Dr. Neugebauer's CV

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Dr. Neugebauer's CV

  1. 1. January 30, 2015 CURRICULUM VITAE NAME: Volker Edgar Neugebauer PRESENT POSITION AND ADDRESS: 09/2007 - Professor, Department of Neuroscience & Cell Biology 01/2009 - Vice Chair for Education, Department of Neuroscience & Cell Biology 01/2009 - Director, Neuroscience Graduate Program 07/2008 - Associate Editor, Journal of Neurophysiology The University of Texas Medical Branch 301 University Boulevard Galveston, TX 77555 - 1069 Phone (409) 772- 5259 FAX (409) 762- 9382 E-mail voneugeb@utmb.edu BIOGRAPHICAL: Date of Birth: June 11, 1964 Place of Birth: Werneck, Germany Citizenship: U.S.A. Home Address: 8 East Dansby Drive Galveston, TX 77551 Home Phone: (409) 741- 3130 EDUCATION: 09/1974 – 06/1983 Celtis- Gymnasium (academic “High School” track with 2 years of college- level courses) Schweinfurt, Germany (“Abitur”; Latinum and Graecum diplomas) 11/1983 – 05/1985 Undergraduate studies in Theology and Philosophy (Hebraicum diploma) University of Würzburg, Würzburg, Germany 05/1985 – 04/1991 Medical School MD (04/24/1991) University of Würzburg, Würzburg, Germany 09/1987 – 10/1987 Medical Clerkship (Internal Medicine) Leopoldina Krankenhaus, Schweinfurt, Germany 09/1988 – 10/1988 Medical Clerkship (Internal Medicine) U.S. Army Hospital, Würzburg, Germany 07/1989 - 10/1989 Visiting Medical Student (Senior Electives in Neurology) The University of Texas Medical Branch, Galveston, TX
  2. 2. Volker Neugebauer 05/1987 – 07/1992 Physiology Graduate Track PhD (equivalent, 07/10/1992) “Summa cum Laude” University of Würzburg, Würzburg, Germany 2
  3. 3. Volker Neugebauer BOARD CERTIFICATION: None LICENSURE INFORMATION: 12/16/1992 German Medical License (“Approbation als Arzt”) Federal DEA (Drug Enforcement Administration) Registration Number RN0259324 Texas DPS (Department of Public Safety) Registration Number A0115397 PROFESSIONAL AND TEACHING EXPERIENCE: 05/1987 – 05/1991 Graduate Assistant (“Wissenschaftliche Hilfskraft”) Department of Physiology University of Würzburg, Würzburg, Germany Dr. Hans- Georg Schaible; Dr. Robert F. Schmidt (Chair) Teaching : Physiology Labs (Medical Students) 06/1991 – 05/1992 Intern (“Arzt im Praktikum”) Department of Neurology University of Würzburg Medical School, Würzburg, Germany Dr. Klaus V. Toyka (Chair) Teaching : Principles of Neurology; Neurological Examination and History Taking; Clinical Electrophysiology; Medical Student Electives 06/1992 – 05/1995 Postdoctoral Fellow (“Wissenschaftlicher Assistent”) Department of Physiology University of Würzburg, Würzburg, Germany Dr. Hans- Georg Schaible; Dr. Robert F. Schmidt (Chair) Teaching : Physiology Labs (Medical Students); Sensory Physiology and Neurobiology Lecture (Students of Pharmacy); Electrophysiology (Graduate Students) 06/1994 – 05/1995 Instructor School of Physical Therapy Hans- Weinberger Akademie, Schweinfurt, Germany Teaching : Neurophysiology Course (PT Students, lectures) 05/1995 – 06/1997 Postdoctoral Fellow (Research Scientist) Department of Pharmacology The University of Texas Medical Branch, Galveston, TX Dr. Patricia Shinnick- Gallagher; Dr. Kenneth Johnson (Director, NIH Training Grant) Teaching : Electrophysiology (Graduate Students) 08/1996 – 08/1999 Clinical Assistant Professor Department of Anesthesiology The University of Texas Medical Branch, Galveston, TX Teaching : Pain Didactics Lecture; Pain Clinic Consultant 3
  4. 4. Volker Neugebauer 07/1997 – 08/1999 Assistant Member Marine Biomedical Institute The University of Texas Medical Branch, Galveston, TX Dr. William D. Willis (Director) Teaching : Electrophysiology (Graduate Students) 02/1998 – 08/1999 Assistant Professor (non- tenure track) Department of Anatomy & Neurosciences Associate Member Marine Biomedical Institute The University of Texas Medical Branch, Galveston, TX Teaching : Neuroscience and Human Behavior Course (Medical and Graduate Students, labs) 09/1999 – 08/2006 Member Marine Biomedical Institute The University of Texas Medical Branch, Galveston, TX 09/1999 – 08/2002 Assistant Professor (tenure track) Department of Anatomy & Neurosciences The University of Texas Medical Branch, Galveston, TX Teaching : Neuroscience and Human Behavior Course (Medical Students, lectures and labs); Neuroscience and Human Behavior Enrichment Course (MD/PhD Students, small groups); Advanced Electrophysiology (Graduate Students, lecture and lab); Basic Neuroscience of Pain Course (Postgraduates, lecture); Electrophysiology (Postdoctoral Fellows, Graduate Students) 02/2000 – 06/2003 Associate Member Graduate School of Biomedical Sciences (GSBS) The University of Texas Medical Branch, Galveston, TX 01/2001 – 02/2001 Visiting Scholar (Sabbatical) Department of Cell and Molecular Physiology School of Medicine University of North Carolina, Chapel Hill, NC Dr. Ed R. Perl 09/2002 – 08/2007 Associate Professor (09/2005, tenure) Department of Neuroscience and Cell Biology (formerly, Department of Anatomy & Neurosciences) The University of Texas Medical Branch, Galveston, Texas Teaching : Neuroscience and Human Behavior Course (Medical Students, lectures and labs); Neuroscience and Human Behavior Enrichment Course (MD/PhD Students, small groups); Advanced Electrophysiology (Graduate Students, lecture and lab); Systems Neuroscience (Graduate Students, lectures and labs); Excitatory Amino Acids in Health and Disease (Graduate Students, lecture); Electrophysiology (Postdoctoral Fellows, Graduate Students and Undergraduate Students) 4
  5. 5. Volker Neugebauer 06/2003 – Member Graduate School of Biomedical Sciences (GSBS) The University of Texas Medical Branch, Galveston, TX 01/2005 – 12/2008 Associat e Director Neuroscience Graduate Program (NGP) The University of Texas Medical Branch, Galveston, TX 01/2005 – 01/2009 Director Neurobiology of Disease Track The University of Texas Medical Branch, Galveston, TX 09/2007 – Profes s or Department of Neuroscience and Cell Biology The University of Texas Medical Branch, Galveston, TX Teaching : Neuroscience and Human Behavior Course (Medical Students, lectures and labs); Neuroscience and Human Behavior Enrichment Course (MD/PhD Students, small groups); Neurobiology of Disease course (Residents and Graduate Students); Systems Neuroscience (Graduate Students, lectures and labs); Systemic Physiology and Translational Biology (Graduate Students); Advanced Electrophysiology (Graduate Students, lecture and lab); Electrophysiology (Postdoctoral Fellows, Graduate Students and Undergraduate Students) 01/2009 – Director Neuroscience Graduate Program (NGP) The University of Texas Medical Branch, Galveston, TX 01/2009 – Vice Chair for Education Department of Neuroscience and Cell Biology The University of Texas Medical Branch, Galveston, TX RESEARCH ACTIVITIES: Area of Research Emotional- affectiv e and cognitiv e brain functions. The overall goal of our research is the better understanding of brain functions and dysfunctions in affective and cognitive behavior and disorders. The focus is on the systems and cellular neurobiology of the emotional- affective component of pain. Pain research is particularly attractive because of its clinical significance and usefulness as a basic science approach to study higher brain functions. Persistent pain has a strong emotional component and can lead to depression and anxiety. Conversely, patients suffering from depression and anxiety experience pain more strongly and are more likely to develop chronic pain. Positive emotional- affective states as created in music therapy can relieve pain. Pain is also known to impair cognitive functions such 5
