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Apoptosis
 

Apoptosis

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general pathology , apoptosis...

general pathology , apoptosis...

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    Apoptosis Apoptosis Presentation Transcript

    •  
    • Apoptosis
      • Types
      Cell Injury ?
    •  
    • Cell Death NECROSIS APOPTOSIS
    • Apoptosis
      • Coordinated Programmed
      • cell death
      • Coordinated Programmed
      • Cell Death
      • Apoptosis
      • * Falling off
      • * Dropping off
    • Features of Apoptosis
      • Involvement of single/group of cells.
      • Shrinkage of cell
      • Formation of Apoptotic bodies
      • No Acute Inflammatory reaction
      • Phagocytosis
      • Molecular Mechanism
      Simplyfy
    • Mechanism of Apoptosis
      • Cascade of molecular events
      • culminating In to activation of
      • caspases.
    • Initiation Death Signals Death receptors : Type 1 TNF receptor EXTRINSIC (DEATH RECEPTOR) PATHWAY
    • Bcl 2 , Bcl x Anti-Apoptotic Proteins Bak, Bax, Bim Pro Apoptotic Proteins Cytochrome C Apaf-1 Caspase 9 INTRINSIC (M itochondrial) PATHWAY
    • Execution Phase
      • Caspase 8 and 9 :
      • Initiator Caspase
      • Caspase 3 and 6 :
      • Executioner Caspase
      • Apoptotic Bodies and
      • Phagocytosis at the end…
    •  
      • p 53 gene
    • Programmed Cell Death a step , towards “Life”
    • Cell Death : Necrosis / Apoptosis Features of Apoptosis Initiation (2 Pathways) & Execution p53 Anti Apoptotic genes Bcl 2 , Bcl x Pro Apoptotic genes Bak Bax Bim Thank You