Cascade of Events Leading to Hemostasis Injured Vessel Platelet System Vascular System Coagulation System Clotting Factors Prothrombin Thrombin Stimulate Fibrin Vasoconstriction Platelet Aggregation Permanent Fibrin-Platelet Plug
Where Do the Drugs Work? Clotting Cascade Platelet System Vascular System Coagulation System Clotting Factors Prothrombin Thrombin Stimulate Fibrin Vasoconstriction Platelet Aggregation Heparin Warfarin GIT Anti-Platelets Fibrinolytics
LR is a 37 yr old, female who returned from an Australian vacation 3 days prior to presenting at clinic. She is experiencing deep left calf pain which came on suddenly yesterday. Her left leg is enlarged, warm & tender to touch. A diagnosis of DVT is made and Heparin 5,000 units IV q 4 hr (1am, 5am, 9am, 1pm, 5pm, 9pm) is started.
Wt 90kg Ht 5’6” BP 110/80 HR 80 T 37
Current Meds: Ortho-novum 1/35 x 25 yr Cimetidine 200mg prn Maalox prn