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CURRICULUM VITAE
I. PERSONAL DATA
Name PHILLIP LAWRENCE PEARL, M.D.
Address Department of Neurology
Children’s National Me...
The George Washington University School of Medicine and
Health Sciences
Washington, D.C.
Chief of General Child Neurology
...
IV. LICENSURES: District of Columbia #18619 (8/17/90)
Virginia #0101 045295 (6/1/90)
CERTIFICATION:
American Board of Pedi...
PROFESSIONAL SOCIETIES/COMMITTEES:
NATIONAL
American Academy of Pediatrics (Fellow, FAAP) 2000-present
American Academy of...
Regional Hospitals
Child Abuse Committee, Arlington Hospital 1997-1998
Education Committee, Chairman, Section of Neruology...
6. Combined Neuropharmacology Elective for MS IV students: Mechanisms of Epilepsy
and Antiepileptic Therapy with Timothy H...
Distinguished Teacher Award 2005, George Washington University School of Medicine
Master Teacher Certificate in Medical Ed...
21. May 2008: Yana Jane Tavyev MD, Visiting Neurodevelopmental Disabilities Resident
from Baylor College of Medicine, Hous...
Pearl PL. Educational Grant in Epilepsy for Child Neurology Fellows, Novartis Neurosciences
Operations, $ 5000 (2003).
Pea...
Pearl PL, Civitello L, McClintock W, Lavenstein B. Safety and Therapeutic Effect of Oxcarbazepine in
Patients with Partial...
Trends in Neurosciences 2007-present.
Medical Reviewer for Informational Brochures:
1. Congenital Bilateral Perisylvian Sy...
36. Knerr I, Pearl PL, Bottiglieri T, Snead OC, Jakobs C, Gibson KM. Therapeutic Concepts in
Succinate Semialdehyde Dehydr...
21. Pearl PL, Novotny EJ, Acosta MT, Jakobs C, Gibson KM. Succinic Semialdehyde Dehydrogenase
Deficiency in Children and A...
7. Philippe A, Martinez M, Guilloud-Bataille M, et al: Paris Autism Res Intl Sibpair Study: USA Group
(Coleman M, Pearl P,...
24. Pearl PL, Capp PK, Gibson KM: Psychiatric Manifestations in SSADH Deficiency, A Disorder of
GABA Metabolism. Psychiat ...
6. Pearl PL, Weiss RE, Stein MA: Medical mimics. Medical and neurological conditions simulating
ADHD. Ann N Y Acad Sci 200...
36. Chang T, Pearl PL: Machado Joseph Syndrome. Guide to Rare Disorders. National Organization
of Rare Disorders, Lippinco...
17. Sahoo S, Pearl PL: Syringomyelia. Guide to Rare Disorders. National Organization of Rare
Disorders, Lippincott, Willia...
108. Pearl PL, Peloquin PB, Fricke S, Knerr I, Depositario-Cabacar D, Khanna P, Khademian Z. Single
Voxel Basal Ganglia Ma...
94. Reis J, Cohen LG, Pearl PL, Gibson KM, Dustin I, Theodore WH. Transcranial Magnetic
Stimulation reveals altered Cortic...
81. Pearl PL, Conry JA, Bennett HD, Tsuchida TN, Elling NJ, Yaun A, Myseros J, Bruce D, Kolodgie
MJ, Cushner-Weinstein S, ...
65. Gaillard WD, Berl MM, Stief E, Xu B, Pearl PL, Weinstein S, Conry J, Moorjani B, Vezina LG,
Theodore WH: Atypical Lang...
50. Gaillard WD,Balsamo LM, Xu B, Sachs BC, Pearl PL, Conry JA, Weinstein S, Salpekar J, Jabbari
B, Fratali C, Kopylev L, ...
35. Gaillard WD, Balsamo L, Xu B, Papero P, Weinstein SL, Conry JA, Pearl PL, Fratalli C, Sato S,
Kopylev L, Vezina LG, Th...
19. Pearl PL, LaFleur B, Reigle SC, Freeman A, McCutchen C, Sato S. REM Sleep Physiology in
Normal and Abnormal Sleep. Ann...
2. Gaillard WD, Weinstein S, Pearl PL, et. al. Natural History of Metabolic Abnormalities in Children
with Partial Epileps...
I. Electronic Media
5. Pearl P: Pediatric Board Review: Neurology I-IV. CME info. Oakstone Medical Publishing, LLC,
Birmin...
Neurology I: Headaches, Intracranial Pressure, Trauma.
Neurology II: CNS Infections, Stroke
Neurology III: Seizures and Ep...
Neurology II: CNS Infections, Stroke
Neurology IV: Cerebral palsy, Degenerative disorders, Spinal cord, Neuropathy, Myopat...
77. Pearl P: Pediatric Neurology Education. Department of Neurology Educational Retreat,
Georgetown University School of M...
60. Pearl PL: Updates in Pedaitric Neurology, Northern VA ADHD Professional Interest Group,
Fairfax, VA, May 10, 2002.
59....
41. Lewis J, Efron L, Marean L, Pearl P, Hamburger E, Stein M. Sleep Difficulties: Child and
Parent Perspectives. 14th
Ann...
25. Pearl PL: ADHD For the Primary Care Physician, Pediatric Advances 1998, Children’s National
Medical Center, Washington...
5. Pearl PL: CPC: Mitochondrial Encephalopathies, Grand Rounds, Dept Pediatrics, Fairfax
Hospital, VA 1991.
4. Pearl PL: E...
CURRICULUM VITAE.doc.doc
CURRICULUM VITAE.doc.doc
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  1. 1. CURRICULUM VITAE I. PERSONAL DATA Name PHILLIP LAWRENCE PEARL, M.D. Address Department of Neurology Children’s National Medical Center 111 Michigan Avenue, NW Washington, DC 20010-2970 Telephone (202) 884-2120 Fax Number (202) 884-5226 E-mail Address ppearl@cnmc.org Date and place of birth: June 22, 1958 Baltimore, Maryland Married: Maria Tartaglia Pearl, M.D. Children: Melinda Erin Pearl (DOB 2/9/87) Adam Timothy Pearl (DOB 3/10/89) Suzanne Elizabeth Pearl (DOB 12/3/03) Natalie Michelle Pearl (DOB 6/16/05) II. EDUCATION Undergraduate: B.A. with Honors (Natural Sciences) 1980 Johns Hopkins University Baltimore, Maryland Medical School: University of Maryland School of Medicine 1984 Baltimore, Maryland Post-Graduate: Pediatric Internship and Residency, 1984-1986 Baylor College of Medicine, Houston, Texas Chief of Service: Ralph D. Feigin, M.D. Neurology and Child Neurology 1986-1989 Baylor College of Medicine, Houston, Texas Chief of Service: Marvin A. Fishman, M.D. Fellowship in Clinical Neurophysiology 1989-1990 Children's Hospital, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts Chief of Service: Gregory L. Holmes, M.D. Graduate Certificate in Leadership Development 2003 Graduate School of Education and Human Development, George Washington University, Washington, DC III. EMPLOYMENT HISTORY CURRENT POSITION: Associate Professor of Pediatrics and Neurology Director of Medical Student Education, Dept Neurology 1
  2. 2. The George Washington University School of Medicine and Health Sciences Washington, D.C. Chief of General Child Neurology Director of Education, Department of Neurology Member, Children’s Research Institute Children's National Medical Center Washington, D.C. Special Volunteer 1997-Present Clinical Epilepsy Branch Office of the Clinical Director Division of Intramural Research National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda, Maryland Scholar, Master Teachers Program in Medical Education 2002-2005 George Washington University School of Education Medical Staff: Children’s National Medical Center Georgetown University Hospital INOVA Fairfax Hospital NIH Clinical Center PRIOR POSITIONS AND ACADEMIC APPOINTMENTS: Assistant Professor of Pediatrics and Neurology 1997-2002 George Washington University School of Medicine Clinical Assistant Professor of Neurology and Pediatrics, George Washington University School of Medicine 1990-97 Clinical Assistant Professor of Pediatrics and Neurology 1990 - present University of Maryland School of Medicine Clinical Assistant Professor of Pediatrics (Neurology), 1994 – present, Clinical Instructor 1990-1994 Georgetown University School of Medicine Visiting Associate Professor of Pediatrics 2006-present Clinical Associate Professor of Pediatrics 2000-2006 Clinical Assistant Professor 1996-2000 University of Virginia School of Medicine The Neurology Center 1990-1995 VA Neuroscience Center 1995-1997 INOVA Fairfax Hospital for Children 2
  3. 3. IV. LICENSURES: District of Columbia #18619 (8/17/90) Virginia #0101 045295 (6/1/90) CERTIFICATION: American Board of Pediatrics, # 41010, 1989, re-certification 1996, 2004, exp 2010. American Board of Psychiatry and Neurology, with Special Qualification in Child Neurology, # 784, 1991. American Board of Clinical Neurophysiology 1993. American Board of Psychiatry and Neurology, Subspecialty Certification in Clinical Neurophysiology, # 1139, 1999, exp 2009. V. HONORS AND AWARDS Michael T. Ty Memorial Lecturer, Massachusetts General Hospital Department of Neurology, Boston 2008 “Best Doctors in America” 2007-2008. “Outstanding Physicians,” Washingtons’ Consumer Checkbook 2007. American Neurological Association, elected 2006. American Pediatric Society, elected 2006. America’s Top Physicians, Consumers’ Research Council of America 2004-2005. Association of American Medical Colleges (AAMC) Faculty Award for Humanism in Medicine, Nominee from George Washington University School of Medicine 2004. Board Examiner, American Board of Psychiatry and Neurology Oral Examinations 1999-present. Local Host Chairman for Washington, DC examinations (2005, 2007) Certificate of Appreciation for Outstanding Performance, Children’s Hospital, Washington, D.C. 2001. Clinical Research Award Winner, Junior Faculty, Children’s Research Institute, 14th Annual Advances in Pediatrics, Children’s National Medical Center, May 4, 2000. “Top Doctors”, Washington Area Specialists, Washingtonian Magazine 2008, 2005, 2002, 1999, 1995. “Best Specialists”, Consumer Checkbook Magazine, Washington, D.C., 1998, 1995. Physician’s Recognition Award, American Medical Association 1996. Certificate of Appreciation, Autism Society of America 1990. Award for Top Score, Epilepsy Mini-Fellowship Program, J.K. Penry, M.D. 1989 Bowman-Grey School of Medicine. American Academy of Neurology Medical Student Essay Contest, Honorable Mention: Spontaneous Regression of Stage IV-S Neuroblastoma 1984. Henry Zoller, Jr., Scholarship Award, 1978 Johns Hopkins University. 3
  4. 4. PROFESSIONAL SOCIETIES/COMMITTEES: NATIONAL American Academy of Pediatrics (Fellow, FAAP) 2000-present American Academy of Neurology Councilor, Child Neurology Section 2006-2008 A.B. Baker Education Section 2000 – present. Child Neurology Section 1999 – present. Counselor to Child Neurology Section, elected 2005. Epilepsy Section 1999 – present. American Board of Psychiatry and Neurology Committee on Written Examination (Neurology questions for Psychiatry examination) 2003- present. Committee on Written Examination (Child Neurology examination) 2005-present. American Clinical Neurophysiology Society 1989-present (elected Fellow 2005) American Epilepsy Society Practice Committee 2000-2003. CME Review Committee 2006-present. Program Committee 2006-present. American Sleep Disorders Association 1998-2006 American Society for Experimental NeuroTherapeutics 2004-2006. CDGS (Congenital Disorders of Glycosylation) Family Network, Medical Advisory Board Child Neurology Foundation Career Development Committee 2002 – present. Medical Student Scholarship Committee 2004-present. Executive Board 2006-present. Child Neurology Society 1989 – present. Awards Committee 2003 – present. Chairman, Awards Committee 2004 – present. Data and Safety Monitoring Board, Cooperative Internatl Neuromuscular Research Group, 2000-2003. Doctors Opposed to Child Soldiers (DOCS) 2000 National Capital Cure Epilepsy Conference, Steering Committee 2004. Pediatric Neurotransmitter Diseases (PND) Association, Medical and Scientific Advisory Board Professors of Child Neurology 2004-present. Secretary-Treasurer, elected 2006. REGIONAL Epilepsy Foundation of America, National Capital Area, Professional Advisory Board Fairfax County Medical Society National Down's Syndrome Congress, National Professional Advisory Board Northern Virginia Pediatric Society Tourette Syndrome Association Virginia Neurological Society VI. ADMINISTRATIVE DUTIES AND UNIVERSITY ACTIVITIES George Washington Universtiy School of Medicine and Health Sciences Admissions Office Interviews 2002 – 2004 Faculty Senate, Department of Neurology 2003 – present Year 3-4 Curriculum Committee 2001-present Children’s National Medical Center Graduate Medical Education Committee 2003-present. Graduate Medical Education Executive Committee 2007-present Institutional Ethics Forum, CNMC, 2004 – 2007 Physician Liasion and Planning Committee, Jazzmatazz, Development Office 2000-2006 Search Committee, Chairman of Pulmonary Department 2001 Specialty Services to Emergency Department Task Force 2000 – 2003 4