  6. 6. Volker Neugebauer as decision making. We have identified the amygdala and its interactions with prefrontal cortical areas as a key player in the emotional- affective and emotion- based cognitive dimensions of pain. Ongoing projects use an integrative approach of systems and cellular electrophysiology, behavior and pharmacology to determine the role of the amygdala and its interactions with the prefrontal cortex (upstream) and spinal cord (downstream) in pain. A patented computerized vocalization analysis system allows the study of nociceptive and affective pain behavior. Visceromotor responses serve as pseudo- affective measures. Anxiety- like behavior is analyzed in the elevated plus- maze test. A novel cognitive behavioral test determines emotion- based decision- making. Pharmacological and electrophysiological changes in the amygdala, medial prefrontal cortex and spinal cord are measured using extracellular single- cell recordings at the systems level and whole- cell patch- clamp and imaging in slice preparations. Recent collaborative research projects include mechanisms of cognitive dysfunctions related to Alzheimer’s disease and schizophrenia. Long- term potentiation is measured in the amygdala, hippocampus and prefrontal cortex in different animal models. Grant support (not includin g pendin g application s) Current R01 NS38261 - NIH/NINDS “Pain, Nociception and the Amygdala” PI, Volker Neugebauer ; 50% effort Total direct costs: $787,500; 02/01/08 - 01/31/12 R01NS038261- 10S1 – NIH/NINDS “Pain, Nociception and the Amygdala” (Supplement) PI, Volker Neugebauer Total direct costs: $25,033; 02/01/09 - 01/31/10 P01 NS11255 - NIH/NINDS “Peripheral and Central Sensitization in Pain” Project 3: Group I mGluR- ROS-ERK dependent sensitization in the amygdala in visceral pain PI, Project 3, Volker Neugebauer ; 20% effort PPG Director, Jin-Mo Chung Total direct costs: $841,500; 04/01/08 - 03/31/13 R01 NS059901 – NIH/NINDS „Calcineurin Inhibition for Reversing the Cognitive Effects of Amyloid“ Co-I, Volker Neugebauer PI, Giulio Taglialatela; 06/15/09 – 05/31/11 IIRG-08- 90755 - Alzheimer Association “Neurobehavioral toxicity of natural amyloid beta oligomers” 6
  7. 7. Volker Neugebauer Co-I, Volker Neugebauer ; 10% effort PI, Giulio Taglialatela; Total direct costs: $240,000; 06/01/08 – 05/31/11 R15 MH80400 – NIH/NIMH “Stress psychopathology and the amygdala” Consultant, Volker Neugebauer PI, N. Bradley Keele 05/01/08 - 04/30/10 Past 61649 - Chemical Works of Gedeon Richter Ltd “Examination of the Effect of RGH-896 on the Activity of Central Amygdala Neurons in Normal and Arthritic Rats” PI, Volker Neugebauer ; 10% effort Total direct costs: $33,650; 06/01/07 – 04/15/09 R01 NS38261 - NIH/NINDS “Pain, Nociception and the Amygdala” (PI, Volker Neugebauer; 60% effort; 03/01/04 - 02/14/08) R01 NS38261- 07S1 - NIH/NINDS “Pain, Nociception and the Amygdala” (Supplement) (PI, Volker Neugebauer; 03/01/06 - 02/28/07) P01 NS11255 - NIH/NINDS, “Pain and Inflammation” (PI, William D. Willis; Co-I, Volker Neugebauer; 15% effort; 08/01/01 - 06/30/07) 58826 - Chemical Works of Gedeon Richter Ltd “Examination of the Effect of NR2B Antagonists on the Activity of Central Amygdala Neurons in Normal and Arthritic Rats” (PI, Volker Neugebauer; 10% effort; 06/01/05 – 10/31/06) 2521- 04 - John Sealy Memorial Endowment Fund for Biomedical Research “Pain, Nociception and the Amygdala”, (PI, Volker Neugebauer; 100% effort; 09/15/03 – 06/30/04) R01 NS38261 - NIH/NINDS “Pain, Nociception and the Amygdala” (PI, Volker Neugebauer; 70% effort; 07/01/99 – 02/29/04) 2528- 99 - John Sealy Memorial Endowment Fund for Biomedical Research “Pain Mechanisms in the Amygdala: Metabotropic Glutamate Receptors” (PI, Volker Neugebauer; 100% effort; 09/01/98 – 08/31/99) Ne 577/1- 1 - Deutsche Forschungsgem einschaft (DFG) ”Cellular Mechanisms of Kindling- Induced Synaptic Plasticity in the 7
  8. 8. Volker Neugebauer Amygdala: Electrophysiological and Neuropharmacological Studies on Single Cells in Vitro ” (PI, Volker Neugebauer; 100% effort; 05/01/95 – 10/01/96) Patent U.S. Patent 7,213,538 “Animal restraining apparatus for physiological and pharmacological studies” by Jeong Han and Volker Neugebauer (filed 2005; granted 2007) 8
  9. 9. Volker Neugebauer COMMITTEE RESPONSIBILITIES: International Associat e Editor , Journal of Neurophysiology, 2008 – External Reviewer, Thesis Committee of Miguel Santos Pais Vieira, PhD Student, University of Porto, Portugal, 2008 – Editorial Board, Recent Patents on Central Nervous System Drug Discovery, Bentham Science Publishers Ltd., 2006 – Deputy Editor , Molecular Pain, 2004 – Editorial Board, Current Drug Targets- CNS and Neurological Disorders, 2004 – Committee on Bylaws, International Association for the Study of Pain (IASP), 2006 – Reviewer, 36 scientific journals (see below) Grant Reviewer (ad- hoc), The Wellcome Trust, UK, 2006 – Grant Reviewer, Alberta Heritage Foundation For Medical Research, 2006 – Grant Reviewer, Canadian Institutes of Health Research, 2006 - Grant Reviewer (ad- hoc), The Biotechnology and Biological Sciences Research Council (BBSRC), UK, 2005 – Grant Reviewer (ad- hoc), U.S. Civilian Research and Development Foundation (CRDF) established by the National Science Foundation (NSF), 2004 – Grant Reviewer (ad- hoc), The Scottish Hospital Endowments Research Trust (SHERT), 2004 – National External Referee, APT committees (University of Washington School of Medicine, Oregon Health & Science University School of Medicine, University of Tulsa) External Advisor, Thesis Committee of Mary O. Adedoyin, PhD Student, Interdisciplinary Program in Neuroscience, Georgetown University Washington, D.C. (Supervisor: Joseph Neale, PhD), 2007 – Grant Reviewer (ad- hoc), NIH, SRG ZRG1- IFCN, 2007 – Grant Reviewer (ad- hoc), NIH, SRG NIGMS-ZGM1, 2004 – Grant Reviewer (ad- hoc), VA grants, 2000 – State/Regional Steering Committee Member, Training Program in Theoretical & Computational Neuroscience, Gulf-Coast Consortia (GCC), Keck Center, Rice University, 2005 – External Advisor, Honors Thesis Committee of Cathryn Hughes, Neuroscience Program, Baylor University, Waco, TX (Supervisor: N. Bradley Keele, PhD), 2006 - 2007 External Advisor, Thesis Committee of Yarimar Carrasquillo, PhD Student, Neuroscience Graduate Program, Baylor College of Medicine, Houston, TX (Supervisor: Robert Gereau, PhD), 2002 – 2006 External Advisor, Thesis Committee of Hita Adwanikar, PhD Student, Neuroscience Graduate Program, Baylor College of Medicine, Houston, TX (Supervisor: Robert Gereau, PhD), 2001 – 2005 9
