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Natural Treatments for Fibromyalgia, Diabetes, Lupus, Cancer, Multiple Sclerosis, Rheumatoid Arthritis
 

Natural Treatments for Fibromyalgia, Diabetes, Lupus, Cancer, Multiple Sclerosis, Rheumatoid Arthritis

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Real Fibromyalgia, Treatment & Emotions ...

Real Fibromyalgia, Treatment & Emotions
A Pituitary Endocrinology Perspective. Effective natural therapies for Fibromyalgia
Hot flashes, memory loss, and a weird polyneuropathy, polymyalgia or polyarthropathy (i.e. adds up to fibromyalgia)?
What is fibromyalgia? The great magical mystery illness! Pituitary endocrinology research.
Fibromyalgia really is…• Simply pituitary damage. • Causing a lack of several key hormones.
Few pituitary endocrinologists out there. Out of 150 endocrinologists there will be 1 true Pituitary Endocrinologist.
Fibromyalgic syndromes: could growth hormone therapy be beneficial?
Diabetes, Lupus, Cancer, multiple sclerosis, gout, rheumatoid arthritis, arthritis, lymphoma, glucose, osteoarthritis, type 2 diabetes, fatigue, chronic fatigue syndrome, dizziness, autoimmune disease, adrenal fatigue, polymyalgia rheumatica, depression, why am I so tires
Actual Causes of Fibromyalgia?
The pituitary secretes hormones that are essential to growth and reproduction. Hormones and vasculature.
Problems that can cause stalk or pituitary damage:
• Whiplash or any MVA
• TBI – even mild (Australian Rules Football would qualify)
• Air Bag Deployment to face or head
• Any Mild to Moderate Blows To The Head – heading a soccer ball! Any concussion!
• Sexual abuse as a child
• Stroke
• Tumors – if you can’t find anything else!
• Sheehan’s Syndrome
• Snorting or huffing drugs (i.e. cocaine)
• Radiation exposure (i.e. MD/DO/DC/DDS)
• Prolonged High Stress (i.e. MD/DO/DC/DDS)
Pituitary Dysfunction = Fibromyalgia = Maybe Even Multiple Sclerosis (MS)
Fibromyalgia Really Occurs from a Lack of Healing Hormones
Occurrence of pituitary dysfunction following traumatic brain injury. “subjects with a history of TBI frequently develop pituitary dysfunction, especially GHD.” (GHD=Growth Hormone Deficiency)
Lack of Testosterone is a problem, too.
Sage (Salvia officinalis), fennel (Foeniculum vulgare), lavender (Lavandula angustifolia), myrtle (Myrtus communis), peppermint (Mentha piperita), and blue yarrow (Achillea millefolium), in a base of sesame seed oil.
Symptoms of Inadequate Progesterone Production?
• Hot Flashes
• Day and Night Sweats
• Migraine Headaches
• Severe PMS
• Endometriosis
• Demyelination Problems
• TMJ Problems (not usually the only cause)
• Libido Problems
For diagnoses related to hypothyroidism, typical problems include fatigue, weight gain, depression, lethargy, dry skin, cold intolerance, voice change, change in menses, muscle cramps, or treatment of a thyroid condition.
Here’s the emotional tie in
• Depression, lethargy, fatigue.
• Lack of HGH causes PTSD, depression, fatigue, confusion.
• Low testosterone causes decreased libido, fatigue, depression.
• Lack of progesterone causes depression, fatigue, PMS.
“Progesterone prevents menstrual migraine headaches in women.”
Lack of Thyroid Causes Hair Loss

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    Natural Treatments for Fibromyalgia, Diabetes, Lupus, Cancer, Multiple Sclerosis, Rheumatoid Arthritis Natural Treatments for Fibromyalgia, Diabetes, Lupus, Cancer, Multiple Sclerosis, Rheumatoid Arthritis Presentation Transcript

    • Real Fibromyalgia,Treatment andEmotionsA Pituitary Endocrinology Perspective
    • Who am I?
    • Aesthetica -- my office in Lindon, Utah,USA.(By Salt Lake City and Near YLEOHeadquarters)My name is Dan Purser, I’m an MD, and I work withplastic, trauma, and neurosurgeons in my area dealingwith healing and pain issuesand proactive prevention .It’s a new concept – ProActive Prevention…
    • Why am I here?
    • PLUSYoung Living has a number ofeffective natural therapies forFibromyalgia!
    • You’ll learn other things here.So be patient!
    • Hang on – save yourquestions!This will be brisk…(I will give Jim O’Reilly a copy of this PPT/pdf)
    • 28 year old mother of 2 is sitting across from you with hot flashes,memory loss, and a weird polyneuropathy, polymyalgia orpolyarthropathy(i.e. adds up to fibromyalgia)?This girl isn’t suddenly old –she doesn’t have some weirdaging disorder – but what doesshe have to cause her to havethese unusual conditions?
    • What is fibromyalgia?
    • What do most doctors think?
    • “It’s MAGICAL!!!”(Ooooooohhhh, no one knows and no one can tell you. Thegreat magical mystery illness!)
    • Magical thinking…huh?
    • No one out there really seemsto know, do they?But I think some do…
    • Who?•  A few researchoriented doctors…•  And bigpharmaceuticalcompanies
    • I also do pituitary endocrinology research inLos Angeles with my team from University ofSouthern California.USC Kleck MedicalCenter and NorrisLibraryBut we hang out in Anaheimon the weekends!
    • Fibromyalgia really is…•  Simply pituitary damage.•  Causing a lack of several key hormones.
    • Why don’t doctors know this?
    • Few of the Right Kind ofDoctorsFew pituitary endocrinologists outthere. Out of 150 endocrinologiststhere will be 1 true PituitaryEndocrinologist.(None in Utah and inAustralia???)
    • Big Pharma Led ConfusionAnd Physicians Are Too Busy
    • Literature confusionThe scope and direction of the BigPharma paid research ismisleading to physicians
    • Given to wrong specialty(Rheumatology)(PROBABLY BECASE NO ON ELSEWANTED IT!)
    • Though the literature isclear…(kind of)
    • Pediatr Endocrinol Rev. 2009 Jun;6 Suppl 4:529-33.Fibromyalgic syndromes: could growth hormone therapy be beneficial?Cuatrecasas G.Endocrinology Department, Centro Medico Teknon & C Sagrada Familia,Barcelona, Spain. gcuatrecasas@cpen.catAbstractFibromyalgia is a chronic, idiopathic condition in which patients experiencepain, asthenia and fatigue. The pathogenesis of the condition is unknown,and numerous mechanisms have been postulated, including neuralhypersensitivity and autoimmunity. Symptoms of fibromyalgia are broadlysimilar to those of growth hormone deficiency (GHD), and there is evidenceof decreased GH secretion and functional GHD in a subset of patients withfibromyalgia. Use of GH therapy in this patient population thereforerepresents a rational treatment strategy. Preliminary placebo-controlledtrials have shown that GH therapy can significantly improve signs andsymptoms of fibromyalgia and quality of life in patients receiving the currentstandard of care. Despite the use of relatively high doses of GH in thesepatients, treatment is well tolerated. Several mechanisms of action for GH infibromyalgia have been suggested, including both central and peripheraleffects.
    • You Do NOT Have a Bunch ofOdd Separate and RareMedical ProblemsSo
    • Actual Causes ofFibromyalgia?
    • Okay, this is serious stuff – and most doctors have not aCLUE!
