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(Microsoft PowerPoint - UK DSV Presentation.ppt [Mode de ... (Microsoft PowerPoint - UK DSV Presentation.ppt [Mode de ... Presentation Transcript

  • CEA - A research body mainly devoted to technology Defense Energy Technologies for Information and Health Life Science Division 1
  • The CEA Five operational divisions Five operational divisions Material Sciences Technological res. Military application Nuclear Energy Life Sciences Five transverse programs Five transverse programs Life Science Division 2
  • Pionner: F.Joliot General presentation The Life Sciences Division Life Science Division 3
  • The Life Sciences Division (DSV) Resources for Research (2006): Post-docs Total: 1890 researchers CEA and technical staff in 2006 151 PhD students 299 + 230 people in 2007 1050 (Genoscope and CNG) 390 Budget for Life Sciences: Other Agencies 180 M€ (including 50 M€ Organization and programs: external resource) Research programs Radiobiology Environmental nuclear Toxicology Nuclear medicine 8 institutes Labelling, structure and engineering of Biomolecules Genomics and large scale biology Biotechnologies Security : nuclear, radiological, biological and chemical risks Life Science Division 4
  • The Life Sciences Division (DSV) National organization Division of Life Sciences Director : Gilles Bloch Fontenay-aux-Roses centre Institute of biology technologies Malgorzata Tkatchenko Saclay (IBITEC-S) Michel Riva Institute of molecular and cellular Institute of life sciences research and radiation biology (IRCM) technologies (IRTSV) Paul-Henri Roméo Jérome Garin Institute of emerging diseases and Jean-Pierre Ebel Institute of structural innovative therapy (IMETI) biology (IBS) Philippe Leboulch Eva Pebay-Peyroula Institute of biological imaging (I²BM) Institute of environmental biology and Malgorzata Tkatchenko biotechnology (IBEB) Thierry Heulin Institute of genomic (IG) Jean Weissenbach Life Science Division 5
  • The Life Sciences Division (DSV) Staff distribution: Fontenay-aux-Roses : 20% Caen Saclay - Orsay : 35% Evry : 11% Grenoble : 14% Cadarache : 12% hôp. St-Louis CEA Fontenay CEA Grenoble Jouy-en-Josas CEA Saclay SHFJ Orsay CEA Marcoule CEA Cadarache Évry CEA DIF Life Science Division 6
  • The Life Sciences Division (DSV) Technological facilities (in addition to genomics facilities) Infrastructures for Biochemistry for In vivo imaging research on Prion post-genomics platforms disease Screening facilities Structural Platforms for for bioactive Biology Platforms biochips molecules Infrastructures for research in radiobiology and nuclear toxicology Proteomics Platform for Technological Platform Phytotechnology Life Science Division 7
  • The Life Sciences Division (DSV) 3 missions in line with the general strategy of CEA Biological bases of a sustainable nuclear option • The scientific nature of medical and environmental risks (radiobiology, environmental toxicology) • Answer to public and political issues (e.g. low doses) • Select and prepare experts for international agencies Energy Provide the health sector with technologies An original set of competences and facilities • In vivo imaging and innovative labelling • Biotechnologies • Structural biology and protein engineering Technologies for health • Computing, bioinformatics Knowledge and tools for biosecurity & biodefense • Emerging diseases (prion, virology) • Bioterrorism (toxins, infectious agents) Global security Life Science Division 8
  • Energy The Life Sciences Division (DSV) Bio for safe nuclear energy Radiobiology Nuclear toxicology Effects of ionizing radiations • Characterization of biological responses Entry routes in the biosphere (molecular damages, cell and tissue and human (from micro-organisms response, cancerogenesis) to plants and humans) • Specific markers of exposure and response Mechanisms of toxicity • Markers of individual susceptibility (radiological and/or chemical) • Effects on germinal cells Quantification of impact to human health Radioprotection Novel protection measures Life Science Division 9