  10. 10. Volker Neugebauer External Advisor, Thesis Committee of Gautam Bhave, MD/PhD Student, Neuroscience Graduate Program, Baylor College of Medicine, Houston, TX (Supervisor: Robert Gereau, PhD), 2000 – 2003 Galveston County Science and Engineering Fair, Judge, 2001 UTMB Neuroscie n c e Graduat e Program (NGP), Director , 2009 – SOM APT committ e e , Member, 2009 – Executiv e Committe e , Member, Graduate School of Biomedical Sciences (GSBS), Member, 2009– Steerin g Committ e e , BBSC, Member, 2009 – Fisher Acade mic Excellenc e Awards Committe e , Chair , 2009 – Neurobiolo g y of Disea s e (NOD) track , NGP, Director , 2005 – 2009 Neuroscience Graduate Program (NGP), Associate Director , 2005 – 2008 NGP Acade mic and Operation al Policies Ad- Hoc Committe e , Chair, 2005 – 2006 Admission s Committ e e , NGP, Chair , 2002 – 2009 Admission s Committ e e , Basic Biomedical Science Curriculum (BBSC), Member, 2002–2009 Examination Committe e , NGP, Member, 2001 – 2003 Curriculum Committe e , Neuroscie nc e of Diseas e (NOD) cours e, Member, 2004 – Governanc e Committe e , William D. and Jean C. Willis Research Endowment in Neuroscience, 2006 – Course Committ e e , Neuroscie n c e and Human Behavior (NHB), Member, 2001 – Medical School Admission s , Interviewer, 1998 – Grant Review er (ad- hoc) , John Sealy Memorial Endowment Fund for Biomedical Research, 2001 – Summ er Undergradu a t e Research Sympo siu m (SURP), Mentor , 2002 - Thesis Committ e e of Huaiyu Tan, MD/PhD Student, UTMB, Member, (Supervisor: Claire Hulsebosch, PhD), 2002 – 2005 Thesis Committ e e of Jeong S. Han, PhD Student, UTMB, Supervisor , 2003 – 2005 Thesis Committ e e of Katherine Ruppert, PhD Student, UTMB, Supervisor , 2007 – 2008 Acade mic Advisor of Jordan Jahrling, PhD Student, BBSC, UTMB, 2008 – 2009 Acade mic Advisor of Ryan Miller, PhD Student, BBSC, UTMB, 2008 – 2009 Acade mic Advisor of Sora Lee, PhD Student, BBSC, UTMB, 2008 – 2009 Acade mic Advisor of Yao Xiao, PhD Student, BBSC, UTMB, 2008 – 2009 Language Assistance Office, Interpreter, 1995- 1999 National Student Research Forum (NSRF), Judge, 1997 – Research Strategy Scenario Planning Mission Group, Committee Member, 2000 Grant Reviewer (ad- hoc), Pilot Research Grants in the Neurosciences (PRN), 2002 Medical Student Summer Research Program (MSSRP), Judge, 2004 10
  11. 11. Volker Neugebauer Pathology Research Day, Judge, 2004 - MD-PhD Program Advisory Committee, Member, 2004 – 2005 Sigma Xi (UTMB Chapter), President, 2004- 2007 Recruitment Committee, Graduate School of Biomedical Sciences (GSBS), Member, 2005- NGP Curriculum Committee & Course Directors Ad-Hoc Committee, 2006 - Member, NIH/NIDA Training Grant “Neural and Pharmacological Mechanisms of Abused Drugs”, Director Dr. Kenneth Johnson, UTMB, 2006 – Member, Addiction Center, Director Dr. Kathryn Cunningham, UTMB, 2007 – Evaluation Committee, James E. Beall II Scholarship in Neuroscience, 2008 – Departmental Executiv e Committe e , Department of Neuroscience and Cell Biology, Member, 2005 – Websit e Develop m e n t Group, Chair , 2007 – 2009 Search Committ e e , NCB faculty positions, Member, 2007 – 2008 Faculty Mentor , Drs. Tang and Kang, 2008 – Strategic Planning Committee, Member, 2001 Faculty Evaluation & Development Committee, Member, 2000 – 2003 Post Tenure Review Committee, Member, 2008 – Scientific Sessions Organized and Chaired Workshop Organizer (with Dr. Karin High), “Spinal Pharmacology of Inflammatory Pain”, SAHS, UTMB, 2000 Organizer and Chair, Symposium "Metabotropic Glutamate Receptors: Novel Targets for Pain Relief? Preclinical and Clinical Aspects", American Pain Society 20 th Annual Meeting, Phoenix, AZ, 2001 Organizing committee, Symposium “Unraveling the Mysteries of Pain – 50 Years of Pain Research”. 70th Birthday Celebration for William D. Willis, Jr., M.D., Ph.D., Galveston, TX, July 31, 2004 Organizer and Chair, Symposium "The Yin-Yang of Supraspinal Pain Modulation", American Pain Society 24 th Annual Meeting, Boston, MA, 2005 Organizer and Chair, Symposium "The Amygdala: Pain Processing and Pain Modulation", Spring Pain Meeting, Grand Cayman, British West Indies, 2006 Organizer and Chair, Symposium "The Pain Within: Pain Modulation by the Amygdala", American Pain Society 25 th Annual Meeting, San Antonio, TX, 2006 Organizer and Chair, Symposium "Forebrain Pain Mechanisms", Spring Pain Meeting, Grand Cayman, British West Indies, 2008 Organizer and Chair, Workshop “Cognitive Aspects of Pain”, American Pain Society, San Diego, CA, May 8, 2009 Session Chair, Trigeminal Neuralgia Association Australia, Melbourne, Australia, August 29, 2009. Organizer and Chair, Symposium "Forebrain Pain Mechanisms", Spring 11
  12. 12. Volker Neugebauer Pain Meeting, Grand Cayman, British West Indies, 2010 TEACHING RESPONSIBILITIES Teaching School of Medicine (SOM): Neuroscience and Human Behavior (NHB) Faculty Assistant and Instructor, 1999 – 2000 13 labs/year plus 13 prelabs/year Neuroscience and Human Behavior (NHB) Lecturer and Lab Instructor, 2001 – 2 lectures/year (1 h ea. = 2 h ) 14 labs/year (13 @ 2 h; 1 @ 1.5 h = 27.5 h ) 2 pre- labs/year (1 h ea. = 2 h ) MDPH 6202 (NHB Enrichment Course) Small Group Instructor/Facilitator, 2001, 2004 – 2 lectures/year (3 h ea. = 6 h ) Graduate School (GSBS): Neuroscience and Human Behavior (NHB, included graduate students), Labs, 1999 Basic Neuroscience of Pain Course, Lecture, 2000 NEUR 6203 (Advanced Electrophysiology Course) Lecturer and Lab Instructor, 2001 – 2006 1 lecture/year (2 h) 1 lab/year (3 h) BBSC 6121 (Excitatory Amino Acids in Health and Disease) Lecturer, 2003 BBSC 6209 (Systemic Physiology and Translational Biology) Lecturer, 2008 BBSC 6301 (Laboratory Rotation) 2000 – Danny Rafati (2000), Jeong S. Han (2001- 02), L. Leanne Lash (2003), Titilope Ishola (2004), Jason R. Thonhoff (2005- 06), Katherine Ruppert (2007), Aimee M. Peterson (2008), Sora Lee (2009), Yao Xiao (2009), Ryan Miller (2009) NEUR 6403 (Integrative Neuroscience) Course director, Lecturer and Lab Instructor, 2003 – 6 lectures/year (1.5 h ea. = 9 h ) 6 labs/year (3 h ea. = 18 h ) NEUR 6097 (Research), 2003 – 2004 (Jeong S. Han), 2007 – 2008 (Katherine Ruppert) NEUR 6099 (Dissertation), 2004 – 2005 (Jeong S. Han) NEUR 6202 (Neurochemistry and Molecular Neuroscience Course), 2007 1 lecture/year (1 h) NEUR 6181 (Neurobiology of Disease) Course director , 2008 - 2009 1 credit hour course NEUR 6183 (Neurobiology of Disease) 12