    • A view of the pituitary in a baby…Notice thestalk andhow fragile itcan be…
    • Another view…LHFSHHGHTSH
    • Hormones and vasculatureThe posteriorpituitary elutesACTH andcontrols theadrenals.TSHHGHLH FSHNotice thefragilevasculature!
    • Another view…This is with a 1.5T MRI view of a macranomatous pituitary.A little blurry…
    • REMEMBER!The pituitary stalk is EXTREMELYfragile and so is the pituitary(especially past age 35).Docs -- should have an extremelevel of suspicion!Most MRIs have very poor resolutionat 0.5T, better at 1.5T, and the best andnewest are 3T (T means Tesla) – stillnot very good.
    • Problems that can cause stalk or pituitary damage:•  Whiplash or any MVA•  TBI – even mild (Australian Rules Football would qualify)•  Air Bag Deployment to face or head•  Any Mild to Moderate Blows To The Head – heading asoccer ball! Any concussion!•  Sexual abuse as a child•  Stroke•  Tumors – if you can’t find anything else!•  Sheehan’s Syndrome – most common in Utah•  Snorting or huffing drugs (i.e. cocaine)•  Radiation exposure (i.e. MD/DO/DC/DDS)•  Prolonged High Stress (i.e. MD/DO/DC/DDS)•  (Can you tell a LOT of my patients are docs?)I ALWAYS LOOK FOR THESE IN YOUR HISTORY!
    • ALWAYS HAVE A HIGH LEVEL OF SUSPICION!And remember – pituitarydysfunction is thegreat mimic!But we’re finding, due to the fragile nature of thepituitary (especially the stalk), damage appears to be aLOT more common than was once thought.
    • Pituitary Dysfunction =Fibromyalgia = Mybe EvenMultiple Sclerosis (MS) ??(I know, I know – this IS VERYcontroversial but TRUE.)
    • Fibromyalgia Really Occursfrom a Lack ofHealing Hormones
    • Italian studies?J Neurotrauma. 2004 Jun;21(6):685-96.Occurrence of pituitary dysfunction following traumaticbrain injury.Bondanelli M, De Marinis L, et alDepartment of Biomedical Sciences and Advanced Therapies-Section ofEndocrinology, University of Ferrara, Ferrara, Italy.“subjects with a history of TBI frequentlydevelop pituitary dysfunction, especiallyGHD.”(GHD=Growth Hormone Deficiency)
    • Lack of HGH(Human Growth Hormone,Somatropin, Saizen™,Norditropin™, etc)
    • Is further evaluation for growth hormone (GH) deficiency necessary infibromyalgia patients with low serum insulin-like growth factor (IGF)-Ilevels?Growth Horm IGF Res. 2007 Feb;17(1):82-8. Yuen KC, Bennett RM, et al. Department ofEndocrinology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, MailcodeL607, Portland, OR USA.OBJECTIVE: Fibromyalgia (FM) is characterized by diffuse pain, fatigue,and sleep disturbances; symptoms that resemble the adult growthhormone (GH) deficiency syndrome. Many FM patients have low serumGH levels, with a hypothesized aetiology of dysregulated GH/insulin-likegrowth factor (IGF)-I axis. CONCLUSION: Our data shows that asubpopulation of FM patients with low serum IGF-I levels will fail theGHRH-arginine test. We, thus, recommend that the GH reserve of thesepatients should be evaluated further, as GH replacement maypotentially improve the symptomatology of those with true GHdeficiency. Additionally, the increased GH response rates to GHRH-arginine stimulation in the majority of FM patients with low serum IGF-Ilevels further supports the hypothesis of a dysregulated GH/IGF-Iaxis in the pathophysiology of FM.
    • What YLEO natural product canyou take that helps HGHproduction?
    • UltraYoungSpray™Contains:Goodies designed tonaturally stimulate yourpituitary!(IF it’s healthy enough!)
    • Lack of Testosteroneis a problem, too.
    • “Hyposecretion of androgens wasdocumented in FM. This was morepronounced in obese patients. Lowserum androgen levels correlatedwith poor health status in FM.”Dessein PH, Shipton EA, et al. Hyposecretion of adrenalandrogens and the relation of serum adrenal steroids, serotoninand insulin-like growth factor-1 to clinical features in womenwith fibromyalgia. Pain. 1999 Nov;83(2):313-9.
    • What natural product can youtake to stimulate your ownproduction of testosterone?
    • Endogize™ for womenContains:Vitamin B6, zinc,eurycoma longifolia root extract,ashwaganda root, muira puamaroot,l-arginine, epimedium leaf,tribulus terrestris fruit,DHEA, phosphatidycholine,lecithin (soy),black pepper fruit extract, amylase5000 FCC, validase AFP protease,cellulase 4000, glucoamylase,Proprietary EndoGize™ Oil Blend:Ginger root, Myrrh gum resin, Cassia
    • In Australia?
    • Mister™ for men (women too?)Contains:Sage (Salvia officinalis),fennel (Foeniculum vulgare),lavender (Lavandula angustifolia),myrtle (Myrtus communis),peppermint (Mentha piperita), andblue yarrow (Achillea millefolium),in a base of sesame seed oil.
    • (Most but not all women withfibromyalgia need progesterone,but only if they have symptoms ofneed.)Lack of Progesterone is a BIGproblem for women with Fibro.
    • Symptoms of InadequateProgesterone Production?•  Hot Flashes•  Day and Night Sweats•  Migraine Headaches•  Severe PMS•  Endometriosis•  Demyelination Problems•  TMJ Problems (not usually the only cause)•  Libido ProblemsMore aboutthese later!
    • Progesterone (P4) for TMJpain“P4 prevents and relieves TMJ inflammation.”-- Kramer PR, Bellinger LL. The effects of cycling levels of 17beta-estradiol andprogesterone on the magnitude of temporomandibular joint-inducednociception. Endocrinology. 2009 Aug;150(8):3680-9.Online atwww.nlm.nih.gov/medlineplus/ency/article/003714.htm.
    • This is Libido Stuff isComplex!
    • Progesterone (P4) improveslibido!Progesterone (P4) increases libido anddesire for women.--Stuckey BG. Female sexual function and dysfunction in thereproductive years: the influence of endogenous and exogenous sexhormones. J Sex Med. 2008 Oct;5(10):2282-90.
    • What product can you take toreplace progesterone in yourbody?
    • Progessence Plus™Natural Progesterone inVitamin E Oil BaseHas awesome Essential Oils ToBoost Absorption and ImmuneSystem Function:FrankincenseSandal WoodCopaiba
    • Now you can try…(It’s coming……)
    • **Progessence Phyto Plus™New plant based that is approvedfor Australia!
    • Progessence Phyto Plus™“P3”For short!
    • Chaste Tree
    • •  Vitex•  Copaiba•  Sacred Frankincense•  Cedarwood•  Bergamot•  Peppermint•  Rosewood•  Clove
    • Benefits of each ingredient in Progessence Phyto-Plus•  Vitex EO–  Vitex is used for female reproductive system conditions ranging from PMS and menstrual cycle irregularities,to mastalgia, menopausal symptoms, and lactation complications.•  Vitamin E–  Antioxidant, skin health•  Wild Yam extract–  historically used for menstrual pain, rheumatoid arthritis, and colic (due to it having some anti-inflammatoryproperties). Wild yam has anti-inflammatory, cholagogue, and antispasmodic effects. It is used forrheumatic conditions, cramps, dysmenorrhea, and gallbladder colic. The diosgenin and glycoside saponinsfound in wild yam are hormonal precursors to corticol steroids and are stated to reduce pain.•  Copaiba EO–  Anti-inflammatory•  Sacred Frankincense EO–  anti-inflammatory, anticancer, supports skin health, calming, promotes spiritual awareness•  Cedarwood EO–  calming, purifying, stimulates the pineal gland – which releases melatonin•  Bergamot EO–  calming, antibacterial, antidepressant, relieves anxiety•  Peppermint EO–  anti-inflammatory, antitumoral, antiparasitic, antibacterial, antiviral, antifungal, pain relieving, appetitecurbing, purifying, stimulating to mind•  Rosewood EO–  improves skin elasticity, antifungal, stimulant•  Clove EO–  antiaging, antitumoral, antimicrobial, analgesic/anesthetic, antioxidant, anti-inflammatory•  Coconut oil (FCO) ––  Skin smoother and softener, facilitates absorption of essential oils
    • Chaste Tree Oil(Vitex Oil)Wait! The most important newingredient?
