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  • 1. BIO-DATA Name : Dr. Birendra Nath Mallick Designation : Professor of Neurobiology Department : School of Life Sciences, Jawaharlal Nehru University Institution & Address : New Delhi - 110 067, INDIA FAX - 011-2671-7586; 011-2671-7558; 011-2671-7580 E. Mail : remsbnm@yahoo.com Date of Birth : 1. 8. 1956 Educational Qualification (starting from Bachelor's Degree) : ____________________________________________________________________________ Degree Year University Subject/s ____________________________________________________________________________ B.Sc. 1978 Calcutta Physiology (Hons) ____________________________________________________________________________ M.Sc. 1981 Calcutta Physiology ____________________________________________________________________________ Ph.D. 1986 AIIMS Neurophysiology of Sleep-Wakefulness _____________________________________________________________________________ D.M.S. 1979 Council of Homoeopathic Medicine(W.B.) Medicine subjects _____________________________________________________________________________ Chronology of Appointments : _____________________________________________________________________________ _ July 1981- August 1983 - Teaching Fellow, Department of Physiology, AIIMS ______________________________________________________________________________ Sept 1983- June 1986 - Senior Demonstrator, Department of Physiology, AIIMS ______________________________________________________________________________ June 1986 - September 1993 - Asstt. Prof., School of Life Sciences, JNU ______________________________________________________________________________ May 1987- July 1988 - Research Assoc., UCLA, USA ______________________________________________________________________________ March 1993 - July 1993 - Visiting Asstt. Prof., Harvard Medical School, USA ______________________________________________________________________________ October 1993 - September 2001 - Assoc. Professor, School of Life Sciences, JNU ______________________________________________________________________________ March 1995 - July 1995 - Visiting Assoc. Prof., Dept. of Neuropsychiatry, UCLA, USA ______________________________________________________________________________ March 1997 - July 1997 - Visiting Assoc. Prof., Dept. of Neuropsychiatry, UCLA, USA ______________________________________________________________________________ October 2001 - Continuing - Professor, School of Life Sciences, JNU ______________________________________________________________________________ Nov-Dec 2002 - Visiting/Guest Professor, Univ of Université de Nice Sophia-Antipolis Faculté des Sciences Nice Cedex 2 FRANCE ________________________________________________________________________________ SOME RELEVANT CREDENTIALS _____________________________________________________________________________
  • 2. __ B. K. S. Medal (1978) --- B.Sc. (1st in College) _____________________________________________________________________________ __ University Gold Medal (1981) --- M.Sc. (1st in Calcutta University) _____________________________________________________________________________ _ B. K. Anand Research Prize (1984) --- Association of Physiologists & Pharmacologists of India _____________________________________________________________________________ _ Shakuntala Amir Chand Award (1992) --- Indian Council of Medical Research, Govt. of India _____________________________________________________________________________ _ National Bioscience Award (1999) ----- Department of Biotechnology, Govt. of India _____________________________________________________________________________ _ Elected Fellow of The National Academy of Sciences (F.N.A.Sc.) (2000) _____________________________________________________________________________ _ Shanti Swarup Bhatnagar Prize ----- Council of Scientific & Industrial Research, Govt. of India (Medical Sciences) (2001) _____________________________________________________________________________ __ Ramendra Sundar Sinha Memorial Oration (2001) ---- Physiological Society of India _____________________________________________________________________________ _ Chandra Kanta Dandiya Prize (2001) --- P C Dandiya Trust, India Elected Fellow of The Indian National