  13. 13. Volker Neugebauer Course director , 2008 – 2009, Lecturer, 2008 – 1 credit hour course 1 lecture (1 h ) NEUR 6182 (Neurobiology of Disease) Course director , 2008 - 2009 1 credit hour course NEUR 6184 (Neurobiology of Disease) Course director , 2008 – 2009, Lecturer, 2008 – 33 lectures (3 h ) Studen t s/Me n t e e s /Ad vis e e s /Train e e s Visiting Scientists N. Bradley Keele, PhD, Baylor University, Waco, TX, 2001, 2008, 2009 Ida Marabese, University of Naples, Italy, 2007 Kyle Halvorson, University of Minnesota, MN, 2005 Stephen D. Hess, PhD, Merck Research Laboratories, La Jolla, CA, 2000 Junior Faculty Myoung- goo Kang, PhD, Assistant Professor, 2009 – Shao- Jun Tang, PhD, Assistant Professor, 2008 – Postdoctoral Fellows Hao Sun, PhD, 2009 – Zhen Li, PhD, 2008 – Guanchen Ji, PhD, 2006 – Hugh Fu, PhD, 2004 – 2009 Enza Palazzo, PhD, 2007 – 2008 Hita Adwanikar, PhD, 2004 – 2007 Jeong S. Han, MD, PhD, 2006 Weidong Li, MD, PhD, 2000 – 2006 Gary C. Bird, PhD, 2000 – 2004 MD/PhD Students Alyssa Baker, 2009 – Mathieu Bakhoum, 2009 – Jason R. Thonhoff, 2005- 06 Huaiyu Tan, thesis committee member, 2000 – 2005 Titilope Ishola, 2004 Danny Rafati, 2000 PhD Students Mary O. Adedoyin, external advisor, 2007 – Yao Xiao, academic advisor, 2008 – 2009 Ryan Miller, academic advisor, 2008 – 2009 Sora Lee, academic advisor, 2008 – 2009 Jordan Jahrling, academic advisor, 2008 – 2009 Katherine Ruppert, supervisor, 2007 – 2008 Yarimar Carrasquillo, external advisor, 2002 – 2005 Jeong S. Han, supervisor, 2001 – 2005 13
  14. 14. Volker Neugebauer Hita Adwanikar, external advisor, 2001 – 2004 Gautam Bhave, external advisor, 2000 – 2003 Master’s Students Cathryn Hughes, external advisor, 2006 - 2007 Undergraduate Students (SURP) Jennifer K. Edwards, 2007 Cara Ramsey, 2006 Michelle Hazel, 2004, 2005 Justina Jones, 2003 L. Leanne Lash, 2002 Chair/Memb er of Ph.D. Supervisory Committ e e for Katherine Ruppert (supervisor/chair), 2007 – 2008 Jeong S. Han (supervisor/chair), 2001 – 2005 Huaiyu Tan (member; chair: Dr. Claire Hulsebosch), 2000 – 2005 External Review er of Ph.D. Dissertatio n for Miguel Santos Pais Vieira, PhD Student, University of Porto, Portugal, 2008 – Mary O. Adedoyin, Georgetown University Washington, D.C., 2007 – Yarimar Carrasquillo, Baylor College of Medicine, Houston, 2002 – 2005 Hita Adwanikar, Baylor College of Medicine, Houston, 2001 – 2004 Gautam Bhave, Baylor College of Medicine, Houston, 2000 – 2003 External Review er of Master’s Dissertatio n for Cathryn Hughes, Baylor University, Waco, TX, 2006 - 2007 14
  15. 15. Volker Neugebauer MEMBERSHIP IN SCIENTIFIC SOCIETIES/PROFESSIONAL ORGANIZATIONS: (* denotes elected membership) German Neuroscience Association*, 1994 – 1997 Society for Neuroscience*, 1994 – International Association for the Study of Pain* (IASP), 1995 – Sigma Xi* (UTMB Chapter), 1996 – American Pain Society* (IASP Chapter), 1997 – HONORS: Citation Poster Award of the American Pain Society. 18th Annual Scientific Meeting, Ft. Lauderdale, FL, 10/1999 Pain Research Award ("Erster Preis des Förderpreises für Schmerzforschung"). German Society for the Study of Pain (IASP Chapter), Heidelberg, Germany, 10/1995 Research Career Development Award ("Habilitationsstipendium"). Deutsche Forschungsge meinschaft (DFG), Bonn, Germany, 06/1995 First Award of the Lower Franconia Memorial Endowment Fund for Science, Würzburg, Germany, 05/1993 P. Maximilian Kolbe – Reinhold Schneider Gedenkpreis. Commemorative Award of the Reinhold- Schneider Stiftung, Hamburg, Germany, 07/1984 ADDITIONAL INFORMATION: Editorial Board Molecular Pain, Deputy Editor , 2004 – Current Drug Targets- CNS and Neurological Disorders, 2004 – Recent Patents on Central Nervous System Drug Discovery, 2006 – Journal of Neurophysiology, Associate Editor , 2008 – Journal Reviewer for American Journal of Physiology, Anesthesia & Analgesia, Arthritis and Rheumatism, Behavioural Brain Research, Brain Research, Brain Research Bulletin, British Journal of Pharmacology, Current Drug Targets, Current Neuropharmacology, Current Pharmaceutical Design, Epilepsy & Behavior, European Journal of Pain, European Journal of Neuroscience, Experimental Brain Research, Histochemistry and Cell Biology, International Journal of Developmental Neuroscience, Journal of Applied Physiology, Journal of Comparative Neurology, Journal of Neurochemistry, Journal of Neurophysiology, Journal of Neuroscience, Journal of Neuroscience Methods, Journal of Neuroscience Research, Journal of Pain, Journal of Physiology, Molecular Pain, Molecular Pharmacology, Neuropharmacology, Neuroscience, Neuroscience Letters, Pain, Pharmacology Biochemistry and Behavior, Science, Synapse, Trends in Neurosciences, Trends in Pharmacological Sciences Grant Reviewer for Department of Veterans Affairs, 2000 – 15
  16. 16. Volker Neugebauer NIH, SRG NIGMS-ZGM1, 2004 – NIH, SRG ZRG1- IFCN, 2007 – U.S. Civilian Research and Development Foundation (CRDF) established by NSF, 2004 – The Scottish Hospital Endowments Research Trust (SHERT), 2004 – The Biotechnology and Biological Sciences Research Council (BBSRC), UK, 2005 – The Wellcome Trust, UK, 2006 – Alberta Heritage Foundation For Medical Research, 2006 – Canadian Institutes of Health Research, 2006 - John Sealy Memorial Endowment for Biomedical Research, 2001 – Pilot Research Grants in the Neurosciences (PRN), 2002 Collaborations International Drs. Henri Doods, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany Dr. Vasco Galhardo, University of Porto, Porto, Portugal Dr. Csilla Horváth, Neuropharmacology, Gedeon Richter Ltd., Budapest, Hungary Dr. Rohini Kuner, Department of Molecular Pharmacology, University of Heidelberg, Germany Dr. Emmanuel Le Poul, Head of CNS Business Unit, Addex Pharmaceuticals, Geneva, Switzerland Dr. Sabatino Maione, Department of Experimental Medicine, Section of Pharmacology, The Second University of Naples, Italy Dr. Luigi F. Rodella, Division of Human Anatomy, Dept. of Biomedical Sciences and Biotechnology Faculty of Medicine, University of Brescia, Italy Dr. Hanns Ulrich Zeilhofer, Institut für Pharmakologie und Toxikologie, Universität Zuerich, Zuerich, Switzerland National David Bleakman, PhD, Neuroscience Research Division, Eli Lilly & Co., Indianapolis, IN Rob W. Gereau, PhD, Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO Smriti Iyengar, PhD, Neuroscience Research Division, Eli Lilly & Co., Indianapolis, IN N. Bradley Keele, PhD, Baylor University, Waco, TX Yan Lu, PhD, Department of Cell and Molecular Physiology, School of Medicine, University of North Carolina, Chapel Hill, NC Edward R. Perl, MD, Department of Cell and Molecular Physiology, School of Medicine, University of North Carolina, Chapel Hill, NC Jean E. Rivier, PhD, Salk Institute, San Diego, CA Darryle D. Schoepp, PhD, Neuroscience Research Division, Eli Lilly & Co., Indianapolis, IN Min Zhuo, PhD, Department of Physiology, University of Toronto, Toronto, Ontario, Canada 16
