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Tablet friability,harness and dissolution testing
 

Tablet friability,harness and dissolution testing

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    Tablet friability,harness and dissolution testing Tablet friability,harness and dissolution testing Presentation Transcript

    • TABLET FRIABILITY,HARDNESS AND DISSOLUTION By Don Jacob
    • Tablet Friability
      • Tablets are constantly subjected to mechanical shocks & aberration during the manufacturing, packing and transportation process.
      • Such stress can lead to capping, aberration or eve breakage of the tablets
      • It is there fore important that the tablet is formulated to withstand such stress
    • Tablet Friability
      • In order to monitor the resistance of tablets to such stress and to decide on their suitability for further processing such as coating, tablets are routinely subjected to friability test
    • Friability Test
      • Friability is defined as the % of weight loss by tablets due to mechanical action during the test. Tablets are weighing before and after testing and friability is expressed as a percentage loss on pre test tablet weight.
      • Friability refers the ability of the compressed tablet to avoid fracture and breaking during transport
    • Friability Test
      • Friability is closely related to tablet harness and is designed to evaluate the ability of the tablet to with stand aberration in packing, Handling and shipping.
      • Friability is usually measured by the use of Roche fibrilator or tumbler test.
    • Friability Test
      • A number of tablets (20 Nos.) are weighed and placed in the apparatus where they are exposed to rolling and repeated shocks as they fall 6 inches in each turn within the apparatus. After 4 minutes of this treatment or 100 revolutions the tablets are weighed and the weight compared with initial weight. The loss due to abrasion is a measure of tablet friability. The value is expressed in percentage.
    • Friability Test
      • Minimum weight loss of the tablet should not be NMT 1%.
      • There should not be any broken tablet.
      • Hardness
    • Hardness
      • The resistance of tablets to capping,aberation or breakage under conditions of storage, transportation and handling before usage depends on its hardness.
      • Hardness is nothing but crushing strength
    • Hardness
      • If tablet is too hard, it may not disintegrate in the required period of time and will fail dissolution test
      • If tablet is too soft it may not be able to withstand handling during subsequent processing such as coating or packaging and shipping operations.
    • Hardness
      • The force required to break tablet is measured in kilograms and a crushing strength of 4 KG is usually considered to be the minimum for satisfactory tablets.
      • Oral tablets normally have a hardness of 4-10kg,However hypodermic and chewable tablets are usually much softer (3 kg) and some substained release tablets are much harder 10-20 kg.
    • Hardness
      • Tablet hardness has been associated with tablet property such as density and porosity.
      • Hardness generally increase with normal storage of tablets & depends on the shape, chemical properties, binding agent & pressure applied during compression.
    • Hardness
      • Hardness is expressed in Newton.
      • Hardness can also expressed in Kpa.
      • DISSOLUTION
    • Dissolution
      • Active absorption of oral dosage forms depends on adequate release of the API from the product. Dissolution or solubility of the API play pivotal role in this aspect.
      • Dissolution testing is used as a tool to identify a crucial effect in the bioavailability of the API.