Apoptosis

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Apoptosis

  1. 2. Apoptosis
  2. 3. <ul><li>Types </li></ul>Cell Injury ?
  3. 5. Cell Death NECROSIS APOPTOSIS
  4. 6. Apoptosis
  5. 7. <ul><li>Coordinated Programmed </li></ul><ul><li>cell death </li></ul>
  6. 8. <ul><li>Coordinated Programmed </li></ul><ul><li>Cell Death </li></ul>
  7. 9. <ul><li>Apoptosis </li></ul><ul><li>* Falling off </li></ul><ul><li>* Dropping off </li></ul>
  8. 10. Features of Apoptosis <ul><li>Involvement of single/group of cells. </li></ul><ul><li>Shrinkage of cell </li></ul><ul><li>Formation of Apoptotic bodies </li></ul><ul><li>No Acute Inflammatory reaction </li></ul><ul><li>Phagocytosis </li></ul>
  9. 11. <ul><li>Molecular Mechanism </li></ul>Simplyfy
  10. 12. Mechanism of Apoptosis <ul><li>Cascade of molecular events </li></ul><ul><li>culminating In to activation of </li></ul><ul><li>caspases. </li></ul>
  11. 13. Initiation Death Signals Death receptors : Type 1 TNF receptor EXTRINSIC (DEATH RECEPTOR) PATHWAY
  12. 14. Bcl 2 , Bcl x Anti-Apoptotic Proteins Bak, Bax, Bim Pro Apoptotic Proteins Cytochrome C Apaf-1 Caspase 9 INTRINSIC (M itochondrial) PATHWAY
  13. 15. Execution Phase <ul><li>Caspase 8 and 9 : </li></ul><ul><li>Initiator Caspase </li></ul><ul><li>Caspase 3 and 6 : </li></ul><ul><li>Executioner Caspase </li></ul>
  14. 16. <ul><li>Apoptotic Bodies and </li></ul><ul><li>Phagocytosis at the end… </li></ul>
  15. 18. <ul><li>p 53 gene </li></ul>
  16. 19. Programmed Cell Death a step , towards “Life”
  17. 20. Cell Death : Necrosis / Apoptosis Features of Apoptosis Initiation (2 Pathways) & Execution p53 Anti Apoptotic genes Bcl 2 , Bcl x Pro Apoptotic genes Bak Bax Bim Thank You

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