  17. 17. Volker Neugebauer UTMB Darren Boehning, PhD, Department of Neuroscience & Cell Biology Susan M. Carlton, PhD, Department of Neuroscience & Cell Biology Jin-Mo Chung, Department of Neuroscience & Cell Biology Kelly T. Dineley, Department of Neurology Joel P. Gallagher, PhD, Department of Pharmacology Claire E. Hulsebosch, PhD, Department of Neuroscience & Cell Biology Kenneth Johnson, PhD, Department of Pharmacology and Toxicology M. Firoze Khan, PhD, Department of Pathology David McAdoo, PhD, Department of Neuroscience & Cell Biology Mary Moslen, PhD, Departments of Pathology and Preventive Medicine and Community Health Qing Lin, MD, PhD, Department of Neuroscience & Cell Biology J. Regino Perez- Polo, PhD, Department of Human Biological Chemistry and Genetics Patricia Shinnick- Gallagher, PhD, Department of Pharmacology Pomila Singh, PhD, Department of Neuroscience & Cell Biology Giulio Taglialatela, PhD, Department of Neuroscience & Cell Biology Shao- Jun Tang, PhD, Department of Neuroscience & Cell Biology William D. Willis, MD, PhD, Department of Neuroscience & Cell Biology Invited Speaker 10/07/2009 “Amygdalo- Cortical Interactions in Pain”. The Queensland Brain Institute, The University of Queensland, Brisban e, Australia. 08/31/2009 “Amygdalo- Cortical Interactions in Pain”. The Queensland Brain Institute, The University of Queensland, Brisban e, Australia. 08/28/2009 “Amygdala Function in Pain”. 3 rd National Conference, Trigeminal Neuralgia Association Australia, Melbourn e, Australia . 08/28/2009 “Amygdalo- Cortical Interactions in Pain”. 3 rd National Conference, Trigeminal Neuralgia Association Australia, Melbourn e, Australia . 05/29/2009 “Amygdala- Cortical Pain Mechanisms”. Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahom a City, OK. 05/08/2009 “Amygdala- Cortical Pain Mechanisms”. 28th Annual Scientific Meeting of the American Pain Society, San Diego, CA. 03/19/2009 “Amygdala- Cortical Plasticity in Pain”. London Pain Consortium, Wellcome Trust, London, UK. 03/02/2009 “Amygdala- Cortical Plasticity in Pain”. Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT. 02/18/2009 “Amygdalo- Cortical Pain Mechanisms”. Department of Pharmacology, The University of Arizona, Tucson, AZ. 09/16/2008 “Differential Roles of mGluR7 and mGluR8 in the Amygdala in Pain- Related Synaptic Plasticity and Behavior”. 6 th International Meeting of Metabotropic Glutamate Receptors. Taormina, Italy. 08/19/2008 “Amygdalo- Cortical Contributions to Arthritic Pain”. Topical Workshop “Neural Integration of Arthritis Pain: From Joint to Brain”, 12 th World Congress on Pain. Glasgo w, Scotland. 07/22/2008 "Amygdala Function in Pain – CRF1 Receptors and 17
  18. 18. Volker Neugebauer Amygdalo- Cortical Interactions. National Institute for Physiological Sciences Myodaiji, Okazaki, Japan . 07/19/2008 “Amygdala Function in Pain”. The Third Asian Pain Symposium, Fukuoka, Japan . 05/12/2008 “Amygdala and Pain - Pharmacological Mechanisms and Targets”. Duke University, Durham, NC. 04/29/2008 “Amygdala- Driven Prefrontal Cortical Inhibition Impairs Cognitive Function in Pain”. Spring Pain Research Conference, Grand Cayman, British West Indies . 03/18/2008 “Amygdala and Pain - Pharmacological Mechanisms and Targets”. 81 st Japanese Pharmacological Society Meeting, Yokoham a , Japan. 03/17/2008 “Role of the amygdala CRF-system in pain”. 81 st Japanese Pharmacological Society Meeting, Yokoha m a, Japan. 11/30/2007 “Emotional- Affective and Cognitive Pain Mechanisms: the Amygdala”. Research Retreat “Molecules and Mechanisms”. Dept. of Neuroscience & Cell Biology, UTMB, Galvest o n , TX. 09/17/2007 “Amygdala Pain Mechanisms: Role of CRF Receptors”. University of Naples, Naples, Italy . 09/14/2007 “Amygdala Pain Mechanisms”. University of Brescia, Brescia, Italy. 05/26/2007 “The Amygdala: Supraspinal Modulation of Arthritis Pain”. Canadian Pain Society 27 th Annual Conference, Ottawa, Ontario, Canada. 01/15/2007 “Role of the Amygdala in Pain”. Northwestern University, Chicago, IL. 11/28/2006 “Amygdala and Pain Modulation”. AstraZeneca R&D, Montreal, Canada. 10/24/2006 “The Amygdala as a Target for Pain Modulation”. Eli Lilly & Company, Indianap olis, IN. 09/14/2006 “AMPA and NMDA Receptor Involvement in Nociceptive Processing”. 5th Congress of the European Federation of IASP Chapters, Istanbul, Turkey . 05/04/2006 "The Pain Within: Pain Modulation by the Amygdala". American Pain Society 25th Annual Meeting, San Antonio, TX. 04/26/2006 “The Amygdala: Pain Processing and Pain Modulation”, Symposium, Spring Pain Research Conference, Grand Cayman, British West Indies . 02/07/2006 “Role of the Amygdala in Arthritic Pain”. Eli Lilly & Company, Indianap olis, IN. 01/28/2006 “Novel Targets for Arthritic Pain Treatment”. Pain and Arthritis Research Workshop, hosted by the Canadian Arthritis Network. Calgary, AB, Canada . 08/25/2005 “Amygdala: Pain- Related Plasticity and Pain Modulation”. International Association for the Study of Pain, 11th World Congress on Pain, Sydney, Australia . 04/25/2005 “The Amygdala: Pain Processing and Pain Modulation”. Eli Lilly & Company, Indianap olis, IN. 04/01/2005 “Supraspinal Pain Modulation: The Amygdala”, Symposium "The Yin-Yang of Supraspinal Pain Modulation", American Pain 18
  19. 19. Volker Neugebauer Society 24th Annual Meeting, Boston, MA. 11/21/2004 “Pain Processing and Pain Relief: Underlying Mechanisms, Components, and Clinical Applications, Workshop (Organizer: Christine T. Neugebauer, MS, MT-BC), American Music Therapy Association (AMTA), Austin, TX. 09/01/2004 “Pharmacology of Pain Mechanisms in the Amygdala”. Gedeon Richter Ltd., Budap e s t, Hungary . 07/31/2004 “The Willis Era – The 90s”. Symposium "Unraveling the Mysteries of Pain”. Galvest o n , TX. 07/09/2004 “Pain Processing in the Amygdala”. Research Retreat “Providing Insights into Mechanisms of Disease and Trauma”. Dept. of Neuroscience & Cell Biology, UTMB, Galvest o n , TX. 06/08/2004 “Pain Mechanisms in the Amygdala”. Boehringer Ingelheim Pharma GmbH, Biberach, Germany . 04/29/2004 “Amygdala and Persistent Pain“. Institut für Physiologie, Universität Jena, Germany. 06/07/2004 “mGluR Function in the Amygdala”. Spring Pain Research Conference, Grand Cayman, British West Indies . 04/27/2004 “Nociceptive Plasticity in the Amygdala”. Spring Pain Research Conference, Grand Cayman, British West Indies . 