    • Chaste Tree (Vitex agnus castus)ž  “Animal and human studies have shown thatextracts of chaste tree bind to dopamine2receptors in the anterior pituitary and decreaseboth basal- and thyrotropin-releasing-hormonestimulated secretion of prolactin. This decreasein prolactin leads to increased progesteroneproduction in the luteal phase of themenstrual cycle, which reduces symptoms ofPMS. Consistent with this theory, PMS sufferershave significantly higher rates of prolactinthroughout their cycles, especially in the secondand third weeks.” Vitex has been speculated tocorrect hyperprolactinemia, thus allowingnormal corpus luteum development andpreventing PMS. (various authors, see Vitexreferences)
    • Chaste Tree Reducesinflammation•  “Vitex extract remarkably inhibited inflammationand [inflammatory pain] and can be used fortreatment of inflammatory diseases.” (Ramezani etal. 2010)ž Moderate anti-inflammatory activity through6a,11a-dihydro-6H-[1]benzofuro[3,2-c][1,3]dioxolo[4,5-g]chromen-9-ol (Ahmad et al.2010)
    • WHAT’S THE KEY PART OFCHASTE TREE?
    • CASTICIN &VITEXICARPINNatural Chemicals called
    • •  Casticin–  “Casticin has potent analgesic and anti-hyperprolactinaemia properties.” (Hu et al 2007)–  “…casticin, isolated from the aerial parts of the V.agnus castus possess significant anti-inflammatory activity.” (Ahmad et al 2010).–  “casticin has significant anti-inflammatoryeffect on acute inflammation.” (Lin et al 2007)–  Significant anti-inflammatory activity fromcasticin, p-hydroxybenzoic acid, and 3,4-dihydroxybenzoic acid (Choudhary et al 2009)–  Casticin and artemetin have potentlipoxygenase inhibition (Choudhary et al 2009)–  “casticin has the potential for use in the treatmentof allergic asthma.” (Koh et al. 2011)
    • •  Vitexicarpin– “showed moderate chymotrypsin ureaseinhibitory and anti-inflammatoryactivities.” (Ahmad et al 2010)– “potential therapeutic agent involved ininflammatory/immunoregulatorydisorders such as rheumatoid arthritisand lymphomas.” (You et al. 1998)– “Vitexicarpin significantly reducedvascular inflammation” (Lee et al 2011)
    • PROGESTERONE!!!!!So this is a lot like
    • WILD YAM(Dioscorea villosa)
    • History of yam use
    • Yam current use
    • Precursor to major hormones
    • References1. Hu, Y et al. 2007. Anti-nociceptive and anti-hyperprolactinemia activities of Fructus viticis and its effective fractions and chemical constituents.Phytomedicine 14:668-674.2. Ahmad, B et al. 2010. Biological activities of a new compound isolated from the aerial parts of Vitex agnus castus L. African Journal of Biotechnology 9(53):9063-9069.3. Lin, S et al. 2007. In vivo effect of casticin on acute inflammation. Zhong Xi Yi Jie He Xue Bao (5):573-576.4. Choudhary, MI et al. 2009. Antiinflammatory and lipoxygenase inhibitory compounds from Vitex agnus-castus. Phytother. Res. 23:1336-1339.5. Koh, DJ et al. 2011. Inhibitory effects of casticin on migration of eosinophil and expression of chemokines and adhesion molecules in A549 lung epithelialcells via NF-κB inactivation. J. Ethnopharmacol. 136(3):399-405.6. You, KM et al. 1998. Vitexicarpin, a flavonoid from the fruits of vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro.Planta Med. 64(6):546-550.7. Lee, SM et al. 2012. Vascular protective role of vitexicarpin isolated from Vitex rotundifolia in human umbilibal vein endothelial cells. Inflammation 35(2):584-593.8. Ramezani, M. et al. 2010. Antinociceptive and anti-inflammatory effects of hydroalcohol extract of Vitex agnus castus fruit. Proceedings of WorldAcademy of Science, Engineering and Technology 64: 619-621.Vitex agnus-castus References9. Kuruüzüm-Uz, A., et al. 2003. Glucosides from Vitex agnus-castus. Phytochemistry 63: 959-964.10. Bruno, M., et al. 2010. Extraction, separation and isolation of volatiles from Vitex agnus-castus L. (Verbenaceae) wild species of Sardinia, Italy, bysupercritical CO2. Natural Product Research, 24(6):569-579.11. Gardiner, P. 2000. Chasteberry (Vitex agnus castus). Http://www.mcp.edu/herbal/default.htm. The Longwood Herbal Taskforce.12. Lucks, B. C., J. Sørensen, and L. Veal. 2002. Vitex agnus-castus essential oil and menopausal balance: a self-care survey. Complementary Therapiesin Nursing & Midwifery 8:148-154.13. Lucks, B. C. 2003. Vitex agnus castus essential oil and menopausal balance: a research update. The International Journal of Aromatherapy 13(4):169-172.14. Hardy, M. L. 2000. Herbs of special interest to women. Journal of American Pharmaceutical Assoc. 40(2):234-242. http://tgmeds.org.uk/herba.html15. Berger, D., et al. 2000. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS). Arch Gynecol Obstet264:150-153.16. Schellenberg, R. 2001. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomized, placebo controlled study.British Medical Journal 322:134-137.Wild Yam References17. PDR for Herbal Medicines. 1998. Montvale, NJ: Medical Economics Company, Inc.18. Swain, Liz. 2005. Mexican Yam. Gale Encyclopedia of Alternative Medicine. The Gale Group, Inc.http://www.encyclopedia.com/doc/1G2-3435100530.html19. Hooker, Eric. 2004. Final Report of the Amended Safety Assessment of Dioscorea villosa (Wild Yam) Root Extract. International Journal of Toxicology23:49-54.20. Rosenberg Zand, R. S., D. J. A. Jenkins, and E. P. Diamandis. 2001. Effects of natural products and nutraceuticals on steroid hormone-regulated geneexpression. Clinica Chimica Acta 312:213-219.21. Wojcikowski, K. et al. 2008. Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways. Food and Chemical Toxicology46:3122-3131.22. Komesaroff, P. A., et al. 2001. Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women.Climacteric 4:144-150.23. Abascal, K. and E. Yarnell. 2005. Combining Herbs in a Formula for Irritable Bowel Syndrome. Alternative & Complementary Therapies 11:17-23.24. Mazzio, E. A. and K. F. A. Soliman. 2009. In Vitro Screening for the Tumoricidal Properties of International Medicinal Herbs. Phytotherapy Research23:385-398.25. Wu,W. et al. 2005. Estrogenic Effect of Yam Ingestion in Healthy Menopausal Women. Journal of the American College of Nutrition 24:235-243.26. Hu, C. et al. 2007. A Spirostanol Glycoside from Wild Yam (Dioscorea villosa) Extract and Its Cytostatic Activity on Three Cancer Cells. Journal ofFood and Drug Analysis 15:310-315.