Science Academy (F.N.A.) (2004) _____________________________________________________________________________ _ Elected Member of the Guha Research Conference (2004) _____________________________________________________________________________ Served Peer Reviewer for International Science Journals (Alphabetical list) : Brain Research; Brain Research Bulletin; Brain Research Protocol; Brazilian Journal of Medicine & Biomedical Research; Developmental Brain Research, European Journal of Neuroscience; Journal of Neuroscience Research; Neuroscience; Pharmacology Biochemistry & Behavior; Pharmacological Research; SCIENCE; Sleep; Sleep & Hypnosis; Sleep Research Online
  • 3. _____________________________________________________________________________ __ Served Peer Reviewer for National Science journals : IJPP IJEB IJMR PINSA Member National Level Scientific/Academic Committees : CSIR DBT DST ICMR UGC _____________________________________________________________________________ _ Editorial Board Member of "Sleep and Hypnosis " (International Journal) Editorial Board Member of "Neurobiology of sleep-wakefulness cycle" (International Journal) Editorial Board Member of "Indian Journal of Physiology and Allied Sciences" _____________________________________________________________________________ _ Research Projects : a) Completed : Ten b) Ongoing : Four _____________________________________________________________________________ __ Ph.D. theses completed under my supervision - Eleven (others are continuing) M.Phil. & M.Sc. dissertation completed under my supervision - Eleven (others are continuing) Others short term trainee in the lab - More than twenty _____________________________________________________________________________ __ Course Co-ordinator - 4th Refresher Course Life Sciences, Academic Staff College, JNU, 1998 _____________________________________________________________________________ ____ Postgraduate and Ph.D. examiner for several Universities _____________________________________________________________________________ ____ Chaired session(s) during conferences/seminars/oration lectures, etc _____________________________________________________________________________ ___ Co-Chair Maj. Gen. S. L. Bhatia Oration Lecture, 1993, Trivandrum Co-Chair Symposium - 3rd World Fed Sleep Res Soc Meeting, Dresden, Germany, Oct 3-9,
  • 4. 1999 Chair Symposium - 3rd Asian Sleep Research Society Meeting, Bangkok, Dec 3-7, 2000 Co-Chair Indo-US Symposium on Brain Research, New Delhi, Jan 10-12, 2002 Chair Symposium - 4th Asian Sleep Research Society Meeting, Zhuhai, China, Feb 28-Mar 2, 2004 Membership : (International) : International Brain Research Organization (IBRO); Sleep Research Society, USA (SRS) _____________________________________________________________________________ ___ (National) : ISCA; ; APPI; NSI; IAN; ISC; ISCB About students : - Five published papers were judged best papers and my students were awarded by APPI - Four posters (students) were judged best poster/presentation during National conferences and students/researchers were awarded. - One of my students was shortlisted for the INSA Young Scientist Award, however, due to unavoidable circumstances she could not come from abroad for the final selection - Two of my Ph.Ds. (doing Post-Doc in USA) received Young Investigators Award in USA. ===================================================================== = Organizational : - Organizing Secretary, 38th Annual Conference of APPI, 1992 - Joint Organizing Secretary of the XI National Symposium of the ISC, 1996 - Organized one day mini-symposium on Neuroscience in SLS, JNU, April 1998 (BIC, JNU) ===================================================================== == Extracurricular : - President's Scout - Divisional School Team Hockey player