  • Technologies The Life Sciences Division (DSV) for health Medical imaging • Methodologies: TEP, MRI, multimodal animal imaging • Imaging of cognitive processes (language, memory, calculation, …) • Nuclear medicine: neurodegenerative diseases, psychiatry, oncology, cardiology • Imaging gene expression (gene and cell therapy) • Drug discovery and development • Image analysis Biomolecules : Labelling, structure and engineering • Novel labelling concepts and methods • Structure and function of biomolecules • Protein engineering Biotechnologies • Diagnostics and medical monitoring Methods for pharmacology and pharmacokinetics, biomarkers, assays for food and environmental safety • Biochips • Bioenergy : bioinspired and biomass Life Science Division 10
  • Security The Life Sciences Division (DSV) Mobilization against CRBN threats Biomolecular technologies Knowledge of biological agents, dedicated facilities Microelectronics, sensors • Characterization of current and potential threats (toxins, virulence factors, genomes, antigens…) • Novel detection assays • Medical protection (vaccines) • Medical treatment (HTS of drug leads, structure- based drug design) • Decontamination (enzyme-based processes) Life Science Division 11
  • Genomics The Life Sciences Division (DSV) In 2007 integration to the Life Sciences Division of the CEA: • Genoscope - French National Sequencing Centre (CNS) • French National Genotyping Centre (CNG) In association with an array of post-genomic platforms (manufacturing DNA chips, high speed screening, proteomic analysis, functional and structural studies, etc.) Service to the scientific community + specific research projects Complementary competences for innovation High-throughput technologies development and bioinformatics applications Individual susceptibilities in radiobiology and toxicology Personalized medicine Life Science Division 12
  • The Life Sciences Division (DSV) Web site: http://www-dsv.cea.fr Life Science Division 13
  • The Life Sciences Division (DSV) Platforms Life Science Division 14
  • The Life Sciences Division (DSV) A unique research platform brain imaging with very high field NMR Development of new concepts and designs for very high field MRI design of a large bore, 11.7 T magnet for human studies Development of new methods and concepts in 4 very high fields magnets: data/image analysis and neuronal modeling for the 17T mouse, 3T human, 7T cognitive sciences human, 11.7T human High resolution anatomical and functional MRI in humans, from newborns to adults Neurophysiology (electrophysiology) and neurochemistry in non human primates using very high field MR imaging and spectroscopy Microscopic imaging of brain development and functional genomics of transgenic mice Life Science Division 15
  • The Life Sciences Division (DSV) A pre-clinical imaging facility for gene and cell therapy New facility under construction in Fontenay (CEA) in collaboration with Inserm (primates, animal PET, MRI, MRS) Development of innovative therapies for neurodegenerative diseases including ex vivo and in vivo gene therapy Avant Development of primate models for human diseases Pre-clinical trials in surgery Development of technologies and assays for imaging molecular/cellular events in living animals (MRI, MRS, PET) especially for therapeutic monitoring and analyzing in vivo gene expression Life Science Division 16
  • The Life Sciences Division (DSV) Isotopic labeling platform Structure and Protein engineering Isotopic labelling Radiation and detection Computer science New methods of isotopic labeling and molecular labeling : chemical, enzymatic and/or genetic methods Structural and functional study of biomolecules : • - X-ray diffraction • - neutron scattering • - NMR • - Modelization, molecular dynamics Protein engineering: biotechnological applications Life Science Division 17
  • The Life Sciences Division (DSV) The tools for structural biology at the CEA Neutron scattering : Institut Laue Langevin NMR Spectroscopy (800 MHz) : CEA Modelization and Grenoble CEA laboratories X ray diffraction : ESRF molecular dynamics Life Science Division 18
  • The Life Sciences Division (DSV) Emerging pathologies and innovative therapies platform Isotopic labelling Diagnostic tests Ultrasensitive detection of biological molecules Prion diseases Chikungunya virus (la Réunion island) Avian flu … Development detection and diagnostic tests • Antibodies A pre-clinical scientific research • DNA (biochips) platform unique in Europe in terms of equipment (3600 m2) Evaluation of immune response and scientific excellence (vaccines) and available treatments A space to accommodate Techniques of decontamination industrial teams in biotechnological fields (1200 m2) Life Science Division 19