Your SlideShare is downloading. ×
Llinás, R.
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×
Saving this for later? Get the SlideShare app to save on your phone or tablet. Read anywhere, anytime – even offline.
Text the download link to your phone
Standard text messaging rates apply

Llinás, R.

1,980

Published on

0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
1,980
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
4
Comments
0
Likes
0
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
No notes for slide

Transcript

  • 1. BIOGRAPHICAL SKETCH NAME: Rodolfo R. Llinás, M.D., Ph.D. Phone: (212) 263-5415 Chairman and Professor Fax: (212) 689-9060 New York University School of Medicine e-mail: llinar01@popmail.med.nyu.edu Dept. of Physiology & Neuroscience 550 First Avenue New York City, NY 10016 EDUCATION: Gimnasio Moderno (Bogota) Bachillerato 1952 Universidad Javeriana (Bogota) M.D. 1959 Medicine Australian Natl. University (Canberra) Ph.D. 1965 Neurophysiology RESEARCH AND/OR EXPERIENCE Instructor Department of Physiology, National Neurophysiology University of Colombia 1959 Postdoctoral Stanley Cobb Laboratory, Massachusetts Research Fellow General Hospital, Harvard Medical School 1960-61 NIH Postdoctoral Department of Physiology, University of Research Fellow Minnesota, Minneapolis 1961-63 Research Scholar Department of Physiology, Institute of Advanced Studies, Australian Natl. Univ. 1963-65 Associate Professor Department of Physiology, University of Minnesota, Minneapolis 1965-66 Member Institute for Biomedical Research, AMA/ERF 1966-67 Chicago, Illinois Head, Department Institute for Biomedical Research, AMA/ERF, of Neurobiology Chicago, Illinois 1968-70 Associate Professor Department of Neurology & Psychiatry, Northwestern University Medical School, Chicago, Illinois 1967-71 Guest Professor Wayne State University School of Medicine of Physiology Detroit, Michigan 1967-74 Professorial Lecturer Department of Pharmacology, University of Illinois College of Medicine, Chicago 1967-68 Clinical Professor University of Illinois College of Medicine 1968-72 Professor and Head, Department of Physiology & Biophysics, Div. of Neurobiology University of Iowa Med.School, Iowa City 1970-76 1
  • 2. Faculty Member Summer Course in Neurobiology, Marine Biological Laboratory, Woods Hole, MA 1971-74 Professor and Dept. of Physiology & Neuroscience, New York 1976- Chairman University School of Medicine, New York Thomas & Suzanne Murphy New York University School of Medicine, 1985- Professor of Neuroscience New York, New York HONORS Bowditch Lecturer, American Physiological Society 1973 The John C. Krantz Award in Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine 1976 Professorial Lecturer, College de France, Paris 1979 Honorary Member, Alpha Omega Alpha 1981 Catedra Ramon y Cajal Inaugural Speaker, Instituto Politecnico Nacional, Mexico City 1981 Lang Lecturer, Marine Biological Laboratory, Woods Hole, MA 1982 McDowall Lecturer in Physiology, King's College, London 1984 "Doctor Honoris Causa" (Medicine), University of Salamanca 1985 Member, National Academy of Sciences, USA 1986 Member, National Academy of Medicine, Colombia 1986 Ralph Gerard Lecturer, Univ. of California, Irvine 1987 Ulf von Euler Lecturer, Karolinska Institutet, Stockholm 1987 Professorial Lecturer, College de France, Paris 1987 Craythorne Lecturer, University of Miami School of Medicine 1988 Luigi Galvani Lecture and Award, Georgetown University Washington, D.C. 1988 F.O. Schmitt Lecture and Award in Neuroscience Rockefeller University, N.Y. 1989 UNESCO Albert Einstein Gold Medal Award in Science 1991 "Augustin Nieto Caballero" Medal, Bogota, Colombia 1991 2
  • 3. Order de Boyaca, Colombian Presidency 1992 Doctor "Honoris Causa" Universidad de Barcelona, Spain 1993 Doctorado "Honoris Causa", Universidad Nacional, Bogota, Colombia 1994 Signoret Award in Cognition, Fondation Ipsen La Salpâtrière, 1994 Paris, France Member, American Academy of Arts and Sciences 1996 Member, American Philosophical Society 1996 Member, Real Academia Nacional de Medicina, Spain 1996 Member, The Prometheus Society,, National Academy of Sciences 1996 Doctor "Honoris Causa" , Universidad Complutense, Facultad de Medicina, 1997 Madrid, Spain Doctorado"Honoris Causa", Universidad de los Andes, Bogota, Colombia 1998 Robert S. Dow Neuroscience Award, Oregon Health Sciences University 1999 Portland, Oregon NATIONAL COMMITTEE MEMBERSHIP Neurological Science Research Training Committee A, National Institute of Neurological Diseases & Stroke, N.I.H. 1971-73 Consultant, USAF School of Aerospace Medicine, San Antonio, TX 1972-75 Corporation Member, Marine Biological Laboratory, Woods Hole, MA 1973-82 Board of Trustees, Marine Biological Laboratory, Woods Hole, MA 1983-85 Board of Trustees, Marine Biological Laboratory, Woods Hole, MA 1990-92 Associate, Neurosciences Research Program, M.I.T., Boston, MA 1974-84 Council Member, Society for Neuroscience 1974-78 Member, Task Force on Neurophysiology, Am. Physiological Society 1974-78 Member, Committee on Committees, Am. Physiological Society 1974-76 Neurology A Study Section, Division of Research Grants, National Institutes of Health 1974-78 Member, National Research Council Committee for IBRO 1978-81 Member, Panel on Basic Neuroscience Research, National Academy 3
  • 4. of Science Task Force 1978-82 Scientific Advisory Board, Division for Basic Research, Max-Planck Institute for Psychiatry, Munich 1979-83 Member, Executive Committee for IBRO 1981-82 Acting Chairman, USA National Committee for IBRO 1982 Chairman, USA National Committee for IBRO 1983-88 Member, European Neuroscience Association 1989- Chairman, NASA/Neurolab Science Working Group 1991- Member, Scientific Advisory Board Roche Institute 1992-94 Member, National Deafness and Other Communication Disorders 1994-98 Advisory Council of the National Institutes of Health EDITORSHIPS Chief Editor, Neuroscience 1974- Editorial Board, Journal of Neurobiology 1980-86 Field Editor, Pfluegers Archiv 1981-86 Editorial Board, Journal of Theoretical Neurobiology 1981-90 BOOKS/MONOGRAPHS/REVIEWS HUBBARD, J.I., LLINAS, R. and QUASTEL, D.M.J. (By invitation of the British Physiological Society) Electrophysiological Analysis of Synaptic Transmission. London: Edward Arnold Publishers; Baltimore: Williams & Wilkins, 1969. LLINAS, R. Editor. Neurobiology of Cerebellar Evolution and Development. Chicago: Am. Med. Association, 1969. LLINAS, R. and PRECHT, W. Editors, Frog Neurobiology: A Handbook. Berlin-Heidelberg-New York: Springer-Verlag, 1976. LLINAS, R.R. and HEUSER, J.E. Depolarization-release coupling systems in neurons. Neurosci. Res. Progr. Bull. Vol 15, pp 557-687, 1977. STERIADE, M. and LLINAS, R. The functional states of the thalamus and the associated neuronal interplay. Physiological Review 68: 699-742, 1988. STERIADE, M., JONES, E. and LLINAS, R. Editors, Thalamic Oscillations and Signaling. John Wiley & Sons Publishers , 1990. 4
  • 5. LLINAS, R. and SOTELO, C. Editors, The Cerebellum Revisited, Springer-Verlag, New York City. 1992. LLINAS, R. and CHURCHLAND, P.S. Editors, The Mind-Brain Continuum, MIT Press, Cambridge, MA, 1996. 5
  • 6. PUBLICATIONS 1961-1963 Abstracts OKUMA, T., LLINAS, R. and ERVIN, F.R. Effects of mesencephalic reticular formation lesion on epileptic seizure threshold in cat. EEG and Clin. Neurophysiol. 13: 304, 1961. (Abst.) MENDELSON, J.A., GRENELL, R.G., ERVIN, F.R. and LLINAS, R. Regional concentration of ATP in cat cerebral cortex. Fed. Proc. 1961. (Abst.) MENDELSON, J.A., GRENELL, R.G., ERVIN, F.R. and LLINAS, R. The effects of deafferentation on ATP in the cerebral cortex. V Intl. Congress of Biochemistry, Moscow, 1961. (Abst.) LLINAS, R. and THOMAS, K. Reticular influences upon spinal motoneurons. Fed. Proc. 1962. (Abst.) LLINAS, R., TERZUOLO, C.A. and THOMAS, K. Reticular inhibitory and excitatory actions upon spinal motoneurons. XXII Intl. Congress of Physiological Sciences, Leiden 1962. (Abst.) LLINAS, R. Diferencias entre la accion inhibidora reticular y cerebelosa sobre las motoneuronas espinals. V Congreso de la Asociacion Latinoamericana de Ciencias Fisiologicas, Caracas 1963. (Abst.) 1964 Full Papers LLINAS, R. and TERZUOLO, C.A. Mechanisms of supraspinal actions upon spinal cord activities. Reticular inhibitory mechanisms on a-extensor motoneurones. J. Neurophysiol. 27: 579-591, 1964. LLINAS, R. Mechanisms of supraspinal actions upon spinal cord activities. Differences between reticular and cerebellar inhibitory actions upon a-extensor motoneurons. J. Neurophysiol. 27: 1117- 1126, 1964. LLINAS, R. Mechanisms of supraspinal actions upon spinal cord activities. Pharmacological studies on reticular inhibition of a-extensor motoneurons. J. Neurophysiol. 27: 1127-1137, 1964. ECCLES, J.C., LLINAS, R. and SASAKI, K. Excitation of cerebellar Purkinje cells by the climbing fibers. Nature 203: 245-246, 1964. ECCLES, J.C., LLINAS, R. and SASAKI, K. Golgi cell inhibition in the cerebellar cortex. Nature 204: 1265-1266, 1964. Abstracts LLINAS, R. Differences between reticular and cerebellar inhibitory actions upon a-extensor motoneurons. Proc. Australian Physiological Society, 1964. (Abst.) STEVENS, J.R., NAKAMURA, Y., MILSTEIN, V., OKUMUA, T. and LLINAS, R. Central and peripheral factors in epileptic discharge: Experimental study in the cat. EEG and Clin. Neurophysiol. 17: 453, 1964. (Abst.) 1965 Full Papers 6
  • 7. LLINAS, R. and TERZUOLO, C.A. Mechanisms of supraspinal actions upon spinal cord activities. Reticular inhibitory mechanisms upon flexor motoneurons. J. Neurophysiol. 28: 413-422, 1965. TERZUOLO, C.A., LLINAS, R. and GREEN-THOMAS, K. Mechanisms of supraspinal actions upon spinal cord activities. Distribution of reticular and segmental inputs in cats' a-motoneurones. Arch. Ital. Biol. 103: 635-651, 1965. ECCLES, J.C., LLINAS, R. and SASAKI, K. Inhibitory systems in the cerebellar cortex. Proc. Australian Assoc. of Neurologists 3: 7-14, 1965. Abstracts LLINAS, R. and SASAKI, K. Antidromic invasion of Purkinje cells in the cat. XXIII Intl. Congress of Physiological Sciences, Tokyo 1965. (Abst.) 1966 Full Papers ECCLES, J.C., LLINAS, R. and SASAKI, K. The excitatory synaptic action of climbing fibres on the Purkinje cells of the cerebellum. J. Physiol. 182: 268-296, 1966. ECCLES, J.C., LLINAS, R., SASAKI, K. & VOORHOEVE, P.E. Interaction experiments on the responses evoked in Purkinje cells by climbing fibres. J. Physiol. 182: 297- 315. 1966. ECCLES, J.C., LLINAS. R. and SASAKI. K. The action of antidromic impulses on the cerebellar Purkinje cells. J. Physiol. l82: 316-345, 1966. ECCLES, J.C., LLINAS, R. and SASAKI. K. The inhibitory interneurones within the cerebellar cortex. Exp. Brain Res. 1:1-16. 1966. ECCLES, J.C., LLINAS, R. and SASAKI, K. Parallel fibre stimulation and responses induced thereby in the Purkinje cells of the cerebellum. Exp. Brain Res. 1: 17-39, 1966. ECCLES, J.C., LLINAS, R. and SASAKI, K. The mossy fibre-granule cell relay of the cerebellum and its inhibitory control by Golgi cells. Exp. Brain Res. 1: 82-101, 1966. ECCLES, J.C., LLINAS, R. and SASAKI, K. Intracellularly recorded responses of the cerebellar Purkinje cells. Exp. Brain Res. 1: 161-183, 1966. BLOEDEL, J.R., GAGE, P.W., LLINAS, R. and QUASTEL, D.M.J. Transmitter release at the squid giant synapse in the presence of tetrodotoxin. Nature 212: 49-50, 1966. 1967 Full Papers LLINAS, R. and BLOEDEL, J.R. Climbing fibre activation of Purkinje cells in the frog cerebellum. Brain Res. 3: 299-302, 1966/67. LLINAS, R. and BLOEDEL, J.R. Frog cerebellum: Absence of long-term inhibition upon Purkinje cells. Science 155: 601-603, 1967. LLINAS, R., PRECHT, W. and KITAI, S.T. Climbing fiber activation of Purkinje cells following primary vestibular afferent stimulation in the frog. Brain Res. 6: 371-375, 1967. 7
  • 8. LLINAS, R., PRECHT, W. and KITAI, S.T. Cerebellar Purkinje cell projection to the peripheral vestibular organ in the frog. Science 158: 1328-1330, 1967. Abstracts LLINAS, R. Una posible relacion entre el potencial de membrana y el sistema de "depolarizacion - secrecion" en el axon aferente de la sinapsis gigante del calamar. VIII Lat. Amer. Congreso, Mexico 1967. (Abst.) 1968 Full Papers LLINAS, R. A possible mechanism for presynaptic inhibition. In: Structure and Function of Inhibitory Neuronal Mechanisms, p. 249-250, edited by C. von Euler. Oxford and N.Y.: Pergamon Press, 1968. LLINAS, R., NICHOLSON, C., FREEMAN, J.A. and HILLMAN, D.E. Dendritic spikes and their inhibition in alligator Purkinje cells. Science 160: 1132-1135, 1968. Abstracts PRECHT, W. and LLINAS, R. Functional organization of the direct vestibular nerve projection to the flocculus and nodulus in the cat cerebellum. Fed. Proc. 27:2, 1968. (Abst.) LLINAS, R., PRECHT, W., BRACCHI, F. and HUERTAS, J. The inhibitory cerebello vestibular system in the frog. Proc. IUPS 7: Abst. 806, p. 269, 1968. PRECHT, W. and LLINAS, R.. Direct vestibular afferents to cat cerebellar nuclei. Proc. IUPS 7: Abst. 1063, p. 355, 1968. 1969 Full Papers LLINAS, R., NICHOLSON, C., FREEMAN, J.A. and HILLMAN, D.E. Reply to technical comment by W.H. Calvin and D. Hellerstein, "Dendritic spikes vs cable properties" Science 163: 96-97, 1969. LLINAS, R., NICHOLSON, C. and PRECHT, W. Preferred centripetal conduction of dendritic spikes in alligator Purkinje cells. Science 163: 184-187, 1969. NICHOLSON, C. and LLINAS, R. Inhibition of Purkinje cells in the cerebellum of elasmobranch fishes. Brain Res. 12: 477-480, 1969. LLINAS, R. and PRECHT, W. The inhibitory vestibular efferent system and its relation to the cerebellum in the frog. Exp. Brain Res. 9: 16-29, 1969. PRECHT, W. and LLINAS, R. Functional organization of the vestibular afferents to the cerebellar cortex of frog and cat. Exp. Brain Res. 9: 30-52, 1969. LLINAS, R., BLOEDEL, J.R. and HILLMAN, D.E. Functional characterization of the neuronal circuitry of the frog cerebellar cortex. J. Neurophysiol. 32: 847-870, 1969. BLOEDEL, J.R. and LLINAS, R. Neuronal interactions in the frog cerebellum. J. Neurophysiol. 32: 871- 880, 1969. 8