  • 5. OVERSEAS VISIT ___________________________________________________________________________ S.No Period Place visited Purpose of visit ___________________________________________________________________________ 1. May 87 - July 88 UCLA, USA Research on Sleep-wakefulness ___________________________________________________________________________ 2. July 88 (3 days) Osaka Bioscience Institute, Japan Delivered lecture ___________________________________________________________________________ 3. March 13-17, 1993 Mauii, USA WFSRS Meeting ___________________________________________________________________________ 4. Mar 93 - July 93 Harvard University, USA Research on Sleep-wakefulness __________________________________________________________________________ 5. Mar 95 July 95 Univ. of California, USA Research on Sleep-wakefulness ___________________________________________________________________________ 6. May 30 - June 4, 95 Nashville, USA Sleep Research Society Meeting _____________________________________________________________________________ 7. Mar 97 - July 97 UCLA, USA Research on Sleep-wakefulness _____________________________________________________________________________ 8. June 10 - 15, 97 SanFrancisco, USA Sleep Research Society Meeting ____________________________________________________________________________ 9. Aug 25-28, 97 Jerusalem, Israel Lecture during 2nd Asian Sleep Res Soc ______________________________________________________________________________ 10. Oct 4-9, 99 Dresden, Germany Co-Chair symposium, lectures during WFSRS Meeting _________________________________________________________________________________ 11. Oct 10-12, 99 Max Planck Institute for Psychiatry, Munich 2 Lectures ________________________________________________________________________________ 12. Dec 3-7, 2000 Bangkok, 3rd Asian Sleep Res. Soc. Meet Plenary Talk & Session Chair (2 talks) ________________________________________________________________________________ 13. June 28-30, 2001 INSERM Lyon, France Lectures _______________________________________________________________________________ 14. July 1-6, 2001 Berlin, Germany, 7th WCBP Symposium talk 15. Nov – Dec 2002 Univ of Université de Nice Sophia-Antipolis Guest Professor Faculté des Sciences Nice Cedex 2 FRANCE ______________________________________________________________________________
  • 6. 16. Feb 24-26, 2004 Neuro-Behavioural Biology Center Two Invited Lectures Mahidol University, Bangkok, Thailand ______________________________________________________________________________ 17. Feb 27-Mar 2, 2004ASRS Meeting, Zuhai, China Plenary Talk & Session Chair (2 Talks) _______________________________________________________________________________ 18. Mar 3-7, 2004 National Chung-Cheng University, Taiwan Two Invited Lectures ____________________________________________________________________________________ 19. Mar 3-7, 2004 Taipei Veterans General Hospital, Taiwan Invited Lecture ____________________________________________________________________________________ __ 20. Mar 3-7, 2004 Show Chwan Memorial Hospital, Taiwan Invited Lecture _____________________________________________________________________________ 21. Mar 3-7, 2004 Taiwan Invited Lecture ======================================================================= Invited lectures (International) : Outside India : 1. Talk at Sepulveda VA Medical Centre, 1988 2. Talk at Osaka Biosciences Institute, Japan, 1988 3. Effects of REM sleep deprivation on brain biochemistry, Focus Group Meeting at the Conference, World Federation of Sleep Research Societies, Mauii, March 13-17, 1993. 4. Possible cellular mechanism(s) of rapid eye movement sleep deprivation induced changes in brain excitability, Asian Sleep Research Society meeting, Second Congress, Jerusalem/Israel, August 25-28, 1997. 5. "Possible interaction of neurotransmitters in the locus coeruleus for the regulation of rapid eye movement (REM) sleep in rats", during the 3rd Congress of the World Federation of Sleep Research Societies Meeting, Dresden, Germany, October 5-9, 1999. 6. Invited to participate in the Focus Group Meeting titled `Where Does REM sleep begin?' during the 3rd Congress of the World Federation of Sleep Research Societies Meeting, Dresden, Germany, October 5-9, 1999. 7. `Possible cellular and molecular mechanism(s) of action during spontaneous and disturbed REM sleep in animal models', Invited lecture at Max Planck Institute for Psychiatry, Munich, Germany on Oct 11, 1999. 8. `Cholinergic and GABA-ergic interaction in the locus coeruleus for the regulation of REM sleep in rats', 3rd Asian Sleep Research Society Meeting, Bangkok, 3-7 Dec 2K . 