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  • 1. Syncom b.v. Contract Research Organization for Synthetic Organic Chemistry
  • 2. Location • Syncom is based in Groningen, The Netherlands • Groningen is located 200 km from Amsterdam, Schiphol airport • 2 hrs (car or train)
  • 3. Syncom Facilities
  • 4. Syncom b.v. • Syncom provides intellectual and practical chemistry services for the construction of small molecules. • Syncom supports drug discovery and development programs • 100% service company
  • 5. Company History • 1988 Founded by Professor Wynberg • 2000 Dedicated building (3000 m2) • 2003 New Laboratories (2500 m2) • 2007/2008 Additional lab space (20 chemists) Private company with 714 shares - Kellogg Beheer 400 - Vries Beheer 100 - DSM Pharma Chemicals 214
  • 6. Personnel • Employees: 141 • 131 chemists - 76 PhD, - 55 MSc & BSc, - including 8 analytical chemists • Average experience 5-6 years • Turnover personnel < 5% last 5 years • Administrative 5-6 FTE
  • 7. Personnel • Highly educated: currently 60% Ph.D and rest masters and bachelors degree. • Young: average age 32. • Everyone works at least part time in laboratory: a chemist does chemistry. • Currently 140 people.
  • 8. Personnel This is Syncom October 2008
  • 9. Facilities • 5200 m2 (two buildings) 45,000 square feet • 155 hoods up to 5 L • 20 walk-in hoods up to 20 L • Special Equipment (almost everything, parallel synthesis, automated column chromatography; microwave, ozone, etc) • Analytical equipment (NMR; HPLC-MS; HPLC (prep); GC-MS; DSC; UV) • Library; Beilstein; SciFinder
  • 10. What do we do? • Resolutions • Synthesis of: New Leads – Small Libraries – Cores, Scaffolds and Building Blocks for CC – Advanced (Optically Pure) Intermediates – Biological Standards/Reference Compounds – Metabolites and Impurities – Labeled Compounds (D ,13C and 15N) • Route Scouting and Process Research
  • 11. Chemical Services for Pharma Lead Lead Preclinical & Clinical Registration discovery optimization early clinical development & phase 2 + 3 launch Synthetic service & supply of Syncom preclinical material (first cGMP project now underway) Supply of preclinical & early ResCom® clinical material (cGMP) Route DSM Pharma Chemicals development & manufacuring (DPC) of advanced intermediates and API’s
  • 12. Capabilities • Drug Discovery Services Hit and lead optimization, libraries based upon original scaffolds and building blocks, reference compounds, synthesis support • Development and scale-up Route scouting, GLP synthesis for tox studies, metabolites, impurities, scale-up, intermediates • Chirality, first-time-right concept Integral approach: simultaneous
  • 13. New resolving agents via Dutch Resolution O SO3H NH2 OH X Y X chalcone sulfonic acids Amino alkohols O OH P OH O O OH O X Mandelic acids Phoshoric acid Synthesis 2003, 10, 1626
  • 14. Metabolites O OH HN HN Cl Cl HO Bupropion metabolites O HO2C O O R HO OH O HO O Glucuronides O OH O Cl 15-β-Cyproteron acetate
  • 15. Reference compounds OH .HCl HO N Cl Cl HO OH (-)-SB612111 Vitamin D analogue
  • 16. Labeled Compounds Cl D H D N OH D4-4'-hydroxydiclofenac D Cl D CO2H Cl H * * * N OH C6-4'-hydroxydiclofenac 13 * * Cl * CO2H
  • 17. Route scouting F F HO O OH O O H O OH H OH OH HO NH2 O OSO3H O OSO3H OH O OO OSO3H OSO3H CO2H HN CO2H OSO3H OH SO3H O O OO N OH OH HN OSO3H Ph SO3H Ph OH OH O HN OH OH SO3H
  • 18. Chirality, first-time-right concept time-right Chirality, first- Simultaneous screening of chiral technologies in early phase development Biocatalysis Chemocatalysis Preferential Resolution Chirality Crystallization Chiral Chromatography Chiral pool Improvements in discovery are implemented into process
  • 19. Parallel Synthesis • Small Libraries (10-20 compounds; 100-250 mg) • Libraries up to 60-200 compounds; 10-25 mg • Cores, Scaffolds and Building Blocks for combinatorial chemistry: exclusive compounds, designed by customer, developed and prepared (10-500 g) by Syncom Access to cores, scaffolds and building blocks > 7000 chemicals in stock for discovery programs
  • 20. Syncom library services Syncom SAR Solutions Decoration of client scaffolds with ‘monomers’ Focused libraries, manual synthesis/purification Mettler Reactor Blocks, Biotage Initiator microwave ISCO automated CC, prep-HPLC
  • 21. Project Management • Project Managers; Group Leaders; Chemists • Weekly updates • Teleconferences • Reports • Import/export according to client regulations
  • 22. Business Model • FTE 220 working days including analytical/management • 65% FTE work • 35% Fee for Service work • Several customers combination of both.
  • 23. Clients •Solvay •Pfizer •Organon (Schering-Plough) •Sanofi-Aventis •Eli Lilly •Wyeth •DSM •Vertex •Philips •Merck •Fuji •Another 40 companies
  • 24. Why Syncom? • Chiral Technologies (scientific programs) • Strong project management • Problem solving capability (good chemists) • Broad expertise; 20 years of small molecule synthesis • Good track record (references) • Monomer collection on stock • Scale-up possibility (also with DSM Pharma/ResCom)
  • 25. Key success factors • Everyone works in laboratory; almost no full time managers • Long standing decision to market intellectual service rather than intellectual property •Avoidance of temptation to go outside expertise • Give highly trained synthetic chemists the opportunity to practice their profession • Hire on the basis of chemical skills rather than personality profiles • Don’t hesitate to invest in buildings and apparatus necessary for synthetic work
  • 26. Current challenges • Financial situation for everyone is difficult; Syncom position relatively good and portfolio 2009 well filled • New service “Chirality First Time Right” just set up in Geleen on DSM terrain • Busy with drug design consortium centered for a large part in northern Holland • Very active in fundamental research; high profile via scientific publications.

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