestinal tract  Bifidobacterium longum is among the first to colonise the sterile digestive tract of newborns and predominates in breast-fed infants.
  • 11. Saccharomyces boulardii   Saccharomyces boulardii is a strain of yeast  S. boulardii has been shown to maintain and restore the natural flora.  Mechanism of action involves-inhibition of pathogen adhesion, enhancement of the mucosal immune response.
  • 12. Prebiotics • Non-digestible food ingredients that stimulate the growth or activity of bacteria in the digestive system.
  • 13. The Ideal Properties of Prebiotics : ● Should be a non-digestible food ingredient ● Should be principally an oligosaccharide ● Neither be hydrolysed nor be absorbed in the upper part of the GI tract ● Should reduce the gut pH ● Should promote the growth and activity of probiotics ● Beneficially affects the host health ● Must be selectively fermented so that it is able to alter the colonic microflora towards a healthier composition
  • 14. Polyols (sugar alcohols) Xylitol Sorbitol Mannitol Disaccharides Lactulose Oligosaccharides Fructo- oligosaccharides (FOS) – the most commonly used prebiotic Polysaccharides Inulin . Types of prebiotics
  • 15. Gutplus COMPOSITION Probiotic Lactobacillus acidophilus - 0.75 billion Lactobacillus rhamnosus - 0.75 billion Bifidobacterium longum - 0.75 billion Bifidobacterium bifidum - 0.50 billion Saccharomyces boulardii - 0.10 billion Prebiotic Fructo Oligo Saccharides - 100 mg Dosage : One to two capsules per day or as directed by physician.