    • Lack of Estradiolis a problem, too!!THIS IS WHY FIBRO GETSWORSE WITH MENOPAUSE!!!(Not all women with fibromyalgianeed estradiol.)
    • “E2 (estradiol) significantlyincreased wound healing.”Florian M, Florianova L., et al. Interaction of estrogen and tumornecrosis factor alpha in endothelial cell migration and early stage ofangiogenesis. Endothelium. 2008 Sep-Oct;15(5-6):265-75.
    • What YLEO product bestelevates estradiol levelsnaturally?
    • Clary Sage™•  Mostly phytoestrogens•  Natural plant estrogens•  Can apply topically ortake in capsule form
    • Lack of CortisolCAN BE A BIG PROBLEM!!(Addison’s Disease)
    • “Patients with FMS hadsignificantly lower cortisollevels during the day, mostpronounced in the morning.”Riva R, Mork PJ, et al. Fibromyalgia syndrome is associatedwith hypocortisolism. Int J Behav Med. 2010 Sep;17(3):223-33.
    • How to increase your owncortisol levels?
    • Thyromin™Contains:Vitamin E (as mixedtocopherols),iodine (from kelp &potassium iodide),potassium (as potassiumcitrate and potassiumiodide),proprietary Thyromin blend:parsley (Petroselinumcrispum) leaf,thyroid powder,L-Tyrosine, pituitary extract
    • Why the associated horribleChronic Fatigue?
    • Chronic Fatigue Syndrome•  If it’s not anemia and not a viralcondition then it’s pituitary (rememberthe STALK is VERY FRAGILE)…(Thisis NOT magical)•  Think about it – low thyroid, low tes, lowGH can and do all cause fatigue.•  So does low progesterone.•  “When you hear hoofbeats – think ofhorses!”
    • Fatigue after TBI: associationwith neuroendocrine abnormalities.Brain Inj. 2007 Jun;21(6):559-66. Bushnik T, Englander J, Katznelson L.Rehabilitation Research Center, San Jose, CA 95128, USA. tamara@tbi-sci.orgOBJECTIVE: Evaluate the association between neuroendocrine findings and fatigueafter traumatic brain injury (TBI)“Given the high prevalence of pituitaryabnormalities, screening forhypopituitarism after TBI is areasonable recommendation.”
    • As in your AFL.Right?
    • Low Thyroid is a Cause ofFatigue“For diagnoses related tohypothyroidism, typical problemsinclude fatigue, weight gain, depression,lethargy, dry skin, cold intolerance, voicechange, change in menses, musclecramps, or treatment of a thyroidcondition.”-- Melish JS. Thyroid Disease. In: Walker HK, Hall WD, Hurst JW, editors.Clinical Methods: The History, Physical, and Laboratory Examinations. 3rdedition. Boston: Butterworths; 1990. Chapter 135.
    • "the hypocortisolism found inchronic fatigue syndrome may besecondary to reduced adrenalgland output."Cleare AJ, Miell J, et al. Hypothalamo-pituitary-adrenal axisdysfunction in chronic fatigue syndrome, and the effects oflow-dose hydrocortisone therapy. J Clin Endocrinol Metab.2001 Aug;86(8):3545-54.
    • What can deal with both ofthese?
    • Thyromin™Contains:Vitamin E (as mixed tocopherols),iodine (from kelp & potassiumiodide),potassium (as potassium citrate andpotassium iodide),proprietary Thyromin blend:parsley (Petroselinum crispum) leaf,thyroid powder,L-Tyrosine, pituitary extract (frombovine),adrenal extract (from bovine),L-cystine, L-cysteine HCl,peppermint (Mentha piperita)† leaf,spearmint (Mentha spicata)† leaf,myrtle (Myrtus communis)† leaf, andmyrrh (Commiphora myrrha)† resin.
    • Woah, let’s look at that again.
    • Low Thyroid is a Cause ofFatigue“For diagnoses related tohypothyroidism, typical problemsinclude fatigue, weight gain, depression,lethargy, dry skin, cold intolerance, voicechange, change in menses, musclecramps, or treatment of a thyroidcondition.”-- Melish JS. Thyroid Disease. In: Walker HK, Hall WD, Hurst JW, editors.Clinical Methods: The History, Physical, and Laboratory Examinations. 3rdedition. Boston: Butterworths; 1990. Chapter 135.
    • What YLEO oil can you get inAustralia that helps withhypothyroidism?(Can Improve Low Thyroid)45min
    • Myrtle™
    • Anyone here with cold handsand feet?RAISE YOUR HANDS!
    • Here’s the emotional tie in•  Depression, lethargy, fatigue.•  Lack of HGH causes PTSD, depression,fatigue, confusion.•  Low tes causes decreased libido,fatigue, depression.•  Lack of progesterone causesdepression, fatigue, PMS.•  FIBRO IS 50% EMOTIONAL!!!
    • What oil helps you deal withhard past adversity?Trauma Life™QUIZ TIME!!
    • What oil helps you deal withadversity and pull good thingsunto you?Abundance™
    • What oil blend makes you feelyour pain and happiness inyour life again?Sensation™
    • Why does fibro get worse withmenopause?Because you quit producingestradiol, andprogesterone, andtestosteronewhich are ALL very healing towomen.
    • Do you know who the7 Menopausal Dwarves are?•  Sweaty•  Bloaty•  Sleepy•  Forgetful•  Itchy•  Witchy (with a B??!?!)•  and Psycho!If you don’t want to be one of thesedwarves then let’s look at theliterature…
    • PMS/Early Menopause/MigrainesThese are often thought by most physicians to becaused by low estradiol (estrogen).Most physicians are wrong.Most medical articles are wrong.A decline in progesterone usually is the cause.There are good articles that are correct.Joel Hargrove, MD’s work at Vanderbilt is correctand good.Europeans make fun of American doctors becausewe don’t get it. (Do Australians??)
    • PMS/Early Menopause/MigrainesLow progesterone causes these problems.Low progesterone is caused by lack of FSH,usually.FSH comes from the front of the pituitary –remember?Lack of FSH occurs with pituitary damage orwith real and timely (age 51) menopause fromfailure of the ovaries.
    • Hormones and vasculatureThe posteriorpituitary elutesACTH andcontrols theadrenals.TSHHGHLH FSHNotice thefragilevasculature!
    • How does FSH work in women?FSH StimulatesovariesOutcomesP4P4 ishumanprogesterone!
    • The majority of so-called medical expertssay you should go quietly into the dark…•  “Don’t treat those symptoms – those medscause breast cancer.”•  “Grow up! Hot flashes won’t hurt you!”•  “Night sweats eventually go away – just turn ona fan.”•  “Wear a wig – that’s what they’re for.”•  “We’ll just cut out that nasty uterus – you don’tneed it anyway!”•  Don’t sweat the petty things and NEVER petthe sweaty things!
    • Human P4!What’s that answer again?Though human estrogen (17β-estradiol) has athousand benefits, too but my time tonight islimited so…
    • Human Progesterone (P4)Progesterone (4-pregnene-3,20-dione or P4 in this case[i])is the “feel good” hormone of pregnancy. We are strictlytalking about naturally occurring biologically identical humanprogesterone – not synthetic progestational agents such asprogestin, medroxyprogesterone acetate, or norethisterone –these are not the natural progesterone and are veryproblematic and side effect intensive (they have almost exactlythe opposite of the side effects to the benefits of naturalprogesterone).[i] Hargrove, JT; Osteen, KC. An Alternative Method of Hormone Replacement Therpay Using the NaturalSex Steroids. Infertility and Reproductive Medicine Clinics of North America. Volume 6, Number 4, October1995.
