Pathogenesis of asthma and omalizumab action
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Pathogenesis of asthma and omalizumab action

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Pathogenesis of asthma and omalizumab action Presentation Transcript

  • 1. Pathogenesis of asthma
  • 2. Pathogenesis of Br Asthma antigens Air Way EP I DC DC DC G C G C Interstitium Cytokines release Th2 IL-4 IL-5 IL-13
  • 3. Causes eosinophilia IL-4 IL-5 IL-13 IL-13 also causes: IL-4 IL-13 B Cell  Inc. mucus secretion Mast Cell  Hyperresponsiveness IgE release Activation & Converted to Plasma cells Basphil
  • 4. Cytokines release IL-4 Mast Cell B Cell IgE release Plasma cells Basphil
  • 5. Mechanism of action of Omalizumab Bound Ig E Mast Cell Free Ig E FcεRI receptor Cε3 domain Basphil Omalizumab binds to free IgE with Cε3 domain
  • 6. Mechanism of action of Omalizumab Bound Ig E Mast Cell FcεRI receptor Basphil