9. `One of the Functions of REM Sleep is to Maintain Brain Excitability : Possible Cellular Mechanism of Action', 3rd Asian Sleep Research Society Meeting, Bangkok, 3-7 Dec 2K. 10. When And How Do Locus Coeruleus Neurons Cease Firing? 3rd Asian Sleep Research Society Meeting, Bangkok, 3-7 Dec 2K, talk during the workshop. 11. Neuronal Basis of REM Sleep Generation, At Inserm, Claude Bernard Univ., Lyon/France, June 2001. 12. REM Sleep Maintains Brain Excitability - Cellular and Molecular Mechanism(s) of Action, At Inserm, Claude Bernard Univ., Lyon/France, June 2001. 13. GABA in Locus Coeruleus in REM Sleep Regulation, 7th World Congress of Biological Psychiatry, July 1-6, 2001, Berlin, Germany. 14. Univ of Nice-Sophia Antipolis 2002 15. Feb-Mar 2004, ASRS China 16. Feb-Mar 2004, ASRS China 17. Feb-Mar 2004, Lecture in Bangkok 18. Feb-Mar 2004, Lecture in Bangkok 19. March 2004, Neural Basis of REM Sleep Regulation : Its Possible Role in Normal and Disordered States, Lecture in Taiwan
  • 7. 20. March 2004, Mechanism of changes in body temperature during REM sleep and its Deprivation Lecture in Taiwan 21. Mar 2004, Interactions Between Neurons For The Generation Of Rapid Eye Movement Sleep Lecture in Taiwan 22. Mar 2004, Rapid Eye Movement Sleep Loss Alters Brain Excitability : Cellular Mechanism of Action Lecture in Taiwan 23. Mar 2004 Lecture in Taiwan _____________________________________________________________________________ _ Invited lectures (International) : Within India : 1. Sleep-awake-temperature regulation by medial and lateral preoptic areas, Second Cong. Asian-Oceanian Physiological Societies Meeting, New Delhi 12-15 Nov, 1990. 2. I was invited to teach in the "Third Intensive Workshop on Basic Neuroscience" as a member of the International Teaching Team, held at AIIMS, 1990. 3. Independent regulation of sleep-wakefulness-body temperature by the medial preoptic area, Int. Conf. Sleep-wakefulness, New Delhi 9-11, September 1992. 4. Possible cellular mechanism for rapid eye movement sleep loss induced changes in brain functions, Second APSN Meeting, Hyderabad, September 14-16, 1994. 5. "Communication between neurons during REM sleep regulation and molecular mechanism of action during their disturbances", International Colloquium on "Brain Research" National Brain Research Centre, Oct 1-3, 1999, New Delhi. 6. "How And What Do Neurons Share For The Generation Of Rapid Eye Movement Sleep". International Colloquium on "Brain Research" National Brain Research Centre, Dec 15- 17, 2003, Manesar, Gurgaon. 7. “Rapid Eye Movement (REM) Sleep Physiology and Effects of its Deprivation” Sleep Medicine in the 21st Century, Feb 11-12, 2005, Dept of Neurology, AIIMS, New Delhi. 8. “GABA-ergic Involvement in REM-Sleep Deprivation” Symposium talk during WFSRSSM meeting in Delhi Sept 22-26, 2005 9. “Role of GABA in LC and PPT in the Regulation of REM Sleep in Rats” Symposium talk during WFSRSSM meeting in Delhi Sept 22-26, 2005 _____________________________________________________________________________ _ Invited lectures (National) : 1. Sleep-awake related neuronal behavior during spontaneous and induced changes, Ind. Acad. Neurosci. New Delhi 12-14 Dec, 1990. 2. Changes in neuronal physiology on rapid eye movement sleep loss and its implications, 39th APPI Conf. Trivandrum, 27-29 Dec, 1993. 3. Rapid eye movement sleep - Effects on neurons to gross behavior, ISCA Meeting, Frontiers of Neuroscience, Jan 3-8, 1996, Punjabi University, Patiala.
  • 8. 4. Study of brain functions in vivo : From gross to cellular level, Fifth workshop on Techniques in Neurobiology, 9-20, Dec, 1996, Dept of Biochemistry, AIIMS, New Delhi. 5. Possible cellular mechanism for physiological changes in the brain due to disturbance in rapid eye movement sleep, XIth Nat. Symp. Ind. Soc. Chronobiol., New Delhi, 1996. 6. Behaviour and nature of functioning of neurons in relation to sleep-wakefulness- Workshop on Interaction between Biology and Computer Science, at IIT Kanpur Feb 13- 15, 1997. 7. Can Yoga Help Improve Sleep Loss Related Problems? World Householders' Yoga: Conference on sane living. Dec 25-26, 1997, Bombay, India. 8. Invited lecture at IIT Delhi, Electrical Engineering Department, 1998. 9. Rapid Eye Movement Sleep Maintains Brain Excitability : Possible Cellular Mechanism(s) Of Action, Soc of Biol Chem Ind, Dec 19-21, 1998, New Delhi. 