  5. 5. Regional Hospitals Child Abuse Committee, Arlington Hospital 1997-1998 Education Committee, Chairman, Section of Neruology, INOVA Fairfax Hospital 1997-1998 Education Committee, Co-chairman, Section of Neurology, Fairfax Hospital 1994 – 1997 Neurophysiology Technology Committee, Section of Neurology, Fairfax Hospital 1993-1994 VII. EDUCATIONAL ACHIEVEMENTS A. Courses Taught 1. Director, ICM (Introduction to Clinical Medicine): Neurology Portion, GWU 2nd Year Medical School Course, 2001-present. 2. Lecturer, Neurology Update Course, CNMC: i. Genetics of Sleep Disorders 1998 ii. Biological Basis of Autism 1999 iii. Sleep Disorders in Children 2000 iv. Sleep Investigations 2001 v. Therapies in Sleep Disorders of Childhood 2002 vi. Alternative Medicines in Epilepsy 2003 vii. Seizures and Metabolic Disease2004 viii. Case Studies in Neurogenetics: Diagnostic Dilemmas 2005 ix. Neurology of Famous Musicians: In Words and Music 2006 x. Biological Basis of Autism 2007 xi. Moderator of General Child Neurology Session 2008 3. Neurology Lecturer: Pediatric Board Review Course, CNMC 1998-present. 4. Lecturer: Seizures and Epilepsy, GWU 3rd Year Pediatrics Rotation, CNMC 2000-2004 5. Lecturer: Headaches, GWU 3rd Year Pediatrics Rotation, CNMC, 2001-2004 6. Lecturer: Introduction to Practice of Medicine Course, GWU School of Medicine, 2001- present. i. Neurological Examination ii. Neurology Case Vignettes iii. Localization in the Nervous System iv. Epilepsy v. Congenital Brain Development 7. Intake Attending, CNMC Pediatric Residency Program, 2000-2004 8. Walk Rounds Teaching Attending, GWU Medical Students, 1998-2005 9. Professorial Rounds, CNMC, Pediatric Residency Program i. Neurocutaneous Syndromes 2000 ii. Gait Dysfunction 2001 iii. Encephalitis 2003 iv. Complex partial seizures 2006 10. Preceptor and Director: Localization in the Nervous System, Dept. Neurology, CNMC 1997-Present. 11. Program Director, Institutionalization and the Brain: The Internationally Adopted Child, CNMC, Oct 14-16, 1998. B. New Courses or Programs Developed 1. Director, Neurology Clerkship Year IV, GWU School of Medicine, July 2004- present. 2. Director, Neurology Fellowship Training Program, CNMC 2002-present. 3. Coordinator, Neurology Fellowship Training Program, CNMC 1997-2002. 4. Program Director: CNMC Pediatric Neurology CME (Mary Washington Hospital) 2007 5. Seminar on Neurology in Great Musicians: In Words and Music. Annual Meeting of the Child Neurology Society 2006, 2007 5
  6. 6. 6. Combined Neuropharmacology Elective for MS IV students: Mechanisms of Epilepsy and Antiepileptic Therapy with Timothy Hales PhD, Dept. Pharmacology, GWU 2007. 7. Use and Misuse of Alternative and Complementary Medicines in Epilepsy, Annual Meeting of the American Academy of Neurology, with Joan Conry MD, Denver, CO 2002, Honolulu, HA 2003, San Francisco, CA 2004. 8. Program Director, Institutionalization and the Brain: The Internationally Adopted Child, CNMC 1998. C. Students mentored as primary advisor 1. Sophie Rich, Yale University Undergraduate, Epilepsy Research Program, Summer 2000, CNMC, cf publications: Sleep Medicine 2002, and abstracts 39, 43. 2. Elizabeth Allen, Yale University Undergraduate, Epilepsy Research Program, Summer 2000, CNMC, cf publications: Epilepsy 2000; 3:9-11, and abstracts 39, 43. 3. Amanda Stahl, Cornell University Undergraduate, Epilepsy Research Program, Summer 2000, CNMC, cf publications: abstracts 39, 43. 4. Molly Galgano MS IV, GWU School of Medicine, Senior project: Assessment of EEG Characteristics in Patients with Landau-Kleffner Syndrome 2001. 5. Emily Robbins, Georgetown University Undergraduate, Research Project: Clinical Database and Antiepileptic Drug Treatments in the Murine Model of SSADH Deficiency, Summer 2003. Research published in the Georgetown Undergraduate Science Bulletin 2004. 6. Sarah Reece-Staunton, GWU Medical Student, Project: Alternative Therapies in Epilepsy, Winner of Joseph Collins Scholarship Award for Medical Students interested in careers in neuroscience 2003. 7. Philip Cap, MD 2005, GWU Medical Student, Project: Pediatric Sleep Disorders: Seminars in Primary Care (publication 2005); Pediatric Neurotransmitter Diseases (publication 2005); Methylphenidate Pharmacology and Therapy (publication 2005). 8. Heather D. Bennett, BA, Johns Hopkins Postbaccalaureate Premedical Student, Research in Pediatric Neurotransmitter Diseases, Sept 2004-June 2005; matriculates into medical school Fall 2005. 9. Jessica Cabalza, BA, Johns Hopkins Postbaccalaureate Premedical Student, Research in Pediatric Neurotransmitter Diseases and Educational Coordinator, July 2005-present. 10. Thomas Hartka, BA, Johns Hopkins Postbaccalaurate Premedical Student, Research in Neurogenetics, February 2006 – present. 11. Elizabeth Molloy, BA, MD 2006, GWU Medical Student, Research Elective: MRI abnormalities associated with vigabatrin therapy; Dorsal midbrain MRI abnormalities in acute encephalopathies; Pontocerebellar hypoplasia in neurocutaneous hypermelanosis; February/March 2006. 12. Stacey Trzcinski, MS III-IV, University of Pittsburgh School of Medicine, Research Year 2006-2007 in conjunction with NIH sponsored GCRC research program for medical students. 13. Jacob Taylor BA Yale University, Johns Hopkins Postbaccalaureate Premedical School, Research and Education Coordinator, 2006-2007. 14. Alexander Sokohl BA Duke University, Johns Hopkins Postbaccalaureate Premedical Program, Research Assistant in Neurogenetics 2006-2007. 15. Peter Peloquin BA, MS, Johns Hopkins Postbaccalaureate Premedical School, Research and Education Coordinator, 2007-2008. 16. Janis Sethness BA, Johns Hopkins Postbaccalaureate Premedical Program, Research Assistant in Neurogenetics 2007-2008. 17. Jennifer Pettiford MA, MS III, GWU School of Medicine, Clinical Research Year 2008- 2009. 18. Katherine Forester BA, Johns Hopkins Postbaccalaureate Premedical School, Research and Education Coordinator, 2007-2008. D. Educational Awards 6
  7. 7. Distinguished Teacher Award 2005, George Washington University School of Medicine Master Teacher Certificate in Medical Education, Children’s National Medical Center and George Washington University Medical Center, June 30, 2003. Certificate in Leadership Development, Graduate School of Education and Human Development, George Washington University, May 15, 2003. Teacher Recognition Certificate, American Academy of Neurology 2002. Outstanding Teacher Commendation, 1990 Harvard-Longwood Neurology House Staff Children's Hospital, Harvard Medical School. Outstanding Teacher Commendation, 1987 Dept. Neurology, Baylor College of Medicine. E. Training of Graduate Students/Post Doctoral as Program Director 1. 1997-2000 Kimberly Krohn MD, Pediatric Neurology Fellow; Current: Staff Neurologist, Duluth Clinic, Duluth, MN 2. 1998-2001 Susanne Schmandt MD, Pediatric Neurology Fellow; Current: Child Neurology Clinic, Germany 3. 1999-2002 Tena Rosser MD, Pediatric Neurology Fellow; Current: Assistant Professor of Pediatrics and Neurology, GWU, CNMC 2002-2004; Children’s Hosp Los Angeles 2004-present. 4. 1999-2002 Sylvia Mandler MD, Pediatric Neurology Fellow; Current: Pediatric Neurology practice, Bethesda, MD. 5. 2000-2003 Taeun Chang MD, Pediatric Neurology Fellow; Current: Assistant Professor of Pediatrics and Neurology, GWU, CNMC 6. 2000-2003 Maria Acosta, MD, Pediatric Neurology Fellow; Current: Pediatric Residency, GWU, CNMC; Clinical Fellow in SSADH Deficiency Research 2004-2005; Current: Assistant Professor, GWU, CNMC.. 7. 2001-2004: Adeline Vanderver MD, Pediatric Neurology Fellow; Current: Assistant Professor, GWU, CNMC. 8. 2002-2005: William Benko MD, Pediatric Neurology Fellow; Current: Practice, Hershey, PA. 9. 2003-2006: Janet Lam MD, Pediatric Neurology Fellow; Current: Dept Neurology, Univ Maryland School of Medicine, Baltimore, MD. 10. 2003-2006: John Crawford MD, Pediatric Neurology Fellow; Current: NSADA fellow, CNMC. 11. 2003-2004: Denise Wallis MD, Post-doctoral Research in Pediatric Neurotransmitter Diseases; Current: Psychiatry Residency for 7/04, Chicago Medical School. 12. 2004-2007: Tarannum Lateef MD, Pediatric Neurology Fellow; Current: Assistant Professor, GWU, CNMC. 13. 2004-2007: Jessica Carpenter MD, Pediatric Neurology Fellow; Current: Assistant Professor, GWU, CNMC. 14. 2005-2008: Joseph Scafidi DO, Pediatric Neurology Fellow; Current: Instructor, GWU, CNMC. 15. 2005-2008: David Hsieh MD, Pediatric Neurology Fellow; Current: San Antonio, TX, US Air Force, Chief of Neurogenetics Clinic. 16. 2005-2008: Kevin DeBrangca MD, Pediatric Neurology Fellow; Current: Fellow, Memorial Sloan Kettering Institute, New York, NY. 17. 2006: Ana Roche Martinez MD, Visiting Pediatrician from Spain, Clinical Research summer program. 18. 2007-present: Emily Freilich MD, Pediatric Neurology Fellow 19. 2007-present: Carolina Tesi-Rocha MD, Pediatric Neurology Fellow 20. Oct-Dec 2007: Ina Knerr MD, Visiting Scientist-Metabolic Pediatrician, Nuremberg- Erlangen Children’s Hospital: SSADH research. 7
  8. 8. 21. May 2008: Yana Jane Tavyev MD, Visiting Neurodevelopmental Disabilities Resident from Baylor College of Medicine, Houston, TX 22. 2007-2008: Ari Heffron MD, Research Coordinator for NIH R-01 Study: Levetiracetam for the Prevention of Post-traumatic Seizures, Current: Resident in Obstetrics/Gynecology, Wayne State University, Detroit, MI. VIII. CONSULTANT APPOINTMENTS National Tuberous Sclerosis Alliance Mid-Atlantic Region Clinic, Fairfax, VA 1996 – present (voluntary). School for Contemporary Education, Neurology Educator and Consultant, Fairfax, VA 1992-1996 (voluntary). Hospital Consulting Privileges: NIH Clinical Center, Bethesda, MD Georgetown University Hospital, Wash., DC INOVA Fairfax Hospital for Children, Fairfax, VA VII. RESEARCH PROTOCOLS/GRANTS/CONTRACTS AWARDED (In chronological order) Pearl PL. Clinical Studies on SSADH Deficiency,” Pediatric Neurotransmitter Disease Association $ 40,000, 2007-2009. Pearl PL. Cerebral MRI Abnormalities Associated with Vigabatrin Therapy. CNMC IRB #3953, approval 12/5/06. Pearl PL. Master Teacher Funding Bridge Award, CNMC Department of Medical Education. 0.1 support award 2005-2006; $ 15,000 award on competitive renewal 2006-2007. Conry JA (PI), Gaillard WD, Lavenstein B, Pearl PL, Tsuchida TN, Weinstein SL, Moorjani B. A Double-Blind, Placebo-Controlled, Parallel-Group Study of Rufinamide given as Adjunctive Therapy in Paitents with Refractory Partial Seizures. Eisai Global Clinical Development, IRB submission 10/06. Theodore WH (PI), Pearl PL, Cohen L, Sato S, Floeter MK, Acosta M. Cortical Excitability in SSADH Deficiency Patients. Approved by IRB #05-N-0224, NINDS, NIH 8/11/05. CNMC IRB #3686, approval 10/28/05. Theodore WH (PI), Pearl PL, Acosta M, Van de Veen JW, Herscovitch P, Bennett H: PET (FMZ) Imaging of GABA Receptors in Patients with SSADH Deficiency. Approved by IRB #06-N-0022, NINDS, NIH 7/20/05. CNMC IRB #3687, approval 10/28/05. Winnie G, Pearl P, Robb A. A Randomized Double-Blind Parallel Placebo Controlled Study of Dopaminergic Agents in ADHD and RLS/PLMS. Multicentered NIH grant. Pearl PL. Collection of Specimens for the Development of Diagnostic Assays of Neurotransmitter Disorders. IRB #3398, approval 7/15/04. Pearl PL. Questionnaire Study of SSADH Deficiency. IRB approval 5/27/04. Klein P (PI), Pearl PL (CNMC site-PI), Natale J, Soldin S, Van dan Anker J. Pilot: Levetiracetam to prevent post-traumatic epilepsy. NINDS (R01 NS045656-01), $ 1,869,088 (Total Costs) 2004-present. Pearl PL. Pediatric Neurotransmitter Diseases Foundation for Clinical Research in SSADH Deficiency $30,000, 2004-2005. 8