  • 9. LLINAS, R., BLOEDEL, J.R. and ROBERTS, W. Antidromic invasion of Purkinje cells: in the frog cerebellum. J. Neurophysiol. 32: 881-891, 1969. Abstracts NICHOLSON, C. and LLINAS, R. Dendritic spikes recorded at different levels from alligator Purkinje cells. Fed. Proc. 28: 784 (Abst.) 1969. LLINAS, R. and PRECHT, W. Frog cerebellar activity evoked by constant angular acceleration. The Physiologist 12: 3 (Abst.) 1969. PRECHT, W. and LLINAS, R. Electrical analysis of an agranular cerebellum. Proc. 9th Intl. Congress of Neurology. 1969 Excerpta Medica Int. Congress Series #193, 754 (Abst.). 1970 Full Papers KUNO, M. and LLINAS, R. Enhancement of synaptic transmission by dendritic potentials in chromatolysed motoneurones of the cat. J. Physiol. (Lond.) 210: 807-821, 1970. KUNO, M. and LLINAS, R. Alterations of synaptic action in chromatolysed motoneurones of the cat. J. Physiol. (Lond.) 210: 823-838, 1970. Abstracts BAKER, R. and LLINAS, R. Electrotonic coupling between neurons in the mesencephalic root of the Vth nerve in the rat. Biophys. Soc. Abstracts 10: 64a, 1970. NICHOLSON, C. and LLINAS, R. Intradendritic recording from Purkinje cells in alligator cerebellum. Fed. Proc. 29: 2, A453 (Abst.), 1970. 1971 Full Papers BAKER, R.G. and LLINAS, R. Electrotonic coupling between neurones in the rat mesencephalic nucleus. J. Physiol. (Lond.) 212: 45-63, 1971. LLINAS, R. Frog cerebellum: Biological basis for a computer model. Math. Biosci. 11: 137-151, 1971. LLINAS, R. Electrofisiologia de los circuitos neuronales en la corteza cerebel Acta Cientifica Venezolana 22, Suppl. 2: 119-125, 1971. NICHOLSON, C. and LLINAS, R. Field potentials in the alligator cerebellum and theory of their relationship to Purkinje cell dendritic spikes. J. Neurophysiol. 34: 509-531, 1971. LLINAS, R. and NICHOLSON, C. Electrophysiological properties of dendrites and somata in alligator Purkinje cells. J. Neurophysiol. 34: 532-551, 1971. PRECHT, W., LLINAS, R. and CLARKE, M. Physiological responses of frog vestibular fibers to horizontal angular rotation. Exp. Brain Res. 13: 378-407, 1971. LLINAS, R., PRECHT, W. and CLARKE, M. Cerebellar Purkinje cell responses to physiological stimulation of the vestibular system in the frog. Exp. Brain Res. 13: 408-431, 1971. Abstracts 9
  • 10. BAKER, R., PRECHT, W. and LLINAS, R. Intracellular potentials evoked in trochlear motoneurones by vestibular nerve activation. Fed. Proc. 30: A105, 1971. LLINAS, R. and PRECHT, W. Functional properties of frog cerebellar Purkinje cells receiving bilateral vestibular inputs. Proc. IUPS 9: 350 (Abst.), 1971. PRECHT, W., BAKER, R. and LLINAS, R. Cerebellar control of ipsilateral vestibular inhibition of trochlear motoneurons. Proc. IUPS 9:460 (Abst.), 1971. NICHOLSON, C. and LLINAS, R. Purkinje cell spike bursts in elasmobranch cerebellum as an intrinsic cellular property. Proc. IUPS 9: 418 (Abst.), 1971. 1972 Full Papers BAKER, R., PRECHT, W. and LLINAS, R. Mossy and climbing fiber projections of extraocular muscle afferents to the cerebellum. Brain Res. 38: 440-445, 1972. SOTELO, C. and LLINAS, R. Specialized membrane junctions between neurons in the vertebrate cerebellar cortex. J. Cell Biol. 53: 271-289, 1972. BAKER, R., PRECHT, W. and LLINAS, R. Cerebellar modulatory action on the vestibulo-trochlear pathway in cats. Exp. Brain Res. 15: 484-492, 1972. LLINAS, R., BLINKS, J.R. and NICHOLSON, C. Calcium transient in presynaptic terminal of squid giant synapse: Detection with aequorin. Science 176: 1127- 1129, 1972. LLINAS, R. and PRECHT, W. Vestibulocerebellar input: Physiology. In: Progress in Brain Research, Vol. 37, p 341-359. Basic Aspects of Central Vestibular Mechanisms, edited by A. Brodal and O. Pompeiano. Amsterdam: Elsevier, 1972. PRECHT, W. and LLINAS, R. Responses of vestibular nuclear neurons to ampullar input. Ibid., p 89- 107, 1972. LLINAS, R. and BAKER, R. A chloride dependent inhibitory postsynaptic potential in cat trochlear motorneurons. J. Neurophysiol. 35: 484-492, 1972. Abstracts LLINAS, R. and NICHOLSON, C. Reversal potential for EPSP in squid stellate ganglion tested in isopotential conditions. Biophys. Soc. Abstracts 1972. LLINAS, R. and VOLKIND, R.A. Repetitive climbing fiber activation of Purkinje cells in the cat cerebellum following administration of harmaline. Fed. Proc. 31: 377a, (Abstract) 1972. LLINAS, R. and WOLFE, J.W. Single cell responses from the cerebellum of rhesus preceding voluntary, vestibular and optokinetic saccadic eye movements. Soc. for Neuroscience. 2: 201, 1972. LLINAS, R. and VOLKIND, R.A. Functional organization of neuronal circuits in cerebellar cortex: Activation of the climbing fiber system by harmaline. Cerebellum Session, Symposium on Communication and Control Processes in Biological Systems, Proc. IVth Intl. Biophysics Congress, Moscow 1972. 10
  • 11. LLINAS, R. Integrative properties of neurons with complex dendritic structures. Proc. Symposium on Mechanisms of Neuronal Integration in Nerve Centers, Kiev 1972. 1973 Full Papers LLINAS, R., HILLMAN, D.E. and PRECHT, W. Neuronal circuit reorganization in mammalian agranular cerebellar cortex. J. Neurobiol. 4: 69-97, 1973. LLINAS, R. and VOLKIND, R.A. The olivo-cerebellar system: Functional properties as revealed by harmaline-induced tremor. Exp. Brain Res. 18: 69-87, 1973. LLINAS, R., NICHOLSON, C. and JOHNSON, K. Implantable monolithic wafer recording electrodes for neurophysiology. In: Brain Unit Activity During Behavior, p. 105-111, edited by M.I. Phillips. Charles C. Thomas, Springfield, Ill., 1973. WOLFE, J.W., RAWLINGS, C.A. and LLINAS, R. A procedure for chronic microelectrode recording from cerebellar cortex in the awake cat and monkey. Physiol. Behav. 10: 967-970, 1973. MASOTTI, L., URRY, D.W. and LLINAS, R. Circular dichroism of lobster axonal membranes. Acta Vitaminologica et Enzymologica 27: 154-158, 1973. LLINAS, R. Procion yellow and cobalt as tools for the study of structure-function relationships in vertebrate central nervous systems. In: Intracellular Staining in Neurobiology, p. 211-225, edited by S.B. Kater and C. Nicholson. Springer-Verlag N.Y., 1973. Abstracts LLINAS, R., NICHOLSON, C. and BLINKS, J.R. Aequorin detection of calcium concentration changes in the presynaptic fiber of the squid stellate ganglion during synaptic transmission. J. Gen. Physiol. 61: 259, 1973. ALLEY, K., LLINAS, R. and HILLMAN, D. E. Neuronal and synaptic morphology in the optic tectum of a "blind" cavefish. Anat. Rec. 175: A263, 1973. HACKETT, J.T. and LLINAS, R. Functional properties of frog cerebellar circuit in vitro. Fed. Proc. 32: 443A, 1973. LLINAS, R., BAKER, R. and SOTELO, C. Electrical transmission between cells in the inferior olive of the cat. Soc. for Neurosci. 3: 156, 1973. 1974 Full Papers LLINAS, R. and HILLMAN, D.E. Some comments on structure-function relationships in the peripheral vestibular system. In: Regulation and Control in Physiological Systems, p. 180-184, edited by A.S. Iberall, 1974. HILLMAN, D. E. and LLINAS, R. Calcium-containing electron-dense structures in the axons of the squid giant synapse. J. Cell Biol. 61: 146-155, 1974. LLINAS, R. 18th Bowditch Lecture: Motor aspects of cerebellar control. The Physiologist 17: 19-46, 1974. LLINAS, R. La forme et la fonction des cellules nerveuses. La Recherche 5: 232-240, 1974. 11
  • 12. LLINAS, R., BAKER, R. and PRECHT, W. Blockage of inhibition by ammonium acetate action on chloride pump in cat trochlear motoneurons. J. Neurophysiol. 37: 522-532, 1974. SOTELO, C., LLINAS, R. and BAKER, R. Structural study of the inferior olivary nucleus of the cat. Morphological correlates of electrotonic coupling. J. Neurophysiol. 37: 541-559, 1974. LLINAS, R., BAKER, R. and SOTELO, C. Electrotonic coupling between neurons in the cat inferior olive. J. Neurophysiol. 37: 560-571, 1974. BERTHOZ, A. and LLINAS, R. Afferent neck projection to the cat cerebellar cortex. Exp. Brain Res. 20: 385-401, 1974. SIMPSON, J. I., PRECHT, W. and LLINAS, R. Sensory separation in climbing and mossy fiber inputs to cat vestibulocerebellum. Pflug. Arch. 351: 183-193, 1974. LLINAS, R., JOYNER, R.W. and NICHOLSON, C. Equilibrium potential for the postsynaptic response in the squid giant synapse. J. Gen. Physiol. 64: 519-535, 1974. LLINAS, R. and NICHOLSON, C. Analysis of field potentials in the central nervous system. In: Handbook of EEG and Clin. Neurophysiol., Vol. 2, Part B: Basic Neurophysiology of Neuronal and Glial Potentials, p. 2B-61 to 2B-84, edited by C.F. Stevens. Amsterdam: Elsevier, 1974. Abstracts HILLMAN, D. E., CHUJO, M. and LLINAS, R. Quantitative computer analysis of the morphology of cerebellar neurons. Anat. Rec. 178: 375a, 1974. LLINAS, R., BAKER, R. and SOTELO, C. Electrotonic coupling between inferior olive neurons in the cat. EEG Clin. Neurophysiol. 37: 2 (Abst.), 1974. LLINAS, R., PRECHT, W. and BAKER, R. Blockage of chloride pump in trochlear motoneurons by ammonium acetate. Pflugers Arch. Suppl. 347: R29 (Abst. 58), 1974. LLINAS, R. and NICHOLSON, C. Aequorin study of the suppression potential in the squid giant synapse. Biol. Bull. 147: 489, 1974. SIMPSON, J.I., LLINAS, R. and PRECHT, W. Unit activity in the cerebellar flocculus of alert rabbit during physiological vestibular and visual stimulation. Proc. IUPS 11: A685, 1974. LLINAS, R. and NICHOLSON, C. Reversal properties of climbing fiber potential in Purkinje cells of cat cerebellum. 4th Annual Mtg., Soc. for Neuroscience, Abst. 410, 1974. BAKER, R., LLINAS, R. and PRECHT, W. Evidence for chloride pump in cat ocular motoneurons. Proc. Symposium on Mechanisms of Synaptic Action (Jerusalem, 1974) Abst. 4. LLINAS, R. and NICHOLSON, C. The mechanism for the suppression potential in the squid giant synapse. Proc. Symposium on Mechanism of Synaptic Action (Jerusalem, 1974), Abst. 34. 1975 Full Papers LLINAS, R. and NICHOLSON, C. Calcium role in depolarization-release coupling: An aequorin study in squid giant synapse. Proc. Natl. Acad. Sci. (USA) 72: 187-190, 1975. 12
  • 13. SOTELO, C., HILLMAN, D. E., ZAMORA, A.J. and LLINAS, R. Climbing fiber deafferentation: Its action on Purkinje cell dendritic spines. Brain Res. 98: 574-581, 1975. LLINAS, R., WALTON, K., HILLMAN, D. E. and SOTELO, C. Inferior olive: Its role in motor learning. Science 190: 1230-1231, 1975. NICHOLSON, C. and LLINAS, R. Real time current source density analysis using multi-electrode array in cat cerebellum. Brain Res. 100: 418-424, 1975. BAKER, R., LLINAS, R. and SOTELO, C. Internal organization of the cat inferior olive. J. Postgrad. Med. 21: S1, 16, 1975. LLINAS, R. Structure and function of the cerebellar cortex. Scientific American 232: 56-71, 1975. LLINAS, R. Electrical synaptic transmission in the mammalian central nervous system. In: Golgi Centennial Symposium, edited by M. Santini, pp. 379-386. New York: Raven Press, 1975. LLINAS, R. and HILLMAN, D.E. A multipurpose tridimensional reconstruction computer system for neuroanatomy. In: Golgi Centennial Symposium, edited by M. Santini, pp. 71-79. New York: Raven Press, 1975. LLINAS, R. Electroresponsive properties of dendrites in central neurons. In: Physiology and Pathology of Dendrites (Advances in Neurology, Vol. 12), edited by G.W. Kreutzberg, pp. 1-13. New York: Raven Press, 1975. LLINAS, R. The cerebellar cortex. In: The Nervous System (Vol. 1: The Basic Neurosciences), edited by D.B. Tower, pp. 235-244. New York: Raven Press, 1975. LLINAS, R. Evolution of LCN's in the cerebellar cortex. In: P. Rakic, Local circuit neurons. Neurosciences Res. Progr. Bull. 13: 393-400, 1975. Abstracts LLINAS, R., WALTON, K. and BOHR, V. The action of 3- and 4-aminopyridine on synaptic transmission in the squid giant synapse. Biol. Bull. 149: 435, 1975. LLINAS, R., WALTON, K., HILLMAN, D.E. and SOTELO, C. Role of the inferior olive in vestibular compensation. Neurosci. Abst. 1: 213, 1975. PELLIONISZ, A. and LLINAS, R. Simple and complex spike generation in a computer model of cerebellar Purkinje cells. Neurosci. Abst. 1: 203, 1975. PELLIONISZ, A. and LLINAS, R. Synthesis of fragmented data on neuronal systems: A computer model of the cerebellum. Abstracts, European Meeting on Cybernetics and Systems Research. Vienna, 1975. 1976 Full Papers LLINAS, R. and NICHOLSON, C. Reversal properties of climbing fiber potential in cat Purkinje cells: An example of a distributed synapse. J. Neurophysiol. 311-323, 1976. LLINAS, R. and HESS, R. Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells. Proc. Natl. Acad. Sci. (USA) 73: 2520-2523, 1976. 13
  • 14. LLINAS, R., STEINBERG, I.Z. and WALTON, K. Presynaptic calcium currents and their relation to synaptic transmission: A voltage clamp study in squid giant synapse and a theoretical model for the calcium gate. Proc. Natl. Acad. Sci (USA) 73: 2918-2922, 1976. PRECHT, W., SIMPSON, J.I. and LLINAS, R. Responses to Purkinje cells in rabbit nodulue and uvula to natural vestibular and visual stimuli. Pfluz. Arch. 367: 1-6, 1976. LLINAS, R., SIMPSON, J I. and PRECHT, W. Nystagmic modulation of neuronal activity in rabbit cerebellar flocculus. Pflug. Arch. 367: 7-13, 1976. LLINAS, R. and WALTON, K. Neuronal Systems in the Cerebellum. In: Simpler Networks: An Approach to Patterned Behavior and Its Foundations, pp. 274-279, edited by J.C. Fentress. Sunderland, MA: Sinauer Assoc., 1976. LLINAS, R. Physiology of the cerebellum. In: Frog Neurobiology: A Handbook, pp. 892-923, edited by R. Llinás & W. Precht. Berlin-Heidelberg-New York: Springer-Verlag, 1976. Abstracts LLINAS, R. WALTON, K. and HESS, R. Voltage clamp study of presynaptic calcium current in squid giant synapse. Fed. Proc. 35: 696, 1976. LLINAS, R., WALTON, K. and BOHR, V. Synaptic transmission in squid giant synapse after potassium conductance blockage with external 3- and 4-aminopyridine. Biophy. J. 16: 83-86, 1976. ROWLANDS, J.F., LLINAS, R. and BERTHOZ, A. Correlation of brain stem and spinal cord activity during harmaline-induced tremor. Soc. Neurosci. Abst. 2: 1976. LLINAS, R. and HESS, R. Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells. Soc. Neurosci. Abst. 2: 1976. PELLIONISZ, A. and LLINAS, R. Analysis of spatial distribution of Purkinje cells with individual dynamisms activated by vestibular input: A computer simulation study. Proc. of Symposium: Neuron Concept in 1976. Tihany: Publ. Hse. of Hungarian Academy of Science, 1976. PELLIONISZ, A. and LLINAS, R. Multicompatmentalis Hodgkin-Huxley Kabellmodell a Purkinje seijt kuszorostvalaszanak analizisere. A Magyar Elettanitarsasag XLII. Vandorgyulese. Eloadaskionatok, 1976. PELLIONISZ, A. LLINAS, R. and PERKEL, D.H. System method for interpretation of experimental data within holistic neuronal circuitry: A computer model of the cerebellum of frog. Proc. of Symposium: Neuron Concept in 1976. Tinhany Publ. Hse. of Hung. Acad. Sci., Budapest, 1976. 1977 Full Papers HEYER, C.B. and LLINAS, R. The control rhythmic firing in normal and axotomized cat spinal motoneurons. J. Neurophysiol. 40: 480-488, 1977. LLINAS, R.R. and IBERALL, A. A global model of neuronal command-control systems. Biosystems 8: 233-235, 1977. 14
