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Gutplus

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  • 1. GUTPLUS
  • 2. GUTGUT FLORAFLORA CarbohydrateCarbohydrate fermentation andfermentation and absorptionabsorption PreventPrevent pathogenicpathogenic microbialmicrobial growthgrowth ImmunityImmunity MetabolicMetabolic functionfunction Main Functions of GUT FLORA
  • 3. Antibiotic Induced Diarrhoea Antibiotics depletes normal Body's Lactobacilli Alteration of colonic Microflora Colonisation by Pathogens Release of Toxins Colonic mucosal injury and inflammation Diarrhoea Diarrhoea: It is a condition in which a sufferer has frequent watery loose stool more than three times a day.
  • 4. GI Infections
  • 5. Irritable Bowel Syndrome A functional Bowel disorder in which abdominal pain is associated with the defecation or change in bowel habit.
  • 6. Post Surgical Prophylaxis • Post: After • Surgical: Related to surgery. • Prophylaxis: Treatment given to prevent the disease before it occurs.
  • 7. Probiotics • Pro : For & Bio : Life • Live microorganisms thought to be healthy for the host. • Criteria for bacteria to be included as a Probiotic - Survives the stomach acid and bile - Non-pathogenic and non-toxic - Must be of human origin and should be able to survive in the intestinal ecosystem. - Adheres to the intestinal lining
  • 8.  Production of inhibitory substances like bacteriocins, acidophylins  Reduction of pH  Blocking of adhesion sites  Degradation of toxin receptors  Competition for nutrients MOA of Probiotics
  • 9. Lactobacillus rhamnosus  Great ability to adhere to human mucosa cells  Found in human intestinal microflora Add two points
  • 10. Bifidobacterium longum  One of the most important residents in the human gastrointestinal tract  Bifidobacterium longum is among the first to colonise the sterile digestive tract of newborns and predominates in breast-fed infants.
  • 11. Saccharomyces boulardii   Saccharomyces boulardii is a strain of yeast  S. boulardii has been shown to maintain and restore the natural flora.  Mechanism of action involves-inhibition of pathogen adhesion, enhancement of the mucosal immune response.
  • 12. Prebiotics • Non-digestible food ingredients that stimulate the growth or activity of bacteria in the digestive system.
  • 13. The Ideal Properties of Prebiotics : ● Should be a non-digestible food ingredient ● Should be principally an oligosaccharide ● Neither be hydrolysed nor be absorbed in the upper part of the GI tract ● Should reduce the gut pH ● Should promote the growth and activity of probiotics ● Beneficially affects the host health ● Must be selectively fermented so that it is able to alter the colonic microflora towards a healthier composition
  • 14. Polyols (sugar alcohols) Xylitol Sorbitol Mannitol Disaccharides Lactulose Oligosaccharides Fructo- oligosaccharides (FOS) – the most commonly used prebiotic Polysaccharides Inulin . Types of prebiotics
  • 15. Gutplus COMPOSITION Probiotic Lactobacillus acidophilus - 0.75 billion Lactobacillus rhamnosus - 0.75 billion Bifidobacterium longum - 0.75 billion Bifidobacterium bifidum - 0.50 billion Saccharomyces boulardii - 0.10 billion Prebiotic Fructo Oligo Saccharides - 100 mg Dosage : One to two capsules per day or as directed by physician.