  9. 9. Pearl PL. Educational Grant in Epilepsy for Child Neurology Fellows, Novartis Neurosciences Operations, $ 5000 (2003). Pearl, PL. Crown Books Foundation/Delman Family Fund for Research $87,500, 1999-present. Pearl, PL. Effective Teaching of EEG, IRB approval 7/03. Pearl PL, Conry J, Weinstein SL, Gaillard WD, Lavenstein BL, McClintock WM. A multicenter, rater- blind, randomized, age-stratified parallel-group study comparing two doses of oxcarbazepine as monotherapy in pediatric patients with inadequately-controlled partial seizures. Novartis Pharmaceuticas Protocol CTR1476E2339, 2003-2004. Pearl PL, Conry JA, Weinstein SL, Gaillard WD, Lavenstein BL, McClintock WM. A multicenter, rater-blind, randomized, age-stratified parallel-group study comparing two doses of oxcarbazepine as adjunctive therapy in pediatric patients with inadequately-controlled partial seizures. Novartis Pharmaceuticals Protocol No. CTR1476E2340, 2003-2004. Conry J, Gaillard WD, Pearl PL, Weinstein SL. A Double-Blind, Randomized, Multicenter, Parallel Group Study of the safety and efficacy of Zonisamide 5 mg/kg/day Versus 12 mg/kg/day as Adjunctive Therapy in Children with Partial Seizures. Elan Pharmaceuticals 46046-305, 2003. Conry J, Gaillard WD, Pearl PL, Weinstein SL. An Open-Label, Long-Term Safety Study of Zonisamide as Adjunctive Therapy in Children with Partial Seizures. Elan Pharmaceuticals 460460-306, 2003. Conry J, Gaillard WD, Pearl PL, Weinstein SL, Lavenstein B. Open-Label, Long-Term Safety Study of Zonisamide (Zonegran) Administered to Children with Epilepsy. Elan Pharmaceuticals #354, 2001, $107,380. Conry J, Gaillard WD, Pearl PL, Weinstein SL. A Multicenter, Open-Label, Assessment of the Safety of Zonisamide (Zonegran) as Adjunctive Therapy in Patients with Primary Generalized Epilepsy. Elan Pharmaceuticals #504, 2001, $39,850. Conry J, Gaillard WD, Pearl PL, Weinstein SL. A Multicenter, Open-Label, Safety Study to Evaluate the Use of 25 mg and 50 mg of Zonisamide (Zonegran) in the initiation of therapy in patients with epilepsy. Elan Pharmaceuticals 2000 – 2001, $4500. Conry J, Gaillard WD, Pearl PL, Weinstein SL, Lavenstein B. LAM 20006: A Double-Blind, Placebo- Controlled, Add-On Clinical Trial of the Safety, Pharmacokinetics and Efficacy of Lamictal in Pediatric Age Subjects (1-24 Months). GlaxoSmithKline 2001, $127,800. Conry J, Gaillard WD, Pearl PL, Weinstein SL, Lavenstein B. An Open-Label, Uncontrolled, Long- Term Study to Assess the Safety of Lamictal in Pediatric Subjects who have previously taken part in Study LAM 20007. GlaxoSmithKline 2001, $54,000. Conry JA, Pearl PL, Weinstein S, Gaillard WD, Co-PI. Evaluation of the Efficacy and Tolerability of Levetiracetam Add-On Treatment in Refractory Pediatric Patients with Partial Onset Seizures: A 28 Week double-blind, placebo-controlled Multicenter Trial. UCB Pharma/Quintiles #N 159, 2000-2002, $33,980. Conry JA, Pearl PL, Weinstein S, Gaillard WD, Co-PI. A Multicenter, Open Label, Long Term Follow up Study of the Safety and Efficacy of Levetiracetam in Children with Epilepsy. UCB Pharma/Quintiles #N 157, 2000-2002, $30,850. Conry JA, Pearl PL, Weinstein S, Gaillard WD, Co-PI. A Multicenter, Open Label Safety and Efficacy Study of Zonegran (zonisamide) in Patients with Progressive Myoclonic Epilepsy. Elan Pharmaceuticals #505, 2000-2002, $16,250. 9
  10. 10. Pearl PL, Civitello L, McClintock W, Lavenstein B. Safety and Therapeutic Effect of Oxcarbazepine in Patients with Partial Seizures (STOPS trial). Principal Investigator. Novartis Pharmaceuticals, 1999- 2000, $6000. Stein MA and Pearl PL. Multicenter Stage II Clinical Trial: Tomoxetine Treatment of ADHD, Co-PI, Eli Lilly 8/98-8/99, $291,979. Stein MA and Pearl PL. Multicenter Stage II Clinical Trial: OROS Treatment of ADHD, Co-PI, Alza Pharmaceuticals 8/98-8/99, $155,055. Stein MA and Pearl PL. A Randomized Double-Blind Study of Tomoxetine HCl, Methylphenidate, and Placebo in Pediatric Outpatients with ADHD, Eli Lilly 1999-2001, $202,444. Pearl PL. Use of Oral Sumatriptan in Adolescent Migraine, Co-PI, Glaxo Pharmaceuticals, 1994-1995. Pearl PL. Compassionate Use Protocol for Rx Felbatol in Patients with Epilepsy, Investigator, Wallace Laboratories, 1992-1993. VIII. EDITORIAL RESPONSIBILITIES Editorial Board: Pediatric Neurology 2004-present. Future Neurology 2005-present. Pediatric Health 2006-present. Intl J Clinical Practice 2007-present. Journal of Child Neurology 2007-present. Music and Medicine 2008-present. Guest Editor: Holmes GL, Pearl PL, Lachhwani DK: Consensus in Pediatrics: Epilepsy Diagnosis and Treatment in Infants and Children. Series Editors: J. Hyams and L. Feld 2008;1(10). Pearl PL: Inherited Disorders of Neurotransmitters: An Enlarging Group of Neurometabolic Diseases. Special Focus Issue of Future Neurology 2006. Reviewer: Section Reviewer: Neurologic Disorders; Neuromuscular Disorders; NORD Guide to Rare Disorders, The National Organization for Rare Disorders, Lippincott Williams & Wilkins 2003. Ad hoc Reviewer: Annals of Neurology, 2003 – present. Archives of Pediatrics and Adolescent Medicine, 2000 - present. Archives of Diseases of Childhood, 2002 – present. British Medical Journal, 2002 – present. Clinical Neurophysiology, 2001 – present. Epilepsia 2008-present. International Journal of Clinical Practice, 2006-present. International Journal of Sleep and Wakefulness, 2007-present. Journal of the American Medical Association (JAMA), 2001-present. Journal of Inherited Metabolic Disease, 2006-present. Journal of Neurology, 2006 – present. Journal of Sleep Research, 2003-present. Molecular Genetics and Metabolism, 2003-present. Neurochemistry International, 2006-present. Neurology, 2005-present. Neuroscience Letters, 2005-present. Pediatric Drugs, 2003 - present. Sleep Medicine, 2002 – present. 10
  11. 11. Trends in Neurosciences 2007-present. Medical Reviewer for Informational Brochures: 1. Congenital Bilateral Perisylvian Syndrome. National Organization of Rare Disorders 2003. 2. DOOR Syndrome (Deafness, Onychodystrophy, Osteodystrophy, Retardation). National Organization of Rare Disorders 2003. 3. Multiple System Atrophy. National Organization of Rare Disorders 2003. 4. Neu Laxova Syndrome. National Organization of Rare Disorders 2003. 5. Olivopontocerebellar Atrophy. National Organization of Rare Disorders 2003. 6. Schwartz Jampel Syndrome. National Organization of Rare Disorders 2003. 7. Suzac Syndrome. National Organization of Rare Disorders 2003. IX. PUBLICATIONS A. Peer-Reviewed Manuscripts 46. Pearl PL: New Treatment Paradigms in Neonatal Seizures. J Inherit Metab Dis 2009: in press. 45. Mbwana J, Berl MM, Ritzl EK, Rosenberger L, Mayo J, Weinstein S, Conry JA, Pearl PL, Shamim S, Moore EN. Sato S, Vezina LG, Theodore WH, Gaillard ED. Limitations to plasticity of language network reorganization in localization related epilepsy. Brain 2008 Dec 5. [Epub ahead of print] 44. Pearl PL, Gibson KM, Cortez MA, Wu Y, Snead OC, Knerr I, Forester K, Pettiford JM, Jakobs C, Theodore WH: Succinic semialdehyde dehydrogenase deficiency: Lessons from Mice and Men. J Inherit Metab Dis 2009: in press. 43. Pearl PL, Vezina LG, Saneto RP, McCarter R, Molloy-Wells E, Heffron A, Trzcinski S, McClintock WM, Conry JA, Elling NJ, Goodkin HP, Sotero de Menezes M, Ferri R, Gilles E, Kadom N, Gaillard WD: Cerebral MRI Abnormalities Associated with Vigabatrin Therapy. Epilepsia 2008: E-pub ahead of print. 42. Knerr I, Gibson KM, Jakobs C, Pearl PL: Neuropsychiatric Morbidity in Adolescent and Adult Succinic Semialdehyde Dehydrogenase Deficiency Patients. CNS Spectr 2008;13:598-605. 41. Cushner-Weinstein S, Dassoulas K, Salpekar JA, Henderson SE, Pearl PL, Gaillard WD, Weinstein SL: Parenting stress and childhood epilepsy: the impact of depression, learning, and seizure-related factors. Epilepsy Behav. 2008;13(1):109-14. 40. Hsieh DT, Gropman A, Pearl PL: A 2-year-old Male with Developmental Delay, Irritability, and Failure-to-Thrive. Ped Annals 2008;37:459-463. 39. Pearl PL, Conry JA, Yaun A, Taylor JL, Heffron AM, Sigman MM, Tsuchida TT, Elling NJ, Bruce DA, Gaillard WD: Misidentification of Vagus Nerve Stimulator for IV access and other major adverse events. Pediatric Neurology 2008; 38:248-251. 38. Gaillard WD, Berl MM, Moore EN, Ritzl EK, Rosenberger LR, Weinstein SL, Conry JA, Pearl PL, Ritter FF, Sato S, Vezina LG, Vaidya CJ, Wiggs E, Fratalli C, Risse G, Ratner NB, Gioia G, Theodore WH: Atypical language in lesional and nonlesional complex partial epilepsy. Neurology 2007; 60:1761. 37. Gaillard WD, Weinstein S, Conry J, Pearl PL, Fazilat S, Fazilat S, Vezina LG, Reeves-Tyer P, Theodore WH. Prognosis of children with partial epilepsy: MRI and serial 18 FDG-PET. Neurology 2007;68:655-659. 11
  12. 12. 36. Knerr I, Pearl PL, Bottiglieri T, Snead OC, Jakobs C, Gibson KM. Therapeutic Concepts in Succinate Semialdehyde Dehydrogenase (SSADH; ALDH5a1) Deficiency (Gamma-Hydroxybutyric Aciduria) - Hypotheses evolved from 25 years of patient evaluation, studies in Aldh5a1-/- mice and characterization of gamma-hydroxybutyric acid pharmacology. J Inherit Metab Dis 2007;30:279-294. 35. Pearl PL, Taylor J, Trzcinski S, Sokohl A. Pediatric Neurotransmitter Disorders. J Child Neurol 2007; 22:606-616. 34. Cushner-Weinstein S, Berl M, Salpekar J, Johnson JL, Pearl PL, Conry JA, Kolodgie M, Scully A, Gaillard WD, Weinstein SL. The benefits of a camp designed for children with epilepsy: Evaluating adaptive behaviors over 3 years. Epilepsy & Behavior 2007; 10:170-178. 33. Salpekar JA, Conry JA, Doss W, Cushner-Weinstein S, Pearl PL, Weinstein SL, Gaillard WD. Clinical Experience with Anticonvulsant Medication in Pediatric Epilepsy and Comorbid Bipolar Spectrum Disorder. Epilepsy and Behavior 2006; 9:327-334. 32. Donarum EA, Stephan DA, Larkin K, Murphy EJ, Gupta M, Senephansiri H, Switzer RC, Pearl PL, Snead OC, Jakobs C, and Gibson KM. Expression profiling reveals multiple myelin alterations in murine succinate semialdehyde dehydrogenase deficiency. J Inherit Metab Dis 2006; 29:143-156. 31. Pearl PL, Capp PK, Novotny EJ, Gibson KM. Inherited disorders of neurotransmitters in children and adults. Clin Biochem 2005; 38: 1051-1058. 30. Berl MM, Balsamo LM, Xu B, Moore EN, Weinstein SL, Conry JA, Pearl PL, Sachs BC, Grandin CB, Frattali C, Ritter FJ, Sato S, Theodore WH, Gaillard WD: Seizure Focus Affects Regional Language Networks Assessed by fMRI. Neurology 2005; 65: 1604-1611. 29. Gibson KM, Jakobs C, Pearl PL, Snead OC: Murine Succinate Semialdehyde Dehydrogenase (SSADH) Deficiency, A Heritable Disorder of GABA Metabolism with Epileptic Phenotype. IUBMB Life 2005; 57: 639-644. 28. Delorme R, Betancur C, Wagner M, Krebs MO, Gorwood P, Pearl P, Nygren G, Durand CM, Buhtz F, Pickering P, Melke J, Ruhrmann S, Anckarsäter H, Chabane N, Kipman A, Reck A, Millet B, Roy I, Mouren-Simeoni MC, Maier W, Råstam M, Gillberg C, Leboyer M , Bourgeron T. Support for the association between the rare functional variant I425V of the serotonin transporter gene and susceptibility to obsessive compulsive disorder. Biol Psych 2005;10:1059-1061. 27. Gaillard WD, Balsamo L, Xu B, McKinney C, Papero PH, Weinstein S, Conry J, Pearl PL, Sachs B, Sato S, Vezina LG, Frattali C, Theodore WH. FMRI Language Task Panel Improves Determination of Language Dominance. Neurology 2004; 63: 1403-1408. 26. Barakat AJ, Pearl PL, Acosta MT, Runkle BP. 22q13 Deletion Syndrome with Central Diabetes Insipidus: A Previously Unreported Association. Clinical Dysmorphology 2004; 13: 191-194. 25. Dervent A, Gibson KM, Pearl PL, Salomons GS, Jakobs C, Yalcinkaya G. Photosensitive absence epilepsy with myoclonias and heterozygosity for succinic semialdehyde dehydrogenase (SSADH) deficiency. Clin Neurophysiol. 2004; 115: 1417-1422. 24. Novotny EJ, Fulbright RK, Pearl PL, Gibson KM, Rothman DL. Magnetic Resonance Spectroscopy of Neurotransmitters in Human Brain. Ann Neurol 2003; 54 (suppl 6): S25-S31. 23. Stein MA, Sarampote CS, Waldman ID, Robb AS, Conlon C, Pearl PL, Black D, Seymour KE, Newcorn JH. A Dose-Response Study of OROS Methylphenidate in Children with Attention- Deficit/Hyperactivity Disorder. Pediatrics 2003; 112:e404. 22. Gupta M, Hogema BM, Grompe M, Bottiglieri T, Concas A, Biggio G, Sogliano C, Rigamonti A, Pearl PL, Snead OC, Jakobs C, Gibson KM: Murine Succinate Semialdehyde Dehydrogenase. Ann Neurology 2003; 54 (suppl 6): S81-S90. 12
  13. 13. 21. Pearl PL, Novotny EJ, Acosta MT, Jakobs C, Gibson KM. Succinic Semialdehyde Dehydrogenase Deficiency in Children and Adults. Ann Neurol 2003; 54 (suppl 6): S73-S80. 20. Pearl PL, Acosta MT, Gibson KM, Vezina LG, Conry JA, Gropman A, Rogawski MA, Theodore WH, Novotny EH, Berry G, Tuchman M. Clinical Spectrum of Succinic Semialdehyde Dehydrogenase Deficiency. Neurology 2003; 60: 1413-1417. 19. Gibson KM, Gupta M, Pearl PL, Tuchman M, Vezina LG, Snead OC, Smit LME, Jakobs C. Significant behavioral disturbances in succinic semialdehyde dehydrogenase (SSADH) deficiency (gamma-hydroxybutyric aciduria). Biol Psych 2003; 54:763-768. 18. Jamain S, Quach H, Betancur C, Rastam M, Colineaux C, Gillberg IC, Soderstrom H, Giros B, Leboyer M, Gillberg C, Bourgeron T, Nyden A, Philippe A, Giros B, Colineaux C, Cohen D, Chabane N, Mouren-Simeoni MC, Brice A, Sponheim E, Spurkland I, Skjeldal OH, Coleman M, Pearl PL, Cohen IL, Tsiouris J, Zappella M, Menchetti G, Pompolla A, Aschauer H, Van Maldegem L: Mutations of the X- linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nature Genetics 2003;34:27-29. 17. Gaillard WD, Balsamo L, Xu B, Grandin CB, Braniecki SH, Papero PH, Weinstein S, Conry J, Pearl PL, Sachs B, Sato S, Jabbari B, Vezina LG, Frattali C, Theodore WH. Language dominance in partial epilepsy patients identified with an fMRI reading task. Neurology 2002; 59: 256-265. 16. Philippe A, Guilloud-Bataille M, Martinez M, et al: Paris Autism Res Intl Sibpair Study: USA Group (Coleman M, Pearl P, Cohen I, Tsiouris J): Analysis of ten candidate genes in autism by association and linkage. Am J Med Genetics 2002; 114: 125-128. 15. Krebs MO, Betancur C, Leroy S, Bourdel MC, Gillberg C, Leboyer M, and the Paris Autism Res Intl Sibpair Study: USA Group (Coleman M, Pearl P, Cohen I, Tsiouris J): Absence of association between a polymorphic GGC repeat in the 5’ untranslated region of the reelin gene and autism. Molec Psychiatry 2002; 7: 801-804. 14. Sarampote CS, Efron LA, Robb AS, Pearl PL, Stein MA. Can Stimulant Rebound Mimic Pediatric Bipolar Disorder? J Child Adolesc Psychopharm 2002; 12: 63-67. 13. Pearl PL, LaFleur B, Reigle S, Rich S, Freeman A AH, McCutchen C, Sato S. Sawtooth Wave Density Analysis During REM Sleep in Normal Volunteers. Sleep Medicine 2002; 3: 255-258. 12. Gaillard WD, Kopylev L, Weinstein SL, Conry JC, Pearl PL, Spanaki MV, Fazilat S, Reeves-Tyer P, Dubovsky ED, Vezina LG, Theodore WH. Low incidence of abnormal (18)FDG-PET in children with new onset partial epilepsy: a prospective study. Neurology 2002; 58: 717-722. 11. Jamain S, Betancur C, Quach H, et al: Paris Autism Res Intl Sibpair Study: USA Group (Coleman M, Pearl P, Cohen I, Tsiouris J): Linkage and association of the glutamate receptor 6 gene with autism. Molec Psychiatry 2002; 7: 302-310. 10. Betancur C, Corbex M, Spielewoy C, et al: Paris Autism Res Intl Sibpair Study: USA Group (Coleman M, Pearl P, Cohen I, Tsiouris J): Serotonin Transporter Gene Polymorphisms and Hyperserotonemia in Autistic Disorder. Molec Psychiatry 2002; 7: 67-71. 9. Pearl PL, Krasnewich D. Neurological Course of Congenital Disorders of Glycosylation. J Child Neurology 2001; 16:409-13. 8. Cadavid D, Pearl PL (corresponding author), Dubovsky EC, Vezina LG: Stroke After Zoster Ophthalmicus In A 12-Year Old Girl with Protein C Deficiency. Neurology 1999; 53:1128-1129. 13