  • 15. PELLIONISZ, A., LLINAS, R. & PERKEL, D.H. A computer model of the cerebellar cortex of the frog. Neuroscience 2: 19-35, 1977. PELLIONISZ, A. and LLINAS, R. A computer model of cerebellar Purkinje cells. Neuroscience 2: 37-48, 1977. LLINAS, R. and WOLFE, J. W. Functional linkage between the electrical activity in the vermal cerebellar cortex and saccadic eye movements. Exp. Brain Res. 29: 1-14, 1977. TRAUB, R. D. and LLINAS, R. Spatial distribution of ionic conductances in normal and axotomized motoneurons. Neuroscience 2: 829-849, 1977. LLINAS, R. and WALTON, K. Significance of the olivo-cerebellar system in compensation of ocular position following unilateral labyrinthectomy. In: Control of Gaze by Brain Stem Neurons, pps. 399-408, edited by R. Baker and A. Berthoz. Amsterdam; Elsevier/North Holland, 1977. HILLMAN, D.E., LLINAS, R. and CHUJO, M. Automatic and semi-automatic analysis of nervous system structure. In Computer Analysis of Neuronal Structures, pp. 73-90, edited by R.D. Lindsay. New York and London: Plenum, 1977. LLINAS, R. Calcium and transmitter release in squid synapse. In: Society for Neuroscience Symposia, Vol 2, pp. 139-160, edited by W.M. Cowan and J.A. Ferendelli. Bethesda: Society for Neuroscience, 1977. Abstracts LLINAS, R. and HESS, R. Tetrodotoxin-resistant dendritic spikes in Purkinje cells of pigeons. Pflug. Arch Suppl. 368: R34 1977. LLINAS, R., SUGIMORI, M. and WALTON, K. Calcium dendritic spikes in the mammalian Purkinje cells. Soc. Neurosci. Abst. 3: 58, 1977. PELLIONISZ, A. and LLINAS, R. Analysis of anuran vestibulo-cerebellar control by computer modeling. Soc. Neurosci. Sci. 3: 60, 1977. LLINAS, R., WALTON, K. and SUGIMORI, M. Presynaptic calcium currents in squid stellate ganglion: A voltage clamp study using TTX and TEA. Biol. Bull. 153: 436, 1977. 1978 Full Papers LLINAS, R. and BUNGE, M. Restricted applicability of the concept of command in neuroscience: Dangers of metaphor. Commentary in: Kupfermann, I. and Weiss, K.R., The command neuron concept. Behav. Brain Sci. 1: 3-39, 1978. Abstracts BLIGHT, A.R. and LLINAS, R. Depolarization-release coupling at a synapse lacking regenerative spikes. Soc. Neurosci. Abst. 4: 577, 1978. LLINAS, R. and SUGIMORI, M. Dendritic calcium spiking in mammalian Purkinje cells: In vitro study of its function and development. Soc. Neurosci. Abst. 4: 66, 1978. PELLIONISZ, A. and LLINAS, R. A formal theory for cerebellar function: The predictive distributed property of the cortico-nuclear cerebellar system as described by tensor network theory and computer simulation. Soc. Neurosci. Abst. 4: 68, 1978. 15
  • 16. WALTON, K. and LLINAS, R. The role of cerebellar and brain stem nuclei in vestibular compensation in rats: A 2-deoxy-D-glucose study. Soc. Neurosci. Abst. 4: 70, 1978. LLINAS, R. and SUGIMORI, M. Double voltage clamp study in squid giant synapse. Biol. Bull. 155: 454, 1978. LLINAS, R., WALTON, K. and SUGIMORI, M. Voltage-clamp study of the effects of temperature on synaptic transmission in the squid. Biol. Bull. 155: 454, 1978. 1979 Full Papers TRAUB, R. D. and LLINAS, R. Hippocampal pyramidal cells: Significance of dendritic ionic conductances for neuronal function and epileptogenesis. J. Neurophysiol. 42: 476-496, 1979. PELLIONISZ, A. and LLINAS, R. Brain modeling by tensor network theory and computer simulation. The cerebellum: distributed processor for predictive coordination. Neuroscience 4: 323-348, 1979. LLINAS, R., STEINBERG, I. and WALTON, K. A model for synaptic transmission. Brain Res. Bull. 4: 170-173, 1979. PELLIONISZ, A. and LLINAS, R. A note on a general approach to the problem of distributed brain function. Matrix & Tensor Quarterly 30/2: 48-50, 1979. LLINAS, R. and SUGIMORI, M. Calcium conductances in Purkinje cell dendrites: Their role in development and integration. Progress in Brain Res. 51: 323-334, 1979. LLINAS, R. and WALTON, K. The place of the cerebellum in motor learning. In Brain Mechanisms in Memory and Learning, pp. 17-36, edited by M.A.B. Brazier, New York: Raven Press, 1979. LLINAS, R., SPITZER, R., HILLMAN, D. and CHUJO, M. Computer graphics analysis of stem images. In: Scanning Electron Microscopy 1979/II, pp. 367-374. Chicago: SEM, Inc., 1979. LLINAS, R. and WALTON, K. Vestibular compensation: A distributive property of the central nervous system. In: Integration in the Nervous System, pp. 145-166, edited by H. Asanuma and V.J. Wilson. Tokyo: Ijaku Shoin, 1979. LLINAS, R. The role of calcium in neuronal function. In: The Neurosciences: Fourth Study Program, pp. 555-571, edited by F.O. Schmitt and F.G. Worden. Cambridge, MA: M.I.T. Press, 1979. Abstracts PUMPLIN, D.W., LLINAS, R. and REESE, T.S. Morphological parameters of the squid giant synapse: Relationship of active zone particles to ionic conductance. Soc. Neurosci. Abst. 5: 259, 1979. LLINAS, R., SUGIMORI, M. and SIMON, S.M. Presynaptic calcium current and postsynaptic response generated by a presynaptic action potential; a voltage clamp study in the squid giant synapse. Biol. Bull. 157: 380, 1979. AMAT, J. and LLINAS, R. Interaction between signals from the vestibular and forelimb receptors as recorded from Purkinje cells of the frog vestibulo-cerebellum. Soc. Neurosci. Abst. 5: 97, 1979. 16
  • 17. BLIGHT, A.R. and LLINAS, R. Presynaptic mechanisms for capacity-compensation in anon-impulsive neuron. Soc. Neurosci. Abst. 5:737, 1979. LLINAS, R. and YAROM, Y. Long-term excitability changes in mammalian inferior olive neurons in vitro. Soc. Neurosci. Abst. 5: 105, 1979. PELLIONISZ, A. and LLINAS, R. Cerebellar coordination: Covariant analysis and contravariant synthesis via metric tensor. A tensorial approach to the geometry of brain function. Soc. Neurosci. Abst. 5:105, 1979. SUGIMORI, M. and LLINAS, R. A non-inactivating voltage-dependent sodium conductance in mammalian Purkinje cells somata, studied in vitro. Soc. Neurosci. Abst. 5:107, 1979. YAROM, Y. and LLINAS, R. Electrophysiological properties of mammalian inferior olive neuron in in vitro brain stem slices and in vitro whole brain stem. Soc. Neurosci. Abst. 5:109, 1979. 1980 Full Papers BLIGHT, A. R. and LLINAS, R. The nonimpulsive stretch-receptor complex of the crab: A study of depolarization-release coupling at a tonic sensorimotor synapse. Phil. Trans. Roy. Soc. B 290: 219-276, 1980. PELLIONISZ, A. and LLINAS, R. Tensorial approach to the geometry of brain function. Cerebellar coordination via metric tensor. Neuroscience 5:1125-1136, 1980. LLINAS, R. and SUGIMORI, M. Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. J. Physiol. (London) 305: 171-195, 1980. LLINAS, R. and SUGIMORI, M. Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices. J. Physiol. (London) 305: 197-213, 1980. LLINAS, R., STEINBERG, I. Z. and WALTON, K. Transmission in the squid giant synapse: A model based on voltage clamp studies. J. Physiol. (Paris) 76: 413-418, 1980. LLINAS, R. and YAROM, Y. Electrophysiological properties of mammalian inferior olivary cells in vitro. In: The Inferior Olivary Nucleus: Anatomy and Physiology, pp. 379-388, edited by J. Courville, C. de Montigny and Y. Lamarre. New York: Raven Press, 1980. LLINAS, R. and WALTON, K. Voltage-dependent calcium conductances in neurons. Cell Surface Rev. 6 (C.W. Cotman, G. Poste & G.L. Nicholson, eds.): 87-118, 1980. HILLMAN, D.E., LLINAS, R., CHUJO, M. and CRANK, R. Direct analysis of nervous system ultrastructure by computer control of STEM. Scanning Electron Microscopy 1980/I, pp. 125-135. Chicago: SEM Inc. Abstracts LLINAS, R., YAROM, Y. and SUGIMORI, M. In vitro studies of the brain stem cerebellar system perfused via the basilar arterial system. Soc. Neurosci. Abst. 6: 513, 1980. 17
  • 18. SUGIMORI, M. and LLINAS, R. Lidocaine differentially blocks fast and slowly inactivating sodium conductance in Purkinje cells: An in vitro study in guinea pig cerebellum using iontophoretic glutamic acid. Soc. Neurosci. Abst. 6: 468, 1980. GRUNER, J. and LLINAS, R. Origin of high-frequency tumor in early postnatally x-irradiated rats. Soc Neurosci. Abst. 6: 205, 1980. PELLIONISZ, A. and LLINAS, R. Tensorial representation of space-time in the CNS: Sensorimotor coordination via distributed cerebellar space-time metric. Soc. Neurosci. Abst. 6: 510, 1980. YAROM, Y., SUGIMORI, M. and LLINAS, R. Inactivating fast potassium conductance in vagal motoneurons in guinea pigs: An in vitro study. Soc. Neurosci. Abst. 6: 198, 1980. STRICHARTZ, G., SMALL, R., NICHOLSON, C. , PENNINGER, K.H. and LLINAS, R. Ionic mechanisms for impulse propagation in growing nonmyelinated axons: Saxitoxin binding and electrophysiology. Soc. Neurosci. Abst. 6: 661, 1980. 1981 Full Papers LLINAS, R., STEINBERG, I. Z. and WALTON, K. Presynaptic calcium currents in squid giant synapse. Biophys. J. 33: 289-322, 1981. LLINAS, R., STEINBERG, I. Z. and WALTON, K. Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse. Biophys. J. 33: 323-352, 1981. LLINAS, R., YAROM, Y. and SUGIMORI, M. The isolated mammalian brain in vitro: A new technique for the analysis of the electrical activity of neuronal circuit function. Fed. Proc. 40: 2240-2245, 1981. LLINAS, R. and YAROM, Y. Electrophysiology of mammalian inferior olivary neurones in vitro. Different types of voltage-dependent ionic conductances. J. Physiol. (London) 315: 549-567, 1981. LLINAS, R. and YAROM, Y. Properties and distribution of ionic conductances generating electroresponsiveness of mammalian inferior olivary neurones in vitro. J. Physiol. (London) 315: 569- 584, 1981. PUMPLIN, D. W., REESE, T. W. and LLINAS, R. Are the presynaptic membrane particles the calcium channels? Proc. Natl. Acad. Sci.. USA 78: 7210-7213, 1981. LLINAS, R. Cerebellar modeling. Nature 291: 279-280, 1981. LLINAS, R. Electrophysiology of the cerebellar networks. Chapter 17 In: Handbook of Physiology, Vol II: The Nervous System, Part II, pp. 831-976, edited by V.B. Brokks, Bethesda: Amer. Physiol. Soc., 1981. LLINAS, R. and SIMPSON, J.I. Cerebellar control of movement. In: Handbook of Behavioral Neurobiology, Vol. 5: Motor Coordination, pp. 231-302, edited by A.L. Towe and E.S. Luschei. New York: Plenum, 1981. LLINAS, R. and WALTON, K. A presynaptic voltage clamp study in the squid stellate ganglion. In: Regulatory Mechanisms of Synaptic Transmission, edited by R. Tapia and C.W. Cotman, pp. 154-167. New York: Plenum, 1981. 18
  • 19. Abstracts LLINAS, R., SUGIMORI, M. and SIMON, S.M. Further studies on transmission by presynaptic spike- like voltage clamp depolarizations in squid giant synapse. Biol. Bull . 161: 348, 1981. PELLIONISZ, A. and LLINAS, R. Genesis and modification of the geometry of CNS hyperspace. Cerebellar space-time metric tensor and "motor learning". Soc. Neurosci. Abst. 7: 641, 1981. LLINAS, R., SUGIMORI, M. and SIMON, S.M. Properties of transmitter release in the squid giant synapse via voltage clamp reconstructed presynaptic action potentials. Soc. Neurosci. Abst. 7:270.6, 1981. SUGIMORI, M. and LLINAS, R. Localization of onic conductances in soma-dendritic regions of Purkinje cells: An in vitro study in guinea pig cerebellar slices. Soc. Neurosci. Abst. 7:76, 1981. YAROM, Y. and LLINAS, R. Oscillatory properties of inferior olive cells: A study of guinea pig brain stem slices in vitro. Soc. Neurosci. Abst. 7: 864, 1981. 1982 Full Papers LLINAS, R., SUGIMORI, M. and SIMON, S. M. Transmission by presynaptic spike-like depolarization in the squid giant synapse. Proc. Natl. Acad. Sci.. U.S.A. 79: 2415-2419, 1982. LLINAS, R. and JAHNSEN, H. Electrophysiology of mammalian thalamic neurons in vitro. Nature 297: 406-408, 1982. LLINAS, R. and SUGIMORI, M. Functional significance of the climbing fiber input to Purkinje cells: An in vitro study in mammalian cerebellar slices. Exp. Brain Res. Suppl. 6: 402-411, 1982. PELLIONISZ, A. and LLINAS, R. Space-time representation in the brain. The cerebellum as a predictive space-time metric tensor. Neuroscience 7: 2949-2970, 1982. LLINAS, R., WALTON, K., SUGIMORI, M. and SIMON, S. 3- and 4-Aminopyridine in synaptic transmission as the squid giant synapse. In: Aminopyridines and Similarly Acting Drugs, Adv. Biosci. 35, pp.69-79, edited by P. Lechat et al. Oxford & New York: Pergamon Press, 1982. LLINAS, R. Calcium in synaptic transmission. Scientific American 247: No. 4: 56-65, 1982. LLINAS, R. General Discussion. Radial connectivity in the cerebellar cortex: A novel view regarding the functional organization of the molecular layer. Exp. Brain Res. Suppl. 6: 189-194, 1982. Abstracts BOWER, J. and LLINAS, R. Simultaneous sampling and analysis of the activity of multiple, closely adjacent, cerebellar Purkinje cells. Soc. Neurosci. Abst. 8: 830, 1982. JAHNSEN, H. and LLINAS, R. Electrophysiological properties of guinea pig thalamic neurons studied in vitro. Soc. Neurosci. Abst. 8:413, 1982. MacVICAR, B.A. and LLINAS, R. Calcium spikes in regenerating giant axons of the lamprey spinal cord. Soc. Neurosci. Abst. 8: 914, 1982. MALINOW, R., PELLIONISZ, A. and LLINAS, R. Tensor network theory providing a paradigm for motor control of posture and movement in multilegged systems. Soc. Neurosci. Abst. 8: 283, 1982. 19