10. Invited by the Organizers of Guha Research Committee, 1998. 11. Cellular mechanism of rapid eye movement sleep generation role of sleep and waking areas in the brain, during 11th Annual Conference of the Physiological Society of India, Delhi, 28- 30, Nov 1999. 12. Rapid Eye Movement Sleep Function and its Cellular Mechanism of Action - lecture delivered in the Department of Physiology, Calcutta University, on May 5, 2000 on the occasion of felicitation by the Department to me. 13. REM sleep maintains brain excitability: Mechanism of action from neuron to behaviour- invited lecture delivered at the Dabur Research Foundation, on May 20, 2000. 14. Norepinephrine Plays a Key Role in Rapid Eye Movement Sleep Deprivation Induced Changes in Brain Functions, Soc of Biol Chem Ind, Dec 7-9, 2000, Calcutta. 15. Neural Basis of Rapid Eye Movement Sleep Generation, ISCA Jan 3-7, 2002, Lucknow. 16. Neuro-behavioural correlates of REM sleep Regulation, Jamia Millia Islamia, Feb 19, 2002. 17. Mechanism of Rapid Eye Movement (REM) Sleep Regulation, 3th Annual Conf. PSI, Calcutta, Feb 23-24, 2002. (Ramendra Sundar Sinha Memorial Oration) 18. Norepinephrine and Rapid Eye Movement (REM) Sleep, Indian Statistical Institute, Kolkata, Feb 25, 2002. 19. Neuron and its Functions – lecture at the ACBR, Delhi Univ., June 25, 2002. 20. Neuronal Mechanism of REM Sleep generation, lecture at ACBR, Delhi Univ., June 26,2002. 21. REM Sleep Loss Disturbs Brain Excitability : Its Possible Mechanism of Action – Talk given at AIIMS as part of Institute Science Seminar, invited by the Society of Young Scientists (SYS), AIIMS, July 18, 2002. 22. Why does REM Sleep occur ? A popular Lecture delivered on Jan 29, 2003 on invitation by Neuroscience Centre, Jiwaji University, Gwalior, Indian Academy of Neurosciences and Society for Neurochemistry (India) Gwalior Branch. 23. How Does Rapid Eye Movement (REM) Sleep Loss Mediate its Effects? Symposium on RAS, Mahavir Medical College and S. J. Hospital, New Delhi, Sept 20, 2003 24. Lecture at ACTREC, Mumbai, Nov 3, 2004 (Wednesday Forum) 25. Panelist at BARCOA, meeting (Science Policy, Implementation and Assessment) Nov 4, 2004, BARC, Mumbai. 26. Lecture at Sophia College, Mumbai, Nov 5, 2004 27. Lecture at Central Institute For Fisheries Education (CIFE), Mumbai, Nov 5, 2004
  • 9. 28. Lecture at BIC, JNU Nov 17, 2004 29. Lecture at Daulat Ram College, Oct 28, 2005 (at Biomania 2005) Neuron to Brain : Behaviour Modulation 30. Lecture at Lucknow University, Zoology Dept, Nov 12, 2005. “REM sleep maintain brain Excitability”. 31. Lecture at Annamali University, Chidambaram, 4th SERC School Dec 28, 2005 32. Lecture at Annamali University, Chidambaram, 4th SERC School Dec 29, 2005 33. (In addition, Academic Staff College Lectures – average 4 lectures per year for at least past 12 years i.e. approx 50 lectures until 2005) LIST OF PUBLICATIONS A. Research papers : Mallick,B.N., Chhina,G.S., Sundaram,K.R., Singh,B. and Mohan Kumar, V. Activity of preoptic neurons during synchronization and desynchronization, Exp. Neurol., 81 (1983) 586 - 597. Mohan Kumar,V., Mallick,B.N., Chhina,G.S. and Singh,B., Influence of ascending reticular activating system on preoptic neuronal activity, Exp. Neurol., 86 (1984) 40 - 52. Mallick,B.N., Mohan Kumar,V., Chhina,G.S. and Singh,B., Responses of preoptic neurons to stimulation of caudal and rostral brain stem reticular structures, Brain Res.Bull., 13 (1984) 353 - 356. Mohan Kumar,V., Mallick,B.N., Chhina,G.S. and Singh,B., Alterations in preoptic unit activity on stimulation of caudal brain stem synchronizing structures, Exp.Neurol., 89 (1985) 304 - 313. Mallick,B.N., Mohan Kumar,V., Chhina,G.S. and Singh,B., Comparison of rostro-caudal brain stem influence on preoptic neurons and cortical EEG, Brain Res. Bull., 16 (1986) 121-125. Mohan Kumar,V., Mallick,B.N., Chhina,G.S. and Singh,B., Correlation of preoptic neuronal activity with spontaneous and induced cortical EEG change, Ind.J.Physiol. Pharmacol., 32 (1988) 83-92. Wu,M.F., Mallick,B.N. and Siegel,J.M., Lateral geniculate spikes, muscle atonia and startle response elicited by auditory stimuli as a function of stimulus parameters and arousal state, Brain