  14. 14. 7. Philippe A, Martinez M, Guilloud-Bataille M, et al: Paris Autism Res Intl Sibpair Study: USA Group (Coleman M, Pearl P, Cohen I, Tsiouris J): Genome-wide scan for autism susceptibility genes. Human Molec Genetics 1999; 8:805-812. 6. Pearl PL, Abu-Farsakh H, Starke JP, et al: Neuropathology of Two Fatal Cases of Measles in the Current Houston Epidemic, Pediatric Neurology 1990; 6: 126-130. 5. Butler IJ, Rouah E and Pearl PL: Dementia, Rigidity, and Seizures in an Adolescent Boy. Pediatric Neuroscience 1989; 14: 307-314. 4. Pearl PL: Childhood Stroke Following Intraoral Trauma, Journal of Pediatrics 1987; 110:574-575. 3. Medani CR, Pearl PL, Hall-Craggs M: Acute Renal Failure, Hemolytic Anemia, and Thrombocytopenia in Poststreptococcal Glomerulonephritis, Southern Medical Journal 1987; 80:370-373. 2. Pearl PL: Options for Spina Bifida Newborns from the Affected Adolescent's Perspective, Johns Hopkins University Undergraduate Science Bulletin 1979; 2:35-53. 1. Frees LC, Pearl PL, Koski WS: Cross Section for the Reaction CO+ (CO,O)CCl+: Heat Of Formation of CCl+, Chemical Physics Letters 1979; 63:108-110. B. Invited Papers 35. Hsieh DT, Walker JM, Pearl PL: Infantile seizures: infants are not just little children. Curr Neurol Neurosci Rep 2008; 8:139-144. 34. Pearl PL: Antiepileptic Drug Therapy in Children. Consensus in Pediatrics 2008;1:11-20. 33. Pearl P, Hartka T, Cabalza J, Gibson KM (updated July 2006) Succinic Semialdehyde Dehydrogenase Deficiency in: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle. 1997-2006. Available at http://www.genetests.org. 32. Pearl PL, Cabalza JL, Gibson KM. SSADH Deficiency (update). In: Percy AK, Editor. MedLink Neurology. San Diego: MedLink Corporation. 2006; Available at http://www.medlink.com. 31. Pearl PL, Hartka TR, Taylor J. Diagnosis and Treatment of Neurotransmitter Disorders. Curr Treat Options Neurol 2006; 8:441-450. 30. Pearl PL, Hartka TR, Cabalza J, Taylor J, Gibson M. Inherited Disorders of GABA Metabolism. Future Neurology 2006; 1:631-636. 29. Pearl PL, Acosta MT, Theodore WH, Novotny EJ, Bennett HD, Jakobs C, Gibson KM. Human SSADH Deficiency – Phenotype and Treatment Strategies. Diseases of Neurotransmission: From Bench to Bed. Symposia Proceedings, G. F. Hoffmann, Ed. SPS Publications. 2006; 1:187-198. 28. Pearl PL, Bennett HD, Capp P, Gibson KM. SSADH Deficiency (update). In: Percy AK, Editor. MedLink Neurology. San Diego: MedLink Corporation. 2005; Available at http://www.medlink.com. 27. Capp PK, Pearl PL (corresponding author), Conlon C. Methylphenidate HCl: Treatment for Attention Deficit Hyperactivity Disorder. Exp Rev Neurotherap 2005; 5: 325-331. 26. Pearl PL, Bennett HD, Khademian Z: Seizures and Metabolic Disease. Curr Neurology and Neuroscience Reports 2005; 5: 127-133. 25. Pearl PL, Robbins EL, Bennett HD, Conry JA: Alternative Therapies in Epilepsy: Cause For Concern. Archives of Neurology 2005; 62: 1472-1475. 14
  15. 15. 24. Pearl PL, Capp PK, Gibson KM: Psychiatric Manifestations in SSADH Deficiency, A Disorder of GABA Metabolism. Psychiat Rev 2005: 1: 18-20. 23. Acosta MT and Pearl PL: Neuroimaging in Autism: From Structure to Malfunction. Sem Ped Neuro 2004; 11: 205-213. 22. Capp P, Pearl PL (corresponding author), Lewin DS: Pediatric Sleep Disorders. Prim Care Clinics in Office Practice 2005; 32(2): 549-562. 21. Pearl PL, Robbins E, Capp P, Gasior M, Gibson KM (May 2004) Succinic Semialdehyde Dehydrogenase Deficiency. In: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2004. Available at http://www.genetests.org. 20. Pearl PL, Robbins EH, Acosta MT, Gibson KM: SSADH Deficiency. In: Percy AK, Editor, MedLink Neurology. San Diego: MedLink Corporation. 2004; Available at http://www.medlink.com. 19. Pearl PL, Remolina ST, Acosta MT, Elsas L: Galactosemia. In: Percy AK, Editor. MedLink Neurology. San Diego: MedLink Corporation. 2004; Available at http://www.medlink.com. 18. Pearl PL and Gibson KM: Clinical Aspects of Disorders of GABA Metabolism in Children. Curr Opin Neurology 2004; 17: 107-113. 17. Pearl PL, Wallis DD, Gibson KM. Pediatric Neurotransmitter Disorders. Curr Neurol and Neurosci Reports 2004; 4: 147-152. 16. Pearl PL, Gibson KM, Sahoo S: SSADH Deficiency. In: Percy AK, Editor. MedLink Neurology. San Diego: MedLink Corporation. 2003; Available at http://www.medlink.com. 15. Rotenberg J, Pearl PL (corresponding author): Landau-Kleffner Syndrome. Arch Neurology 2003; 60:1019-1021. 14. Efron LA, Pearl PL: Too much energy for rest. Sleep problems in children with ADHD. Adv Nurse Pract 2003; 11: 57-8, 91. 13. Acosta MT, Pearl PL. The Neurobiology of Autism: New Pieces of the Puzzle. Current Neurology and Neuroscience Rep 2003; 3: 149-156. 12. Pearl PL: Epilepsy in Children: Minimizing Cognitive Impairment Associated with Antiepileptic Drugs. Cognitive and Behavioral Aspects of Neuropsychiatric Disorders. Postgraduate Institute for Medicine 2002: 21-23. 11. Pearl PL, Gibson KM: GABA-Transaminase Deficiency. In: Percy AK, editor. MedLink Neurology. San Diego: MedLink Corporation. 2002; Available at http://www.medlink.com. 10. Pearl PL, Childhood Sleep Disorders: Diagnostic and Therapeutic Approaches. Current Neurology and Neuroscience Reports 2002; 2:150-157. 9. Pearl PL, Efron LA, Stein MA. Children, Sleep, and Behavior: A Complex Association. Minerva Pediatrica 2002; 54: 79-91. 8. Efron L and Pearl PL: Sleep Disorders in Children with ADHD, Adv Man Resp Care 2001. 7. Pearl PL, Allen E. A 9-Year-Old Boy With Gelastic Seizures. Epilepsy: Clinical Lessons in Epilepsy 2000: 3:9-11. 15
  16. 16. 6. Pearl PL, Weiss RE, Stein MA: Medical mimics. Medical and neurological conditions simulating ADHD. Ann N Y Acad Sci 2001; 97-112. 5. Pearl PL, Carrazzana E, Holmes GL: Landau-Kleffner Syndrome, Epilepsy Currents 2001; 1:39-45. 4. Efron LA, Pearl PL: Children with ADHD. Too Much Energy To Sleep. Adv Man Resp Care 2001; 45-48. 3. Stein MA, Pearl PL: Conducting a Feedback Session. ADHD Report 1998; 6:10-13. 2. Pearl PL, Coleman M: Autosomal Disorders and Autism. Brain Dysfunction 1996; 9:224-229. 1. Pearl PL, Percy AK: Rett Syndrome. Current Opinion in Neurology and Neurosurgery 1988; 1: 327- 331. C. Chapters in Books 47. Pearl PL: Pediatric Neurotransmitter Disorders. In: Current Management in Child Neurology. Ed. BL Maria. B.C. Decker Inc, Shelton, CT 2009: 504-510. 46. Pearl PL: The Neurological Examination – Pediatrics. In: Educational Review Manual in Neurology, 2nd Edition. Eds. M. Levin, G.L. Holmes, J.A. Cohen. Castle Connolly Graudate Medical Publishing, New York, NY 2008: 42-62. 45. Pearl PL, Jakobs C, Gibson KM: Disorders of beta- and gamma-amino acids in free and peptide- linked forms. Chapter 91 in: Online Molecular and Metabolic Bases of Inherited Disease. Scriver CR et al, editors. Online: www.ommbid.com 2007. 44. Gibson KM and Pearl PL: Neurotransmitter Disorders. In: Chapter XX, Inborn Errors of Metabolism: Biochemical Genetics. Forfar and Arneil’s Textbook of Pediatrics, Eds. N McIntosh, P Helms, R Smyth, S Logan, 7th Edition. Churchill Livingstone Elsevier, Edinburgh 2008: 1119-1122. 43. Pearl PL, Holmes GL: Childhood Absence Epilepsies. In: Pediatric Epilepsy: Diagnosis and Therapy. Eds. JM Pellock, WE Dodson, BF Bourgeois, 3rd edition, Demos Med. Pubs, NY 2008:323-334. 42. Holmes GL, Pearl PL: Gabapentin and Pregabilin. In: Pediatric Epilepsy: Diagnosis and Therapy. Eds. JM Pellock, WE Dodson, BF Bourgeois, 3rd edition, Demos Med. Pubs, NY 2008:593-602. 41. Pearl PL: The Neurological Examination – Pediatrics. In: Education Manual for Neurology, Ed. Gregory L. Holmes, M.D., Jeffrey A. Cohen, M.D., Morris Levin, M.D., Castle Connolly Graduate Medical Publishing, New York, NY, 2006: 35-50. 40. Pearl PL, Acosta MT, Wallis DD, Bottiglieri T, Miotto K, Jakobs C, Gibson KM. Dyskinetic Features of Succinate Semialdehyde Dehydrogenase Deficiency, a GABA Degradative Defect. In: Paediatric Movement Disorders: Progress in Understanding. Fernandez-Alvarez E, Arzimanoglu A, Tolosa E (eds). Editions John Libbey Eurotext, 2005: 203-212. 39. Pearl PL: The Role of the Pediatric Neurologist. In: Pediatric Life Care Planning and Case Management. Ed. S. Riddick-Grisham. CRC Press, London, pp. 117-124, 2004. 38. Conry JA, Pearl PL: Herbal Therapies in Epilepsy. In: Complementary and Alternative Therapies for Epilepsy. Eds. O. Devinsky, S. Schachter, S. Pacia. Demos, NewYork, pp. 129-142, 2005. 37. Rosser T, Pearl PL: Cerebro-Oculo-Facio-Skeletal Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 520-521, 2003. 16
  17. 17. 36. Chang T, Pearl PL: Machado Joseph Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 555, 2003. 35. Acosta MT, Pearl PL: Joubert Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 542, 2003. 34. Acosta MT, Pearl PL: Lennox Gastaut Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 549-550, 2003. 33. Vanderver A, Pearl PL: Turner Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 264-265, 2003. 32. Passel-Clark L, Pearl PL: Krabbe’s Disease. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 551-552, 2003. 31. Sahoo S, Pearl PL: Locked In Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 554, 2003. 30. Passel-Clark L, Pearl PL: Canavan Disease. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 550-551, 2003. 29. Passel-Clark L, Pearl PL: Pelizaeus-Merzbacher Disease. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 578-579, 2003. 28. Hashisho H, Pearl PL: Meniere’s Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 558, 2003. 27. Sahoo S, Pearl PL: Parsonage Turner Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 577-578, 2003. 26. Sahoo S, Pearl PL: Complex Regional Pain Syndrome I. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 523-524, 2003. 25. Sahoo S, Rosser T, Pearl PL: Alpers Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 511-512, 2003. 24. Schmandt S, Pearl PL: Three-M Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 259, 2003. 23. Schmandt S, Pearl PL: Filippi Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 194-195, 2003. 22. Schmandt S, Pearl PL: Cockayne Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 170-171, 2003. 21. Sahoo S, Pearl PL: Kernicterus. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 543, 2003. 20. Acosta M, McClintock WM, Pearl PL: Hyperekplexia. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 540, 2003. 19. Rosser T, Pearl PL: Metachromatic Leukodystrophy. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 552-553, 2003. 18. Sahoo S, Pearl PL: Syringobulbia. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 589-590, 2003. 17