    • Known Side Effects From TakingMedroxyprogesterone (Provera® or MPA)•  MPA is a teratogen and cannot be used in pregnancy•  MPA increases cholesterol and increases risk of heart disease•  MPA increases foam cell formation, endothelial inflammation,plaque formation, strokes and heart attacks.•  MPA is carcinogenic and causes breast cancer[i] (see PEPI[ii]trial).•  MPA has no effect on osteoporosis (i.e. does not help)•  MPA is associated with side effects of increased bleeding,bloating, depression•  MPA provides a serum progesterone level of zero.[i] Campagnoli C, Clavel-Chapelon F, Kaaks R, Peris C, Berrino F. Progestins and progesterone in hormonereplacement therapy and the risk of breast cancer. J Steroid Biochem Mol Biol. 2005 Jul;96(2):95-108.[ii] Cushman M, Legault C, Barrett-Connor E, et al. Effect of postmenopausal hormones on inflammation-sensitiveproteins: the Postmenopausal Estrogen/Progestin Interventions (PEPI) Study. Circulation. 1999;100:717-722.
    • Benefits of Biologically Identical Human Progesterone (P4)Lowers cholesterol [at 200 mgm of micronized progesterone a day in onePEPI study arm[i] – sound familiar? Program 120 Team](especiallywhen given in conjunction with E2)[ii].Elevates HDL levels (hard to do)[iii].Decreases foam cell formation[iv], endothelial inflammation, plaqueformation, and thus strokes and heart attacks.Decreases breast density and thus breast cancer[v].[i] Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. Writing Group for the PEPI Trial. JAMA.1995;273:1389-96.[ii] Hargrove JT, Maxson WS, Wentz AC, Burnett LS. Menopausal hormone replacement therapy with continuous daily oral micronized estradiol and progesterone.Obstet Gynecol. 1989 Apr;73(4):606-12.[iii] Sitruk-Ware R, Bricaire C, DeLignieres B, et al. Oral Micronized progesterone. Bioavailability pharmacokinetics, pharmacological and therapeutic implications—A Review, Contraception. 1987; 36:373-402.[iv] WEN-SEN LEE, CHAO-WEI LIU, SHU-HUI JUAN, YU-CHIH LIANG, PEI-YIN HO, AND YI-HSUAN LEE. Molecular Mechanism of Progesterone-InducedAntiproliferation in Rat Aortic Smooth Muscle Cells. Endocrinology 144(7):2785–2790. Copyright © 2003 by The Endocrine Societydoi: 10.1210/en.2003-0045.[v] Campagnoli C, Clavel-Chapelon F, aaks R, Peris C, Berrino F. Progestins and progesterone in hormone replacement therapy and the risk of breast cancer. JSteroid Biochem Mol Biol. 2005 Jul;96(2):95-108.
    • Benefits of Biologically Identical Human Progesterone (P4)Increases bone density preventing osteoporosis and related fractures[i].Prevents and treats endometrial hyperplasia (use triple or quadruple the usualdose)[ii].If you give enough progesterone almost always halts uterine bleeding (cyclicalbleeding)[iii].Can act as a hypersomniac (sleep aid) if you give 100 mgm at night orally forsleep[iv] problems. Orally administered progesterone may have advantagesover other routes of administration in the treatment of premenstrualsyndrome (PMS) because of substantially higher levels of the anxiolyticmetabolites 5 alpha and 5 beta pregnanolone[v] which also causedrowsinesss[vi].[i] Lydeking-Olsen E, Beck-Jensen JE, Setchell KD, Holm-Jensen T.Soymilk or progesterone for prevention of bone loss--a 2 year randomized, placebo-controlled trial. Eur J Nutr. 2004 Aug;43(4):246-57.[ii] Randall TC, Kurman RJ. Progestin treatment of atypical hyperplasia and well-differentiated carcinoma of the endometrium in women under age 40. Obstet Gynecol 1997;90:434-40.[iii] Fraser IS. Regulating menstrual bleeding. A prime function of progesterone. J Reprod Med 1999;44(2 suppl):158-64.[iv] Arafat ES, Hargrove JT, Maxson WS, Desiderio DM, Wentz AC, Andersen RN. Sedative and hypnotic effects of oral administration of micronized progesterone may be mediatedthrough its metabolites. Am J Obstet Gynecol. 1988 Nov;159(5):1203-9.[v] Vanselow W, Dennerstein L, Greenwood KM, de Lignieres B. Effect of progesterone and its 5 alpha and 5 beta metabolites on symptoms of premenstrual syndrome according toroute of administration. J Psychosom Obstet Gynaecol. 1996 Mar;17(1):29-38.[vi] Maxson WS. The use of progesterone in the treatment of PMS. Clin Obstet Gynecol. 1987:30:465-477
    • Benefits of Biologically Identical Human Progesterone (P4)Improves(along with testosterone)[i].Synthetic progestins, on the other hand, often cause androgenic sideeffects (acne, body and facial hair), depression, and weight gain.Micronized progesterone is devoid of the androgenic effects onthe lipid profile seen with MPA and other synthetic progestationalagents; for that reason, it may be preferable in HRT protocols forperimenopausal and postmenopausal women[ii].Men should not take progesterone unless they are a sex offender in jail[iii].[i] Davis SR, Guay AT, Shifren JL, Mazer NA. Endocrine aspects of female sexual dysfunction. J SexMed. 2004 Jul;1(1):82-6.[ii] Hargrove JT, Maxson WS, Wentz AC, Burnett LS. Menopausal hormone replacement therapy withcontinuous daily oral micronized estradiol and progesterone. Obstet Gynecol. 1989:73:606-612.[iii] Zumpe D, Clancy AN, Michael RP. Progesterone decreases mating and estradiol uptake inpreoptic areas of male monkeys. Physiol Behav. 2001 Nov-Dec;74(4-5):603-12.
    • Oh, for weight gain…
    • Dr. P’s New ExerciseProgram!!!The Block Program
    • Here it is!
    • Benefits of Biologically Identical Human Progesterone (P4)Oral P4 for also treats PMS in the same manner (give double or triplethe usual dose for about a week)[i].Remember -- an oral micronized progesterone given sublinguallypreparation has improved bioavailability and much fewer reportedside effects compared with synthetic progestins[ii].P4, when given with estradiol, improves the quality of life according to aMayo Clinic report[iii][i] Ahlgrimm, M. (May 2003). Managing pms and perimenopause symptoms The role of compoundedmedications, Advance for Nurse Practitioners, (11)5, p. 53.[ii] APGAR, B.S., GREENBERG, G. Practical Therapeutics Using Progestins in Clinical Practice. AFP- October 15, 2000.[iii] Fitzpatrick, LA; Pace, C; Wiita, B. Comparison of Regimens Containing Oral MicronizedProgesterone or Medroxyprogesterone Acetate on Quality of Life in Postmenopausal Women:A Cross-Sectional Survey. Journal of Womens Health & Gender-Based Medicine. May 2000,Vol. 9, No. 4 :381 -387.