  • 20. OSTRIKER, G., PELLIONISZ, A. and LLINAS, R. Tensor network theory applied to the oculomotor system. CNS activity expressed with natural, nonorthogonal coordinates. Soc. Neurosci. Abst. 8:155, 1982. SUGIMORI, M. and LLINAS, R. Role of dendritic electroresponsiveness in neuronal integration: In vitro study of mammalian Purkinje cells. Soc. Neurosci. Abst. 8: 446, 1982. WALTON, K. and LLINAS, R. Electrophysiological activity recorded from the cerebral cortex of an isolated mammalian brain maintained in vitro. Soc. Neurosci. Abst. 8: 935, 1982. 1983 Full Papers MC COLLUM, G., PELLIONISZ, A. and LLINAS, R. Tensorial approach to color vision. J. Theor. Neurobiol. 2: 23-23, 1983. LLINAS, R. and SUGIMORI, M.: Ionic basis for the electrophysiological activity of mammalian neurons. In: Epilepsy, pp. 19-28, edited by A.W. Ward, Jr., K. Penry and D. Purpura. New York: Raven, 1983. PELLIONISZ, A. and LLINAS, R. Tensor theory of brain function. The cerebellum as a space-time metric. Chapter 23, pp. 394-417, In: Lecture Notes in Biomathematics, Vol. 45: Competition and Cooperation in Neural Nets, edited by M. Arbib and S. Amari. Berlin-Heidelberg-New York: Springer-Verlag, 1983. Abstracts SIMON, S.M., SUGIMORI, M. and LLINAS, R. Resting potential modulates transmitter release in squid giant synapse. Biophys. J. 41: No. 2:2, 136a, 1983. LLINAS, R. Transmission in the squid giant synapse: A double voltage clamp approach. Proc. Intl. Union Physiol. Sci. 15: 110, 1983. LLINAS, R. Active properties of neuronal membrane. Proc. Intl. Union Physiol. Sci. 15: 231, 1983. PELLIONISZ, A., OSTRIKER, G. and LLINAS, R. Generation and modification of neuronal networks acting as metric tensors: A computer demonstration of the process of organizing. Soc. Neurosci. Abst. 9: 310, 1983. LLINAS, R and LOPEZ-BARNEO, J. Adaptation of the electrical activity of single elements in the optic tectum of guinea pigs in vitro: Its possible role in visual habituation. Soc. Neurosci. Abst. 9: 601, 1983. LLINAS, R., SUGIMORI, M. and BOWER, J.M. Visualization of depolarization evoked presynaptic calcium entry and voltage dependence of transmitter release in squid giant synapse. Biol. Bull. 165: 529, 1983. BOWER, J. and LLINAS, R. Simultaneous sampling of the responses of multiple, closely adjacent, Purkinje cells responding to climbing fiber activation. Soc. Neurosci. Abst. 9: 607, 1983. 20
  • 21. SUGIMORI, M. and LLINAS, R. Voltage clamping of Purkinje cells in vitro: A study in guinea pig cerebellar slices. Soc. Neurosci. Abst. 9: 681, 1983. LOPEZ-BARNEO, J. and LLINAS, R. Electrophysiological properties of superior colliculus (SC) neurons in in vitro guinea pig brainstem slices. Proc. European Neurosci. Assoc., 1983. 1984 Full papers LLINAS, R., GREENFIELD, S. A. and JAHNSEN, H. Electrophysiology of pars compacta cells in the in vitro substantia nigra - A possible mechanism for dendritic release. Brain Res. 294. 127-132, 1984. JAHNSEN, H. and LLINAS, R. Electrophysiological properties of guinea pig thalamic neurones: An in vitro study. J. Physiol. (London) 349: 205-226, 1984. JAHNSEN, H. and LLINAS, R. Ionic basis for the electroresponsiveness and oscillatory properties of guinea pig thalamic neurones in vitro J. Physiol. (London) 349: 227-247, 1984. JAHNSEN, H. and LLINAS, R. Voltage-dependent burst-to-tonic switching of thalamic cell activity: An in vitro study. Arch. Ital. Biol. 122: 73-82, 1984. LLINAS, R. Tre sofismi della neurobiologia. In: Livelli di realta, pp. 165-172, edited by M. Piattelli Palmarini. Milano:Feltrinelli, 1984. LLINAS, R. and PELLIONISZ, A. La mente in quanto proprieta tensoriale dei circuite cerebrali. In: Livelli di realta, pp. 191-198, edited by M. Piattelli Palmarini. Milano: Feltrinelli, 1984. LLINAS, R. The squid giant synapse. In: The Squid Axon, Vol. 22 of Current Topics in Membranes and Transport, pp. 519-546, edited by P.F. Baker, New York: Academic Press, 1984. LLINAS, R. Rebound excitation as the physiological basis for tremor: A biophysical study of the oscillatory properties of mammalian central neurons in vitro. In: Movement Disorders: Tremor, pp. 165-182, edited by L.J. Findley and R. Capildeo. London: MacMillan, 1984. LLINAS, R. Possible role of tremor in the organization of the nervous system. In: Movement Disorders: Tremor, pp. 475-477, edited by L.J. Findley and R. Capildeo. London: MacMillan, 1984. LLINAS, R. Comparative electrobiology of mammalian central neurons. In: Brain Slices. ed. Raymond Dingledine, Plenum Publishing Corporation, Chapter 1, pp 7-24, 1984. LLINAS, R. Oscillation and resonance as the basic mechanism for the dynamic organization of the CNS. Trab. Inst. Cajal, Madrid, Vol. LXXV (Suppl.): 32-35, 1984. LLINAS, R. Functional significance of the basic cerebellar circuit in motor coordination. In: Cerebellar Functions, pp. 170-185, edited by J.R. Bloedel, J. Dichgans and W. Precht. Berlin-Heidelberg-New York-Tokyo: Springer-Verlag, 1984. Abstracts SIMON, S.M., SUGIMORI, M. and LLINAS, R. Modelling of submembranous calcium-concentration changes and their relation to rate of presynaptic transmitter release in the squid giant synapse. Biophys. J. 45: 264a, 1984. 21
  • 22. MUHLETHALER, M. and LLINAS, R. Studies on the optimal conditions for long-term survival of mammalian brain in vitro. Soc. Neurosci. Abst. 10: 31, 1984. OSTRIKER, G., PELLIONISZ, A. and LLINAS, R. Tensorial computer movie display of the metaorganization of oculomotor metric network. Soc. Neurosci. Abst. 10: 162, 1984. SIMON, S.M. and LLINAS, R. Residual free calcium hypotheses may not account for facilitation of transmitter release in the squid giant synapse. Soc. Neurosci. Abst. 10: 194, 1984. MINAMI, T., OOMURA, Y., SUGIMORI, M. and LLINAS, R. Electrophysiological properties of ventromedial hypothalamic neurons in guinea pig and their responses to glucose - An in vitro study. Soc. Neurosci. Abst. 10: 612, 1984. LLINAS, R. and SUGIMORI, M. Simultaneous intracellular somatic and dendritic recording from Purkinje cells in vitro; dynamic soma-dendritic coupling. Soc. Neurosci. Abst. 10: 659, 1984. GRACE, A.A. and LLINAS, R. Electrophysiology and morphology of four classes of prefrontal neocortical neurons studied in vitro. Soc. Neurosci. Abst. 10: 739, 1984. LLINAS, R., SUGIMORI, M. and LEONARD, C.S. Transmitter release by local increase in [Ca++]o and by prolonged presynaptic voltage steps in the squid giant synapse. Biol. Bull. 167: 529, 1984. McGUINNESS, T.L., LEONARD, C.S., SUGIMORI, M., LLINAS, R. and GREENGARD, P. Possible roles of synapsin I and Ca++/calmodulin-dependent protein kinase II in synaptic transmission as studied in the squid giant synapse. Biol. Bull. 167: 530, 1984. LLINAS, R., WALTON, K. and FERNANDEZ DE MOLINA, A. Electrophysiological properties of neurons in the central nucleus of the amygdaloid complex of guinea pig: An in vitro study. Proc. Cajal Conference on Neurobiology (Abst.) Sept. 1984. 1985 Full Papers OSTRIKER, G., PELLIONISZ, A. and LLINAS, R. Tensorial computer model of gaze - I. Oculomotor activity is expressed in non-orthogonal natural coordinates. Neuroscience 14: 483-500, 1985. MacVICAR, B. A. and LLINAS, R. R. Barium action potentials in regenerating axons of the lamprey spinal cord. J. Neurosci. Res. 13: 323-335, 1985. LLINAS, R., McGUINNESS, T. L., LEONARD, C. S., SUGIMORI, M. and GREENGARD, P. Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse. Proc. Natl. Acad. Sci. (USA). 82: 3035-3039, 1985. SIMON, S. M. and LLINAS, R. R. Compartmentalization of the submembrane calcium activity during calcium influx and its significance in transmitter release. Biophys. J. 48: 485-498, 1985. PELLIONISZ, A. and LLINAS, R. Tensor network theory of the metaorganization of functional geometries in the central nervous system. Neuroscience 16: 245-273, 1985. 22
  • 23. LLINAS, R. and PELLIONISZ, A. Cerebellar function and the adaptive feature of the central nervous system. In: Review of Oculomotor Research, Vol. 1, Adaptive Mechanisms in Gaze Control: Facts and Theories, edited by A. Berthoz and G. Melvill-Jones. Elsevier, 1985. GRACE, A. A. and LLINAS, R. Morphological artifacts induced in intracellularly stained neurons by dehydration: Circumvention using rapid DMSO clearing. Neuroscience 16: 461-475, 1985. YAROM, Y., SUGIMORI, M. and LLINAS, R. Ionic currents and firing patterns of mammalian vagal motoneurons in vitro. Neuroscience 16: 719-737, 1985. Abstracts SASAKI, K. and LLINAS, R. Dynamic electrotonic coupling in mammalian inferior olive as determined by simultaneous multiple Purkinje cell recording. Biophys. J. 47: 53a, 1985. LLINAS, R. Electrotonic transmission in the mammalian central nervous system. In: Gap Junctions, pp. 337-353, edited by M.V.L. Bennett and D.C. Spray. Cold Spring Harbor Laboratory, 1985. LLINAS, R., SUGIMORI, M., McGUINNESS, T., GRUNER, J. and GREENGARD, P. Further studies on the effect of presynaptic injection of synapsin I Ca/calmodulin-dependent kinase II (CaM kinase II) in the squid giant synapse. Biol. Bull. 169:2 554, 1985. GRACE, A.A. and LLINAS, R. Circumvention of dehydration-induced morphological artifacts in intracellularly stained neurons by a rapid DMSO clearing process. Soc. Neurosci. Abst. 11: 441, 1985. SUGIMORI, M. and LLINAS, R. Direct demonstration of dendritic inhibition in cerebellar Purkinje cells in vitro. Soc. Neurosci. Abst. 11: 689, 1985. KAPOOR, R., JAEGER, C.B. and LLINAS, R. Some properties of organotypic culture model of the cerebellum. Soc. Neurosci. Abst. 11: 689, 1985. MUHLETHALER, M. and LLINAS, R. Burst firing properties of deep cerebellar nuclei cells studied in the isolated guinea-pig brainstem cerebellum in vitro. Soc. Neurosci. Abst. 11: 689, 1985. SASAKI, K. and LLINAS, R. Evidence for dynamic electrotonic coupling in mammalian inferior olive in vivo. Soc. Neurosci. Abst. 11: 181, 1985. 1986 Full Papers LLINAS, R. and YAROM, Y. Oscillatory properties of guinea-pig inferior olivary neurones and their pharmacological modulation: An in vitro study. J. Physiol. (Lond.) 376: 163-182, 1986. LLINAS, R. Neuronal oscillators in mammalian brain. In: Comparative Neurobiology: Modes of Communication in the Nervous System, edited by M.J. Cohen and F. Strumwasser. New York: John Wiley, 1986, pp. 279-290. Abstracts LLINAS, R. and YAROM, Y. Specific blockage of the low threshold calcium channel by high molecular weight alcohols. Soc. Neurosci. Abst. 12: 174, 1986. SUGIMORI, M., LLINAS, R. and ANGELIDES, K. Fluorescence localization of tetrodotoxin receptors in mammalian cerebellar cortex in vitro. Soc. Neurosci. Abst. 12: 464, 1986. 23
  • 24. WALTON, K. and LLINAS, R. Calcium-dependent low threshold rebound potentials and oscillatory potentials in neonatal rat spinal motors in vitro. Soc. Neurosci. Abst. 12: 386, 1986. WALTON, K. and LLINAS, R. Spontaneous oscillatory potentials in lumbar spinal cord of neonatal rat studied in vitro. Proc. Internat. Physiol. Sciences 16: 118,1986. YAMAMOTO, T., FUKUDA, M. and LLINAS, R. Bilateral synchronization of climbing fiber activity. Soc. Neurosci. Abst. 12: 577, 1986. LLINAS, R. Intrinsic neuronal electroresponsiveness and its possible role in epileptogenesis. Congress on Migraine and Epilepsia, Rome, 1986. Functional Neurology. 1987 Full Papers LLINAS, R. R. and GREENFIELD, S. A. On-line visualization of dendritic release of acetylcholinesterase from mammalian substantia nigra neurons. Proc. Natl. Acad. Sci. USA 84: 3047-3050, 1987. YAROM, Y. and LLINAS, R. Long-term modifiability of anomalous and delayed rectification in guinea pig inferior olivary neurons. J. Neuroscience 7: 1166-1177, 1987. LLINAS, R. Functional compartments in synaptic transmission. In: Synaptic Function, edited by G.M. Edelman, W.E. Gall and W.M. Cowan, pp. 7-20, Neurosciences Institute/John Wiley, 1987. LLINAS, R. Purkinje cell electrophysiology. In: Encyclopedia of Neuroscience, edited by G. Adelman. Birkhauser Boston Inc., 1987. LLINAS, R. Cerebellum network physiology. In: Encyclopedia of Neuroscience, edited by G. Adelman. Birkhauser Boston Inc., 1987. LLINAS, R. Inferior olive electrophysiology. In: Encyclopedia of Neuroscience, edited by G. Adelman. Birkhauser Boston, Inc., 1987. LLINAS, R., SUGIMORI, M. and WALTON, K. Further studies on depolarization release coupling in squid giant synapse. In: Molecular Mechanisms of Neuronal responsiveness, edited by Y.H. Ehrlich, R.H. Lenox, E. Kornecki and W.O. Berry. New York and London: Plenum Press, 1987. GREENGARD, P. BROWNING, M.D., McGUINNESS, T.L. and LLINAS, R. Synapsin I, a phosphoprotein associated with synaptic vesicles: Possible role in regulation of neurotransmitter release. In: Molecular Mechanisms of Neuronal Responsiveness, edited by Y.H. Ehrlich, R.H. Lenox, E. Kornecki and W.O. Berry. New York and London: Plenum Press, 1987. LLINAS, R. 'Mindness' as a functional state of the brain. In: Mind Waves, edited by C. Blakemore and S.A. Greenfield. Basil Blackwell, Oxford (1987). Abstracts ALONSO, A. and LLINAS, R. Electrophysiology of guinea pig mammillary bodies in vitro. Soc. Neurosci. Abst. 13: 536, 1987. LLINAS, R. Depolarization-release coupling in the squid giant synapse. Abst. Second World Congress of Neuroscience, Budapest, 1987. 24
  • 25. LLINAS, R. Depolarization-release coupling in the squid giant synapse. Abst. 9th International Biophysics Congress, Jerusalem, 1987. LLINAS, R. Electrophysiology of the olivo-cerebellar system as studied with multiple microelectrode recording. Symposium on the Olivocerebellar System in Motor Control, Turin, 1987. FUKUDA, M. ,YAMAMOTO, T. and LLINAS, R. Simultaneous recordings from Purkinje cells of different folia in the rat cerebellum and their relation to movement. Soc. Neurosci. Abst. 13, 603, 1987. GEIJO-BARRIENTOS, E. and LLINAS, R. Pharmacological differences between inferior olive and thalamic low threshold calcium conductances. Soc. Neurosci. Abst. 13: 1012, 1987. LEONARD, C.S. and LLINAS, R. Low-threshold calcium conductance in parabrachial reticular neurons studied in vitro and its blockage by 1-octanol. Soc. Neurosci. Abst. 13: 1012, 1987. LLINAS, R., PARE, D., DESCHENES, M. and STERIADE, M. Differences between thalamocortical spindling and PGO wave generation demonstrated by low-threshold calcium current blockage by octanol. Soc. Neurosci. Abst. 13: 1012, 1987. NAVARRETE, R., WALTON, K. and LLINAS, R. Spinal network development and its relation to hindlimb movement. Soc. Neurosci. Abst. 13: 824, 1987. SUGIMORI, M. and LLINAS, R. Spider venom blockade of dendritic calcium spiking in Purkinje cells studied in vitro. Soc. Neurosci. Abst. 13: 228, 1987. McGUINNESS, T., BRADY, S., GRUNER, J., SUGIMORI, M., LLINAS, R. and GREENGARD, P. Inhibition by synapsin I of membranous organelle movement in isolated squid axoplasm. Soc. Neurosci. Abst. 13: 1239, 1987. SINTON, C.M. ,KROSSER, B. ,WALTON, K. and LLINAS, R. Blockade of harmaline-induced tremors by alcohols may be mediated by the low-threshold calcium channel. Soc. Neurosci. Abst. 13: 228, 1987. 1988 Full Papers LLINAS, R. and MUHLETHALER, M. An electrophysiological study of the in vitro, perfused brainstem- cerebellum of adult guinea pig. J. Physiol. 404: 215-240, 1988. LLINAS, R. and MUHLETHALER, M. Electrophysiology of guinea pig cerebellar nuclear cells in the in vitro brainstem-cerebellar preparation. J. Physiol.404: 241-258, 1988 LOPEZ-BARNEO, J. and LLINAS, R. Electrophysiology of mammalian tectal neurons in vitro: 1. transient ionic conductances. J. Neurophysiol. 60: 853-868, 1988. LLINAS, R. and LOPEZ-BARNEO, J. Electrophysiology of mammalian tectal neurons in vitro 2. long- term adaptation. J. Neurophysiol. 60: 869-878, 1988. KAPOOR, R., JAEGER, C. and LLINAS, R. Electrophysiology of the mammalian cerebellar cortex in organ culture. Neuroscience 26: 493-507, 1988. JAEGER, C., KAPOOR, R. and LLINAS, R. Cytology and organization of rat cerebellar organ cultures. Neuroscience 26: 509-538, 1988. 25