  18. 18. 17. Sahoo S, Pearl PL: Syringomyelia. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 590-591, 2003. 16. Sahoo S, Pearl PL: Thalamic Pain Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 593, 2003. 15. Rosser T, Pearl PL: Dejerine Sottas Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 527-528, 2003. 14. Sahoo S, Pearl PL: Korsakoff Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 546, 2003. 13. Sahoo S, Pearl PL: Arnold Chiari Syndrome. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 515-516, 2003. 12. Vanderver A, Pearl PL: Giant Axonal Neuropathy. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 569, 2003. 11. Rosser T, Pearl PL: Congenital Hypomyelination Neuropathy. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 568, 2003. 10. Mandler S, Pearl PL: Hereditary Sensory Neuropathy Type II. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 571, 2003. 9. Mandler, S, Pearl PL: Hereditary Sensory Neuropathy Type I. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 570, 2003. 8. Sahoo S, Pearl PL: Hydrocephalus. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 539, 2003. 7. Sahoo S, Pearl PL: Primary Lateral Sclerosis. Guide to Rare Disorders. National Organization of Rare Disorders, Lippincott, Williams & Wilkins, Philadelphia, 548-549, 2003. 6. Pearl PL and Gibson KM: SSADH (Succinic Semialdehyde Dehydrogenase Deficiency). Guide to Rare Disorders. National Organization of Rare Disorders (NORD), Lippincott, Williams & Wilkins, Philadelphia, 499, 2003. 5. Pearl PL, Holmes GL. Absence Seizures, in Pediatric Epilepsy: Diagnosis and Therapy. Eds. JM Pellock, WE Dodson, BF Bourgeois, 2nd edition, pp. 219-231, Demos Med. Pubs, NY 2001. 4. Holmes GL, Pearl PL. Gabapentin, in Pediatric Epilepsy: Diagnosis and Therapy. Eds. JM Pellock, WE Dodson, BF Bourgeois, 2nd edition, pp. 453-459, Demos Med. Pubs., NY 2001. 3. Pearl PL, Frishberg BM: "Migraines in Children", Decision Making in Pediatric Ophthalmology, Edited by CW Cibis, AC Tongue, MS Isern, Mosby Yearbook, Philadelphia 1993. 2 Pearl PL, Holmes GL: "Absence Seizures", Pediatric Epilepsy: Diagnosis and Therapy, Edited by WE Dodson and JM Pellock, Demos Publications, New York 1993. 1. Pearl PL, Holmes GL: "Epilepsy Syndromes and their Prognosis", Surgical Management of Epilepsy, Edited by AR Wyler and BP Hermann, Demos Publications, New York 1992. D. Abstracts 18
  19. 19. 108. Pearl PL, Peloquin PB, Fricke S, Knerr I, Depositario-Cabacar D, Khanna P, Khademian Z. Single Voxel Basal Ganglia Magnetic Resonance Spectroscopy: Establishment of Pediatric Normative Database. Program No. 3.166. 2008 Abstract Viewer. Seattle, WA: American Epilepsy Society. 107. Gaillard WD, Mbwana J, Mayo J, Rosenberger LR, Ritzl EK, Weinstein SL, Conry JA, Pearl PL, Sato S, Vezina LG, Berl MM, Theodore WH. Voxel Based and ROI Determination of Atypical Language Dominance in Left Hemisphere Focus Partial Epielspy. Program No. 3.174. 2008 Abstract Viewer. Seattle, WA: American Epilepsy Society. 106. Yaun AL, Bruce D, Conry JA, Pearl PL, Weinstein SL, Tsuchida T, Walker J, Vezina GL, Gaillard WD. Proximity of Focal Cortical Dysplasia to the Motor Strip in Pediatric Patients. Program No. 2.300. 2008 Abstract Viewer. Seattle, WA: American Epilepsy Society. 105. Henderson SE, Cushner Weinstein S, Gaillard WD, Pearl PL, Weinstein SL. How Perception of Resources Impacts Parenting Stress and Anxiety in Parents of Children with Epilepsy. Program No. 2.097. 2008 Abstract Viewer. Seattle, WA: American Epilepsy Society. 104. Klein P, Herr D, Pearl PL, Sandoval F, Trzcinski S, Nogay C, Heffron A, Tsuchida T, VandenAnker J, Natale J, Soldin S, Levine Z, McCarter R. Safety, tolerability and pharmacokinetics of levetiracetam in patients with acute traumatic brain injury with high risk for developing post-traumatic epilepsy. Program No. 1.187. 2008 Abstract Viewer. Seattle, WA: American Epilepsy Society. 103. Pearl PL, Peloquin P, Sokohl A, Hartka T, Fricke S, Khanna P, Khademian Z: Pediatric Normative Database in Basal Ganglia Magnetic Resonance Spectroscopy. Ann Neurol 2008;64(Suppl 12):S104. 102. Knerr I, Gibson KM, Murdoch G, Salomons GS, Pope L, Jakobs C, Catanaese GA, Pearl PL: Neuropathology of SSADH Deficiency. J Inherit Metab Dis 2008;31(Suppl 1):26. 101. Mayo J, Rosenberger L, Berl M, Ritzl E, Moore E, Wohlschlager A, Pearl PL, Conry JA, Weinstein SL, Sato S, Theodore WH, Gaillard WD: Language Lateralization in Left Focal Epilepsy As Determined by Four Methods. Abstract Viewer, Program B.04, American Epilepsy Society, Philadelphia, PA 2007. 100. Gaillard WD, Rosenberger LR, Ritzl EK, Moore EN, Berl MM, Pearl PL, Conry JA, Weinstein SL, Tsuchida T, Ritter FJ, Sato S, Theodore WH: Rates of Success in Language fMRI Acquisition in Children and Adolescents with Epilepsy. Abstract Viewer, Program 2.114, American Epilepsy Society, Philadelphia, PA 2007. 99. Salpekar JA, Foster L, Cushner-Weinstein S, Conry JA, Yaun A, Tsuchida T, Heath C, Pearl PL, Berl M, Weinstein SL, Bruce D, Gaillard WD: Psychiatric Profiles of Presurgical Pediatric Epilepsy Patients. Abstract Viewer, Program 1.306, American Epilepsy Society, Philadelphia, PA 2007. 98. Cushner-Weinstein S, Watt-Marin N, Dassoulas K, Pearl P, Gaillard W, Weinstein SL: Adaptive Coping in Parents of Children with Epilepsy: A Comparison of Two Interventions. Abstract Viewer, Program 1.224, American Epilepsy Society, Philadelphia, PA 2007. 97. Conry J, Yaun A, Pearl PL, Elling N, Sullivan M: Efficacy of Vagus Nerve Stimulator for Treatment of Drop Seizures. Abstract Viewer, Program 1.174, American Epilepsy Society, Philadelphia, PA 2007. 96. Walker J, Hepner S, Scafidi J, Bruce D, Pearl P, Weinstein S, Conry J, Tsuchida T, Heath C, Kolodgie M, Vezina LG, Salpekar J, Yaun A, Gaillard D: Pediatric Surgery Outcome for Localization Related Epilepsy. Ann Neurol 2007; 62 (suppl 11): S135. 95. Pearl PL, Taylor JT, Trzcinski S, Sokohl A, Dustin I, Reeves-Tyer P, Herscovitz P, Carson R, Liew C, Shamim S, Quezado Z, Gibson KM, Theodore WH. 11C-Flumazenil PET Imaging in Patients with SSADH Deficiency. Abstract Viewer, Program 2.140, American Epilepsy Society, Philadelphia, PA 2007. 19
  20. 20. 94. Reis J, Cohen LG, Pearl PL, Gibson KM, Dustin I, Theodore WH. Transcranial Magnetic Stimulation reveals altered Cortical Excitability in Succinic Semialdehyde Dehydrogenase Deficiency. Abstract Viewer, Program No. 3.029, American Epilepsy Society, Philadelphia, PA 2007. 93. Mehta L, Ramanathan S, Maytal J, Salazar D, Neidich J, Jakobs D, Gibson M, Pearl P: SSADH deficiency – an underdiagnosed cause of mental retardation and behavioral problems. Am Soc Hum Genet. 2007. 93. Pearl PL, Taylor JL, Trzcinski S, Sokohl A, Dustin I, Reeves-Tyer P, Herskovitch P, Carson R, Gibson KM, Theodore WH. 11C-Flumazenil PET Imaging in Patients with SSADH Deficiency. J Inherit Metab Dis 2007; 30(Suppl 1):43. 92. Pearl PL, Molloy-Wells E, McClintock WM, Vezina LG, Conry JA, Elling NJ, Tsuchida T, Heath C, Cushner-Weinstein S, Kolodgie M, Weinstein SL, Gaillard WD. MRI Abnormalities Associated with Vigabatrin Therapy: Higher Risk in Infants? Epilepsia 47 (s4), doi: 10.1111/j.152801167.2006. 91. Rosenberger LR, Berl MM, Rizal EK, Moore EN, Fieldstone S, Weber DA, Pearl PL, Conry JA, Weinstein SL, Sato S, Theodore WH, Gaillard WD. Atypical Frontal Language Activation Occurs in the Right Homologue of Broca’s Area. Epilepsia 47 (s4), doi: 10.1111/j.152801167.2006. 90. Klein P, Herr D, Pearl P, Natale J, Levine Z, Nogay C, Mendoza M, Scarito J, Tadzong B, Tsuchida T, VandenAnker J, Soldin S, McCarter R. Tolerability of Acute and Chronic (1 Month) 55 mg/kg/day Levetiracetam Treatment in Patients with Acute Traumatic Brain Injury with High Risk for Developing Post-Traumatic Epilepsy. Epilepsia 47 (s4), doi: 10.1111/j.152801167.2006. 89. Pearl PL, Molloy-Wells E, McClintock WM, Vezina LG, Conry JA, Elling NJ, Tsuchida T, Heath C, Cushner S, Kolodgie M, Weinstein SL, Gaillard WD. Cerebral MRI Abnormalities Associated with Vigabatrin Therapy. Ann Neurol 2006: 60 (Suppl 3): S146. 88. Pearl PL, Conry JA, Cabalza JL, Renuart AJ, Hartka T, Nguy M, Bennett HD, Tsuchida T, Heath C, Yaun A, Bruce D, Kolodgie M, Cushner-Weinstein S, Weinstein SL, Gaillard WD. Major Adverse Events of the Vagus Nerve Stimulator in a Pediatric Epilepsy Program. Ann Neurol 2006: 60 (Suppl 3): S118. 87. Pearl PL, Cabalza JL, Bottiglieri T, Gibson KM: SSADH Deficiency: Sleep Pathology in Inherited Gamma-Hydroxytyric Acidemia. Ann Neurol 2006; 60 (Suppl 3): S23. 86. Salpekar JA, Cushner-Weinstein S, Conry JA, Pearl PL, Weinstein SL, Berl M, Kolodgie M, Gaillard WD: Attention Deficit Hyperactivity Disorder Symptoms in Pediatric Epilepsy Patients. Epilepsia 2005; 46 (Suppl 8):80. 85. Moore EN, Berl MM, Rizl EK, Cho Y-W, Weber D, Pearl PL, Weinstein SL, Conry JA, Sato S, Theodore WH, Gaillard WD: Association Between Epilepsy Etiology and Atypical Language Dominance Assessed by a Panel of fMRI Tasks. Epilepsia 2005; 46 (Suppl 8):53-54. 84. Cushner-Weinstein SM, Bethke-Pope L, Salpekar J, Gaillard WD, Pearl PL, Kolodgie M, Scully A, Conry J, Weinstein SL: Camps Designed for Children with Epilepsy: A Change Over Four Years. Epilepsia 2005; 46 (Suppl 8):15-16. 83. Pearl PL, Bottiglieri T, Bennett HD, Acosta MT, Gibson KM: Inherited Gamma-Hydroxybutyric Acidemia and Sleep. Ann Neurol 2005; 58: S105. 82. Acosta MT, Munasinghe J, Theodore WH, Gibson KM, Gupta M, Pearl P, Rogawski MA: Neuroimaging in A Murine Model of Inherited Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency. Ann Neurol 2005; 58: S96. 20
  21. 21. 81. Pearl PL, Conry JA, Bennett HD, Tsuchida TN, Elling NJ, Yaun A, Myseros J, Bruce D, Kolodgie MJ, Cushner-Weinstein S, Weinstein SL, Gaillard WD. Misidentification of VNS lead for IV access and Major Adverse Events of VNS in a Pediatric Epilepsy Program. Epilepsia 2005; 46 (Suppl 8):158-159. 80. Gaillard WD, Weinstein S, Conry J, Pearl PL, Fazilat S, Vezina LG, Reeves-Tyer P, Theodore WH: Serial 18FDG-PET in Children with Partial Epilepsy. Epilepsia 2005; 46 (Suppl 8):149. 79. Acosta M, Munasinghe J, Theodore WH, Gibson KM, Gupta M, Pearl P, Rogawski MA. Brain MRI and Histology in a Murine Model of Inherited Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency. J Inherit Metab Dis 2005; 28 (Suppl 1): 234. 78. Pearl PL, Bottiglieri T, Theodore WH, Acosta MT, Bennett HD, Miotto KA, Gibson KM: SSADH Deficiency and Extrapyramidal Manifestations: A More Severe Phenotype and Relevance to GHB Toxicity. Neurology 2005; 64 (suppl 1): A433. 77. Pearl PL, Acosta MT, Gasior M, Theodore WH, Rogawski MA, Gibson M: Epilepsy and Movement Disorders in Succinate Semialdehyde Dehydrogenase (SSADH) Deficiency: Relevance to Human Gamma- Hydroxybutyrate (GHB) Toxicity. Epilepsia 2004; 45 (suppl 7): 94. 76. Salpekar JA, Conry JA, Doss W, Weinstein SL, Cusher-Weinstein S, Pearl PL, Berl M, Kolodgie M, Gioia G, Gaillard WD: Treatment of Bipolar and Explosive Mood Disorder Comorbid with Pediatric Epilepsy. Epilepsia 2004; 45 (suppl 7): 95. 75. Conry JA, Gaillard WD, Pearl PL, Weinstein SL, Krohn K: Efficacy of Zonisamide in Progressive Myoclonic Epilepsy: Long-Term Follow-Up. Epilepsia 2004; 45 (suppl 7): 368. 74. Gaillard WD, Conry JA, Pearl PL, Weinstein SL, Moorjani B, Kolodgie M, Salpekar J, Vezina G: Mesial Temporal Sclerosis in Children Identified by MRI. Epilepsia 2004; 45 (suppl 7): 368. 73. Berl MM, Moore E, Xu B, Pearl PL, Conry JA, Weinstein SL, Ritter FJ, Theodore WH, Gaillard WD: Atypical Language Dominance and Patterns of Reorganization in Epilepsy as Assessed by a Panel of fMRI Tasks. Epilepsia 2004; 45 (suppl 7): 366. 72. Gaillard WD, Salpekar , Conry J, Berl M, Cushner-Weinstein S, Kolodgie M, Pearl P, Weinstein S: Psychiatric Issues in Medically Refractory Pediatric Epilepsy. American Academy of Child and Adolescent Psychiatry 2004. 71. Salpekar JA, Gaillard WD, Conry J, Cushner-Weinstein S, Pearl P, Weinstein S: The Association of Psychiatric Symptoms with Epilepsy Classification and Treatment. American Academy of Child and Adolescent Psychiatry 2004. 70. Tuck M, Rosser T, McClintock W, Elling N, Pearl P: Epilepsy Characteristics in a Population of 69 Patients with Tuberous Sclerosis. Ann Neurol 2004; 56 (suppl 8): S117-118. 69. Pearl PL, Acosta MT, Bottiglieri T, Miotto K, Novotny EJ, Gibson KM: Movement Disorders in SSADH Deficiency: More Severe Phenotype and Relevance to GHB Toxicity. Ann Neurol 2004; 56 (suppl 8): S120. 67. Benko WS, Vanderver A, Chang T, Acosta MT, Rosser T, Johnson J, Kolodgie M, Pearl PL, Weinstein S, Conry JA, Vezina LG, Gaillard WD: Diagnostic Value of Magnetic Resonance Imaging in Children with New Onset Seizures and Normal Computed Tomography. Ann Neurol 2004; 56 (suppl 8): S99. 66. Acosta MT, Pearl PL, Novotny E, Gibson KM: Role of GABA in Autism: New Clues from Hyper- GABAergic States. Ann Neurol 2004; 56 (suppl 8): S103. 21