10/23/2003 “Pain Mechanisms in the Amygdala”. Dept. of Anesthesiology, UTMB, Galvest o n , TX. 05/14/2002 “Metabotropic Glutamate Receptors and Pain- Related Synaptic Plasticity in the Amygdala”. Department of Medical Pharmacology & Toxicology, Texas A&M University System Health Science Center, Colleg e Station, TX. 03/24/2002 “Pain Processing in the Amygdala: Role of Metabotropic Glutamate Receptors”. NY Academy of Sciences Conference “The Amygdala in Brain Function: Basic and Clinical Aspects”, Galvest o n , TX. 02/30/2002 “Pain Processing in the Amygdala”. Dept. of Anatomy & Neurosciences, UTMB, Galvest o n , TX. 10/12/2001 “Changes of metabotropic glutamate receptors in the amygdala in a model of arthritis pain”. Division of Neuroscience, Baylor College of Medicine, Housto n, TX. 08/20/2001 “Role of metabotropic glutamate receptors in arthritis pain- related changes in the amygdala”. IUPS Satellite Symposium on Pain Mechanisms, Sydney, Australia . 04/21/2001 “Metabotropic Glutamate Receptors: Novel Targets for Pain Relief? Preclinical and Clinical Aspects”. American Pain Society 20th Annual Meeting, Phoenix, AZ. 11/16/2000 “Spinal Pharmacology of Inflammatory Pain”. Workshop, SAHS, UTMB, Galvest o n , TX. 06/23/2000 “Nociceptive Processing in the Amygdala. Electrophysiological and Pharmacological Studies in Vivo and in Vitro ”. International Symposium “From Primary Afferent Function to Central Processing of Pain” sponsored by the Deutsche Forschungsgemeinschaft and SFB 353, Würzburg, Germany . 11/10/1999 “Role of the Amygdala in Persistent Pain. Electrophysiological and Pharmacological Studies in Vivo and in Vitro ”. Dept. of Psychology 19
  20. 20. Volker Neugebauer & Neuroscience, Baylor University, Waco, TX. 06/03/1999 “Metabotropic Glutamate Receptors, Persistent Pain Mechanisms and Neuroplasticity in the Amygdala - Electrophysiological and Pharmacological Studies in Vivo and in Vitro ”. Dept. of Biological Structure & Function, Oregon Health Sciences University, Portland, OR. 05/21/1999 “Metabotropic Glutamate Receptors, Persistent Pain Mechanisms and Neuroplasticity in the Amygdala - Electrophysiological and Pharmacological Studies in Vivo and in Vitro ”. Dept. of Biomedical Sciences, College of Veterinary Medicine, Univ. of Iowa, Ames, IA. 05/18/1999 “Metabotropic Glutamate Receptors: Novel Targets for Pain Relief? Electrophysiological and Pharmacological Studies in the Spinal Cord and in the Amygdala. Center for Anesthesiology Research, The Cleveland Clinic Foundation, Cleveland, OH. 05/07/1999 “Metabotropic Glutamate Receptors, Persistent Pain Mechanisms and Neuroplasticity in the Amygdala - Electrophysiological and Pharmacological Studies in Vivo and in Vitro ”. Dept. of Cellular Biology and Anatomy, School of Medicine, Louisiana State University Medical Center, Shrev e p ort, LA. 03/04/1999 “Metabotropic Glutamate Receptors and Neuroplasticity in the Amygdala: Electrophysiological and Pharmacological Studies in Vivo and in Vitro ”. Division of Basic Biomedical Sciences, Univ. of South Dakota, School of Medicine, Vermillion, SD . 01/13/1999 “Metabotropic Glutamate Receptors and Neuroplasticity in the Amygdala: Electrophysiological and Pharmacological Studies in Vivo and in Vitro ”. Dept. of Anatomy & Neurosciences, UTMB, Galvest o n , TX. 07/07/1998 “Inflammatory Joint Pain and the Amygdala. Electrophysiological and Pharmacological Studies in Vivo and in Vitro ”. Department of Endodontics, Dental School, University of Texas Health Science Center, San Antonio, TX. 07/18/1997 “Spinal Pharmacology of Inflammatory Joint Pain”. Dept. of Anesthesiology, UTMB, Galvest o n , TX. 05/23/1997 “Cocaine, Presynaptic Metabotropic Glutamate Receptors and CRF Receptors in the Amygdala “. Dept. of Pharmacology, UTMB, Galvest o n , TX. 11/04/1993 “The Importance of NMDA, non- NMDA, and Metabotropic Glutamate- Receptors for the Hyperexcitability of Nociceptive Spinal Neurons in Acute Arthritis”. Annual Meeting of The German Society for the Study of Pain, Mannh eim, Germany . 10/06/1993 “Pain in the Perioperative Period: Origin of the Postinjury Stimulus”. 6th International Congress on Pain, Anesthesia and Endocrinology, Chicago, IL. 05/12/1992 “Neurophysiology of Joint Pain: Spinal Mechanisms”. Defense Seminar. Department of Physiology, University of Würzburg, Würzburg, Germany . 09/24/1988 “Ketamine Depresses Inflammation- Induced Activity in Spinal Neurons With Articular Input. 66th Meeting of the Deutsche Physiologische Gesellschaft, Würzburg, Germany. 20
  21. 21. Volker Neugebauer Community Service Galveston Symphony Orchestra, Board of Directors, 2003 – CODA Society Galveston, Planning Group, 2003 – Catholic Medical Student Organization (MSAO), Faculty Advisor, 2008 – 21
  22. 22. Volker Neugebauer PUBLISHED: A. ORIGINAL ARTICLES IN PEER-REVIEWED JOURNALS: 1. Neug e b a u er, V. and Schaible, H.-G. Peripheral and spinal components of the sensitization of spinal neurons during an acute experimental arthritis. Agents Actions 25:234- 236, 1988 . PMID: 3218600. 2. Schaible, H.-G., Neug e b a u er, V. and Schmidt, R.F. Osteoarthritis and pain. Sem. Arthritis Rheumatism 18:30- 34, 1989 . PMID: 2543081. 3. Neug e b a u er, V., Schaible, H.-G. and Schmidt, R.F. Sensitization of articular afferents to mechanical stimuli by bradykinin. Pflügers Arch. 415:330- 335, 1989 . PMID: 2622760. 4. Neug e b a u er, V. and Schaible, H.-G. Evidence for a central component in the sensitization of spinal neurons with joint input during development of acute arthritis in cat's knee. J. Neurophysiol. 64:299- 311, 1990 . PMID: 2388073. 5. Schaible, H.-G., Grubb, B.D., Neug e b a u er, V. and Oppmann, M. The effects of NMDA antagonists on neuronal activity in cat spinal cord evoked by acute inflammation in the knee joint. Eur. J. Neurosci. 3:981- 991, 1991 . PMID: 12106256. 6. Schaible, H.-G., Neug e b a u er, V., Cervero, F. and Schmidt, R.F. Changes in tonic descending inhibition of spinal neurons with articular input during the development of acute arthritis in the cat. J. Neurophysiol. 66:1021- 1032, 1991 . PMID: 1753273. 7. Neug e b a u er, V., Lücke, T. and Schaible, H.-G. Differential effects of the NMDA and the non- NMDA antagonists on the responses of rat spinal neurons with joint input. Neurosci. Lett. 155:29- 32, 1993 . PMID: 7689717. 8. Neug e b a u er, V., Kornbuber, J., Lücke, T. and Schaible, H.-G. The clinically available NMDA receptor antagonist memantine is antinociceptive on rat spinal neurones. NeuroReport 4:1259- 1262, 1993 . PMID: 7693015. 9. Neug e b a u er, V., Lücke, T. and Schaible, H.-G. N-methyl- D-aspartate (NMDA) and non- NMDA receptor antagonists block the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat’s knee joint. J. Neurophysiol. 