  • 10. Res., 499 (1989) 7-17. Mallick,B.N., Siegel,J.M. and Fahringer,H., Changes in pontine unit activity after REM sleep deprivation, Brain Res., 515 (1990) 94-98. Alam,M.N. and Mallick,B.N., Differential acute influence of medial and lateral preoptic areas on sleep-wakefulness in freely moving rats, Brain Res., 525 (1990) 242-248. Mallick, B. N. and Alam, M. N., Medial preoptic area affects sleep independent of associated body temperature change in free moving rats, Brain Res. Bull., 26 (1991) 215-218. Thakkar, M. and Mallick, B. N., Effect of REM sleep deprivation on rat brain acetyl- cholinesterase, Pharmacol.Biochem. Behav., 39 (1991) 211-214. Mallick, B. N. and Thakkar, M., Short term REM sleep deprivation increases acetyl- cholinesterase activity in the medulla of rats, Neurosci. Lett., 130 (1991) 221-224. Mallick, B. N., Fahringer, H., Wu, M. F. and Siegel, J. M., REM sleep deprivation reduces auditory evoked inhibition of dorsolateral pontine neurons, Brain Res., 552 (1991) 333-337. Alam,M.N. and Mallick,B.N., Differential influence of medial and lateral preoptic areas on body temperature in conscious and unconscious rats, Brain Res., 566 (1991) 303-307. Mallick, B. N. and Thakkar, M., Effect of REM sleep deprivation on molecular forms of acetylcholinesterase, Neuroreport, 3 (1992) 676-678. Mallick, B. N., Alam, M. N., Different types of norepinephrinergic receptors are involved in preoptic area mediated independent modulation of sleep-wakefulness and body temperature, Brain Res., 591 (1992) 8-19. Gulyani, S. and Mallick, B. N., Effect of rapid eye movement sleep deprivation on rat brain Na-K ATPase activity, J.Sleep Res., 2 (1993) 45-50. Thakkar, M. and Mallick, B. N., Effect of REM sleep deprivation on rat brain monoamine oxidases, Neuroscience, 55 (1993) 677-683. Mallick, B. N. and Gulyani, S., Rapid eye movement sleep deprivation increases chloride sensitive ATPase activity in the rat brain, Pharmacol. Biochem. Behav., 45 (1993)359-362. Thakkar, M. and Mallick, B. N., Rapid eye movement sleep deprivation induced changes in glucose metabolic enzymes in rat brain, Sleep 16 (1993) 691-694.
  • 11. Alam, M. N. and Mallick, B. N., Role of lateral preoptic area alpha-1 and alpha-2 adrenoceptors in sleep-wakefulness and body temperature regulation, Brain Res. Bull., 35 (1994) 171 - 177. Gulyani, S. and Mallick, B. N., Possible mechanism of rapid eye movement sleep deprivation induced increase in Na-K ATPase activity, Neuroscience, 64 (1995) 255 - 260. Mallick, B. N., Thakkar, M. and Gangabhagirathi, R. Rapid eye movement sleep deprivation decreases membrane fluidity in the rat brain, Neurosci. Res., 22 (1995) 117-122. Thakkar, M. and Mallick, B. N., Effect of rapid eye movement sleep deprivation on 5'nucleotidase activity in the rat brain, Neurosci. Lett. 206 (1996) 177-180. Singh, S. and Mallick, B. N. Mild electrical stimulation of pontine tegmentum around locus coeruleus reduces rapid eye movement sleep in rats, Neurosci. Res., 24 (1996) 227-235. Mallick, B. N. and Gulyani, S., Alterations in synaptosomal calcium concentrations after rapid eye movement sleep deprivation in rats, Neuroscience, 75 (1996) 729-736. Mallick, B. N. and Joseph, M. M., Role of cholinergic inputs to the medial preoptic area in regulation of sleep-wakefulness and body temperature in freely moving rats, Brain Res. 750 (1997) 311-317. Kaur, S., Saxena, R. N. and Mallick, B. N., GABA in locus coeruleus regulates spontaneous rapid eye movement sleep by acting on GABAA receptors in freely moving rats, Neurosci. Lett. 223 (1997) 105-108. Mallick, B. N., Thankachan, S. and Islam, F., Differential responses of brain stem neurons during spontaneous and stimulation induced desynchronization of the cortical EEG in freely moving cats, Sleep Res. Online, 1(1998) 132-146. Mallick, B. N. and Joseph, M. M., Adrenergic and cholinergic inputs in preoptic area of rats interact for sleep-wake-thermo-regulation, Pharmacol. Biochem. Behav. , 61 (1998) 193-199. Adya, A. and Mallick, B. N. , Comparison of Na-K ATPase activity in rat brain synaptosome under various conditions, Neurochem. Intnl. , 33 (1998) 283-286. Thankachan, S., Islam F. and Mallick B. N., Adrenergic and cholinergic modulation of spontaneous and brain stem reticular formation stimulation induced desynchronization of the cortical EEG in freely moving behaving cats, Sleep and Hypnosis, 1 (1999) 14-21.