    • Hargrove, JT et al fromInfertility and Reproductive Clinics of North America1. Titrate progesterone to pre-menopausal levels. Progesterone isprotective!2. Treat menopause as a deficiency state.3. Correct all hormone levels that are deficient (remember: it’s the hormonalmilieu!).4. Use human micronized bio-identical hormones[i].5. Metabolized by normal metabolic pathways.6. This approach avoids problem causing metabolites.7. There is absolutely NO reason to not give progesterone to ALLpostmenopausal women – hysterectomy or not.8. There is no good reason NOT to give these bio-identical estrogens andprogesterone every day[ii]. Do not cycle – give them all every day.[i] Hargrove JT, Maxson WS, Wentz AC, Burnett LS. Menopausal hormone replacement therapy withcontinuous daily oral micronized estradiol and progesterone. Obstet Gynecol. 1989 Apr;73(4):606-12.[ii] Hargrove JT, Maxson WS, Wentz AC, Burnett LS. Menopausal hormone replacement therapy withcontinuous daily oral micronized estradiol and progesterone. Obstet Gynecol. 1989 Apr;73(4):606-12.
    • Why the hot flashes and nightsweats?98% Due to Lack of Progesterone!2% Due to Lack of Estradiol
    • Why the horrible PMS?
    • Progesterone (P4) for PMSBenefits or halts symptoms of premenstrualsyndrome (PMS).-- Vanselow W, Dennerstein L, Greenwood KM, de Lignieres B. Effect ofprogesterone and its 5 alpha and 5 beta metabolites on symptoms ofpremenstrual syndrome according to route of administration. J PsychosomObstet Gynaecol. 1996 Mar;17(1):29-38.
    • Why the endometriosis?
    • Progesterone (P4) for EndometriosisThere is a current belief among researchers thatendometriosis occurs secondary to endometrialresistance to progesterone in some women. The onlyway known to overcome this resistance is it to take largerdoses of progesterone (it’s better than narcotics andhysterectomies).--Young SL, Lessey BA. Progesterone function in human endometrium: clinicalperspectives. Semin Reprod Med. 2010 Jan;28(1):5-16.
    • Why the migraine headaches?
    • Progesterone (P4) forMigraine Headaches“Progesterone preventsmenstrual migraine headaches inwomen.”-- Somerville BW. The role of progesterone in menstrual migraine. Neurology. 1971Aug;21(8):853-9.WIDELY KNOWNSINCE 1971 -- DOYOU KNOW HOWIMPORTANT THISIS?
    • Why the bad insomnia?
    • “Insomnia is mostly due to low GH. LowHGH is associated with the inability toenter REM and Stage IV sleep – thelightest level of sleep and the deepestand most restful respectfully.”-Hayashi M, Shimohira M, Saisho S, Shimozawa K, Iwakawa Y. Sleepdisturbance in children with growth hormone deficiency. Brain Dev. 1992 May;14(3):170-4.-Guilhaume A, Benoit O, Gourmelen M, Richardet JM. Relationship betweensleep stage IV deficit and reversible HGH deficiency in psychosocial dwarfism.Pediatr Res. 1982 Apr;16(4 Pt 1):299-303.
    • Best natural option here?
    • ImmuPro™Contains:MelatoninNingxia wolfberry (Lyciumbarbarum), reishi (Ganodermalucidum) mycelia‡, maitake (Grifolafrondosa) mycelia‡, agaricus blazeimycelia‡, arabinogalactin (larchtree extract)‡, limonene (fromorange essential oil), strawberrypowder‡,fructose,raspberry juice,pure lemon powder.
    • What oil can take your highnerves away allowing you torest a little?Stress Away™
    • Why the muscle and jointpain?
    • Lack of HGH, testosterone,progesterone, etc.
    • Anything acutely you can dofor this?YES!!
    • Any ideas?
    • Deep Relief™Contains:Peppermint (Mentha piperita),Balsam Fir (Abies balsamea),Clove (Syzygium aromaticum),Vetiver,Wintergreen (Gaultheriaprocumbes),Lemon (Citrus limon),Helichrysum (Helichrysumitalicum),Copaiba (Copaifera reticulate),Coconut oil.
    • Why the weird numbness andtingling in your extremities?(Or all over for that matter!)Lack of various hormonescause demyelination of nerves– especially in the extremityand the Vagal Nerve!
    • So What is myelin?And what is demyelination”?
    • myelin sheath, a segmented fatty lamination composed of myelin thatwraps the axons of many nerves in the body. The usual thickness of themyelin sheath is between 200 and 800 μm. Various diseases such asmultiple sclerosis can destroy myelin wrappings.Mosbys Medical Dictionary, 8th edition. © 2009, Elsevier.MYELIN
    • The Vagal Nerve Often Demyelinates First!•  Vagal Nerve controls the sympatheticnervous system•  It runs from your head to bladder•  It controls swallowing and stomach•  It controls your small bowels anddigestion•  It controls your heart rate•  It controls your colon•  It controls your bladder
    • MS is also a demyelinating disease.Neurology. 2003 Sep 23;61(6):851-3.Fatigue in MS is related to sympathetic vasomotor dysfunction.Flachenecker P, Rufer A, Bihler I, Hippel C, Reiners K, Toyka KV, Kesselring J.Department of Neurology, Julius-Maximilians-Universität, Würzburg, Germany.peter.flachenecker@surfeu.deAbstractThe authors studied standard autonomic function tests and measuresof heart rate variability in 60 patients with multiple sclerosis (MS) andcorrelated results with the Fatigue Severity Scale and the ModifiedFatigue Impact Scale. The authors found that autonomicresponses correlated with fatigue resembling ahypoadrenergic orthostatic response, possibly due toa sympathetic vasomotor lesion with intact vagal heartcontrol. Treatments to control sympathetic dysfunction for MS-associated fatigue deserve further study
    • Progesterone (P4) for nervehealing (remyelination)P4 assists in myelination of nerves – so womenwith low P4 levels often have tingling or burningor a gross neuropathy – and normalizing P4 canreverse this demyelination.-- De Nicola AF, Labombarda F, et al. Progesterone neuroprotection in traumatic CNSinjury and motoneuron degeneration. Front Neuroendocrinol. 2009 Jul;30(2):173-87.
    • Lack of testosterone causesdemyelination
    • Tes is a Neuroactive SteroidPeripheral neuropathy, either inherited or acquired, represents a verycommon disorder for which effective clinical treatments are not availableyet. Observations here summarized indicate that neuroactive steroids,such as progesterone, testosterone and their reduced metabolites,might represent a promising therapeutic option. Neuroactive steroidsmodulate the expression of key transcription factors for Schwann cellfunction, regulate Schwann cell proliferation and promote theexpression of myelin proteins involved in the maintenance of myelinmultilamellar structure, such as myelin protein zero and peripheralmyelin protein 22.Roglio I, Giatti S, et al. Neuroactive steroids and peripheral neuropathy. Brain Res Rev.2008 Mar;57(2):460-9.Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases,University of Milan, Via Balzaretti 9, 20133, Milan, Italy.
    • Arch Neurol. 2007 May;64(5):683-8.Sicotte NL, Giesser BS, Tandon V, Klutch R, Steiner B, Drain AE, Shattuck DW, Hull L, Wang HJ, Elashoff RM, Swerdloff RS,Voskuhl RR.Division of Brain Mapping, Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, California,USA.OBJECTIVE: To study the effect of testosterone supplementation on men with multiplesclerosis (MS). RESULTS: One year of treatment withtestosterone gel was associated with improvement incognitive performance (P = .008) and a slowing of brainatrophy (P <.001). There was no significant effect of testosterone treatment on gadolinium-enhancing lesion numbers (P = .31) or volumes (P = .94). Lean body mass (muscle mass) wasincreased (P = .02). CONCLUSION: These exploratory findingssuggest that testosterone treatment is safe and welltolerated and has potential neuroprotective effects in menwith relapsing-remitting MS.Testosterone treatment in multiple sclerosis: a pilot study.