  • 26. STERIADE, M. and LLINAS, R. The functional states of the thalamus and the associated neuronal interplay. Physiological Reviews. 68: 649-742, 1988. LLINAS, R. The intrinsic electrophysiological properties of mammalian neurons: A new insight into CNS function. Science 242, 1654-1664, 1988. TANK, D., SUGIMORI, M., CONNOR, J. and LLINAS, R. Spatially resolved calcium dynamics of mammalian Purkinje cells in cerebellar slice. Science 242, 773-777, 1988. LLINAS, R. and GEIJO-BARRIENTOS, E. In vitro studies of mammalian thalamic and reticularis thalami neurons. In: Cellular Thalamic Mechanisms. ed. M. Bentivoglio and R. Spreafico. Amsterdam; Elsevier/Holland, pp 23-33, 1988. YAMAMOTO, T., WILLIAMSON, S., KAUFMAN, L., NICHOLSON, C. and LLINAS, R. Magnetic localization of neuronal activity in the human brain. Proc. Natl. Acad. Sci. 85:8732-8736, 1988. 1988 Abstracts LIN, J.W. and LLINAS, R. Depolarization release coupling in the in vitro crab t-fiber synapse. Biophys. J., Vol. 53, 428a, 1988. SUGIMORI, M., TANK, D., CONNOR, J. and LLINAS, R. Activity-dependent intracellular calcium distribution in guinea pig cerebellar Purkinje cells: an in vitro study. Soc. Neurosci. Abst. 14: 136, 1988. NAVARRETE, R., WALTON, K. and LLINAS, R. Postnatal changes in the electrical properties of muscle-identified rat motoneurons: an in vitro study. Soc. Neurosci. Abst. 14: 1060, 1988. LIN, J.W. and LLINAS, R. Dynamic properties of chemical transmission in the crab t-fiber synapse. Soc. Neurosci. Abst. 14: 1207, 1988. LEONARD, C. and LLINAS, R. Electrophysiology of thalamic-projecting cholinergic brainstem neurons and their inhibition by ACH. Soc. Neurosci. Abst. 14: 297, 1988. GEIJO-BARRIENTOS, E. and LLINAS, R. Dopamine and haloperidol modify low-threshold calcium spike and transient calcium current in guinea pig thalamic neurons in vitro. Soc. Neurosci. Abst. 14: 932, 1988. CHERKSEY, B., SUGIMORI, M., RUDY, B. and LLINAS, R. Isolation of a voltage-dependent calcium channel from mammalian CNS. Soc. Neurosci. Abst. 14: 901, 1988. ALONSO, A. and LLINAS, R. Voltage-dependent calcium conductances and mamillary body neurons and autorhythmicity: an in vitro study. Soc. Neurosci. Abst. 14: 900, 1988. CHERKSEY, B., SUGIMORI, M., LIN, J.W. and LLINAS, R. Isolation of voltage dependent calcium channel from the squid central nervous system. Biol. Bull. 175:2 304, 1988. SUGIMORI, M., LIN, J.W., CHERKSEY, B. and LLINAS, R. Blockage of calcium current by a factor from spider toxins. Biol. Bull. 175:2 308, 1988. 26
  • 27. LLINAS, R., SUGIMORI, M., LIN, J.W., McGUINNESS, T.L. and GREENGARD, P. Effect of Synapsin I and CAM kinase II on evoked and spontaneous transmitter release in the squid giant synapse. Biol. Bull.175:2 307, 1988. LIN, J.W., SUGIMORI, M. and LLINAS, R. The analysis of miniature synaptic potentials in the squid giant synapse. Biol. Bull. 175:2 306, 1988. 1989 Full Papers SASAKI, K., BOWER, J.M. and LLINAS, R. Multiple Purkinje cell recording in rodent cerebellar cortex. Eur. J. Neurosci. Vol. 1, pp 572-586, 1989. LLINAS, R. and SASAKI, K. The functional organization of the olivo-cerebellar system as examined by multiple Purkinje cell recordings. Eur. J. Neurosci. Vol. 1, pp 587-602, 1989. LLINAS, R., SUGIMORI, M., LIN, J.W., and CHERKSEY, B. Blocking and isolation of calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison. Proc. Natl. Acad. Sci., USA, Vol. 86, pp 1689-1693, 1989. LLINAS, R., SUGIMORI, M., LIN, J.W., LEOPOLD, P. and BRADY, S. ATP-Dependent directional movement of rat synaptic vesicles injected into the presynaptic terminal of squid giant synapse. Proc. Natl. Acad. Sci. , USA, Vol. 86, pp 5656-5660, 1989. OKADA, Y., NICHOLSON, C. and LLINAS, R. Magnetoencephalography (MEG) as a new tool or non- invasive real time analysis of normal and abnormal brain activity in humans. In: Visualization of Brain Functions, Vol. 53, pp 245-266, ed. D. Ottoson and W. Rostene, Stockton Press. LLINAS, R. Electrophysiological properties of the olivo-cerebellar system. In: The Olivocerebellar System in Motor Control, ed. Piergiorgio Strata, Springer-Verlag 1989. LLINAS, R. Calcium and presynaptic voltage as modulators of the synaptic release process. In: Neuromuscular Junction. ed. L. Sellin, R. Libelius, S. Thesleff. Amsterdam; Elsevier/Holland, Chapter 8, pp 101-109, 1989. LLINAS, R., SUGIMORI, M. and CHERKSEY, B. Voltage-dependent calcium conductances in mammalian neurons: The P channel. Annals of the New York Academy of Sciences Vol. 560, pp. 103-111, 1989. ALONSO, A. and LLINAS, R. Subthreshold Na+-dependent theta-like rhythmicity in entorhinal cortex layer II stellate cells. Nature, 342: 175-177, 1989. McGUINNESS, T., BRADY, S., GRUNER, J., SUGIMORI, M., LLINAS, R. and GREENGARD, P. Phosphorylatin-dependent inhibition by synapsin I of organelle movement in squid axoplasm. J. Neuroscience Vol. 9(12) 4138-4149, 1989 LLINAS, R. The role of the intrinsic electrophysiological properties of central neurons in oscillation and resonance. In: Theoretical Models for Cell to Cell Signalling, pp 3-16, ed. A. Goldbeter Academic Press, 1989. SINTON, C., KROSSER, B., WALTON, K. and LLINAS, R. The effectiveness of different isomers of octanol as blockers of harmaline-induced tremor. Plugers Arch., 414: 31-36, 1989. 27
  • 28. LLINAS, R. Voltage-dependent calcium conductance in mammalian neurons and its possible role in neuronal death. Fidia Research Foundation Symposium, "Neurotoxicity of Excitatory Amino Acids" Satellite of the 19th Annual Meeting of The Society for Neuroscience, 1989. Abstracts CHERKSEY, B., SUGIMORI, M., LIN, J.W. and LLINAS, R. Isolation of a voltage dependent calcium channel from the squid central nervous system. Biophy J. Vol. 55:438a 1989. COTTRELL, G., LIN, J.W., LLINAS, R. and SUGIMORI, M. The mollouscan neuropeptide FLRFamide potentiates transmission at the isolated squid giant synapse. J. Physiology 412:64P, 1989. JAEGER, C., GONZALO-RUIZ, A. and LLINAS, R. Organotypic slice cultures of dopaminergic neurons of substantia nigra. Brain Res. Bull., Vol. 22, 6 1989. LLINAS, R., MUHLETHALER, M. and WALTON, K. Electrophysiology of the isolated adult guinea-pig brain in vitro. J. Physiology, 414: 16P, 1989. RIBARY, U., LLINAS, R., KLUGER, A., SUK, J. and FERRIS, S. Meg (Magnetoencephalography) mapping of auditory evoked steady-state responses in Alzheimer patients. Soc. Neurosci. Abst. 15:1240, 1989. LANG. E., CHOU, M., SUGIHARA, I. and LLINAS, R. Intraolivary injection of pricrotoxin reorganization of complex spike activity. Soc. Neurosci. Abst. 15:179, 1989. CHERKSEY, B., LIN.J.W., SUGIMORI, M. and LLINAS, R. Further studies on the P type calcium channel in lipid bilayers and on the nature of FTX calcium channel blocker. Soc. Neurosci. Abst. 15:652, 1989. LLINAS, R. and GRACE, A.A. Intrinsic 40 Hz oscillatory properties of layer IV neurons in guinea pig cerebral cortex in vitro. Soc. Neurosci. Abst. 15:660, 1989. SUGIMORI, M. and LLINAS, R. Real time visualization of calcium entry into guinea pig Purkinje cells in vitro. Soc. Neurosci. Abst. 15:179, 1989. LEONARD, C. and LLINAS, R. Subthreshold membrane potential oscillations modulate repetitive firing of mesopontine cholinergic neurons in vitro. Soc. Neurosci. Abst. 15:1144, 1989. DeCURTIS, M. and LLINAS, R. Spontaneous and evoked cortical activity in the isolated adult guinea pig brain maintained in vitro. Soc. Neurosci. Abst. 15:660, 1989. LIN, J.W., RUDY, B., CHERKSEY, B. SUGIMORI, M. and LLINAS, R. A funnel-web spider toxin (FTX) fraction blocks calcium currents induced by rat brain mRNA in xenopus oocytes. Soc. Neurosci. Abst. 15:652, 1989. ALONSO, A. and LLINAS, R. Sodium conductance generates theta rhythmicity in entorhinal cortex layer II stellate cells in vitro. Soc. Neurosci. Abst. 15:1143, 1989. COTTRELL, G. A., STANLEY, M., LIN, J.W., and LLINAS, R. Arterial perfusion of FMRFamide related peptides potentiate transmission at the giant synapse of the squid. Biol. Bull.,177:2 322, 1989. CHERKSEY,B., LLINAS, R., SUGIMORI, M., LIN, J.W. Preliminary molecular structure of FTX and synthesis of analogs that block I(Ca) in the squid giant synapse. Biol. Bull., 177:2 321, 1989. 28
  • 29. SUGIMORI, M. and LLINAS, R. On-line rapid determination of [Ca]i by means of Fura-II and high speed video imaging. Biol. Bull., 177:2 326, 1989. LIN, J.W., RUDY, B. and LLINAS, R. FTX blocks calcium current expressed from rat brain mRNA in Xenopus oocytes. Biol. Bull., 177:2 323, 1989. LLINAS, R., SUGIMORI, M., LIN, J.W. and CHERKSEY, B. Dose response for FTX blockade of presynaptic I(Ca) in the squid giant synapse. Biol. Bull., 177:2 324, 1989. SASAKI, K., GEMBA, H., NAMBU, A., ISUJIMOTO, T., YAMAMOTO, T., and LLINAS, R. No-go potentials in human subjects. Neurosci. Res. Suppl. 9:595, 1989. 1990 Full Papers LIN, J.W., RUDY, B. and LLINAS, R. Funnel web spider venom and a toxin fraction, FTX, block calcium current expressed from rat brain mRNA in Xenopus oocytes. Proc. Natl. Acad. Sci. Vol. 87(12) 4538- 4542, 1990. HILLMAN, D., LLINÁS, R., CANADAY, M. and MAHONEY, G. Concepts and methods of image acquisition, frame processing, and image data presentation. In: Three-Dimensional Neuroimaging, ed. A. Toga, Raven Press, Ltd., New York, Chapter. 1, pp 3-38, 1990. SUGIMORI, M. and LLINAS, R. Real-time imaging of calcium influx in mammalian cerebellar Purkinje cells in vitro. Proc. Natl. Acad. Sci. Vol. 87, 5084-5088, 1990. LIN, J.W., SUGIMORI, M., LLINAS, R., MC GUINNESS, T. and GREENGARD, P. Effects of synapsin I and calcium/calmodulin-dependent protein kinase II on spontaneous neuro-transmitter release in the squid giant synapse. Proc. Natl. Acad. Sci. Vol . 87(21) 8257-8261, 1990. LEONARD, C. and LLINAS, R. Electrophysiology of mammalian pedunculopontine and laterodorsal tegmental neurons in vitro: Implications for the control of REM sleep. In: Brain Cholinergic Systems, ed. M. Steriade and D. Biesold, Oxford University Press, New York, pp. 205-223, 1990. ALONSO, A., DE CURTIS, M. and LLINAS, R. Postsynaptic hebbian and non-hebbian long-term potentiation of synaptic efficacy in the entorhinal cortex in slices and in the isolated adult guinea-pig brain. Proc. Natl. Acad. Sci. Vol. 87(23) 9280-9284, 1990. LLINAS, R. Intrinsic electrical properties of mammalian neurons and CNS function. In: Fidia Research Foundation Neuroscience Award Lectures, Vol. 4, Raven Press, Ltd., New York, pp 175-194, 1990. LLINAS, R. and SUGIMORI, M. Intracellular calcium concentration changes during cell death. In: Neurotoxicity of Excitatory Amino Acids, ed. A. Guidoti. Raven Press, Ltd., New York, pp 1-10, 1990. STERIADE, M., GLOOR, P., LLINAS, R., LOPES daSILVA, F.H. and MESULAM. M.-M. Basic mechanisms of cerebral rhythmic activities. Electronencephal. Clin. Neurophysiol. 76:481-508, 1990. Abstracts RIBARY, U. and LLINAS, R. The spatial and temporal organization of the 40-Hz response in humans as analyzed by magnetic recording (MEG). European J. Neurosci. Supplement 3: 51, 1990. 29
  • 30. YAROM, Y and LLINAS, R. An in vitro study of the requirements for rhythmic activity in thalamic neurons utilizing a crossbreed bioelectronic feedback. European J. Neurosci. Supplement 3: 52, 1990. LLINAS, R., SUGIMORI, M. and SHELTON, D. Purkinje cell electroresponsiveness-model predictions and experimental facts. European J. Neurosci. Supplement 3: 255, 1990. CHERKSEY, B., LIN, J.W., SUGIMORI, M. and LLINAS, R. Synthetic FTX-like toxin blocks P-type calcium currents. Biophys. J. Vol. 57, 305a 1990. SALZBERG, B., OBAID, A., STANLEY, K., LIN, J.W., SUGIMORI, M., CHERKSEY, B. and LLINAS, R. FTX, a low molecular weight fraction of funnel web spider venom, blocks calcium channels in nerve terminals of vertebrates. Biophys. J. Vol. 57, 305a 1990. CHERKSEY, B., SUGIMORI, M. and LLINAS, R. Isolation of a calcium channel from mammalian cerebellar tissue using synthetic FTX. Soc. Neurosci. Abst. 16:956, 1990. RIBARY, U., SUK, J., CAPPELL, J., LADO, F., MOGILNER, A. and LLINAS, R. Limit of accuracy of MEG dipole localization on the human somatosensory cortex revealed by mapping magnetic (MEG) recordings onto three-dimensional MRI reconstructions. Soc. Neurosci. Abst. 16:1080, 1990. NOMURA, M., RIBARY, U., LOPEZ, L., MOGILNER, A., LADO, F. and LLINAS, R. Spatial location of magnetic trigeminal somatosensory response by tactile stimulation and correlation of the MRI. Soc. Neurosci. Abst. 16:702, 1990. SUGIHARA, I., LANG, E. and LLINAS, R. Uniform conduction times of climbing fibers determined at different folial depths using a multiple electrode recording paradigm. Soc. Neurosci. Abst. 16:637, 1990. DE CURTIS, M., ALONSO, A. and LLINAS, R. Homo- and hetero-synaptic long-term potentiation in the olfactory-hippocampal circuit in the adult guinea pig isolated brain maintained in vitro. Soc. Neurosci. Abst. 16:146, 1990. WALTON, K. YAROM, Y. and LLINAS, R. Intrinsic subthreshold 10-50 Hz membrane oscillations in interneurons in the fourth layer of the frontal cortex. Soc. Neurosci. Abst. 16:1134, 1990. SUGIMORI, M. and LLINAS, R. Fura-2 imaging of intracellular calcium transients in Purkinje cells following glutamate inotoporesis. Soc. Neurosci. Abst. 16:894, 1990. ALONSO, A. and LLINAS, R. In vitro hebbian and non-hebbian LTP in entorhinal cortex layer II stellate cells. Soc. Neurosci. Abst. 16:146, 1990. LANG, E. SUGIHARA, M. and LLINAS, R. Lesions of the cerebellar nuclei, but not of mesencephalic structures alters the spatial pattern of complex spike synchronicity as demonstrated by multiple electrode recordings. Soc. Neurosci. Abst. 16:894, 1990. LIN, J.W. and LLINAS, R. Single channel properties of Ca channels expressed from rat brain mRNA in Xenopus Oocytes. Soc. Neurosci. Abst. 16:1175, 1990. BERTOLINO, M., VICINI, S. LLINAS, R. and COSTA, E. Voltage-dependent calcium currents in rat cerebellar granule neurons (CGN). Soc. Neurosci. Abst. 16:956, 1990. 30