70:1365- 1377, 1993 . PMID: 7904298. 10. Neug e b a u er, V., Schaible, H.-G., He, X., Lücke, T., Gündling, P. and Schmidt, R.F. Electrophysiological evidence for a spinal antinociceptive action of dipyrone. Agents Actions 41:62- 70, 1994 . PMID: 8079823. 11. Neug e b a u er, V., Lücke, T., Grubb, B.D. and Schaible, H.-G. The involvement of N-methyl- D-aspartate (NMDA) and non- NMDA receptors in the responsiveness of rat spinal neurons with input from the chronically inflamed ankle. Neurosci. Lett. 170:237- 240, 1994 . PMID: 7914683. 12. Neug e b a u er, V., Lücke, T. and Schaible, H.-G. Requirement of metabotropic glutamate receptors for the generation of inflammation- evoked hyperexcitability in rat spinal cord neurons. Eur. J. Neurosci. 6:1179- 1186, 1994 . PMID: 7524965. 13. Schaible, H.-G., Freudenberger, U., Neug e b a u er, V. and Stiller, R.U. Intraspinal release of immunoreactive calcitonin gene- related peptide during development of inflammation in the joint in vivo - a study with antibody microprobes in cat and rat. Neuroscience 62:1293- 1305, 1994 . PMID: 7845599. 22
  23. 23. Volker Neugebauer 14. Neug e b a u er, V., Schaible, H.-G., Weiretter, F. and Freudenberger, U. The involvement of substance P and neurokinin 1 receptors in the responses of rat dorsal horn neurons to noxious but not to innocuous mechanical stimuli applied to the knee joint. Brain. Res. 666:207- 215, 1994 . PMID: 7533634. 15. Neug e b a u er, V., Weiretter, F. and Schaible, H.-G. The involvement of substance P and neurokinin- 1 receptors in the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat’s knee joint. J. Neurophysiol. 73:1574- 1583, 1995 . PMID: 7643168. 16. Neug e b a u er, V., Geisslinger, G., Rümenapp, P., Weiretter, F., Szelenyi, I., Brune, K. and Schaible, H.-G. Antinociceptive effects of R(-)- and S(+)- flurbiprofen on rat spinal dorsal horn neurons rendered hyperexcitable by an acute knee joint inflammation. J. Pharmacol. Exp. Ther. 275:618- 628, 1995 . PMID: 7473147. 17. Neug e b a u er, V., Rümenapp, P. and Schaible, H.-G. The role of spinal neurokinin- 2 receptors in the processing of nociceptive information from the joint and in the generation and maintenance of inflammation- evoked hyperexcitability of dorsal horn neurons in the rat. Eur. J. Neurosci. 8:249- 260, 1996 . PMID: 8714696. 18. Neug e b a u er, V., Rümenapp, P. and Schaible, H.-G. Calcitonin gene- related peptide is involved in the spinal processing of mechanosensory input from the rat’s knee joint and in the generation and maintenance of hyperexcitability of dorsal horn neurons during development of acute inflammation. Neuroscience 71:1095- 1109, 1996 . PMID: 8684614. 19. Neug e b a u er, V., Vanegas, H., Nebe, J., Rümenapp, P. and Schaible, H.-G. Effects of L- and N-type calcium channel antagonists on the responses of nociceptive spinal cord neurons to mechanical stimulation of the normal and the inflamed knee joint. J. Neurophysiol. 76:3740- 3749, 1996 . PMID: 8985872. 20. Neug e b a u er, V., Keele, N.B. and Shinnick- Gallagher, P. Epileptogenesis in vivo enhances the sensitivity of inhibitory presynaptic metabotropic glutamate receptors in basolateral amygdala neurons in vitro. J. Neurosci. 17:983- 995, 1997 . PMID: 8994053. 21. Nebe, J., Vanegas, H., Neug e b a u er, V. and Schaible, H.-G. ω-Agatoxin IVA, a P-type calcium channel antagonist, reduced nociceptive processing in spinal cord neurons with input from the inflamed but not from the normal knee joint - an electrophysiological study in the rat in vivo . Eur. J. Neurosci. 9:2193- 2201, 1997 . PMID: 9421179. 22. Neug e b a u er, V., Keele, N.B. and Shinnick- Gallagher, P. Loss of long- lasting potentiation mediated by group III mGluRs in amygdala neurons in kindling- induced epileptogenesis. J. Neurophysiol . 78:3475- 3478, 1997 . PMID: 9405564. 23. Schaible, H.-G., Neug e b a u er ,V ., Geisslinger, G. and Beck, U. The effects of S- and R-flurbiprofen on the inflammation- evoked intraspinal release of immunoreactive substance P - a study with antibody microprobes. Brain Res. 798:287- 293, 1998 . PMID: 9666149. 24. Keele, N.B., Neug e b a u er, V. and Shinnick- Gallagher, P. Differential effects of metabotropic glutamate receptor antagonists on bursting activity in the amygdala. J. Neurophysiol. 81:2056- 2065, 1999 . PMID: 10322047. 25. Neug e b a u er, V., Chen, P.-S. and Willis, W.D. Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central 23
  24. 24. Volker Neugebauer sensitization of primate STT cells. J. Neurophysiol. 82:272- 282, 1999 . PMID: 10400956. 26. Keele, N.B., Zinebi , F., Neug e b a u er, V. and Shinnick- Gallagher, P. Epileptogenesis up- regulates metabotropic glutamate receptor activation of sodium- calcium exchange current in the amygdala. J. Neurophysiol. 83:2458- 2462, 2000 . PMID: 10758147. 27. Neug e b a u er, V., Zinebi, F., Russell, R., Gallagher, J.P. and Shinnick- Gallagher, P. Cocaine and kindling alter the sensitivity of group II and III metabotropic glutamate receptors in the central amygdala. J. Neurophysiol. 84:759- 770, 2000 . PMID: 10938303. 28. Neug e b a u er, V., Chen, P.-S. and Willis, W.D. Groups II and III metabotropic glutamate receptors differentially modulate brief and prolonged nociception in primate STT cells. J. Neurophysiol. 84:2998- 3009, 2000 . PMID: 11110827. 29. Neug e b a u er, V. and Li, W. Processing of nociceptive mechanical and thermal information in central amygdala neurons with knee joint input. J. Neurophysiol. 87:103- 112, 2002 . PMID: 11784733. 30. Neug e b a u er, V., Li., W., Bird, G.C., Bhave, G. and Gereau, R.W. Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5. J. Neurosci. 23:52- 63, 2003 . PMID: 12514201. 31. Neug e b a u er, V. and Li, W. Differential sensitization of amygdala neurons to afferent inputs in a model of arthritic pain. J. Neurophysiol. 89:716- 727, 2003 . PMID: 12574449. 32. Li, W. and Neug e b a u er, V. Differential roles of mGluR1 and mGluR5 in brief and prolonged nociceptive processing in central amygdala neurons. J. Neurophysiol. 91:13- 24, 2004 . PMID: 13679408. 33. Han, J.S., Bird, G.C. and Neug e b a u er, V. Enhanced group III mGluR- mediated inhibition of pain- related synaptic plasticity in the amygdala. Neuropharmacology 46:918- 926, 2004 . PMID: 15081788. 34. Liu, J., Yu, B., Neug e b a u er, V., Grigoriadis, D.E., Rivier, J., Vale, W.W., Shinnick- Gallagher, P. and Gallagher, J.P. Corticotropin releasing factor and urocortin I regulate glutamatergic synaptic transmission. J. Neurosci. 24:4020- 4029, 2004 . PMID: 15102917. 35. Han, J.S. and Neug e b a u er, V. Synaptic plasticity in the amygdala in a visceral pain model in rats. Neurosci. Lett. 361:254- 257, 2004 . PMID: 15135941. 36. Li, W. and Neug e b a u er, V. Block of NMDA and non- NMDA receptor activation results in reduced background and evoked activity of central amygdala neurons in a model of arthritic pain. Pain 110:112- 122, 2004 . PMID: 15275758. 37. Palecek, J., Neug e b a u er, V., Carlton, S. M., Iyengar, S. and Willis, W. D. The effect of a kainate GluR5 receptor antagonist on responses of spinothalamic tract neurons in a model of peripheral neuropathy in primates. Pain 111:151- 161, 2004 . PMID: 15327819. 38. Han, J.S., Bird, G.C., Li, W., Jones, J. and Neug e b a u er, V. Computerized analysis of audible and ultrasonic vocalizations of rats in a model of arthritic pain. J. Neurosci. Meth. 141:261- 269, 2005 . PMID: 15661308. 39. Han, J.S. and Neugebauer, V. mGluR1 and mGluR5 antagonists in the amygdala inhibit different components of audible and ultrasonic 24