  22. 22. 65. Gaillard WD, Berl MM, Stief E, Xu B, Pearl PL, Weinstein S, Conry J, Moorjani B, Vezina LG, Theodore WH: Atypical Language Dominance Associated with Early Seizure Onset and Early Remote Symptpomatic Cause. Ann Neurol 2004; 56 (suppl 8): S83. 64. Lupu V, Chang T, Vanderver A, Kennedy C, Acosta M, Conry J, Pearl P, Weinstein S, Benko W, Kolodgie M, Johnson P, Pastor W, Gaillard W: Utility of Routine Serum Electrolyte and Glucose Testing in Children with New Onset Seizures. Neurology 2004: 62 (Suppl 5): A69. 63. Salpekar J, Cushner-Weinstein S, Conry J, Pearl P, Berl M, Weinstein S, Gioia G, Kolodgie M, Gaillard W. Psychiatric Referral Patterns in Pediatric Epilepsy Patients. Epilepsia 2003: 44; suppl 9: 239. 62. Berl MM, Papero PH, Cushner-Weinstein S, Conry JA, Pearl PL, Weinstein SL, Schiff S, Kolodgie M, Salpekar J, Gaillard WD. Pediatric Outcome After Temporal Lobe Resection: Intellectual and Social- Emotional Functioning. Epilepsia 2003: 44; suppl 9: 150. 61. Cushner-Weinstein S, Weinstein S, Bethke L, Salpekar J, Elling N, Pearl P, Conry J, Berl M, Kolodgie M, Scully A, Gaillard W. What Parents and Children Worry About With a New Diagnosis of Epilepsy: The Benefit of Educational Groups. Epilepsia 2003: 44; suppl 9: 117. 60. Gaillard WD, Sachs BC, Balsamo LM, Zu B, Berl MM, Grandin CB, Pearl PL, Conry JA, Weinstein SL, Ritter FJ, Sato S, Theodore WH. Reduced Degree of Language Dominance in Left Hemisphere Localization-Related Epilepsy Assessed by an fMRI Reading-Comprehension Task. Epilepsia 2003: 44; suppl 9: 88. 59. Pearl PL, Acosta MT, Novotny EJ, Rogawski MA, Gaillard WD, Weinstein SL, Conry JA, Gioia G, Kenealy L, Berl M, Cushner-Weinstein S, Kelodgnie M, Elling N, Salpekar J, Gibson KM. Paradoxical Convulsive Seizures in SSADH Deficiency, a Hyper-GABA’ergic Syndrome. Epilepsia 2003: suppl 9: 138. 58. Novotny EJ, de Graaf R, Graeme FM, Appel M, Pearl P, Wong KL, Gibson KM, Rothman DL. Brain GABA in SSADH Deficiency. Epilepsia 2003; suppl 9: 248-9. 57. Pearl PL, Acosta MT, Novotny EJ, Jakobs C, Gibson KM. Clinical and Metabolic Investigations Offer New Insights into Pathophysiology of SSADH Deficiency. Ann Neurol 2003; 54: S107. 56. Novotny EJ, de Graff R, Mason G, Appel M, Wong K, Gibson KM, Pearl P, Rothman DL. Brain GABA in SSADH Deficiency. Ann Neurol 2003; 54: S106-7. 55. Efron LA, Lewis J, Lewin D, Pearl P, Stein M: Sleep Difficulties and Attention Deficit Hyperactivity Disorder: Children’s Perspectives. Sleep 2003; 26: A378. 54. Novotny EJ, de Graaf R, Mason G, Appel M, Gibson KM, Pearl P, Rothman DL (2002) Brain GABA in SSADH Deficiency. International Society of Magnetic Resonance in Medicine, Annaul Meeting, May 20-24, Montreal, Quebec, Canada. MR Spectroscopy Imaging of GABA in SSADH Deficiency. Amer Soc Magn Reson in Medicine 2003. 53. Cushner-Weinstein S, Schlumpf K, Salpekar J, Gaillard W, Kolodgie M, Scully A, Pearl P, Conry J, McClintock W, Weinstein S: The Benefits of a Camp Designed for Children with Epilepsy: Evaluating Adaptive Behaviors in a 3-Year Study. Epilepsia 2002; 43 (Suppl 7): 227. 52. Bethke L, Cushner-Weinstein S, Salpekar J, Gaillard W, Pearl P, Weinstein S: Similarities and Differences Between Camps for Children with Epilepsy. Epilepsia 2002; 43 (Suppl 7): 226. 51. Pearl PL, Gaillard WD, Conry JA, Weinstein SL, Cogen PH, Salpekar J, Acosta MT, Rosser T, Elling NJ, Cushner-Weinstein S, Kelodgie M, Klein P, Rogawski MA, Theodore WH, Gibson KM: Epilepsy and EEG Characteristics in Succinic Semialdehyde Dehydrogenase Deficiency. Eplepsia 2002; 43 (Suppl 7): 170. 22
  23. 23. 50. Gaillard WD,Balsamo LM, Xu B, Sachs BC, Pearl PL, Conry JA, Weinstein S, Salpekar J, Jabbari B, Fratali C, Kopylev L, Sato S, Theordore WH: Functional Magnet Resonance Imaging Panel of Verbal Fluency and Auditory and Reading-Comprehension Tasks Identifies Language Dominance Compared with The Intracarotid Amytal Test. Epilepsia 2002; 43 (Suppl 7): 89. 49. Acosta MT, Chang T, Rosser T, Kolodgie M, Conry JA, Pearl PL, Weinstein SL, Johnson P, Vezina G, Dubovsky E, Gaillard WD: Neuroimaging in Children During the Immediate Evaluation of New- Onset Seizures. Epilepsia 2002; 43 (Suppl 7): 74-75. 48. Salpekar JA, Orell-Valente J, Cushner-Weinstein S, Pearl PL, Weinstein SL, Conry JA, Kolodgie MJ, Gaillard WD: Anxiety and Depressive Symptoms in Pediatric Epilepsia Patients. Epilepsia 2002; 43 (Suppl 7): 72. 47. Acosta MT, Huang ZH, Rosser T, Change T, Conry JA, Pearl PL, Weinstein SL, Kolodgie MJ, Mandler S, Cushner-Weinstein S, Johnson P, Gaillard WD: Cerebrospinal Fluid and Peripheral Leukocyte Count in Children during the Acute Evaluation of New-Onset Seizures. Ann Neuro 2002; 52 (Suppl 1): S147. 46. Acosta MT, Pearl PL, Vezina LG, Gibson KM: Neuroimaging Findings in Patients with Succinic Semialdehyde Dehydrogenase Deficiency. Ann Neuro 2002; 52 (Suppl 1): S137-138. 45. Chang T, Acosta MT, Rosser T, Conry JA, Pearl PL, Weinstein SL, Kolodgie M, Johnson P, Vezina G, Dubovsky E, Gaillard WD: Neuroimaging in Chilren during the Acute Evaluation of New-Onset Seizures. Ann Neuro 2002; 52 (Suppl 1): S134-135. 44. Gibson KM, Gupta M, Callan M, Senephansiri H, Polinsky M, Novotny EH, Pearl P, Jansen EEW, Kabbali A, Jakobs C: Abnormal GABA/Glutamine Metabolism in SSADH Deficiency, An Epilepsy Syndrome With Elevated CSF GABA. Am Soc Hum Gen 2002. 43. Pearl PL, Gibson M, Acosta MT, Weinstein SL, Tuchman M: SSADH Deficiency: Selective Ion Monitoring for 4-OH-Butyrate is Necessary in the Diagnosis of a Potentially Treatable Cause of Mental Retardation and Autistic Syndrome. Neurology 2002; 58 (Suppl 3): A8. 42. Pearl PL, Conry JA, Rosser T, Acosta MT, Chang T, Stahl AM, Allen E, Rich S, Reigle S, Mott SH, Weinstein SL, Gaillard WD: Role of EEG Monitoring in Autistic Syndrome Patients for the Identification of Landau-Kleffner Syndrome. Neurology 2002; 58 (Suppl 3): A28. 41. Acosta MT, Molina PA, Rosser T, Chang T, Reigle SC, Kolodgie MJ, Mandler S, Conry JA, Pearl PL, Weinstein SL, Gaillard WD: Acute Changes in Peripheral WBC Count in Children with Seizures. Neurology 2002; 58 (Suppl 3): A28. 40. Rosser T, Acosta MT, Pearl PL, Packer RJ: Aicardi Syndrome: Long-term Prognosis in 77 Patients. Neurology 2002; 58 (Suppl 3): A27. 39. Lavenstein BL, McClintock WM, Pearl PL: Childhood Sporadic Presentation of Dominantly Inherited Spinocerebellar Ataxia, Type 8 (SCA 8) with Molecular Genetic and Clinical Analysis. Neurology 2002; 58 (Suppl 3): A25-26. 38. Stein MA, Sarampote CS, Barueco S, Keymour K, Robb A, Conlon C, Pearl P: Effects of OROS methylphenidate on Parent and Teacher Ratings. J Am Acad Child Adol Psychiatr 2002. 37. Acosta MT, Reigle SC, Kolodgie MJ, Rosser T, Conry JA, Pearl PL, Weinstein SL, Vezina LG, Gaillard WD. Diagnostic Evaluation in New-Onset Seizure Patients. Epilepsia 2001; 42 (S7): 169. 36. Tran TD, Dubovsky EC, Pearl PL,Conry JA, Weinstein SL, Phulwani P, Whitnaw JR, Kondapanini P, Shao C, Gaillard WD. Magnetic Resonance Imaging (MRI) Evidence for Progressive Hippocampal Atrophy in Children with Complex Partial Epilepsy. Epilepsia 2001; 42 (S7): 168. 23
  24. 24. 35. Gaillard WD, Balsamo L, Xu B, Papero P, Weinstein SL, Conry JA, Pearl PL, Fratalli C, Sato S, Kopylev L, Vezina LG, Theodore WH. Functional Magnetic Resonance Imaging (fMRI) Identification of Language Dominance: Comoparison of Visual Reading, Region-of-Interest Analysis, and the Intracarotid Amytal Test. Epilepsia 2001; 42 (S7): 77-78. 34. Reigle SC, Gaillard WD, Pearl PL, Weinstein SL, Krohn K, Conry JA. Progressive Myoclonic Epilepsy (PME): Response of Seizures to Zonisamide. Epilepsia 2001; 42 (S7): 54. 33. Salpekar JA, Cushner-Weinstein S, Weinstein SL, Pearl PL, Conry JA, Kolodgie MJ, Papero P, Reigle SC, Gaillard WD. Behavioral Problems in a Sample of Pediatric Epilepsy Patients Prior to Epilepsy Surgery. Epilepsia 2001; 42 (S7): 162. 32. Pearl PL, Conry JA, Galgano M, Reigle S, Stahl A, Allen E, Rich S, Mott S, Weinstein SL, Gaillard WD. Overnight EEG Monitoring in Autistic Syndrome. Epilepsia 2001; 42 (S7): 50. 31. Rosser T, Acosta MA, Pearl PL, Packer RJ. Epilepsy Characteristics in 79 Patients with Aicardi Syndrome. Epilepsia 42 (S7): 51. 30. Gibson KM, Pearl PL, et al. Benzodiazepines in Adult Succinic Semialdehyde Dehydrogenase Deficiency (SSDD). J Inher Metab Dis 2001; 24 Suppl 1: 64. 29. Pearl PL, Conry JA, Reigle S, Stahl AM, Allen E, Rich S, Mott SH, Weinstein SL, Gaillard WD. Lack of Utility of EEG Monitoring in Autistic Syndrome Patients for the Identification of Landau- Kleffner Syndrome. Ann Neuro 2001; 50: S126. 28. Pearl PL, Tuchman M, Gibson KM, Gropman A, Lavenstein B, McClintock WM, Vezina LG, Weinstein SL. Succinic semialdehyde Dehdrogenase Deficiency: A Potentially Treatable Cause of Mental Retardation and Autistic Behaviors. Ann Neuro 2001; 50: S115. 27. Stahl A, Loh J, Vezina LG, Dubovsky EC, Pearl PL, Conry JA, Weinstein S, Mott SH, Gaillard WD. Left Hippocampal Abnormalities in Children with Pervasive Developmental Disorder. Ann Neuro 2001; 50: S95. 26. Acosta MT, Reigle SC, Kolodgie MJ, Rosser T, Conry JA, Pearl PL, Weinstein SL, Vezina LG, Gaillard WD. Diagnostic Evaluation in New-Onset Seizure Patients. Ann Neuro 2001; 50: S107. 25. Conry JA, Reigle SC, Gaillard WD, Pearl PL, Weinstein SL, Krohn K. Efficacy of Zonisamide in Progressive Myoclonic Epilepsy: A Case Series. Ann Neuro 2001; 50: S104. 24. Conry JA, Reigle SC, Gaillard WD, Pearl PL, Weinstein SL, Krohn K. Progressive Myoclonic Epilepsy: An Underrecognized Childhood Disease. Ann Neuro 2001; 50: S101. 23. Sarampote CS, Kissel AW, Efron L, Lewis J, Bromberg BA, Conlon C, Pearl P, Robb A, Stein MA. Tolerability and side effects for OROS methylphenidate: Dose response? Am Acad Child Adolesc Psych: in press. 22. Pearl PL, LaFleur BJ, Reigle SC, Sato S. Ultradian Rhythm Model Analysis of Cyclical REM Sleep Features. Epilepsia 41 (S7): 213-214, 2000. 21. Gaillard W, Xu B, Balsamo L, Grandin C, Papero P, Weinstein S, Conry J, Pearl P, Spanaki M, Petrella J, Sato S, Theodore W. FMRI Identification of Language Dominance in Patients with Complex Partial Epilepsy Using an Auditory Based Language Comprehension Task. Epilepsia 41 (S7), 83, 2000. 20. Papero P, Cushner-Weinstein S, Engel L, DeJonge M, Kologie M, Gaillard W, Pearl P, Conry J, Weinstein S. Behavioral Symptomatology in Relation to Social-Adaptive Behavior in Children at Epilepsy Summer Camp. Epilepsia 41 (S7): 196, 2000. 24
  25. 25. 19. Pearl PL, LaFleur B, Reigle SC, Freeman A, McCutchen C, Sato S. REM Sleep Physiology in Normal and Abnormal Sleep. Ann Neurology, 48: 524, 2000. 18. Pearl PL, LaFleur BJ, Reigle SC, Sato S. REM Sleep Neurophysiology: An Ultradian Rhythm Model Analysis. J Clin Neurophysiology, Suppl, 2000.. 17. Efron L, Lewis J, Marean L, Talebi H, Pearl P, Hamburger E, Stein M. Children’s Sleep Problems: Child and Parent Perspectives. J Dev Behav Ped, 21: 390, 2000. 16. Efron LA, Marean L, Schuman WB, Pearl P, Conlon C, Lewis J, Hamburger E, Stein M. Assessment of Parent and Pediatrician Satisfaction with Two Multidisciplinary Evaluation Clinics. Pediatric Research, 47(S4): 25A, 2000. 15. Lewis J, Efron L, Marean L, Pearl P, Hamburger E, Stein M. Sleep Difficulties: Child and Parent Perspectives. 14th Annual Advances in Pediatrics, Children’s Research Institute, Children’s National Medical Center, May 4, 2000. 14. Pearl P, Sato S, McCutchen C, LaFleur B, Reigle S, Freeman AH. Sawtooth Wave Density Analysis During REM Sleep in Normal Volunteers. Neurology 54 (S3): A31, 2000. 13. Krohn K, Lavenstein B, Pearl P, McClintock W: Pain as the Presentation of Childhood Tourette Syndrome: An Unrecognized Clinical Manifestation. Neurology 54 (S3): A49, 2000. 12. Conry JA, Cogen P, Gaillard WD, Pearl PL, Pincus D, Weinstein S: Efficacy of Vagus Nerve Stimulation (VNS) in Severely Impaired Children with Early Onset Epilepsy. Epilepsia 40(S7):123, 1999. 11. Cushner-Weinstein S, Smulowitz P, Papero P, Kolodgie M, Gaillard W, Pearl P, Conry J, Weinstein S: The Evaluation of Adaptive Behaviors in a Camp for Children with Epilepsy. Epilepsia 40(S7):65, 1999. 10. Kolodgie M, Cushner-Weinstein S, Papero P, Gaillard W, Pearl P, Weinstein S: A Clinic to Help Families Adapt to the New Diagnosis of Epilepsy. Epilepsia 40(S7):65, 1999. 9. Pearl PL, Stein MA, Broitman M, Efron L, Hamburger E: Sleep Disturbances in Children with ADHD. Ann Neurology 46:524, 1999. 8. Gropman A, Chen T, Sands N, Pearl P, Tifft C, Wong L: Pediatric Dystonia due to mtDNA Mutation at np 14459: Report of the Fourth Family. Ann Neurology 46:548, 1999. 7. Pearl PL, Krasnewich MD, Tartaglia ME, Gaillard WD, Weinstein SL, Conry JA: Neurodevelopmental Deficits and Paroxysmal Events in Carbohydrate-Deficient Glycoprotein Syndrome. Developmental Medicine and Child Neurology, 40, Suppl. 80:40-41, 1999. 6. Johnson DE, Aronson J, Federici RS, Pearl PL, Zeanah C. Growth Parameters Predict Neurological Status in Institutionalized Romanian Orphans. Pediatric Research, May(Suppl) 1999. 5. Pearl PL, Krasnewich D, Gaillard WD, Weinstein SL, Conry JA, Vezina LG, Dubovsky E, Krohn KA, Packer RJ. Neurological Course and Complications in Carbohydrate-Deficient Glycoprotein Syndrome, Ann Neurol, 44: 579, 1998. 4. Gaillard WD, Pearl PL, Conry JA, et al. Organ Failure, Organ Transplant and Immune Compromise: Newly Identified Risk Factors for Partial Epilepsy and Mesial Temporal Sclerosis, Ann Neurol, 44: 556, 1998. 3. Conry JA, Gaillard WD, Pearl PL, Weinstein S. Differentiating Seizures from Gastroesophageal Reflux Using Simultaneous Video Electroencephalogram and pH Probe,” Ann Neurol, 44: 571, 1998. 25