    • Lack of HGH REALLY causesa demyelination.
    • Glia. 2009 Aug 1;57(10):1062-71.Adult-onset deficiency in growth hormone and insulin-like growthfactor-I alters oligodendrocyte turnover in the corpus callosum.Hua K, Forbes ME, et al.“adult-onset GH/IGF-Ideficiency decreased cellproliferation in the whitematter and decreased thesurvival of newbornoligodendrocytes”
    • ScientificWorldJournal. 2006 Jan 18;6:53-80.Aspects of growth hormone and insulin-like growth factor-I related toneuroprotection, regeneration, and functional plasticity in the adultbrain.Aberg ND, Brywe KG, Isgaard J.“accumulating evidence suggests that thegrowth hormone (GH)/insulin-likegrowth factor-I (IGF-I) axis is involved inthe regulation of brain growth,development, and myelination. Inaddition, both GH and IGF-I affectcognition and biochemistry in the adultbrain”
    • A product to help this too?
    • PD 80/20™Contains:PregnenoloneDHEA(Both heal nerves andremyelinate)
    • Or (oil blend)?Mister™
    • Why the hair loss?
    • Lack of Thyroid Causes HairLossClinical observations of hair conditions involving hormones beyond theandrogen horizon have determined their role in regulation of hair growth:estrogens, prolactin, thyroid hormone, cortisone, growth hormone (GH),and melatonin. Primary GH resistance is characterized by thin hair, whileacromegaly may cause hypertrichosis. Hyperprolactinemia may causehair loss and hirsutism. Partial synchronization of the hair cycle in anagenduring late pregnancy points to an estrogen effect, while aromataseinhibitors cause hair loss. Hair loss in a causal relationship tothyroid disorders is well documented.Trüeb RM.[Hormones and hair growth]. [Article in German] Hautarzt. 2010Jun;61(6):487-95.
    • Lack of HGH Causes hair lossClinical observations of hair conditions involving hormones beyond theandrogen horizon have determined their role in regulation of hair growth:estrogens, prolactin, thyroid hormone, cortisone, growth hormone (GH), andmelatonin. Primary GH resistance is characterized by thin hair, whileacromegaly may cause hypertrichosis. Hyperprolactinemia may cause hairloss and hirsutism. Partial synchronization of the hair cycle in anagen duringlate pregnancy points to an estrogen effect, while aromatase inhibitorscause hair loss. Hair loss in a causal relationship to thyroid disorders is welldocumented.Trüeb RM.[Hormones and hair growth]. [Article in German] Hautarzt. 2010 Jun;61(6):487-95.
    • Lack of Estradiol causes hairloss, too!This hypoestrogenemia may be spontaneously attenuatedby local synthesis of oestradiol in peripheral target tissuesaccording to the intracrine process. This new hormonalpattern is associated with skin atrophy, hyperseborrhea,increased pilosity on the cheeks and upper lip, loss ofscalp hair, increase in degeneration of elastic tissue,atrophy and dryness of the vaginal mucosa. Estrogentreatment in post menopausal women has been shown toincrease collagen content, dermal thickness and elasticity.Bensaleh H, Belgnaoui FZ, et al. [Skin and menopause]. [Article in French] AnnEndocrinol (Paris). 2006 Dec;67(6):575-80.
    • Why the cold hands and feet?(It’s DEFINITELY NOT Raynaud’s– even though your doctor toldyou so.)
    • HYPOTHYROIDISM!!!“For diagnoses related to hypothyroidism,typical problems include fatigue, weightgain, depression, lethargy, dry skin, coldintolerance, voice change, change inmenses, muscle cramps, or treatment of athyroid condition.”-- Melish JS. Thyroid Disease. In: Walker HK, Hall WD, Hurst JW, editors. ClinicalMethods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston:Butterworths; 1990. Chapter 135.
    • Hypothyroidism causesbrutally cold extremitiesEighteen patients had ongoing or intermittent ongoing distal pain intheir limbs. Of these, 8 reported evoked and 10 reported paroxysmalpain. Fifteen patients had only diffuse musculoskeletal pain. A total of16 patients had "hyperphenomena" (brush-evoked allodynia, punctatehyperalgesia, or cold allodynia or a combination of these, in their feetor hands or both). Eight patients were classified as having large fiberneuropathy, whereas 20 had "hypophenomena" (34 out of 38total had problems with cold extremities)Ørstavik K, Norheim I, Jørum E. Pain and small-fiber neuropathy in patients with hypothyroidism.Neurology. 2006 Sep 12;67(5):786-91.
    • Why are you often told youhaveRaynaud’s Phenomenon?
    • It’s really hypothyroidism!"Raynauds Phenomenon is oftenmistakenly diagnosed when the signsand symptoms are really felt to be theinitial manifestation of hypothyroidism."Coleman CE, Sessoms SL. Raynauds Phenomenon as the Initial Manifestation ofHypothyroidism. J Clin Rheumatol. 1998 Oct;4(5):270-3.
    • What oil for hypothyroidism?Myrtle™!
    • Why the IBS?
    • Demyelination OccursRheumatology (Oxford). 2008 Feb;47(2):208-11.A subset of fibromyalgia patients have findingssuggestive of chronic inflammatorydemyelinating polyneuropathy and appear torespond to IVIg.Caro XJ, Winter EF, Dumas AJ.Division of Rheumatology, David Geffen School of Medicine at UCLA,Los Angeles, CA, USA
    • MainlyDemyelination of theVagal NerveAnd the Vagal Nerve supplies thesmall bowels
    • Vagal Nerve supplies the Small BowelsAm J Physiol. 1998 Mar;274(3 Pt 1):G552-60.Vagal involvement in dietary regulation of nutrient transport.Bates SL, Sharkey KA, Meddings JB.“a role for the vagus nerve in regulatingintestinal transport function”So if the Vagal Nerve demyelinates, nutrients cannot beabsorbed!
    • Why the ICS?Interstitial Cystitis Syndrome –syndrome means know oneknows what causes it.
    • ICS Starts as BladderProblems•  Frequency and Urgency.•  Check for low tes or low GH.•  Remember bladder problems are oftencaused by demyelination of the VagalNerve.•  Be patient – can take 9-12 months toresolve.
    • Interstitial cystitis (IC)•  Especially bad IC – this is a SEVERE bladder problem.These women are in AGONY.•  Low GH rather than low testosterone. Usually boththough.•  Horribly worse after menopause starts (double whammyagain).•  These patients often present with fibromyalgia andsarcopenia.•  Get a good history and labs.•  Start low and go slow.•  Some are on IC diets so just start them on an injectabletiny dose (.05) GH and topical tes.•  Be patient! Can take months to improve or resolve.•  Remember – you cannot undo the damage that otherdoctors (though well meaning) have done to them withDMSO flushes, etc.
    • Comorbidity of interstitial cystitis with otherunexplained clinical conditions.Urol. 2004 Oct;172(4 Pt 1):1242-8. Buffington CA. Department of Veterinary Clinical Sciences, College ofVeterinary Medicine, Ohio State University, Columbus, Ohio, USA.RESULTS: A significant overlap of symptoms existsamong a number of unexplained clinical conditionsand a common stress response pattern of increasedsympathetic nervous system function in theabsence of comparable activation of thehypothalamic-pituitary-adrenal axis occurs in asubset of patients with many of these conditions.