  25. 25. Volker Neugebauer vocalizations in a model of arthritic pain. Pain 113:211- 222, 2005 . PMID: 15621382. 40. Bird, G.C., Lash, L.L., Han, J.S., Zou, X., Willis, W.D. and Neug e b a u er, V. PKA-dependent enhanced NMDA receptor function in pain- related synaptic plasticity in amygdala neurons. J. Physiol. 564.3:907–921, 2005 . PMID: 15760935. PMCID: PMC1464474. 41. Han, J.S., Li, W. and Neug e b a u er, V. Critical role of CGRP1 receptors in the amygdala in synaptic plasticity and pain behavior. J. Neurosci. 25:10717- 10728, 2005 . PMID: 16291945. 42. Han, J.S., Fu, Y., Bird, G.C., and Neug e b a u er, V. Enhanced group II mGluR- mediated inhibition of pain- related synaptic plasticity in the amygdala. Mol. Pain 2:18- 29, 2006 . PMID: 16681859. PMCID: PMC1471776. 43. Li, W. and Neug e b a u er, V. Differential changes of group II and group III mGluR function in central amygdala neurons in a model of arthritic pain. J. Neurophysiol. 96: 1803- 1815, 2006 . PMID: 16760343. PMCID: PMC Journal – In Progress. 44. Bird, G.C., Han, J.S., Fu, Y., Adwanikar, H., Willis, W.D. and Neug e b a u er, V. Pain- related synaptic plasticity in spinal dorsal horn neurons: role of CGRP. Mol. Pain 2:31- 42, 2006 . PMID: 17002803. PMCID: PMC1592081. 45. Adwanikar, H., Ji, G., Li, W., Doods, H., Willis, W.D. and Neug e b a u er, V. Spinal CGRP1 receptors contribute to supraspinally organized pain behavior and pain- related sensitization of amygdala neurons. Pain 132:53–66, 2007 . PMID: 17335972. PMCID: PMC2066202. 46. Ji, G. and Neug e b a u er, V. Differential effects of CRF1 and CRF2 receptor antagonists on pain- related sensitization of neurons in the central nucleus of the amygdala. J. Neurophysiol. 97: 3893- 3904, 2007 . PMID: 17392412. 47. Ji, G., Fu, Y., Ruppert, K.A. and Neug e b a u er, V. Pain- related anxiety- like behavior requires CRF1 receptors in the amygdala. Mol. Pain 3:13- 17, 2007 . PMID: 17550594. PMCID: PMC1891279. 48. Ji, G. and Neug e b a u er, V. Pro- and anti- nociceptive effects of corticotropin- releasing factor (CRF) in central amygdala neurons are mediated through different receptors. J. Neurophysiol. 99:1201- 1212, 2008 . [Evaluated in Faculty of 1000 Biology: http://www.f1000biology.com/article/id/1097676/evaluation . PMID: 18171711. Accepted before April 8, 2008. 49. Fu, Y. and Neug e b a u er, V. Differential mechanisms of CRF1 and CRF2 receptor functions in the amygdala in pain- related synaptic facilitation and behavior. J. Neurosci. 28:3861- 3876, 2008 . PMID: 18400885. PMCID: PMC2557030. 50. Palazzo, E., Fu, Y., Ji, G., Maione, S. and Neug e b a u er, V. Group III mGluR7 and mGluR8 in the amygdala differentially modulate nocifensive and affective pain behaviors. Neuropharmacology 55:537- 545, 2008 . PMID: 18533199. PMCID: PMC2601632. 51. Fu, Y., Han, J., Ishola, T., Scerbo, M., Adwanikar, H., Ramsey, C. and Neug e b a u er, V. PKA and ERK, but not PKC, in the amygdala contribute to pain- related synaptic plasticity and behavior. Mol. Pain 4:26, 2008 . PMID: 18631385. PMCID: PMC2490682. 52. Lei, G., Anastasio, N., Fu, Y., Neug e b a u er, V. and Johnson, K.M. Activation of dopamine D1 receptors prevents phencyclidine- induced neurotoxicity by 25
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  35. 35. Volker Neugebauer 100. Palazzo, E., Fu, Y., Maione, S., Neug e b a u er, V. Differential effects of mGluR7 and mGluR8 agonists on synaptic transmission in the amygdala in a model of arthritic pain. Soc Neurosci. Abstracts 38: 369.22, 2008. 101. Reese, L.C., Zhang, W.-R., Kayed, R., Neug e b a u er, V. , Hogan, D., Dineley, K., Taglialatela, G. Oligomeric amyloid beta induces calcineurin in models of Alzheimer's Disease. Soc. Neurosci. Abstracts 38: 829.15, 2008. 102. Taglialatela, G., Reese, L.C., Zhang, W.-R., Neug e b a u er, V. , Dineley, K., Kayed, R. A common mechanism of action of amyloid oligomers. Soc. Neurosci. Abstracts 38: 829.18, 2008. 103. Taglialatela, G., Reese, L., Zhang, W., Dineley, K., Neug e b a u er, V., Kayed, R. Alpha synuclein oligomers induce calcineurin- dependent neurobehavioral deficits. ICAD, Vienna, 2009. 104. Ji, G., Neug e b a u er, V. Reactive oxygen species (ROS) are involved in mGluR5- mediated increased responsiveness of nociceptive amygdala neurons. Soc. Neurosci. Abstracts 39: 339.12, 2009. 105. Li, Z., Neug e b a u er, V. Reactive oxygen species (ROS) are involved in mGluR5- mediated increased excitability of amygdala neurons. Soc. Neurosci. Abstracts 39: 339.13, 2009. 106. Keele, N.B., Neug e b a u er, V. CRF increases excitability of CeA neurons by enhancing Kv3-like voltage- gated potassium channels. Soc. Neurosci. Abstracts 39: 339.14, 2009. 107. Sun, H., Neug e b a u er, V. Group I mGluR activation increases inhibitory transmission at the BLA-mPFC synapse more strongly than excitatory transmission. Soc. Neurosci. Abstracts 39: 339.15, 2009. 108. Neug e b a u er, V., Li, Z., Ji, G., Xiao, Y. IP3 receptors contribute to increased excitability and responsiveness of amygdala neurons and to increased pain behavior induced by group I mGluR activation. Soc. Neurosci. Abstracts 39: 339.16, 2009. 109. Xiao, Y., Ji, G, Neug e b a u er, V. Reactive oxygen species (ROS) in the amygdala are involved in mGluR5- mediated increased audible and ultrasonic vocalizations to noxious stimuli. Soc. Neurosci. Abstracts 39: 339.17, 2009. 110. Taglialatela, G., Reese, L.C., Martin, Z., Zhang, W., Dineley, K., Neug e b a u er, V. , Kayed, R. Alpha synuclein oligomers induce calcineurin- dependent neurobehavioral deficits. Soc. Neurosci. Abstracts 39: 431.28, 2009. D. POPULAR PRESS: “Toward clearer thinking - Research to explore effects pain has on the decision- making process”. The Galveston County Daily News, C1, C8, April 13, 2008. http://galvestondailynews.com/story.lasso?ewcd = 5 a16f0a56c5e5f26 “UTMB news: Researcher to study pain's effect on brain”. Houston Chronicle, March 27, 2008. http://www.chron.com/CDA/archives/archive.mpl?id=2008_4537785 35

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