Anabolic steroids

  • 677 views
Uploaded on

 

  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Be the first to comment
    Be the first to like this
No Downloads

Views

Total Views
677
On Slideshare
0
From Embeds
0
Number of Embeds
0

Actions

Shares
Downloads
22
Comments
0
Likes
0

Embeds 0

No embeds

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
    No notes for slide

Transcript

  • 1. Performance Enhancing Drugs
  • 2. The Word “Steroid” a Primer
    • Adrenal glands just above the kidneys synthesize:
    • Glucocorticoids (cortisol)
      • Antiinflammatory (treat allergic reactions, skin, respiratory, opthalmic, RA, CA)
      • Maintain BP
      • Carbohydrate, Protein, Fat metabolism
      • Stress and CNS mood effects
      • Cortisone, Prednisone, Hydrocortisone, Prednisolone
  • 3. Role of Glucocorticosteroid
    • Inhibit inflammation
      • Cause leukocytes to be sluggish
    • Complications with long term use
    • Rebound deterioration
    • Importance of Taper
    • Sample Agents
      • Prednisone, prednisolone, dexamethasone
  • 4. Glucocorticoids Adverse Effects
  • 5. Glucocorticoids Adverse Effects
    • CV
      • Na retention
    • GI
      • PUD
    • Metabolic
      • Redistribution of fat, hyperglycemia
    • Immune
      • infections
    • Dematologic
      • Impair wound healing
    • Musculoskeletal
      • Osteoporosis
      • Bone fractures
    • Neuropsychiatric
      • Psychosis/mood
    • Opthalmic
      • Cataracts/glaucoma
  • 6.
    • Mineralcorticoids (primarily aldosterone)
      • Production of aldosterone stimulated by salt depletion and causes sodium retention in the kidney
      • Increases urinary excretion of potassium
      • Job is to regulate the balance of Na ++ and K+ in the blood.
    • Androgens (primarily dehydroepiandrosterone)
      • Enhance male characteristics and control growth of hair follicles in the skin
      • Anabolic-Androgenic steroids are synthetic formulations produced from testosterone, the male hormone.
      • Estimated use by 80% of weightlifters & bodybuilders
  • 7. Tissues Targeted by Testosterone and Anabolic Steroids
  • 8. Major Effects of Anabolic Steroids
    • Androgen Type Effects
    • Increased growth of :
      • prostate gland
      • Body/facial hair
      • Oil production
    • Deepening voice
    • Increased sexual interest and desire
    • Enhancement of abstract thinking
    • Increased aggression
    • Anabolic Type Effects
    • Increased:
      • Organ and skeletal muscle mass
      • Calcium in bones
      • Retention of nitrogen
      • Hemoglobin concentration
      • Protein synthesis
  • 9. Long Term Adverse Effects
    • Females
      • Oily skin acne
      • Decrease
        • breast size, ovulation, lactation, menstruation
      • Hoarse/deep voice
      • Clitoral enlargement
      • Unusual hair growth +/- male patterned baldness
    • Males
      • Increase penis size, # of erections, & secondary male characteristics
      • Priapism (continuing erections)
      • Gynecomastia (increased breast size)
      • Testicular atrophy, impotence
  • 10. BOTH Genders
    • Gastric ulcers
    • Liver Complications
    • Hyperglycemia
    • Reduction in HDL
    • Increased platelet aggregation with increased risk of CV disorders
    • Hypercalcemia
    • Edema
    • Urinary calculi
    • Insomnia
    • Iron deficiency anemia
    • Nausea, vomiting, anorexia, stomach pains