  26. 26. 2. Gaillard WD, Weinstein S, Pearl PL, et. al. Natural History of Metabolic Abnormalities in Children with Partial Epilepsy Determined by FDG-PET. Epilepsia 39, suppl 6:101, 1998. 1. Flockhart DA, Richard E, Woosley RL, Pearl PL, Drici MD, A Metabolic Interaction Between Clarithromycin and Pimozide May Result In Cardiac Toxicity, Am Soc Clin Pharmacol and Therap. 59: 189, 1996. E. Invited Newsletter Publications 7. Pearl PL: Analysis of REM Sleep Physiology. American Academy of Sleep Medicine Pediatric Section Newsletter, 3, 2001. 6. Pearl PL: Sleep Disorders in Adolescents. American Academy of Pediatrics Adolescent Health Section Newsletter, Spring 2000. 5. Pearl PL: Sleep Disorders and ADHD: True, True, and Unrelated? American Academy of Sleep Medicine Pediatric Section Newsletter, 2: 1-3, 2000. 4. Pearl PL: “Institutionalization and the Brain”, The Post: Bulletin of the PNPIC (Parent Network for the Post-Institutionalized Child), No. 15, Jan/Feb 1998. 3. Pearl PL: “The Ketogenic Diet: An Alternative Approach to Seizures,” Dialogue: National Tuberous Sclerosis Foundation Newsletter, Spring 1997. 2. Pearl PL: “Migraine and its Equivalents in Children,” Neurology Center Report, Chevy Chase, MD, 1992. 1. Pearl PL: “Antiepileptic Drug Therapies in Children,” Neurology Center Report, Chevy Case, MD, 1991. F. Editorials 4. Knerr I and Pearl PL: Ketogenic Diet – Stoking Energy Stores and Still Posing Questions. Exp Neurol: 2008;211:11-13. 3. Pearl PL and Gospe SM: Pyridoxal Phosphate Dependency: A Newly Described Treatable Catastrophic Infantile Epilepsy. J Inherit Meb Dis 2007;30:2-4. 2. Pearl PL: Inherited Disorders of Neurotransmitters: An Enlarging Group of Neurometabolic Diseases. Future Neurology 2006: 1:589-591. 1. Pearl PL: Sleep Problems, ADHD, and Stimulants: True, True, Unrelated? Sleep Medicine 2003; 4:271-2. G. Book Review Pearl PL: Clinical Use of Anticonvulsants in Psychiatric Disorders, RM Post, MR Trimble, and CE Pippenger, Demos Publications, J Epilepsy 4:245-246, 1991. H. Letters to the Editor 2. Pearl PL and McClintock WM: Addendum to assessment: Prevention of post-lumbar puncture headaches: Report of the TTAS of the AAN. Neurology 2006; 66: 1285. 1. Pearl PL and Gropman A: Monitoring Gamma-hydroxybutyric acid in SSADH Deficiency. Ann Neurol 2004; 55:599. 26
  27. 27. I. Electronic Media 5. Pearl P: Pediatric Board Review: Neurology I-IV. CME info. Oakstone Medical Publishing, LLC, Birmingham, AL 2007. 4. Pearl PL: Ketogenic Diet and Alternative Therapies for Epilepsy. DVD: Educational Program in Epilepsy. Comprehensive Pediatric Epilepsy Program, CNMC 2004. 3. Pearl PL: Encouraging Words Videotape: Language Development from Birth to Age Five, Part I: Stimulating Receptive Language. Center for Promotong Family Learning and Involvement, Fairfax County Public Schools 2002. 2. Pearl PL: Encouraging Words Videotape: Language Development from Birth to Age Five, Part 2: Enriching Expressive Language. Center for Promotong Family Learning and Involvement, Fairfax County Public Schools 2002. 1. Pearl PL: Encouraging Words Videotape: Language Development from Birth to Age Five, Part 3: Print Awareness – Beyond the Spoken Word. Center for Promotong Family Learning and Involvement, Fairfax County Public Schools 2002. J. Miscellaneous 2. Music CD: Live at Jazzmatazz: The Drs. Phil Pearl/Jorge Rodriguez Children’s Hospital Jazz Band, Kross Link Management/Studio, Washington, DC 2005. 1. Pearl PL: Preface, Help for the Hopeless Child. RS Federici, Hennage Creative Printers, Alexandria, VA 1998. X. PRESENTATIONS A. Regional Presentations 116. Pearl PL: Neurology I-IV, Pediatric Board Review Course, Children’s National Medical Center, August 21, 2008. 115. Pearl PL: New Treatment Paradigms in Neonatal Epilepsies. Neurology Grand Rounds: Veterans Affairs Hospital, Washington, DC, August 2008. 114. Peloquin P, Khademian Z, Fricke S, Pearl PL: Pediatric Normative Database in MR Spectroscropy. Eighth Annual CNMC Research Day, May 15, 2008. 113. Pearl PL: Sleep and Epilepsy: Interrelationships. Sleep Laboratory Conference, CNMC, December 13, 2007. 112. Pearl PL: New Biology and Recommendations in Autism. Neurology Grand Rounds, GWU School of Medicine, December 12, 2007, Washington, DC. 111. Pearl PL: What’s NEW in Pediatric Epilepsy? CNMC Pediatric Neurology CME Program, Mary Washington Hospital, Fredericksburg, VA, December 11, 2007. 110. Pearl PL: The Biology of Autism. 27th Annual US Army Medical Department of Neurology Conference, November 14, 2007, Washington, DC. 109. Pearl P: Pediatric Board Review Course, Children’s National Medical Center, August 23, 2007. 27
  28. 28. Neurology I: Headaches, Intracranial Pressure, Trauma. Neurology II: CNS Infections, Stroke Neurology III: Seizures and Epilepsy Neurology IV: Cerebral palsy, Degenerative disorders, Spinal cord, Neuropathy, Myopathy 108. Pearl PL, Trzcinski S, Molloy-Wells E, McClintock WM, Vezina LG, Conry JA, Elling NJ, Tsuchida T, Weinstein SL, Gaillard WD: Cerebral MRI Abnormalities Associated with Vigabatrin Therapy: Higher Risk in Infants? 7th Annual Children’s National Medical Center Research Day, May 17, 2007. 107. Taylor JL, Pearl PL, Trzcinski S, Sokohl A, Gibson KM, Theodore WH: 11C-Flumazenil PET Imaging in Patients with SSADH Deficiency. 7th Annual Children’s National Medical Center Research Day, May 17, 2007. 106. Trzcinski S, Pearl PL, Sandoval F, Klein P: Demographic Data of Acute Traumatic Brain Injury Patients Based on a Levetiracetam Tolerability and Feasibility Study. 7th Annual Children’s National Medical Center Research Day, May 17, 2007. 106. Pearl P: Heritable Succinate Semialdehyde Dehydrogenase Deficiency: A Disorder of GABA Catabolism. Grand Rounds, NINDS (National Institute of Neurological Disorders and Stroke), NIH, Bethesda, MD, Feb 6, 2007. 105. Pearl P: Alternative Therapies. Partnerships to Improve Care for Children and Youth with Epilepsy. DC Dept Public Health, EFA, CNMC. Galludet University, Washington, DC, Nov 9, 2006. 105. Pearl P: Pediatric Board Review Course, Children’s National Medical Center, August 23, 2006. Neurology I: Headaches, Intracranial Pressure, Trauma. Neurology II: CNS Infections, Stroke Neurology III: Seizures and Epilepsy Neurology IV: Cerebral palsy, Degenerative disorders, Spinal cord, Neuropathy, Myopathy 104. Pearl P: Pediatric Neurotransmitter Diseases. Genetics Fellows Interest Group, NIH, Bethesda MD, May 31, 2006. 103. Pearl P, Conry J, Renuart A, Cabalza T, Tsuchida T, Elling N, Yaun A, Myseros J, Bruce D, Kolodgie M, Cushner-Weinstein S, Weinstein S, Gaillard W. Misidentification of VNS Wire for IV Access and Other Adverse Events in a Pediatric Epilepsy Program. 6th Annual Pediatric Research Poster Day, Children’s Research Institute, May 11, 2006. 102. Pearl P, Cabalza J, Harka T, Bottiglieri T, Acosta M, Gibson K. Inherited Gamma- Hydroxybutyric Acidemia and Sleep. 6th Annaul Pediatric Research Poster Day, Children’s Research Institute, May 11, 2006. 101. Pearl PL: Herbs in Epilepsy. Epilepsy Foundation of the Chesapeake Region, Falls Church, VA, April 19, 2006. 100. Pearl PL: Neurology of Famous Musicians: In Words and Music. Neurology Update Course 2006. Children’s National Medical Center, March 1, 2006. 99. Pearl PL: Inherited Disorders of Neurotransmitters. Grand Rounds, Department of Neurology, George Washington University School of Medicine and Health Sciences, Nov 30, 2005. 97. Pearl PL: Pediatric Neurotransmitter Diseases. Neuroscience Conference, CNMC, Sept 15, 2005. 96. Pearl P: Pediatric Board Review Course, Children’s National Medical Center, August 24, 2005. Neurology I: Headaches, Intracranial Pressure, Trauma. 28
  29. 29. Neurology II: CNS Infections, Stroke Neurology IV: Cerebral palsy, Degenerative disorders, Spinal cord, Neuropathy, Myopathy 95. Pearl PL: Teaching a Medical Skill. LEND (Leadership Education in Neurodevelopmental Disabilities) Program, CNMC, Washington, DC, May 25, 2005. 94. Pearl PL, Bottiglieri T, Acosta MT, Bennett HD, Miotto K, Gibson KM: Extrapyramidal Manifestations in SSADH Deficiency: Implications for GHB Toxicity. Children’s Research Institute, Annual Poster Day, CNMC, Washington, DC, May 19, 2005. 93. Pearl PL: Pediatric Neurotransmitter Disorders. Grand Rounds, Dept Ped Neurology, Johns Hopkins Hospital, Baltimore, MD, April 2005. 92. Pearl PL and Bennett HD: What’s your Leadership Potential and Human Capability IQ? NE Group on Educational Affairs, American Association of Medical Colleges, Washington, DC, March 2005. 91. Pearl P: Qualitative Study of Teaching a Clinical Skill: EEG Interpretation. NE Group on Educational Affairs, American Association of Medical Colleges, Washington, DC, March 2005. 90. Pearl P: Diagnostic Dilemmas in Neurogenetics: Case Studies. Neurology Update 2005, CNMC, March 2005. 89. Pearl P: Human Capability and Leadership IQ. Seminars in Faculty Development, GWU School of Medicine, Washington, DC, Dec 21, 2004. 88. Pearl P: Pediatric Neurotransmitter Disorders. Grand Rounds, Dept Neurology, VA Hospital, Washington, DC, Nov 24, 2004. 87. Pearl P: Localization of Gait Disturbances. Dept Ambulatory Pediatrics, CNMC, Washington, DC, Nov 24, 2004. 86. Pearl P: Infantile Spasms. Professorial Rounds, CNMC Dept Pediatrics, October 21, 2004. 85. Pearl P: Pediatric Board Review Course, Children’s National Medical Center, August 26, 2004. Neurology I: Headaches, Intracranial Pressure, Trauma. Neurology II: CNS Infections, Stroke Neurology IV: Cerebral palsy, Degenerative disorders, Spinal cord, Neuropathy, Myopathy 84. Pearl P: Pediatric Neurotransmitter Diseases. Grand Rounds, Dept Neurology, University of Virginia School of Medicine, Charlottesville, VA, Aug 6, 2004. 83. Pearl P: Human Potential and Leadership IQ: The Theories of Eliot Jaques. Master Teacher Program in Medical Education, CNMC, July 28, 2004. 82. Pearl P: Clinical Aspects of SSADH Deficiency. Meeting of the Pediatric Neurotransmitter Disease Association, Crystal City, VA, July 8-11, 2004. 81. Tuck M, Rosser T, McClintock W, Elling N, Pearl P: Epilepsy Characteristics in Tuberous Sclerosis. CNMC Annual Research Day, Washington, DC, May 11, 2004. 80. Pearl P: Recent Trends in Pediatric Epilepsy Research and Practice. National Capital Cure Epilepsy Conference, National Academy of Sciences, Washington, DC, March 12, 2004. 79. Pearl P: Pediatric Neurotransmitter Diseases. Annual Meeting of the Virginia Neurological Society, Hot Springs, VA, Feb 13, 2004. 78. Pearl P: New Treatments in Epilepsy. Epilepsy Foundation Symposium: “Epilepsy, School & Treatments: Helping Your Child with Epilepsy.” Fairfax Hospital for Children, Nov 8, 2003. 29
