Pathogenesis of
asthma
Pathogenesis of
Br Asthma

antigens

Air Way

EP
I

DC

DC

DC
G
C

G
C

Interstitium

Cytokines
release
Th2

IL-4
IL-5
IL...
Causes
eosinophilia

IL-4
IL-5
IL-13

IL-13 also causes:
IL-4
IL-13

B Cell

 Inc. mucus
secretion

Mast
Cell

 Hyperres...
Cytokines release

IL-4

Mast
Cell

B Cell
IgE release

Plasma
cells

Basphil
Mechanism of
action of Omalizumab
Bound Ig E

Mast
Cell

Free Ig E

FcεRI receptor

Cε3 domain
Basphil

Omalizumab binds
t...
Mechanism of
action of Omalizumab
Bound Ig E

Mast
Cell
FcεRI receptor

Basphil
Pathogenesis of asthma and omalizumab action
Pathogenesis of asthma and omalizumab action
Pathogenesis of asthma and omalizumab action
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Pathogenesis of asthma and omalizumab action

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Pathogenesis of asthma and omalizumab action

  1. 1. Pathogenesis of asthma
  2. 2. Pathogenesis of Br Asthma antigens Air Way EP I DC DC DC G C G C Interstitium Cytokines release Th2 IL-4 IL-5 IL-13
  3. 3. Causes eosinophilia IL-4 IL-5 IL-13 IL-13 also causes: IL-4 IL-13 B Cell  Inc. mucus secretion Mast Cell  Hyperresponsiveness IgE release Activation & Converted to Plasma cells Basphil
  4. 4. Cytokines release IL-4 Mast Cell B Cell IgE release Plasma cells Basphil
  5. 5. Mechanism of action of Omalizumab Bound Ig E Mast Cell Free Ig E FcεRI receptor Cε3 domain Basphil Omalizumab binds to free IgE with Cε3 domain
  6. 6. Mechanism of action of Omalizumab Bound Ig E Mast Cell FcεRI receptor Basphil
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