  • 31. KAY, A., SUGIMORI, M. and LLINAS, R. Voltage clamp analysis of a persistent TTX- sensitive Na current in cerebellar Purkinje cells. Soc. Neurosci. Abst. 16:182, 1990. DELANEY, K., LLINAS, R., and TANK, D. A slow component of facilitation is linearly related to presynaptic calcium at crayfish neuromuscular junction. Soc. Neurosci. Abst. 16:504, 1990. LEONARD, C. and LLINAS, R. Serotonin (5-HT) inhibits mesopontine cholinergic neurons in vitro. Soc. Neurosci. Abst. 16:1233, 1990. WILLIAMS, P.J., PITTMAN Q.J., MAC VICAR, B.A. and LLINAS, R. Funnel-web toxin but not ω−conotoxin blocks high threshold Ca++ currents in intermediate pituitary (IP). Soc. Neurosci. Abst. 16:510, 1990. YAROM, Y. and LLINÁS, R. Intracellular autostimulation of in vitro guinea-pig thalamic neurons (TH) utilizing a hardware bio-electric re-entry system. Soc. Neurosci. Abst. 16:955, 1990. ALONSO, A. and LLINAS, R. Different electrophysiological cell types in entorhinal cortex layer II in rat brain slices. Soc. Neurosci. Abst. 16:1296, 1990. NAMBU, A. and LLINAS, R. Electrophysiology of the globus pallidus neurons: an in vitro study in guinea pig brain slices. Soc. Neurosci. Abst. 16:428, 1990. OBAID, A.L., KOMURO, H., KUMAR, S., SUGIMORI, M., LIN, J.W., CHERKSEY, B., LLINAS, R. and SALZBERG, B. FTX, an HPLC-purified fraction of Funnel Web spider venom, blocks calcium channels required for normal release in peptidergic nerve terminals of mammals: Optical measurements with and without voltage-sensitive dyes. Biol. Bull. Vol. 179:232, 1990. DELANEY, K.R., YAMAGATA, Y., TANK., D., GREENGARD, P. and LLINÁS, R. Effects of synapsin I on synaptic facilitation at crayfish neuromuscular junction. Biol. Bull. Vol. 179:229, 1990. 1991 Full Papers LLINAS, R. GRACE, A.A. and YAROM, Y. In vitro neurons in mammalian cortical layer 4 exhibit intrinsic oscillatory activity in the 10 to 50 Hz frequency range. Proc. Natl. Acad. Sci. Vol. 88, 897- 901, 1991. LLINAS, R., GRUNER, J. SUGIMORI, M., MC GUINNESS, T. and GREENGARD, P. Regulation by synapsin I and CA2+/calmodulin-dependent protein kinase II of transmitter release in the squid giant synapse. J. Physiology 436: 257-282, 1991. SUK, J., RIBARY, U., CAPPELL,J. YAMAMOTO, T. and LLINAS, R. Anatomical localization revealed by MEG recordings of the human somatosensory system. EEG J 78:185-196, 1991. LLINAS, R. Intrinsic electrical properties of nerve cells and their role in network oscillation. In: Symposia on Quantitative Biology, Cold Spring Harbor Laboratory Press, Vol. 55. 933-938, 1991. LLINAS, R. The noncontinuous nature of movement execution. In: Motor Control: Concepts and Issues, eds. D.R. Humphrey and H.J. Freund, John Wiley & Sons Ltd., Dahlem Konferenzen pp 223- 242, 1991. 31
  • 32. LLINAS, R., SUGIMORI, M. and SILVER, R. Imaging preterminal calcium concentration microdomains. Biol. Bull. Vol. 181:2, 316-317, 1991. HILLMAN, D., CHEN, S., AUNG, T.T., CHERKSEY, B., SUGIMORI, M. and LLINAS, R. Localization of P-type calcium channels in the central nervous system. Proc. Natl. Acad. Sci. Vol. 88, 7076-7080, 1991. LLINAS, R. Depolarization release coupling: An overview. Annals of the New York Academy of Sciences Vol. 635, 3-17, 1991. CHERKSEY, B., SUGIMORI, M. and LLINAS, R. Properties of calcium channels isolated with spider toxin, FTX. Annals of the New York Academy of Sciences Vol. 635, 80-89, 1991. RIBARY, U., IOANNIDES, A. A., SINGH, K.D., HASSON, R. and LLINÁS, R. Magnetic field tomography (MFT) of coherent thalamo-cortical 40-Hz oscillation in humans. Proc. Natl. Acad. Sci. 88:11037-11041, 1991. DECURTIS, M., PARE, D. and LLINAS, R. The electrophysiology of the olfactory-hippocampal circuit in the isolated and perfused adult mammalian brain in vitro. Hippocampus Vol. 1:4, 341-354, 1991. LLINAS, R. and PARE, D. Of Dreaming and Wakefulness. Neuroscience Vol. 44:3 521-535. 1991. Abstracts RIBARY, U., LLINAS, R., LADO, F., MOGILNER, A., JAGOW, R., NOMURA, N. and LOPEZ, L. The spatial and temporal organization of the 40-Hz response during auditory processing as analyzed by MEG on the human brain. Third International Brain Research Organization (IBRO) World Congress of Neuroscience, Montreal, Canada, pp. 320, P48.22, 1991. LADO, F., RIBARY, U. , LOPEZ, L., NOMURA, M., JAGOW, R., MOGILNER, A. and LLINAS, R. Movement related cortical activity observed during motionless periods in a repetitive task. Third International Brain Research Organization (IBRO) World Congress of Neuroscience, Montreal, Canada, pp. 79, P9.20, 1991. MOGILNER, A., RIBARY, U., NOMURA, M., LADO, F., LOPEZ, L. and LLINAS, R. Neuromagnetic mapping of the somatosensory homunculus onto three-dimensional MRI reconstructions. Third International Brain Research Organization (IBRO) World Congress of Neuroscience, Montreal, Canada, pp. 320, P48.20, 1991. HILLMAN, D., CHEN, S., AUNG, T.T., CHERKSEY, B., SUGIMORI, M. and LLINAS, R. Distribution of P channel antibody labeling in the CNS. Third International Brain Research Organization (IBRO) World Congress of Neuroscience, Montreal, Canada, pp. 66, P7.19, 1991. CHERKSEY, B., GOODNOW, R., SUGIMORI, M., NAKANISHI, K. and LLINÁS, R. Polyamine blockage of P-type calcium channels. Third International Brain Research Organization (IBRO) World Congress of Neuroscience, Montreal, Canada, pp. 64, P7.8, 1991. WALTON, K., LIEBERMAN, D. and LLINAS, R. Hindlimb suspension impairs swimming in neonatal rats: Identification of a "critical period" for motor development. Third International Brain Research Organization (IBRO) World Congress of Neuroscience, Montreal, Canada, pp. 309, P46.5, 1991. 32
  • 33. WALTON, K., BEGIN, M., LLINAS, A., LEE, S. and LLINAS, R. Hindlimb suspension during a "critical period" for motor development impairs locomotion and righting reflexes in neonatal rats. Third International Brain Research Organization (IBRO) World Congress of Neuroscience, Montreal, Canada, pp. 309, P46.6, 1991. STERIADE, M., MESULAM, M.-M., LLINAS, R., McCORMICK, D.A., and WURTZ, R.H. Thalamacortical events in alert states and their modulation by cholinergic systems. Third International Brain Research Organization (IBRO) World Congress of Neuroscience, Montreal, Canada, pp. 9, W15, 1991. KOSTYUK, P.G., MELDOLESI, J., LLINAS, R., LUX, H.D. and NOWYCKY, M. Calcium transients in nerve cells. Third International Brain Research Organization (IBRO) World Congress of Neuroscience, Montreal, Canada, pp. 14, W48, 1991. USOWICZ, M.M., SUGIMORI, M. and LLINAS, R. The input resistance of cerebellar Purkinje cells measured with tight-seal patch pipettes. Biophysical Society Mtg. 1991. YAMAMOTO, T., UEMURA, T. and LLINAS, R. Tonotopic and amplitopic organization of human auditory cortex revealed by multi-channel squid system. Brain Topography. PARE, D. and LLINAS, R. Spatiotemporal organization of the entorhinal (E) input to the hippocampus: multiple electrode recording from the adult guinea pig brain maintained in vitro. Soc. Neurosci. Abst. 17:128, 1991. LADO, F., RIBARY, U., LOPEZ, L., JAGOW, R., MOGILNER, A. and LLINÁS, R. Localized oscillatory activity in the sensorimotor cortex in motionless period of a repetitive motor task. Soc. Neurosci. Abst. 17:310, 1991. CHERKSEY, B., GOODNOW, R., SUGIMORI, M., NAKANISHI, K. and LLINÁS, R. Polyamine block of P-type calcium channels. Soc. Neurosci. Abst. 17:342, 1991. USOWICZ, M.M., SUGIMORI, M. and LLINÁS, R. Elementary properties of calcium channels in cerebellar Purkinje cells. Soc. Neurosci. Abst. 17:342, 1991. LOPEZ, L., MOGILNER, A., LADO, F., RIBARY, U. and LLINÁS, R. Auditory magnetic evoked fields in response to an incongruous note within a musical sequence in musicians and non-musicians. Soc. Neurosci. Abst. 17:655, 1991. MOGA, M., PARE, D. and Llinás, R. REM and slow wave sleep-like states in the whole guinea pig brain maintained in vitro. Soc. Neurosci. Abst. 17: 880, 1 991. NAMBU, A. and LLINÁS, R. Structure-function relation of the globus pallidus neurons: an in vitro study in guinea pig brain slices. Soc. Neurosci. Abst. 17: 850, 1991. WALTON, K., LIEBERMAN, D., BEGIN, M. and LLINÁS, R. Hindlimb suspension for short periods impairs motor development in neonatal rats. Soc. Neurosci. Abst. 17:937, 1991. SUGIHARA, I., LANG, E. and LLINÁS, R. Alteration of complex spike synchronicity by microinjection of tea and 5-HT into the inferior olive studied with multiple electrode recordings. Soc. Neurosci. Abst. 17:919, 1991. 33
  • 34. LANG. E., SUGIHARA, I., WELSH, J.P. and LLINAS, R. Multielectrode recordings of complex spike activity and their relationship to spontaneous and cortically evoked vibrissal movements in the rat. Soc. Neurosci. Abst. 17:920, 1991. WELSH, J.P., SUGIHARA, I., LANG, E.J. and LLINÁS R. Multielectrode recording of Purkinje cell complex spikes during conditioned tongue protrusion in the awake rat. Soc. Neurosci. Abst. 17:920, 1991. MOGILNER, A., LOPEZ, L., RIBARY, U., LADO, F., GROSSMAN, J.A. and LLINÁS, R. Neuromagnetic assessment of somatosensory cortical organization following peripheral nerve injury and reconstruction. Soc. Neurosci. Abst. 17:1126, 1991. SUGIMORI, M., CHERKSEY, B. and LLINAS, R. Dose response relation for synthetic FTX block of voltage-dependent calcium currents in dissociated Purkinje cells. Soc. Neurosci. Abst. 17:1162, 1991. DE CURTIS, M. and LLINAS, R. Heterosynaptic long-term potentiation in the lateral entorhinal cortex: and extra and intracellular study on the isolated in vitro brain preparation. Soc. Neurosci. Abst. 17: 1330, 1991. RIBARY, U., LLINAS, R., LADO, F., MOGILNER, A., JAGOW, R. and LOPEZ, L. Coherent 40-Hz responses during auditory processing in the human brain. Soc. Neurosci. Abst. 17:1582, 1991. 1992 Full Papers LLINAS, R., SUGIMORI, M. and SILVER, R.B. Microdomains of high calcium concentration in a presynaptic terminal. Science Vol. 256, 677-679, 1992. UCHITEL, O.D., PROTTI, D.A., SANCHEZ, V., CHERKSEY, B.D., SUGIMORI, M. and LLINAS, R. P- type voltage-dependent calcium channel mediates presynaptic calcium influx and transmitter release in mammalian synapses. Proc. Natl. Acad. Sci. (USA) Vol. 89: 3330-3333, 1992. COTTRELL, G.A., LIN, J.-W., LLINAS, R., PRICE, D.A., SUGIMORI, M. and STANLEY, E.F. FMRFamide-related peptides potentiate transmission at the squid giant synapse. Exp. Physio. 77, 881-889, 1992. BERTOLINO, M. and LLINAS, R. The central role of voltage-activated and receptor-operated calcium channels in neuronal cells . Ann. Rev. Pharmacol. Toxicol. 32:399-421, 1992. PARE, D., DE CURTIS, M and LLINÁS R. Role of the hippocampal-entorhinal loop in temporal lobe epilepsy: extra- and intracellular study in the isolated guinea pig brain in vitro. J. Neuroscience 12(5):1867-1881, 1992. LLINAS, R. and RIBARY, U. The use of magnetic field tomography in the study of acute alcohol intoxication. In: Imaging in Alcohol Research, National Institute on Alcohol Abuse and Alcoholism Research Monograph No. 21, Chapter 2, pp 13-26. LLINAS, R. and RIBARY, U. Rostrocaudal scan in human brain: A global characteristic of the 40-Hz response during sensory input. In: Induced Rhythms in the Brain, eds. E. Basar and T. Bullock, Birkhauser, Boston, Chapter 7, pp 147-154, 1992. 34
  • 35. LLINAS, R. Oscillations in CNS neurons: A possible role for cortical interneurons in the generation of 40-Hz oscillations. In: Induced Rhythms in the Brain, eds. E. Basar and T. Bullock, Birkhauser, Boston, Chapter 14, pp 269-283, 1992. LLINAS, R., SUGIMORI, M., HILLMAN, D. and CHERKSEY, B. Distribution and functional significance of the P-type, voltage-dependent Ca2+ channels in the mammalian central nervous system. TINS, Vol. 15, No. 9, 351-355, 1992. GONZALO-RUIZ, A., ALONSO, A., SANZ, M.J. and LLINAS, R . Afferent projections to the mammillary complex of the rat, with special reference from those surrounding hypothalamic regions. J. Comp. Neurol. 321:277-299, 1992. GONZALO-RUIZ, A., ALONSO, A., SANZ, M.J. and LLINAS, R. A dopaminergic projection to the rat mammillary nuclei demonstrated by retrograde transport of wheat germ agglutinin-horseradish peroxidase and tyrosine hydroxylase immunohistochemistry. J. Comp. Neuro. 321: 300-312, 1992. LLINAS, R. and ALONSO, A. The electrophysiology of the mammillary complex in vitro. I. Tuberomammillary and lateral mammillary neurons. J. Neurophysiology Vol. 68:4, p1307-1320, 1992. ALONSO, A. and LLINAS, R. The electrophysiology of the mammillary complex in vitro. II. Medial mammillary neurons. J. Neurophysiology Vol. 68:4, p1321-1331, 1992. USOWICZ, M.M., SUGIMORI, M., CHERKSEY, B. and LLINÁS, R. P-type calcium channels in the somata and dendrites of adult cerebellar Purkinje cells. Neuron Vol. 9, 1185-1199, 1992. WALTON, K. D., LIEBERMAN, D., LLINAS, A., BEGIN, M. and LLINAS, R. Identification of a critical period for motor development in neonatal rats. Neuroscience Vol. 51, 763-767, 1992. RIBARY, U., LLINÁS, R., LADO, F., MOGILNER, A., JAGOW, R., NOMURA, M. and LOPEZ, L. The spatial and temporal organization of the 40-Hz response in human brain: A MEG Study. Biomagnetism: Clinical Aspects. M. Hoke et al editors, Elsevier Science Publishers, 1992. LLINÁS, R. and SUGIMORI, M. The electrophysiology of the cerebellar Purkinje cell revisited. In: The Cerebellum Revisited, eds. R. Llinás and C. Sotelo, Springer-Verlag, New York, Chapter 8, pp 167-181, 1992. NOMURA, M., RIBARY, U., LOPEZ, L., MOGILNER, A., LADO, F.., JAGOW, R. and LLINÁS, R. Oscillotopic organization of the human somatosensory cortex of lip using the neuromagnetic method. Biomagnetism: Clinical Aspects. M. Hook et al editors, Elsevier Science Publishers, 1992. LLINAS, R., SUGIMORI, M. and SILVER, R.B. Presynaptic calcium concentration microdomains and transmitter release. J. Physiology (Paris) 86, 135-138, 1992. Abstracts RIBARY, U., LLINÁS, R. LADO, R., MOGILNER, A., IOANNIDES, A. JAGOW, R., JOLIOT, M. and VOLKMANN, J. Origin and characteristic of coherent thalamo-corticol 40-Hz oscillations in the human brain. Soc. Neurosci. Abst. 18:1420, 1992. MOGILNER, A., GROSSMAN, J.A.J., RIBARY, U., LADO, F., VOLKMANN, J., JOLIOT, M. and LLINÁS, R. Abnormal somatosensory cortical organization and cortical plasticity in humans revealed by magnetoencephalography. Soc. Neurosci. Abst. 18:748, 1992. 35