  • 12. Ali, M., Jha, S. K., Kaur, S. and Mallick, B. N., Role of GABA-A receptor in the preoptic area in the regulation of sleep-wakefulness and rapid eye movement sleep, Neurosci. Res., 33 (1999) 245-250. Mallick, B. N. and Adya, H. V. A., Norepinephrine induced alpha-adrenoceptor mediated increase in rat brain Na-K ATPase activity is dependent on calcium ion, Neurochem. Intnl. 34 (1999) 499 - 507. Adya, A. and Mallick, B. N. Uncompetitive stimulation of rat brain Na-K ATPase activity by rapid eye movement sleep deprivation, Neurochem. Intnl., 36 (2000) 249-253. Das, M., Mallick, B. N., Dasgupta, S. C. and Gomes, A., A sleep inducing factor from common indian toad (Bufo melanostictus, Schneider) skin extract, Toxicon, 38 (2000) 1267- 1281. Mallick, B. N. , Adya, H. V. A. and Faisal, M., Norepinephrine stimulated increase in Na-K ATPase activity in the rat brain is mediated through α-1A adrenoceptor possibly by dephosphorylation of the enzyme, J. Neurochem., 74 (2000) 1574-1578. Gulyani, S., Majumdar, S. and Mallick, B. N., Rapid Eye Movement Sleep and Significance of its Deprivation Studies - A Review, Sleep and Hypnosis, 2 (2000) 49-68. Sanan, N., Mallick, B. N. and Sopory, S. Electrical signal from root to shoot in Sorghum bicolor: induction of leaf opening and evidence for fast extracellular propagation, Plant Sci., 160 (2001) 237-245. Mallick, B. N., Kaur, S. and Saxena, R. N. Interactions between cholinergic and GABA-ergic neurotransmitters in and around the locus coeruleus for the induction and maintenance of rapid eye movement sleep in rats, Neuroscience, 104 (2001) 467-485. Thankachan, S., Islam, F. and Mallick, B. N., Role of Wake inducing Brain Stem area on Rapid Eye Movement Sleep regulation in freely moving cats, Brain Res. Bull., 55 (2001) 43-49. Jha, S. K., Islam, F. and Mallick, B. N., GABA exerts opposite influence on warm and cold sensitive neurons in medial preoptic area in rats, J. Neurobiol., 48 (2001) 291-300. Kaur, S., Saxena, R. N. and Mallick, B. N. GABA-ergic neurons in prepositus hypoglossi regulate REM sleep by its action on locus coeruleus in freely moving rats, Synapse, 42 (2001) 141-150
  • 13. Jha, S. K., Yadav, V. and Mallick, B. N. GABA-A receptors in mPOAH simultaneously regulate sleep and body temperature in freely moving rats, Pharmacol. Biochem. Behav., 70 (2001) 115-121. Mallick, B. N., Jha, S. K. and Islam, F. Presence of α-1 adrenoreceptors on thermosensitive neurons in the medial preoptico-anterior hypothalamic area in rats, Neuropharmacology, 42 (2002) 697-705. Mallick, B. N., Majumdar, S., Yadav, V., Faisal, M., Madan, V. and Pal, D. Role of norepinephrine in the regulation of rapid eye movement sleep, J. Biosci. 