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  • 1. NB 200E; Regulatory Systems (4 units) This course will be focused on fundamental topics in homeostatic and regulatory aspects of Neurobiology, with an emphasis on state and hormonal regulation. Meeting time will be 1:00pm - 2:50pm, Mondays and Wednesdays, starting on January 05 and running through March 11, 2009. Final Exam week begins on March 16, 2009. Location is 63-214 CHS (the John Green Room). CHAIRS: Drs. Ron Harper & Ron Szymusiak STAFF: Professors Colwell, Gorski, Harper, Kumar, Macey, Matveyenko, Micevych, McGinty, Szymusiak, Taylor & Wagner Recommended Textbook: Purves et al., Neuroscience, 3rd Edition ADDITIONAL LITERATURE AND REVIEW ARTICLES: Will be assigned to supplement the textbook (see below) LECTURE, LABORATORY, AND PAPER DISCUSSION SCHEDULE Instructor WEEK 1 - 1/05/2009 Monday Jan 05 Basic system integration overview. Sleep, Sleep Harper disordered breathing, cardiovascular consequences Wednesday Jan 07 Harper Sleep pathologies; developmental considerations WEEK 2 - 1/12/2009 Monday 12 Jan Kumar Noninvasive procedures for integrative studies Wednesday Jan 14 Hypocretin Siegel WEEK 3 - 1/19/2009 Monday 19 Jan Martin Luther King Holiday Wednesday Jan 21 Sleep Phylogeny Siegel WEEK 4 – 1/26/2009 Monday Jan 26 Colwell 1
  • 2. Biological Rhythms Wednesday Jan 28 Colwell Rhythms, glycemic regulation, and sleep Matveyenk WEEK 5 - 2/02/2009 Monday Feb 02 Hypothalamic organization Micevych Wednesday Feb 04 Midquarter exam WEEK 6 - 2/09/2009 Monday Feb 09 Szymusiak Fever, Sleep, and cytokines Wednesday Feb 11 McGinty Neurogenesis WEEK 7- 2/16/2009 Monday Feb 16 President’s Day Holiday Wednesday Feb 18 Szymusiak Temperature regulation WEEK 8 - 2/23/2009 Monday Feb 23 Sexual Differentiation of the Gorski Brain: Epigenetic aspects Wednesday Feb 25 Gorski Psychosexual Development Week 9 - 3/02/2009 Monday Mar 02 Wagner Regulation of GnRH secretion Wednesday Mar 04 Wagner Hyperphagia and the brain WEEK 10 - 3/09/2009 Monday Mar 09 Stress, sex and brain function Taylor Wednesday Mar 11 Macey Sex-related brain structural characteristics Final Exam - 3/16/2003 2
  • 3. ADDITIONAL REFERENCES / READINGS: HARPER Harper, R.M., Macey, P.M., Woo, M.A., Macey, K.E., Keens, T.G., Gozal, D. and Alger, J.R. Hypercapnic exposure in Congenital Central Hypoventilation Syndrome reveals central nervous system respiratory control mechanisms. Journal of Neurophysiology 93:1647-1658, 2005. Macey, P.M., Henderson, L.A., Macey, K.E., Alger, J.R., Frysinger, R.C., Woo, M.A., Harper, R.K., Yan-Go, F.L. and Harper, R.M. Brain morphology associated with obstructive sleep apnea. American Journal of Respiratory and Critical Care Medicine 166:1382-1387, 2002. Woo, M.A., Kumar, R., Macey, P.M., Fonarow, G.C. and Harper, R.M. Brain injury in autonomic, emotional, and cognitive regulatory areas in patients with heart failure. Journal of Cardiac Failure In Press. Kumar, R., Woo, M.A., Birrer, B.V., Macey, P.M., Fonarow, G.C., Hamilton, M.A. and Harper, R.M. Mammillary bodies and fornix fibers are injured in heart failure. Neurobiology of Disease. doi:10.1016/j.nbd.2008.10.004. Cross, R.L., Kumar, R., Macey, P.M., Doering, L.V., Alger, J.R., Yan-Go, F.L. and Harper, R.M. Neural alterations and depressive symptoms in Obstructive Sleep Apnea Patients. Sleep 31:1103-1109, 2008. Kumar, R., Macey, P.M., Woo, M.A., Keens, T.G. and Harper, R.M. Neuroanatomic deficits in Congenital Central Hypoventilation Syndrome. Journal of Comparative Neurology 487:361-371, 2005. Kumar, R., Macey, P.M., Woo, M., Alger, J. and Harper, R.M. Diffusion tensor imaging demonstrates brainstem and cerebellar abnormalities in Congenital Central Hypoventilation Syndrome. Pediatric Research 64(3): 275-280, 2008. Henderson, L.A., Woo, M.A., Macey, P.M., Macey, K.E., Frysinger, R.C., Alger, J.R., Yan-Go, F. and Harper, R.M. Neural responses during Valsalva maneuvers in Obstructive Sleep Apnea Syndrome. Journal of Applied Physiology 94:1063-1074, 2003. Harper, R.M., Woo, M.A., Macey, P.M. and Kumar, R. Structural and functional brain abnormalities in Congential Central Hypoventilation Syndrome. In: Genetics of Respiratory Control Disorders. C. Gaultier (Ed.). Norwell, MA: Spring Verlag, 2008, pp. 57-70. Verrier, R.L. and Harper, R.M. Cardiovascular Physiology: Central and autonomic regulation. In: M.H. Kryger, T. Roth and W.C. Dement (Eds.). Principles and Practice of Sleep Medicine, 5th ed. Philadelphia: Elsevier Saunders, 2009 Chapter 27. Purves. KUMAR (Available on request by email: rkumar@mednet.ucla.edu). MRI Physics for Radiologists by Alfred L Horowitz (Book, available in the UCLA library, Record ID: 1638028). Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, Chabriat H. Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging. 2001;13(4):534-46. Govindaraju V, Young K, Maudsley AA. Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed. 2000;13(3):129-53. Winkelman JW, Buxton OM, Jensen JE, Benson KL, O'Connor SP, Wang W, Renshaw PF. Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS). Sleep. 2008;31(11):1499-506. Kamba M, Suto Y, Ohta Y, Inoue Y, Matsuda E. Cerebral metabolism in sleep apnea. Evaluation by magnetic resonance spectroscopy. Am J Respir Crit Care Med. 1997;156(1):296-8. 3
  • 4. McGINTY Ming, G.L. and Song, H. Adult Neurogenesis in the Mammalian Central Nervous System Annu. Rev. Neurosci. 2005. 28:223–50 Eisch, A.L. Cameron, H.A., Encinas, J.M., Meltzer, LA., Ming, G.L., and Overstreet-Wadiche, L.S, Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype? J Neurosci, 2008 • 28(46):11785–11791 Guzman-Marin R., Bashir, T., Suntsova, N., Szymusiak R, and McGinty D. Hippocampal neurogenesis is reduced by sleep fragmentation in the adult rat. Neuroscience 148 (2007) 325–333 Guzman-Marin R; Suntsova N; Bashir T; Nienhuis R; Szymusiak R; McGinty D. Rapid eye movement sleep deprivation contributes to reduction of neurogenesis in the hippocampal dentate gyrus of the adult rat. SLEEP 2008;31(2):167-175. MICEVYCH Brown, Neuroendocrinology (1994), Cambridge University Press. Chapter 1 (pp 1-55). Chappell and Levine, Stimulation of gonadotrophin-releasing hormone surges by estrogen. I. Role of hypothalamic progesterone receptors. Endocrinology, 141: 1477- 1485. Langle, et al., Neuronal-glial remodeling: a structural basis for neuronal-glial interactions in the adult hypothalamus. J. Physiol. (Paris), 96: 169-175 (2002). Miyata, et al., Plasticity of neurohypophyseal terminals with increase hormonal release during dehydration: Ultrastructural and biochemical analyses. J. Comp. Neurol., 434: 413-427 (2001). Swanson, Cerebral hemisphere regulation of motivational behavior. Brain Res., 886: 113-164 (2000). Zwain and Yen, Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain. Endocrinology, 140(8):3843-52 (1999). Zwain et al., A role for hypothalamic astrocytes in dehydroepiandrosterone and estradiol regulation of gonadotropin-releasing hormone (GnRH) release by GnRH neurons. Neuroendocrinology, 75(6):375-83, 2002. Siegel http://www.npi.ucla.edu/sleepresearch Siegel, J.M. Clues to the functions of mammalian sleep. Nature 437:1264-1271, 2005. Mileykovskiy, B.Y., Lyudmila I Kiyashchenko, L.I. and Siegel, J.M. Behavioral correlates of activity in identified hypocretin (orexin) neurons. Neuron, 46:787-798, 2005. Siegel, J.M Hypocretin (orexin): role in normal behavior and neuropathology Annual Review of Psychology 55:125-148, 2004. Siegel JM, Boehmer LN (2006) Narcolepsy and the hypocretin system-where motion meets emotion. Nature Clin Pract Neurol 2:548-556. SZYMUSIAK 1. Morrison, S.F., Nakamura, K. and Madden, C.J. Central control of thermogenesis in mammals. Exp. Physiol. 93:773-797, 2008. 2. Boulant, J.A. Neuronal basis of Hammel’s model for set point thermoregulation. J. Appl. Physiol. 100: 1347-1354, 2006. 4
  • 5. 3. Blatties, C.M. Endotoxic fever: new concepts of its regulation suggest new approaches to management. Pharmacol and Therap. 111:194-223, 2006. 4. Szymusiak, R. and McGinty, D. Hypothalamic regulation of sleep and arousal. Ann. N.Y. Acad. Sci. 1129:275-286, 2008. WAGNER Kelly et. al., Estrogen modulation of K+ channel activity in hypothalamic neurons involved in the control of the reproductive axis. Steroids, 67: 447-456, 2002. Kuehl-Kovarik et. al., Episodic bursting activity and response to excitatory amino acids in acutely dissociated gonadotropin-releasing hormone neurons genetically targeted with green fluorescent protein. J. Neurosci., 22: 2313-2322, 2002. Simonian et. al., Identification and characterization of estrogen receptor a-containing neurons projecting to the vicinity of the gonadotropin-releasing hormone perikarya in the rostral preoptic area of the rat. J. Comp. Neurol., 411: 346-358, 1999. Spergel, et. al., GABA- and glutamate-activated channels in green fluorescent protein-tagged gonadotropin- releasing hormone neurons in transgenic mice. J. Neurosci., 19: 2037-2050, 1999. 5