  • 36. VOLKMANN, J., LADO, F., IOANNIDES, A., MOGILNER, A., JOLIOT., M., RIBARY, U., FAZZINI, E. and LLINÁS, R. Magnetic recording of resting tremor related brain activity in Parkinson's disease. Soc. Neurosci. Abst. 18:936, 1992. LADO, F., RIBARY, U., IOANNIDES, A., VOLKMANN, J., JOLIOT, M., MOGILNER and LLINÁS, R. Coherent oscillations in primary motor and sensory cortices detected using MEG and MFT. Soc. Neurosci. Abst. 18:848, 1992. SKORINA, J., WALTON, K., HILLMAN, D. and LLINÁS, R. Hindlimb suspension in neonatal rats leads to permanent deficits in air righting reflexes. Soc. Neurosci. Abst. 18:961, 1992. WALTON, K.D., JACOBY, J., KO, K., WILLIAMS, S.A. and LLINÁS, R. Changes in locomotion and neuromuscular development in the neonatal rat accompany simulated weightlessness. Soc. Neurosci. Abst. 18:961, 1992. SIVARAMAKRISHNAN, A., LANG, E., SUGIHARA, I., SIVARAMAKRISHNAN, S. and LLINÁS, R. A new treatment of spatio-temporal structure in array recording of the rat inferior olive. Soc. Neurosci. Abst. 18:1206, 1992. MANFRIDI, A., CHERKSEY, B., SUGIMORI, M. and LLINÁS, R. P-channel is responsible for high- threshold dendritic action potential in inferior olive neurons: an FTX study. Soc. Neurosci. Abst. 18:974, 1992. SUGIMORI, M. and LLINÁS, R. Dual patch-clamping of mammalian Purkinje cells in cerebellar slices. Soc. Neurosci. Abst. 18:1358, 1992. LLINÁS, R., SUGIMORI, M. and SILVER, R.B. Calcium microdomains in squid giant presynaptic terminals studied with n-Aequorin-J. Soc. Neurosci. Abst. 18:576, 1992. WELSH, J.P., LANG, E.J., SUGIHARA, I. and LLINÁS, R. Rhythmic olivo-cerebellar control of skilled tongue movement in relation to patterned hypoglossal nerve activity. Soc. Neurosci. Abst. 18:407, 1992. SUGIHARA, I., LANG. E.J., DE ZEEUW, C.I. and LLINÁS, R. Differing climbing fiber length implies variable conduction velocity to establish isochronicity of climbing fiber conduction times. Soc. Neurosci. Abst. 18:1206, 1992. LANG, E.J., SUGIHARA, I. and LLINÁS, R. The ability of motor cortex stimulation to evoke vibrissal movements is modulated by a 10-Hz signal arising in the inferior olive. Soc. Neurosci. Abst. 18:407, 1992. HILLMAN, D., CHEN, S., AUNG, T.T., CHERKSEY, B., SUGIMORI, M. and LLINÁS, R. P-channel and calbindin are differentially affected following corticosterone treatment in aging. Soc. Neurosci. Abst. 18:1435, 1992. CHERKSEY, B., SUGIMORI, M. and LLINÁS, R. Isolation and characterization of the P-type calcium channel from mammalian muscle. Soc. Neurosci. Abst. 18:974, 1992. USOWICZ, M.M., SUGIMORI, M., CHERKSEY, B. and LLINÁS, R. Characterization of P-type calcium channels in cerebellar Purkinje Cells. Soc. Neurosci. Abst. 18:974, 1992. 36
  • 37. CHARPAK, S., PARE, D. and LLINÁS, R. Entorhinal cortex (EC) generates 40-Hz hippocampal oscillations. Soc. Neurosci. Abst. 18:917, 1992. LIN, J.W. and LLINÁS, R. The role of vesicular mobilization in tonic transmitter release and potentiation in the crab T-fiber giant synapse. Soc. Neurosci. Abst. 18:576, 1992. PROTTI, D.A, SANCHEZ, V., CHERKSEY, B.D., SUGIMORI, M., LLINÁS, R. and UCHITEL, O.D. Effect of Cd++ and funnel web spider toxin (FTX) on transmitter release at the mouse neuromuscular junction. Soc. Neurosci. Abst. 18:1357, 1992. 1993 Full Papers LIN, J.W. and LLINÁS, R. Depolarization activated potentiation of the t-fiber synapse in the blue crab. J. Gen. Physiology Vol. 101, 45-65, 1993. DE CURTIS, M and LLINAS, R. Heterosynaptic long-term potentiation in the entorhinal cortex of the guinea pig in vitro isolated brain. Brain Research 600, 327-330, 1993. SUGIHARA, I., LANG, E.J. and LLINÁS, R. Uniform conduction time in the olivocerebellar pathway underlies Purkinje cell complex spike synchronicity in the rat cerebellum. J. Physiology Vol. 470, pp. 243-271, 1993. LLINÁS, R. and RIBARY, U. Coherent 40-Hz oscillation characterizes dream state in humans. Proc. Natl. Acad. Sci. USA Vol. 90, pp. 2078-2081, 1993. MOGILNER, A., GROSSMAN, J.A.I., RIBARY, U., JOLIOT, M., VOLKMANN, J., RAPAPORT, D., BEASLEY, R.W. and LLINÁS, R. Somatosensory cortical plasticity in adult humans revealed by magnetoencephalography. Proc. Natl. Acad. Sci. USA Vol. 90, pp. 3593-3597, 1993. MUHLETHALER, M., DECURTIS, M., WALTON, K. and LLINÁS, R. The in vitro isolated and perfused guinea-pig brain. European J. Neurosci. Vol. 5, pp. 915-926, 1993. LLINAS, R. Is dyslexia a dyschronia? In: Temporal Information Processing in the Nervous System: Special Reference to Dyslexia and Dysphasia. Annals NY Academy Science Vol. 682, p 48-56, 1993. LANG, B., JOHNSTON, I., LEYS, K., ELRINGTON, G., MARQUEZE, B., SEAGAR, M., HOSHINO, T., TAKAHASHI, M., SUGIMORI, M., CHERKSEY, B.D., LLINAS, R. and NEWSOM-DAVIS, J. Autoantibody specificities in Lambert-Eaton Myasthenic Syndrome. Annal New York Academy of Sciences, Vol. 681, pp. 382-393, 1993. PROTTI, D.A., SANCHEZ, V.A., CHERKSEY, B.D., SUGIMORI, M., LLINÁS, R. and UCHITEL, O.D. Mammalian neuromuscular transmission blocked by funnel web toxin. Annals of the New York Academy of Sciences, Vol. 681, 405-407, 1993. LLINÁS, R., SUGIMORI, M., CHERKSEY, B.D., GLEN SMITH, R., DELBONO, O., STEFANI, E. and APPEL, S. IgG from amyotrophic lateral sclerosis patients increases current through P-type calcium channels in mammalian cerebellar Purkinje cells and in isolated channel protein in lipid bilayer. Proc. Natl. Acad. Sci. USA Vol. 90, 11743-11747, 1993. 37
  • 38. BRADY, S.T., SUGIMORI, M., LEOPOLD, P.L., LIN, J.-W., CHU, D.S. and LLINAS, R. Activity- dependent inhibition of neurotransmitter release by Brefeldin A. Biol. Bull. 185:299-300, 1993. LLINAS, R. and WELSH, J.P. On the cerebellum and motor learning. Current Opinion in Neurobiology 3:958-965, 1993. 1993 Abstracts MOREIRA, J.E., REUSS, P.M., RIBEIRO, E.C., REESE, T.S. and LLINÁS, R. Structure of the isolated brain preparation. Soc. Neurosci. Abst. 19: 1075, 1993. RIBARY, U., LLINÁS, R., JOLIOT, M., JAGOW, R. and VOLKMANN, J. Coherent spontaneous 40-Hz oscillations and a lack of reset by sensory stimuli during dream-states in humans. Soc. Neurosci. Abst. 19: 1055,1993. SIVARAMAKRISHNAN, A., WELSH, J.P., LANG, E.J. and LLINÁS, R. Spatio-temporal structure in array recording of the behaving rat inferior olive. Soc. Neurosci. Abst. 19:1279, 1993. MANFRIDI, A., CHARPAK, S., CHERKSEY, B., SUGIMORI, M., and LLINÁS, R. FTX selectively blocks P-type calcium current in hippocampal and olivary neurons. Soc. Neurosci. Abst. 19: 1754, 1993. GONZALEZ-BURGOS, G.R., BIALAI, F.I., CHERKSEY, B., SUGIMORI, M., LLINÁS, R. and UCHITEL, O.D. P-channels are responsible for spike dependent release but sustained release involved other varieties of calcium channels. Soc. Neurosci. Abst. 19: 1756, 1993. CHERKSEY, B.D., SUGIMORI, M., HILLMAN, D. and LLINÁS, R. Ontogeny of P-type calcium channel in the rat cerebellar cortex. Soc. Neurosci. Abst. 19:1480, 1993. SUGIMORI. M., CHERKSEY, B.D. and LLINÁS, R. P-type calcium channels are responsive for transmission at the parallel and climbing fiber synapses in Purkinje cells. Soc. Neurosci. Abst. 19:1526, 1993. WELSH, J.P., LANG, E.J. and LLINÁS, R. The microstructure of coherence in the olivocerebellar system during rhythmic movement in normal and deafferented rats. Soc. Neurosci. Abst. 19: 1279, 1993. 1994 Full Papers LLINAS, R. and PARE, D. The role of intrinsic neuronal oscillations and network ensembles in the genesis of normal and pathological tremors. In: Handbook of Tremor Disorders, eds. Leslie J. Findley and William Koller, Marcel Dekker, Inc., New York, NY , Chapter 2, pp. 7-36, 1994. LEONARD, C.S. and LLINAS, R. Serotonergic and cholinergic inhibition of mesopontine cholinergic neurons controlling REM sleep: An in vitro electrophysiological study. Neuroscience Vol. 59, No. pp. 309-330, 1994. MOGILNER, A., NOMURA, M., RIBARY, U., JAGOW, R., LADO, RUSINEK, H. and LLINÁS, R. Neuromagnetic studies of the lip area of primary somatosensory cortex in humans: evidence for an oscillotopic organization. Exp. Brain Res. 99:137-147, 1994. 38
  • 39. LLINAS, R., RIBARY, U., JOLIOT, M. and WANG, X.-J. Content and context in temporal thalamocortical binding. In: Temporal Coding in the Brain, (Eds. G. Buzaki, R. Llinás, W. Singer, A. Berthoz, Y. Christen) Springer-Verlag, Berlin, Heidelberg, pp 251-272, 1994. LLINÁS, R., SUGIMORI, M. and SILVER, R. Localization of calcium concentration microdomains at the active zone in the squid giant synapse. In: Molecular and Cellular Mechanisms of Neurotransmitter Release. eds. Stjarne/Greengard/Grillner/Hokfelt/Ottoson, Raven Press, NY, Chapter. 9, pp. 133- 137, 1994. LLINAS, R. and RIBARY, U. Perception as an Oneiric-Like State Modulated by the Senses. In: Large- Scale Neuronal Theories of the Brain, Chapter 6, pp 111-124 (eds. C. Koch et al. ) MIT Press , 1994. LLINAS, R., SUGIMORI, M. CHU, D., MORITA, M., BLASI, J., HERREROS, J., JAHN, R. and MARSAL, J. Transmission at the squid giant synapse was blocked by tetanus toxin by affecting synaptobrevin, a vesicle-bound protein. J. Physiology 477.1, 129-133, 1994. NAMBU, A. and LLINÁS, R. Electrophysiology of globus palladus neurons in vitro. J. Neurophys. Vol. 21, No. 3, pp. 1127-1139, 1994. PARE, D. and LLINÁS, R. Non-lamellar propagation of entorhinal influences in the hippocampal formation: multiple electrode recordings in the isolated guinea pig brain in vitro. Hippocampus Vol. 4, No. 4 pp. 403-409, 1994. JOLIOT, M., RIBARY, U. and LLINÁS, R. Neuromagnetic coherent oscillatory activity in the vicinity of 40-Hz coexists with cognitive temporal binding in the human brain. Proc. Natl. Acad. Sci. USA. Vol. 91, p11748-11751, 1994. SILVER, R.B., SUGIMORI, M., LANG. E.J. and LLINÁS, R. Time resolved imaging of Ca2+-dependent aequorin luminescence of microdomains and QEDs in synaptic terminals. Biol. Bull. 187:293-299, 1994. SUGIMORI, M., LANG, E.J., SILVER, R.B. and LLINÁS, R. High-resolution measurement of the time course of calcium-concentration microdomains at squid presynaptic terminals. Biol. Bull. 187:300- 303, 1994. LLINAS, R., SUGIMORI, M., LANG, E.J., MORITA, M., FUKUDA, M., NIINOBE, M., and MIKOSHIBA, M. The inositol high-polyphosphate series blocks synaptic transmission by preventing vesicular fusion: A squid giant synapse study. Proc. Natl. Acad. Sci. (USA) Vol. 91, pp 12990-12993, 1994. Abstracts JOLIOT, M., RIBARY, M. and LLINÁS, R. Human oscillatory brain activity near 40-Hz covaries with cognitive temporal binding. Soc. Neurosci. Abst. Vol. 20 p1270, 521.1, 1994. HILLMAN, D.E., CHEN, S., BING, R., PENNISTON, J.T., and LLINAS, R. Ultrastructural localization of a plasmalemmal calcium pump in the rat cerebellum. Soc. Neurosci. Abst. Vol. 20, p71, 34.19, 1994. SUGIMORI, M., KAY, A.R. and LLINAS, R. The persistent NA+ current in cerebellar Purkinje cells has a single channel conductance distinct from the inactivating current. Soc. Neurosci. Abst. Vol. 20, p63, 33:2, 1994. 39
  • 40. RUDY, B., VEGA-SAENZ DE MIERA, E., SUGIMORI, M. and LLINÁS, R. Molecular characterization of the sodium channels expressed in mammalian cerebellar Purkinje cells. Soc. Neurosci. Abst. Vol. 20, p 64, 33.3, 1994. CHERKSEY, B., SUGIMORI, M. and LLINÁS, R. sFTX -isolated P-type calcium channel proteins is blocked by sFTX and ω-Aga-IVA, but not by ω-conotoxin. Soc. Neurosci. Abst. Vol. 20, p630, 268.9, 1994. RAI, R. and LLINAS., R. Somatostatin effect on guinea-pig dorsal thalamic neurons in vitro. Soc. Neurosci. Abst. Vol. 20, p1349, 553.5, 1994. 1995 Full Papers GONZALEZ BURGOS, G.R., BIALI, F.I., CHERKSEY, B.D., SUGIMORI., M., LLINÁS, R. and UCHITEL, O.D. Different calcium channels mediate transmitter release evoked by transient or sustained depolarization at mammalian sympathetic ganglia. Neuroscience 64:1, pp 117-123, 1995. LLINAS, R. Thorny issues in neurons. Nature (News & Views) 373, 107-108, 1995. WELSH, J.P., LANG, E.J., SUGIHARA, I. and LLINAS, R. Dynamic organization of motor control within the olivocerebellar system. Nature 374, 453-457, 1995. SUGIHARA, I., LANG, E.J. and LLINÁS, R. Serotonin modulation of inferior olivary oscillations and synchroncity: A multiple-electrode study in rat cerebellum. Euro. J. Neurosci. Vol. 7, pp 521-534, 1995. PARE, D. and LLINAS, R. Intracellular study of direct entorhinal inputs to field CA1 in the isolated guinea pig brain in vitro. Hippocampus Vol. 5, 115-119, 1995. LEOPOLD, P.I., LIN, J.-W. , SUGIMORI, M., LLINÁS, R. and BRADY, S.T. The nervous system of Loligo pealei provides multiple models for analysis of organelle motility. In: Cephalopod Neurobiology: Neuroscience studies in squid, octopus, and cuttlefish. Eds. N. Joan Abbott, Roddy Williamson and Linda Maddock, Oxford University Press, Chapter 2, pp 15-34, 1995. LLINÁS, R. and SUGIMORI, M. Synaptic transmission in the squid stellate ganglion. In: Cephalopod Neurobiology: Neuroscience studies in squid, octopus, and cuttlefish. Eds. N. Joan Abbott, Roddy Williamson and Linda Maddock, Oxford University Press, Chapter 17, pp 255-270, 1995. DENK, W., SUGIMORI, M. and LLINAS, R. Two types of calcium response limited to single spines in cerebellar Purkinje cells. Proc. Natl. Acad. Sci. USA, Vol. 92, 18 pp 8279-8282, 1995. CHARPAK, S., PARE, D. and LLINÁS, R. The entorhinal cortex entrains fast CA1 hippocampal oscillations in the anaesthetized guinea-pig: Role of the monosynaptic component of the perforant path. Euro. J. Neurosci. Vol. 7, pp 1548-1557, 1995. LLINÁS, R., SUGIMORI, M. and SILVER, R.B. The concept of calcium concentration microdomains in synaptic transmission. Neuropharmacology, Vol. 34, No. 11, pp. 1443-1451, 1995. KATZ, E., FERRO, P.A., CHERKSEY, B.D., SUGIMORI, M., LLINÁS, R. and UCHITEL, O. Effects of Ca2+ channel blockers on transmitter release and presynaptic currents at the frog neuromuscular junction. J. Physiology, 486.3, pp 695-706, 1995. 40