  30. 30. 77. Pearl P: Pediatric Neurology Education. Department of Neurology Educational Retreat, Georgetown University School of Medicine, October 2003. 76. Pearl P: Infantile Spasms. Pediatric Practice and Residency Program, GW School of Medicine, October 29, 2003. 75. Pearl P: Pediatric Board Review Course, Children’s National Medical Center, August 21, 2003. Neurology I: Headaches, Intracranial Pressure, Trauma. Neurology II: CNS Infections, Stroke Neurology IV: Cerebral palsy, Degenerative disorders, Spinal cord, Neuropathy, Myopathy. 74. Pearl P: Emergency Department CME Series: Localization of Gait Disturbances, May 2003; Coma Examination, June 2003. 73. Pearl P: Apparent Life Threatening Events (ALTE): Neurologic Aspects. 1st Annual Pediatric Hospitalist Conference. Holy Cross Hospital, Silver Spring, MD, May 29, 2003. 72. Pearl P: Effective Teaching of EEG: A Qualitative Research Study. 3rd Annual Pediatric Research Poster Day. Children’s Research Institute, Washington, DC, May 13, 2003. 71. Pearl P, Gaillard W, Conry J, Weinstein S, Cogen P, Salpekar J, Acosta M, Rosser T, Elling N, Cushner-Weinstein S, Kelodgie M, Klein P, Rogawski M, Theodore W, Gibson KM: Epilepsy and EEG Characteristics in Succinic Semialdehyde Dehydrogenase Deficiency. 3rd Annual Pediatric Research Poster Day. Children’s Research Institute, Washington, DC, May 13, 2003. 70. Gaillard W, Balsamo L, Xu B, Sachs D, Grandin C, Pearl P, Conry J, Weinstein S, Salpekar J, Jabbari B, Sato S, Frattali C, Papero P, Ritter F, Vezina G, Theodore WH: fMRI Panel of Verbal Fluency, Auditory, and Reading Comprehension Identifies Language Dominance Compared to the Intracarotid Amytal Test. 3rd Annual Pediatric Research Poster Day. Children’s Research Institute, Washington, DC, May 13, 2003. 69. Salpekar J, Orell-Valente J, Cushner-Weinstein S, Pearl P, Weinstein S, Conry J, Kolodgie M, Gaillard W: Anxiety and Depressive Symptoms in Pediatric Epilepsy Patients. 3rd Annual Pediatric Research Poster Day. Children’s Research Institute, Washington, DC, May 13, 2003. 68. Pearl PL: Clinical Disorders of GABA Metabolism, Grand Rounds, Dept. Neurology, VA Hospital, Washington, DC, April 18, 2003. 67. Pearl PL. Mycoplasma Encephalitis. Professorial Rounds, CNMC, March 6, 2003. 66. Pearl PL and Conry JA. Alternative Medicine for Epilepsy. Neurology Update Course, CNMC, March 5, 2003. 65. Pearl PL: Treating Insomnia in Children, Grand Rounds, Dept. Pediatrics, INOVA Alexandria Hospital, January 17, 2003. 64. Pearl PL and Lewin D: Sleep Disorders in Children: The Art and Science. Combined Division/ Community Pediatrics/ General Pediatrics,Children’s National Medical Center, Sept. 19, 2002. 63. Pearl PL: Neurology IV: Neuropathy/Myopathy/Myelopathy/CP. Pediatric Board Review Course, Children’s National Medical Center, Bethesda, MD, August 2002. 62. Pearl PL: Neurology I: Headaches, Increased Intracranial Pressure. Pediatric Board Review Course, Children’s National Medical Center, Bethesda, MD, August 2002. 61. Pearl PL: Sleep Disorders in Children. Grand Rounds, Dept. Otolaryngology, Children’s National Medical Center, Washington, DC, June 26, 2002. 30
  31. 31. 60. Pearl PL: Updates in Pedaitric Neurology, Northern VA ADHD Professional Interest Group, Fairfax, VA, May 10, 2002. 59. Pearl PL: Epilepsy: New Approaches to Treatment. Grand Rounds, INOVA Alexandria Hospital, Alexandria, VA, March 8, 2002. 58. Pearl PL: Sleep Disorders – Therapy. Neurology Update Course 2002, Children’s National Medical Center, George Washington Univ. Sch. Medicine, Washington, DC, March 6, 2002. 57. Pearl PL: New Treatments for Epilepsy. Grand Rounds, Dept. Pediatrics, Prince William Hospital, Manassas, VA, February 21, 2002. 56. Pearl PL: New Therapies in Epilepsy. Grand Rounds, Dept. Pediatrics, Georgetown University School of Medicine, Washington, DC, January 11, 2002. 55. Pearl PL: Antiepileptic Therapies, Dept. Pediatrics Residency Program, INOVA Fairfax Hospital For Children, December 17, 2001. 54. Pearl PL: Gait Disturbances. Professorial Rounds, Dept. Pediatrics, Children’s Natl Med Ctr, August 30, 2001 53. Pearl PL: Neurology: Differential Diagnosis of Weakness. Pediatric Board Review Course, Children’s National Medical Center, Bethesda, MD, August 23, 2001. 52. Pearl PL: Seizures and Epilepsy, George Washington University School of Medicine, 8/22/01, 9/19/01, 11/14/01. 51. Pearl PL: Coma. Dept. Pediatrics, INOVA Fairfax Hospital for Children, University of Virginia School of Medicine Affiliated Hospital, Fairfax, VA, July 16, 2001. 50. Pearl PL: Neuroembryology and Congenital Brain Malformations, Grand Rounds, Dept. Neurology, Veterans Administration Hospital, Washington, D.C., April 2001. 49. Pearl PL: Epilepsy, Medical Student Course, Children’s National Medical Center, March 29, 2001. 48. Pearl PL: Practice of Medicine Course, George Washington University School of Medicine, March 29, 2001. 47. Pearl PL: Seizures and Epilepsy, George Washington University School of Medicine, March 26, 2001. 46. Pearl PL: Sleep Investigations. Neurology Update Course 2001. Children’s National Medical Center, George Washington University School of Medicine, Washington , D.C., March 14, 2001. 45. Pearl PL: New Therapies in Epilepsy, Grand Rounds, Dept. Pediatrics, INOVA Fairfax Hospital for Children, February 8, 2001. 44. Pearl PL: Neurology: Cerebral Palsy, Spinal Cord, Neuropathy, Myopathy: Pediatric Board Review Course, Children’s National Medical Center, Bethesda, MD, August 24, 2000. 43. Pearl PL: New Agents and Uses of Anticonvulsants, Northern Virginia Training Center, Fairfax, VA, May 24,2000. 42. Pearl PL: Sleep Disorders in Children, Grand Rounds, Dept. Pediatrics, Georgetown University School of Medicine, May 5, 2000. 31
  32. 32. 41. Lewis J, Efron L, Marean L, Pearl P, Hamburger E, Stein M. Sleep Difficulties: Child and Parent Perspectives. 14th Annual Advances in Pediatrics, Children’s Research Institute, Children’s National Medical Center, May 4, 2000. 40. Pearl PL: Sawtooth Wave Density Analysis During REM Sleep in Normal Volunteers, Abstract Winner Presentation, 14th Annual Advances in Pediatrics, Children’s Research Institute, Children’s National Medical Center, May 4, 2000. 39. Pearl PL: Management of Head Trauma, Pediatric Conference, George Washington University School of Medicine, March 29, 2000. 38. Pearl PL: Sleep Disorders, Neurology Update Course 2000, Children’s National Medical Center, Washington, D.C., March 2, 2000. 37. Pearl PL: Autism and Landau-Kleffner Syndrome. Dept. Nursing Neuroscience Course, Children’s National Medical Center, September 30, 1999. 36. Pearl PL: Sleep Disorders in Adolescents. Dept. Adolescent Medicine Grand Rounds, Children’s National Medical Center, September 28, 1999. 35. Pearl PL: Neurology: Cerebral Palsy, Spinal Cord, Neuropathy, Myopathy, Pediatric Board Review Course, Children’s National Medical Center, August 1999. 34. Efron L, Pearl P, Broitman M, Hamburger E, Stein M: Insomnia and ADHD: Exploring the Connections. 13th Annual Advances in Pediatrics: Educational and Scientific Forum. Children’s National Medical Center, April 1999. 33. Gaillard WD, Pearl PL, Conry JA, Weinstein SL, Phulwani P, Whitnaw JR, Braniecki S, Kolodgie M, Dubovsky EC, Vezina LG: Organ Failure, Organ Transplant and Immune Compromise: Newly Identified Risk Factors for Partial Epilepsy and Mesial Temporal Sclerosis. 13th Annual Advances in Pediatrics: Educational and Scientific Forum. Children’s National Medical Center, April 1999. 32. Pearl PL, Krasnewich D, Gaillard WD, Weinstein SL, Conry JA, Vezina LG, Dubovsky E, Krohn KA, Packer RJ: Neurological Course and Complications in CDGS. 13th Annual Advances in Pediatrics Educational and Scientific Forum. Children’s National Medical Center, April 1999. 31. Pearl PL: Disorganization of Personality and Cognitive Development: Autism, Pediatric Neurology Update 1999, Children’s National Medical Center, March 4, 1999. 30. Pearl PL: The Biological Basis of Autism, Dept. Pediatrics Grand Rounds, Georgetown University School of Medicine, February 12, 1999. 29. Pearl PL: Institutionalization and the Brain, Post-Institutionalization: The Internationally Adopted Child, Children’s Natl Med Ctr, October 17, 1998. 28. Pearl PL: Overview, Post-Institutionalization: The Internationally Adopted Child, Children’s National Medical Center, George Washington Univ Sch Medicine, October 16-18, 1998. 27. Pearl PL: Epilepsy, Sexuality, and Pregnancy, Epilepsy Lecture Series, Children’s National Medical Center, October 6, 1998. 26. Pearl PL: Electroencephalography, Seventh Annual Electroneuro-Diagnostic Symposium, INOVA Fairfax Hospital, April 1998. 32
  33. 33. 25. Pearl PL: ADHD For the Primary Care Physician, Pediatric Advances 1998, Children’s National Medical Center, Washington, D.C., March/May 1998. 24. Pearl PL: Medical Therapies in Attention Deficit Hyperactivity Disorder, Learning Disabilities Association International Annual Meeting, Washington, D.C., March 12, 1998. 23. Pearl PL: Genetics and Sleep Disorders of Childhood, Annual Neurology CME Update Course, Children’s National Medical Center, March 5, 1998. 22. Pearl PL: Intracranial Hemorrhage in the Newborn, Neonatal Intensive Care Unit Course, Children’s National Medical Center, Wash., D.C., October 1997. 21. Pearl PL: The Post-Institutionalized Child, Grand Rounds, Dept Pediatrics, Fairfax Hospital, VA, July 1997. 20. Pearl PL: Tics and Tourette Syndrome, Grand Rounds, Dept Pediatrics, Prince William Hospital, VA, June 1997. 19. Pearl PL: New Antiepileptic Drugs, Grand Rounds, Dept Pediatrics, Fairfax Hospital, VA, November 1996. 18. Pearl PL: Attention Deficit Hyperactivity Disorder - Medical Therapies, Arlington Hospital Seminar, February 1996. 17. Pearl PL: Autism and Its Variants, Grand Rounds, Dept Pediatrics, Arlington Hospital, VA, January 1996. 16. Pearl PL: Sleep Disorders in Children, Grand Rounds, Dept Pediatrics, Fairfax Hospital, VA 1995. 15. Pearl PL: Pediatric Sleep Disorders, Grand Rounds, Dept Pediatrics, Georgetown University School of Medicine, Washington, D.C. 1994. 14. Pearl PL: Sleep Disorders in Children, Robert Eckle M.D. Memorial Conference on Pediatric Neurologic Disorders, Kaiser-Permanente Medical Group, Kensington, MD 1994. 13. Pearl PL: Congenital Brain Abnormalities and Teratogen Effects, Grand Rounds, Dept Pediatrics, Fairfax Hospital, VA 1994. 12. Pearl PL: Pediatric Epilepsy Syndromes and EEG, C.R.E.S.T. (Capital Registered Electrophysiology Society Technologists) Annual Meeting, Fairfax Hospital, VA 1992. 11. Pearl PL: Migraine in Children, Grand Rounds, Dept Pediatrics, Alexandria Hospital, VA 1992. 10. Pearl PL: Clinical Neuroembryology, Grand Rounds, Dept Pediatrics, Arlington Hospital, VA 1992. 9. Pearl PL: Coma, Grand Rounds Presentation, Dept Pediatrics, Prince William Hospital, VA 1992. 8. Pearl PL: Neurology Lecture: Coma, Fairfax Family Practice Center, Fairfax, VA 1992. 7. Pearl PL: What is a Seizure, Conference on Epilepsy in Adolescence, Epilepsy Foundation of America National Capital Area, Children's National Medical Center, Wash., D.C. 1992. 6. Pearl PL: Medical Aspects of Autism, Northern Virginia Chapter, Autism Society of America, Fairfax, VA 1991. 33
  34. 34. 5. Pearl PL: CPC: Mitochondrial Encephalopathies, Grand Rounds, Dept Pediatrics, Fairfax Hospital, VA 1991. 4. Pearl PL: Epilepsies in Childhood, Grand Rounds, Dept Pediatrics, Georgetown University School of Medicine, Wash., D.C., 1991. 3. Pearl PL: Pediatric Epilepsy Syndromes, Grand Rounds, Dept Pediatrics, University of Maryland School of Medicine, Baltimore, MD, March 1991. 2. Pearl PL: Epilepsy Syndromes, Grand Rounds Presentation, Dept Pediatrics, Fairfax Hospital, VA, December 1990. 1. Pearl PL: Absence Seizures, Grand Rounds Presentation, Dept Pediatrics, Arlington Hospital, VA, September 1990. B. National Presentations 44. Pearl PL: Treatment Approaches in Gamma-Hydroxybutyric Aciduria: Lessons From Mice and Men and the NIH Protocols. Medical Management of Pediatric Neurotransmitter Disorders: A Multidisciplinary Approach. NINDS Office of Rare Diseases, Johns Hopkins University School of Medicine, and PNDA. Herndon, VA, July 18, 2008. 44. Pearl PL: Neurology of Famous Musicians. American Academy of Neurology, Chicago, IL, May 2008. 43. Pearl PL and Rodriguez J: Neurology of Jazz Giants: In Words and Music. Child Neurology Society, Quebec City, Quebec, Canada, October 10, 2007. 42. Pearl PL, Taylor JT, Trzcinski S, Sokohl A, Gibson KM, Theodore WH. 11C-Flumazenil PET Imaging in Patients with SSADH Deficiency. NIH Center for Rare Diseases: Symposium on Research in Rare Diseases. Bethesda, MD, September 5, 2007. 41. Pearl PL, Newmark J, Pascuzzi R: Neurology of Famous Musicians and Composers. American Academy of Neurology, Boston, MA, April 2007. 40. Pearl PL: Seminar – Neurology of Famous Musicians: In Words and Music. Child Neurology Society. Pittsburgh, PA, October 21, 2006. 39. Pearl PL: Neurological Problems of Famous Jazz Musicians. American Academy of Neurology. San Diego, CA, May 1, 2006. 38. Pascuzzi R and Pearl PL: The Lightning Round. Course: The Neurology of Famous Musicians and Composers. American Academy of Neurology. San Diego, CA, May 1, 2006. 37. Pearl PL: Heritable Succinate Semialdehyde Dehydrogenase Deficiency, a Disorder of GABA Catabolism. American College of Medical Genetics. San Diego, CA, April 23, 2006. 36. Pearl PL: Clinical Features of Aicardi Syndrome. Annual Meeting of the American Epilepsy Society. Washington, DC, December 5, 2005. 35. Pearl PL: Sleep Disorders in Older Children and Adolescents. American Academy of Pediatrics Annual Meeting. Washington, DC, October 8, 2005. 34. Pearl PL, Bottiglieri T, Acosta MT, Bennett HD, Miotto K, Gibson KM: Extrapyramidal Manifestations of SSADH Deficiency: More Severe Phenotype and Relevance to GHB Toxicity. Annual Meeting of the Pediatric Academic Societies (PAS). Washington, DC, May 17, 2005. 34

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