    • Why the palpitations?Again From Vagal NerveDemyelination
    • Ann Neurol. 1987 May;21(5):419-30.Disorders of the autonomic nervous system: Part 1.Pathophysiology and clinical features.McLeod JG, Tuck RR.The peripheral neuropathies most likely to cause severeautonomic disturbance are those in which smallmyelinated and unmyelinated fibers are damaged in thebaroreflex afferents, the vagal efferents to the heart, andthe sympathetic efferent pathways to the mesentericvascular bed. Acute demyelination of the sympatheticand parasympathetic nerves in the Guillain-Barrésyndrome may also cause acute autonomic dysfunction.
    • Why the Joint Problems?
    • Osteoarthritis•  Especially in a younger patient (late 20s),especially male.•  Don’t let them get that knee or hip replaced!•  Protect their heart/brain -- give them other options!•  Beware – orthopods will hate you!•  Properly diagnose them!•  Read them the somatropin package insert (FDAapproved).
    • Effects of chronic growth hormone and insulin-like growthfactor 1 deficiency on osteoarthritis severity in rat kneejoints.Ekenstedt KJ, Sonntag WE, Loeser RF, Lindgren BR, Carlson CS. Arthritis Rheum. 2006 Dec;54(12):3850-8. Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, MN 55108,USA.OBJECTIVE: To determine the effects of chronic deficiency of growth hormone(GH) and insulin-like growth factor 1 (IGF-1) on osteoarthritis (OA) severity.CONCLUSION: These results indicate that chronic GH/IGF-1 deficiency causes an increased severity ofarticular cartilage lesions of OA without the bonylesions normally seen in this disease.
    • What is the Proper Testing forFibromyalgia?•  Starts with Proper Lab Testing•  Next is a really detailed history – in search ofthe “sentinel” event.•  Then a physical exam with EKG if necessary.•  3T MRI of pituitary with contrast (if necessary)•  Then maybe a stress echo – why?•  Mammogram too.•  FOBT if old enough.
    • Serum Labs•  LH/FSH•  Estradiol•  Progesterone•  Free & Total Testosterone•  IGF-1•  Cortisol•  DHEA-SO4•  TSH Free T3 Free T4
    • My Lab Rules•  Fasting at least 12-24 hours.•  Water is okay.•  No nuts, peanut butter or oil for 72 hrs before.•  Off anti-depressants 2-3 days at least before.•  Off Provigil or Nuvigil 2-3 days at least before.•  No melatonin or cantaloupe day/night before.•  No exercise 24 hrs before blood draw.•  Have blood drawn at 8 a.m. – BE THERE!
    • Treatment?(But only if testing shows you’relevels are low. And the naturaloptions have not worked.)
    • Remember – you can’t fix your pituitary but feel you canlive a mostly normal life.•  I think, given tincture of time, I can get ridof 95-98% of their symptoms.•  Treatment, however, is permanent andcontinuous unless they want to go back tothe pain. (Like being a diabetic.)•  Some of them pray for our continuedhealth and safety.•  Remember the “double whammy” patients!
    • Everyone is a SNOWFLAKE!
    • •  Very good if compliant.•  Approx. 40% improvement at 6 months•  Approx. 90% improvement at 12 months•  Approx. 95-8% improvement at 18months•  If REALLY ill –24 months to 98%•  Be patient.•  Start low go slow.Efficacy?
    • Prognosis?•  Good.•  It’s like being a diabetic – if you’re compliantyou can live a mostly normal life. (I do.)•  There is no cure – this is just replacement(again like being a diabetic).•  Normal life if treated early enough.•  I have few patient (none?) who are on painor neuro meds or anti-depressants past 9months of compliance.
    • Vitamins That REALLY Help•  Fish Oil – try Omega Blues™•  You must be on a natural and goodMulti-vitamin -- best is Young LivingMaster His or Master Hers™
    • Finding the right Physician/Medical Doctor(Ugh. Good luck.)
    • Pituitary Endocrinologists?•  Very difficult for you in Utah or Colorado•  Not any true pituitary endocrinologistsavailable here or in any Rocky Mountainstates. (--Surgeon General’s Office)•  1/150 are. 149/150 are “below theneck”•  What do you do in Australia? Ugh…notsure.•  Treat yourself naturally?
    • Good Luck
    • You can also go to my website tolearn morewww.danpursermd.comwww.aespmi.com
    • CANCER BONUSSLIDES
    • Natural ApproachesSupported by the Literature
    • New Data
    • Survivor Tip #1
    • FASTING 48-72 hours every month•  Drink lots of water!•  Cancer cells have a VERY HIGH metabolism!•  Fasting starves cancer cells.•  Fasting can kill cancer cells!•  If you are diagnosed with cancer (and about tostart chemo), always fast 48 hours before eachchemo episode – can improve completeremission rates dramatically (by up to 80+%)!•  Works even in Stage 4 cancers!•  **Prevents cancer formation, too!**
    • This is a GREAT time to drinkSlique Tea™!Helps the appetite and and clearsthe brain!
    • Survivor Tip #2
    • 48 hours prior to surgery ofthe cancer(if you choose that route)ask your doctor to prescribesome PROPANOLOL!
    • Why?•  People get stressed and nervous beforethis very important surgery! (EMOTIONS!)•  That emotional stress is deadly!•  It depresses immune function via adrenalsuppression!•  β – blockers such as PROPANOLOL helpalleviate that stress.•  Pay for it out of pocket (cheap) if needed.•  This trick can dramatically decreasemetastases (70-80%). WOW!
    • This would be a great time totake CortiStop™!(Just 48 hours before and afterthe surgery!)
    • Survival Tip #3
    • Along this same line ofstressfulness of surgeryPain, even while unconscious, is abig cause of stress!
    • Ask your doctor if, duringsurgery, you could haveone dose of IV ketorolac(a NSAID non-narcotic cheappain med)(You could also try Deep Relief™before surgery!!)
    • Again…•  Ketorolac when given IV to help alleviateintraoperative pain•  Seems to dramatically decrease metastasesand survival of the cancer cells•  (Probably reduces stress again.)•  Dramatically increasing Complete Remissionrates!•  Who would have thought?
    • Survival Tip #4(Remember cancer cells have aVERY high metabolism)
    • Ask your doctor to prescribesome inexpensiveMetforminOnly 500 mg a day – cheapenough to buy out of pocket!
    • Metformin is diabetic medicine•  But diabetes IS NOT why you are taking it.•  Same as the fasting 48-72 hours•  Metformin starves the cancer cell dramatically•  Improves cancer cure rates and survival!•  Take for 30-90 days or longer while you areundergoing treatments.•  Won’t make you sick or nauseate you.•  Again in even Stage 4 cancers!•  Again supported by the literature.
    • This trick alone –Triples Complete Remissionrate in Stage 2 & 3 BreastCancersWOW!
    • All these are cutting edgeconcepts now being espousedin the USA by top experts atHarvard and elsewhere…All very easy and inexpensive.(All supported by the literature!)
    • But can increase your survivalrates 70-98%When added together!
    • You might feel terrible doing it.But the cancer cells will feelhorrible (enough to die!)!
    • Go to this website for moreinfo!www.global-cures.orgA non-profit started by a Harvardprofessor of nephrology – supportGlobal Cures!(I have no affiliation with GlobalCures)(A more thoughtful approach to cheaper,more natural, and more effective treatmentsof cancer that improve survival and cure!)