  • 41. LLINÁS, R., SUGIMORI, M. and SILVER, R.B. Time resolved calcium microdomains and synaptic transmission. J. Physiology (Paris) Vol. 89, pp. 77-81, 1995. MIKOSHIBA, K., FUKUDA, M., MOREIRA, J.E., LEWIS, F.M.T., SUGIMORI, M., NIINOBE, M. and LLINAS, R. Role of the C2A domain of synaptotagmin in transmitter release as determined by specific antibody injection into the squid giant synapse preterminal. Proc. Natl. Acad. Sci. (USA) Vol. 92, pp. 10703-10707. FUKUDA, M., MOREIRA, J.E., LEWIS, F.M.T., SUGIMORI, M., NIINOBE, M., MIKOSHIBA, K., and LLINAS, R. Role of the C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into the squid giant synapse preterminal. Proc. Natl. Acad. Sci. (USA) Vol. 92, pp 10708-10712. ALVAREZ, V.A., SANCHEZ, V.N., ROSATO SIRI, M.D., CHERKSEY, B.D., SUGIMORI, M., LLINÁS, R., and UCHITEL, O.D. Pharmacological characterization of the voltage-dependent Ca2+ channels present in synaptosomes from rat and chicken Central Nervous System. J. Neurochem. Vol. 64, No. 6, 2544-2551, 1995. Abstracts HAUSMAN, J., CHEN, S., CHERKSEY, B., LLINÁS, R. and HILLMAN, D. Aging related deficits in rat auditory nuclei. Third Suncoast Workshop on the Neurobiology of Aging. GUTMAN, D., HILLMAN, D., CHEN, S., SMITH, R.G., APPEL, S. AND LLINÁS, R. Human ALS serum causes neuronal death in the hippocampus. Third Suncoast Workshop on the Neurobiology of Aging. RIBARY, U., JOLIOT, M., KRONBERG, E. and LLINAS, R. Human oscillatory brain activity near 40-Hz: Correlation with cognitive temporal binding and alteration during dyslexia. Human Brain Mapping (Supplement Edition) First International Conference on Functional Mapping of the Human Brain, pp 164, 1995. CAPPELL, J., ZONENSHAYN, M., KOPELL, B. and LLINAS, R. Neuromagnetic activity during covert speech. Human Brain Mapping (Supplement Edition) First International Conference on Functional Mapping of the Human Brain, pp 243, 1995. HUND, M., REZAI, A.R., KRONBERG, E., RIBARY, U., ZONENSHAYN, M., KELLY, P.J. and LLINAS, R. Preoperative magnetic source imaging of the sensorimotor cortex in patients with brain lesions and introduction of functional data into the stereotactic technique. Human Brain Mapping (Supplement Edition) First International Conference on Functional Mapping of the Human Brain, pp 350, 1995. LANG. E.J., SUGIHARA, I. and LLINÁS, R. Differential modulation of olivary rhythmicity by the K- channel blockers apamin, charybdotoxin and tea. Soc. Neurosci. Abst. Vol. 21, p271, 115.7 (1995). DENK, W., SUGIMORI, M. and LLINÁS, R. Calcium-dependent electroresponsiveness in single spines of cerebellar Purkinje cells. Soc. Neurosci. Abst. Vol. 21, p598, 244.19 (1995) . LLINÁS, R. and RAI, R. Oscillatory auto-stimulation of thalamic neurons in vitro, using fictive recurrent inhibition (FRIN) reveals a new type of intrinsic plasticity. Soc. Neurosci. Abst. Vol. 21, p934, 372.7 (1995). 41
  • 42. CHEN, S., BING, R., LLINÁS, R. and HILLMAN, D.E. Purkinje cell dendritic spine alterations in aging. Soc. Neurosci. Abst. Vol. 21, p1563, 614.3 (1995). HILLMAN, D.E., APICELLA, S., CHEN, S., BING, R., PENNISTON, J.T.B. and LLINÁS, R. Localization of calcium channel and plasmalemma calcium pump proteins on chochlear stereocilia. Soc. Neurosci. Abst. Vol. 21, p1572, 617.6 (1995). CHERKSEY, B.D., SUGIMORI, M. and LLINÁS, R. Inositolphosphates modulated lipid bilayer reconstituted calcium channel activity. Soc. Neurosci. Abst. Vol. 21, p1755, 690.9 (1995). HUND, M., REZAI, A., KRONBERG, E., CAPPELL, J., RIBARY, U. and LLINÁS, R. Rapid changes in the organization of sensory and motor evoked fields following peripheral ischemia studied by magnetoencephalography. Soc. Neurosci. Abst. Vol. 21, p1901, 747.4 (1995). SUGIMORI, M., CHERKSEY, B.D. and LLINÁS, R. Dendritic apoptosis: A new mechanism for restricted neuronal death. Soc. Neurosci. Abst. Vol. 21, p2019, 793.10 (1995). 1996 Full Papers DE ZEEUW, C.I., LANG, E.J., SUGIHARA, I., RUIGROK, T.J.H., EISENMAN, L.M., MUGNAINI, E. and LLINAS, R. Morphological correlates of bilateral synchrony in the rat cerebellar cortex. J. Neuroscience Vol. 16, p 3412-3426, 1996. VOLKMANN, J., JOLIOT, M., MOGILNER, A., IOANNIDES, A.A., LADO, F., FAZZINI, E., RIBARY, U. and LLINAS, R. Central motor loop oscillations in Parkinsonian resting tremor revealed by magnetoencephalography. Neurology, 46:1359-1370, 1996. REZAI, A.R., HUND, M., KRONBERG, E., ZONENSHAYN, M., CAPPELL, J., RIBARY, U., KALL, B., LLINAS, R. and KELLY, P.J. The interactive use of magnetoencephalography in stereotactic image- guided neurosurgery. Neurosurgery, Vol. 39, p 92-102, 1996. LANG, E.J., SUGIHARA, I. and LLINAS, R. GABA-ergic modulation of complex spike activity by the cerebellar nucleo-olivary pathway in rat. J. Neurophysiology Vol. 76, 255-275, 1996. HILLMAN, D.E., CHEN, S., BING, R., PENNISTON, J.T. and LLINAS, R. Ultrastructural localization of the plasmalemmal calcium pump in cerebellar neurons. Neuroscience, Vol. 72, No. 2 p 315-324, 1996. LLINAS, R. and PARE, D. The brain as a closed system modulated by the senses. In: The Mind-Brain Continuum, eds. R. Llinás and P.S. Churchland, MIT Press, Cambridge, MA Chapter 1, p 1-18, 1996. Abstracts RIBARY, U., MILLER, S.L., JOLIOT, M., KRONBERG, E., CAPPELL, J., TALLAL, P. and LLINAS, R. Human oscillatory brain activity near 40-Hz correlation with cognitive temporal binding and alteration during dyslexia. Soc. Neurosci. Abst. Vol. 22, p 1852, 728.5 (1996). SUGIMORI, M. and LLINAS, R. Use-dependent Purkinje cell death can be retarded by a bath applied short heparin-like protein. Soc. Neurosci. Abst. Vol. 22, p 1486, 590.15 (1996). 42
  • 43. SCHIFF, N., RIBARY, U., PLUM, F. and LLINAS, R. Human oscillatory brain activity near 40-Hz: correlation with cognitive temporal binding and alteration during long term unconsciousness. Soc. Neurosci. Abst. Vol. 22, p 433, 172.12 (1996). PEDROARENA, C. and LLINAS, R. Calcium-dependent dendritic rhythmogenesis in mammalian thalamic neurons. Soc. Neurosci. Abst. Vol. 22, p 906, 356.15 (1996). PESARAN, B., MITRA, P.P. , KRONBERG, E., RIBARY, U. and LLINAS, R. Analysis methodology for MEG data using modern spectral techniques. Soc. Neurosci. Abst. Vol. 22, p 907, 356.22 (1996). CHERKSEY, B.D., SAPIRSTEIN, V.S., SAITO, M., SUGIMORI, M. and LLINAS, R. Molecular cloning of calcium channel subunits using P-channel antibody. Soc. Neurosci. Abst. Vol. 22, p 5, 9.1 (1996). POZZO-MILLER, L.D., MOREIRA, J.E. and LLINAS, R. Electrophysiological and ultrastructural observations on the first-order giant neuron of the giant fiber system of the squid. Soc. Neurosci. Abst. Vol. 22, p 1081, 429.7 (1996). 1997 Full Papers NAMBU, A. and LLINAS, R. Morphology of globus pallidus neurons: Its correlation with electrophysiology in guinea pig brain slices. J. Comparative Neurology 377:85-94, 1997. PEDROARENA, C. and LLINAS, R. Dendritic calcium conductances generate high frequency oscillation in thalamocortical neurons. Proc. Natl. Acad. Sci. (USA) Vol. 94, p 724-728, 1997. MAKARENKO, V., WELSH, J.P., LANG, E.J. and LLINAS, R. A new approach to analysis of multidimensional neuronal activity: Markov Random Fields. Neural Networks, Vol. 10, No. 5, pp. 785-789, 1997. LLINAS, R., MORENO, H, SUGIMORI, M., MOHAMMADI, J. and SCHLESSINGER, J. Differential pre- and postsynaptic modulation of chemical transmission in the squid giant synapse by tyrosine phosphorylation. Proc. Natl. Acad. Sci. (USA) Vol. 94, p 1990-1994, 1997. LANG, E.J., SUGIHARA, I. and LLINAS, R. Differential roles of apamin and charybdotoxin sensitive K+conductances in the generation of inferior olive rhythmicity in vivo. J. Neuroscience 17(8) pp 2825-2838, 1997. WELSH, J. and LLINAS, R. Some organizing principles for the control of movement based on olivocerebellar physiology. In: The Cerebellum: From Structure to Control. (Eds.) C.I. deZeeuw, P. Strata & J. Voogd, Elsevier Science, Chapter 26, pp 449-461, 1997. HUND, M., REZAI, A., KRONBERG, E., CAPPELL, J. RIBARY, U. and LLINAS, R. MEG-mapping: Basis of a new functional risk-profile (FRP) in the selection of patients with cortical brain lesions. Neurosurgery, Vol. 40, No. 5 p 936-943. LLINAS, R., LANG, E.J. and WELSH, J.P. The cerebellum, LTD and memory: Alternative views. Learning & Memory Vol. 3, pp 445-455, 1997. MORENO, H., RUDY, B. and LLINAS, R. β subunits influence the biophysical and pharmacological differences between P- and Q-type calcium currents expressed in a mammalian cell line. Proc. Natl. Acad. Sci. USA Vol. 94, pp 14042-14047, 1997. 43
  • 44. LLINAS, R., SUGIMORI, M. and SILVER, R. Calcium Concentration Microdomains. In: Calcium and Cellular Metabolism: Transport and Regulation. eds. Sotelo and Benech, Plenum Press, New York, Chapter 2, pp 17-23, 1997. MARSAL, J., RUIZ-MONTASELL, B., BLASI, J., MOREIRA, J.E., CONTRERAS, D., SUGIMORI, M. and LLINAS, R. Block of transmitter release by botulinum C1 action on syntaxin at the squid giant synapse. Proc. Natl. Acad. Sci. USA Vol. 94, pp 14871-14876, 1997. APICELLA, S., CHEN, S., BING, R., PENNISTON, J.T., LLINAS, R. and HILLMAN, D.E. Plasmalemmal atpase calcium pump localizes to inner and outer hair bundles. Neuroscience Vol. 79, No. 4, pp. 1145-1151, 1997. Abstracts CHEN, S., LIEBL, D.J., PARADA, L.F., LLINAS, R. and HILLMAN, D. Marked developmental impairment in the forebrain and dienchephalon of BDNF and NT-3 knockout mice. Soc. Neurosci. Abst. Vol. 23, 564.5, p 1427, 1997. PURPURA, K., SCHIFF, N., KALIK, S., RIBARY, U., KRONBERG, E. and LLINAS, R. Brain activation during orienting, looking and reading an MEG study. Soc. Neurosci. Abst. Vol. 23, 864.7, 2222, 1997. PEDROARENA, C. and LLINAS, R. GAMMA band activation of the corticothalamic (CT) pathway results in a distinct short-term facilitation: An in vitro study. Soc. Neurosci. Abst. Vol. 23, p 1011:399, 1997. SUGIMORI, M. and LLINAS, R. Short-term depression in the parallel fiber Purkinje cell synapse. Soc. Neurosci. Abst. Vol. 23, 781.12, 2007, 1997. NAKAGAWA, M., SUGIMORI, M. and LLINAS, R. T-588 blocks synaptic facilitation in crustacean neuromuscular junction and in the parallel fiber Purkinje cell synapse in mammalian cerebellum. Soc. Neurosci. Abst. Vol. 23, p 368:148.16, 1997. MORENO, H., RUDY, B. and LLINAS, R. Electrophysiological and pharmacological characterization of recombinant putative P/Q type calcium channels in HEK 293 cells. Soc. Neurosci. Abst. Vol. 23, 475.3, 1193, 1997. RIBARY, U., SCHIFF, N., LLINAS, R. and PLUM, F. Fractured brain function in unconscious humans. Soc. Neurosci. Abst. Vol. 23, p 497:193.6, 1997. CONTRERAS, D., SUGIMORI, M. and LLINAS, R. Afferent stimulation frequency determines spatial distribution of excitation in neocortex. A voltage-sensitive dye study. Soc. Neurosci. Abst. Vol. 23, p 1005, 397, 1997. RIBARY U., JOLIOT M., MILLER S.L., KRONBERG E., CAPPELL J., TALLAL P. and LLINÁS R. Cognitive temporal binding and its relation to 40-Hz activity in humans: Alteration during dyslexia. In: Biomag'96: Advances in Biomagnetism Research, (eds) C. Aine, Y. Okada, G. Stroink, S. Swithenby and C. Woods, Springer-Verlag, 1997 (in press). LLINAS, R. and SUGIMORI, M. Calcium Microdomains and Transmitter Release. Abstract Presented at the 51st Annual Meeting of the Society of General Physiologists, Marine Biological Laboratory, Woods Hole, MA 1997. 44
  • 45. 1998 Full Papers LLINAS, R. and RIBARY, U. Temporal conjunction in thalamocortical transactions. In: Consciousness: At the Frontiers of Neuroscience, eds. H. Jasper, L. Descarries, V. Castellucci, and S. Rossignol, Lippincott-Raven Publishers, Philadelphia, PA., Vol. 77 Chapter 7, pp. 95- 103, 1998. LLINAS, R., RIBARY, U. and TALLAL, P. Dyschronic language-based learning disability. In: Basic Neural Mechanisms in Cognition and Language. Wenner-Gren International Symposium Series, Elsevier Science Ltd., Oxford, pp. 101-108, 1998. LLINAS, R. and WALTON, K. Cerebellum. In: The Synaptic Organization of the Brain (ed. Gordon M. Shepherd) Oxford Unviersity Press, New York, Chapter 7, pp 255-288, 1997. LLINAS, R. and PARE, D. Coherent oscillations in specific and non-specific thalamocortical networks and their role in cognition. In: Thalamus, Volume II, Experimental and Clinical Aspects, eds. M. Steriade, E.G. Jones and D.A. McCormick, Elsevier Science, Ltd. Chapter 10, pp 501-516. KAY, A.R., SUGIMORI, M. and LLINAS, R. The kinetic and stochastic properties of a persistent sodium current in guinea-pig cerebellar Purkinje cells. J. Neurophysiology, pp. 1167-1179. 1998. SUGIMORI, M., TONG, C.-K., FUKUDA, M., MOREIRA, J.E., KOJIMA, T., MIKOSHIBA, K. and LLINAS, R. Presynaptic injection of syntaxin specific antibodies block transmission in the squid giant synapse. Neuroscience Vol. 86, No. 1, pp. 39-51, 1998. LLINAS, R., RIBARY, U., CONTRERAS, D. and PEDROARENA, C. The neuronal basis for consciousness. Phil. Trans. R. Soc. Lond. B Vol. 353, No. 1377, pp. 1841-1849, 1998. MORENO, H., NADAL, M., LEZNIK, E., SUGIMORI, M., LAX, I., SCHLESSINGER, J. and LLINAS, R. Nerve growth factor acutely reduces chemical transmission via postsynaptic TrkA-like receptors in squid giant synapse. Proc. Natl. Acad. Sci. USA, Vol. 95. Pp 14997-15002, 1998. LLINAS, R. and MORENO, H. Local Ca 2+ signaling in neurons. Cell Calcium Vol. 24, pg. 359-366, 1998. MAKARENKO, V. and LLINAS, R. Experimentally determined chaotic phase synchronization in a neuronal system. Proc. Natl. Acad. Sci. USA 95:26, pg. 15747-15752. Abstracts RIBARY, U., SCHIFF, N., KRONBERG, E., LLINAS, R. and PLUM, F. Fractured brain function correlates with isolated behavioral patterns in the vegetative state. Cognitive Neurosc. Society Abstract (in press). RIBARY , U., MILLER, S.K., JOLIOT, M., KRONBERG, E. , ROLLI, M., BASKIN, J., CAPPELL, J., TALLAL, P. and LLINAS, R. Third International Conference on Functional Mapping of the Human Brain, Copenhagen, Denmark (in press). MORENO, H., SUGIMORI, M. and LLINAS, R. Nerve growth factor acutely inhibits chemical transmission via postsynaptic tyrosine kinase receptors in the squid giant synapse. Biophysical Society Annual Mtg. Abstract (in press). 45
  • 46. LLINAS, R. Temporal binding in motricity and cognition. Experimental Biology ‘98, San Francisco, CA Vol. 12, A971:5627, 1998. PEDROARENA, C., CONTRERAS, D. and LLINAS, R. Frequency dependent spatiotemporal responses in somatosensory thalamocortical slices studied with voltage-sensitive dyes. Soc. Neurosci. Abst. Vol. 24, pg. 129, 55.11, 1998. LANG, E.J., SUGIHARA, I. and LLINAS, R. Patterns of spontaneous complex spike activity in the non- anesthetized rodent. Soc. Neurosci. Abst. Vol. 24, pg. 665, 261.1, 1998. CONTRERAS, D., PEDROARENA, C., SUGIMORI M. and LLINAS, R. Spatiotemporal distribution of excitation in thalamocortical slices studied with voltage-sensitive dyes. Soc. Neurosci. Abst., Vol. 24, pg. 129, 55.12, 1998. SUGIMORI, M., HIRATA, K. and LLINAS, R. Two photon microscopy analysis of Purkinje cell dendritic integration in vitro.. Soc. Neurosci. Abst., Vol. 24, pg. 667, 261.18, 1998. MORENO, H. , LEV, S., HERNANDEZ, J., SCHLESSINGER, J., RUDY, B. and LLINÁS, R. Calcium dependent activation of P-type calcium channel by PYK2 mediated phosphorylation of an auxiliary subunit. Soc. Neurosci. Abst. Vol. 24, pg. 1577, 621.19, 1998. SAUVE, K. WANG, G., ROLLI, M., JAGOW, R., KRONBERG, E. RIBARY, U. and LLINAS, R. Human gamma-band brain activity covaries with cognitive temporal binding of somatosensory stimuli in sighted and blind subjects. Soc. Neurosci. Abst., Vol. 24, pg. 1128, 444.19, 1998. 1999 Full Papers LANG, E.J., SUGIHARA, I., WELSH, J.P. and LLINAS, R. Patterns of spontaneous Purkinje cell complex spike activity in the awake rat. J. Neuroscience (In Press). 46

×