Derived from Odontogenic Connective Tissue                Dr. Ali Tahir. M.Phil Oral Pathology
Odontogenic Fibroma Benign neoplasm derived from connective tissue of  odontogenic origin containing islands & strands of...
Clinical & Radiographic Features Uncommon Wide range of age 4-80    yrs   2.2:1 female: male   Asymptomatic swelling ...
R/F 1/3rd ass. with un-erupted    tooth   Non-specific unilocular    well circumscribed    radiolucency, sclerotic    bo...
Histopathology Simple & WHO type Stellate fibroblasts Fine collagen Scattered islands of  odontogenic epithelium Sphe...
Odontogenic fibroma       Dr. Ali Tahir. M.Phil Oral Pathology
D.DHistological Odontogenic fibroma Ameloblastic fibroma Odontogenic myxoma Desmoplastic fibroma             Dr. Ali T...
Peripheral Odontogenic Fibroma        Dr. Ali Tahir. M.Phil Oral Pathology
Odontogenic Myxoma Aggressive intra-osseous lesion derived from odontogenic connective tissue consisting of mucoid substa...
Clinical & Radiographic Features Uncommon Intra-osseous Aggressive, may show    rapid growth   More common in    mandi...
R/F Unilocular/Multilocular    radiolucency with “soap    bubble” or “honey comb”    appearance resembles    ameloblastom...
Histopathology Grossly gelatinous loose structure Spindled or angular shaped cells Background of mucoid (glycosaminogly...
Histopathology       Dr. Ali Tahir. M.Phil Oral Pathology
Cementoblastoma Benign, well circumscribed neoplasm of cementum-  like tissue growing in continuity with the apical  ceme...
Clinical Features   Uncommon   2nd & 3rd decades of life   75% occur in mandible   Molar premolar area, 50% in first m...
Radiographically Unilocular, well demarcated radio-opaque mass fused  to one or more tooth roots Surrounded by a thin ra...
Clinical & radiographic picture        Dr. Ali Tahir. M.Phil Oral Pathology
Histopathology Resembles osteoblastoma except that it is continuous    with the normal cemental layer of roots   Eosinop...
Histopathology       Dr. Ali Tahir. M.Phil Oral Pathology
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Odontogenic tumours part 3

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Derived from Odontogenic Connective tissue

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  • Filling the marrow spaces between trabeculae of bone
  • Transcript of "Odontogenic tumours part 3"

    1. 1. Derived from Odontogenic Connective Tissue Dr. Ali Tahir. M.Phil Oral Pathology
    2. 2. Odontogenic Fibroma Benign neoplasm derived from connective tissue of odontogenic origin containing islands & strands of odontogenic epithelium & calcifications Central & PeripheralPeripheral: Common Extra-osseous Dr. Ali Tahir. M.Phil Oral Pathology
    3. 3. Clinical & Radiographic Features Uncommon Wide range of age 4-80 yrs 2.2:1 female: male Asymptomatic swelling Maxillary lesions are common anterior to molars Mandibular common in molar region Dr. Ali Tahir. M.Phil Oral Pathology
    4. 4. R/F 1/3rd ass. with un-erupted tooth Non-specific unilocular well circumscribed radiolucency, sclerotic border Radio-opaque flecks may be seen Larger lesions can be multilocular Root resorption/divergence Dr. Ali Tahir. M.Phil Oral Pathology
    5. 5. Histopathology Simple & WHO type Stellate fibroblasts Fine collagen Scattered islands of odontogenic epithelium Spherical/Diffuse dystrophic calcifications A variant found with Central Giant Cell granuloma. Dr. Ali Tahir. M.Phil Oral Pathology
    6. 6. Odontogenic fibroma Dr. Ali Tahir. M.Phil Oral Pathology
    7. 7. D.DHistological Odontogenic fibroma Ameloblastic fibroma Odontogenic myxoma Desmoplastic fibroma Dr. Ali Tahir. M.Phil Oral Pathology
    8. 8. Peripheral Odontogenic Fibroma Dr. Ali Tahir. M.Phil Oral Pathology
    9. 9. Odontogenic Myxoma Aggressive intra-osseous lesion derived from odontogenic connective tissue consisting of mucoid substance & undifferentiated spindled mesenchymal cells Dr. Ali Tahir. M.Phil Oral Pathology
    10. 10. Clinical & Radiographic Features Uncommon Intra-osseous Aggressive, may show rapid growth More common in mandible No sex predilection Maxillary may invade the sinus & mandibular into ramus Painless, slowly enlarging, displaces teeth Pathology Dr. Ali Tahir. M.Phil Oral
    11. 11. R/F Unilocular/Multilocular radiolucency with “soap bubble” or “honey comb” appearance resembles ameloblastoma Root displacement Irregular or scalloped margins Angular-trabeculations Expansion of cortical plates Dr. Ali Tahir. M.Phil Oral Pathology
    12. 12. Histopathology Grossly gelatinous loose structure Spindled or angular shaped cells Background of mucoid (glycosaminoglycans), non- fibrillar ground substance At periphery penetrates trabeculae producing islands of residual bone Islands of odontogenic epithelium, calcifications, focal areas of blood vessels & collagen may be seen Dr. Ali Tahir. M.Phil Oral Pathology
    13. 13. Histopathology Dr. Ali Tahir. M.Phil Oral Pathology
    14. 14. Cementoblastoma Benign, well circumscribed neoplasm of cementum- like tissue growing in continuity with the apical cemental layer of a molar or premolar that produces expansion of cortical plates & pain Neoplasm of cementoblasts, only true neoplasm of cementum Histologically it is remarkably similar to osteoblastoma & osteoid osteoma Periodontal membrane separates it from surrounding bone Dr. Ali Tahir. M.Phil Oral Pathology
    15. 15. Clinical Features Uncommon 2nd & 3rd decades of life 75% occur in mandible Molar premolar area, 50% in first molar, attached to apical third of roots Expands buccal & lingual cortical plates Pain & swelling (in 2/3rd cases) Tooth remains vital Average size 2cm No sex predilection More in children & M.Phil Oral Pathology Dr. Ali Tahir. young adults
    16. 16. Radiographically Unilocular, well demarcated radio-opaque mass fused to one or more tooth roots Surrounded by a thin radiolucent rim May be completely radiolucent/mixed/opaque Root resorption & fusion with the tumour Dr. Ali Tahir. M.Phil Oral Pathology
    17. 17. Clinical & radiographic picture Dr. Ali Tahir. M.Phil Oral Pathology
    18. 18. Histopathology Resembles osteoblastoma except that it is continuous with the normal cemental layer of roots Eosinophilic matrix rimmed by cementoblasts Mineralized areas show reversal lines which indicates extensive remodelling Periodontal ligament surrounding the lesion Relatively acellular at periphery & more mineralized & vascular in the centre Soft tissue areas are cellular & vascular Multinucleated giant cells in the cellular zone Dr. Ali Tahir. M.Phil Oral Pathology
    19. 19. Histopathology Dr. Ali Tahir. M.Phil Oral Pathology

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