27 (2002) 539 – 551. Majumdar, S . and Mallick, B. N. Increased Levels of Tyrosine Hydroxylase and Glutamic Acid Decarboxylase in Locus Coeruleus Neurons after Rapid Eye Movement Sleep Deprivation in Rats, Neurosci. Lett. 338 (2003) 193-196. Majumdar, S., Faisal, M., Madan V. and Mallick, B. N., Increased Turnover of Na-K ATPase Molecules in the Rat Brain After Rapid Eye Movement Sleep Deprivation, J. Neurosci. Res. 73 (2003) 870 - 875. Mallick, B. N., Jha, S. K. and Islam, F., Wakefulness inducing area in the brainstem excites warm sensitive and inhibits cold sensitive neurons in the medial preoptic area in anesthetized rats, Synapse 51 (2004) 59-70. Mallick, B. N., Thankachan, S. and Islam, F., Influence of hypnogenic brain areas on wakefulness and REM sleep related neurons in the brain stem of freely moving cats, J. Neurosci. Res., 75 (2004) 133-42. Kaur, S., Panchal, M., Faisal, M., Madan, V., Nangia, P., and Mallick, B. N., Long Term Blocking of GABA-A receptor in Locus Coeruleus by Bilateral Microinfusion of Picrotoxin Reduced Rapid Eye Movement Sleep and Increased Brain Na-K ATPase Activity in Freely Moving Normally Behaving Rats, Behav. Brain Res., 151 (2004) 185-190. Pal, D. and Mallick, B. N. GABA in pedunculo pontine tegmentum regulates spontaneous rapid eye movement sleep by acting on GABAA receptors in freely moving rats, Neurosci. Lett. 365 (2004) : 200 - 204. Mallick, B. N., Singh, S. and Pal, D. Role of alpha and beta adrenoceptors in locus coeruleus stimulation induced reduction in rapid eye movement sleep in freely moving rats, Behav. Brain Res. 158 (2005) 9-21.
  • 14. Majumdar, S. and Mallick, B. N., Cytomorphometric Changes in Rat Brain Neurons after Rapid Eye Movement Sleep Deprivation, Neuroscience, 135 (2005) 679 - 690. Pal, D., Madan V. and Mallick B. N. Neural Mechanism of Rapid Eye Movement Sleep Generation : Cessation of Locus Coeruleus Neurons is a Necessity, Acta Physiol. Sinica, Sheng Li Xue Bao. 57 (2005)401-413 Book chapters : 1. Mohan Kumar,V., Chhina,G.S., Mallick,B.N., Datta,S., Bagga,N. and Singh,B., Preoptic area in sleep-wakefulness. In: Motivational and emotional stress. Ed: K.V.Sudakov, USSR Academy of Medical Sciences, 1984, p. 67-76. 2. Mallick, B. N. and Alam, M. N., Sleep-awake-temperature regulation by medial and lateral preoptic areas. In : Advances in Physiological Sciences, Eds. S. K. Manchanda, W. Selvamurthy, and V. Mohan Kumar, McMillan India, pp. 575-586, 1992. 3. Mallick, B. N. and Alam, M. N., Independent regulation of sleep-wakefulness-body temperature by the medial preoptic area. In : Sleep-Wakefulness, Eds. V. Mohan Kumar, U. Nayar, H. N. Mallick, Wiley Eastern, pp. 41-47, 1993. 4. Mallick, B. N., Thakkar, M, and Gulyani, S., Rapid eye movement sleep deprivation induced alteration in neuronal excitability - possible role of norepinephrine. In : Environment and Physiology, Eds. B. N. Mallick and R. Singh, Narosa Publishing House, 1994 pp. 196-203. 5. Mallick, B. N., Can yoga help improve sleep loss related problems? Proceedings of the
  • 15. World Householders' Yoga: Conference on sane living, Dec 25-26, 1997, Bombay, India 1997, pp. 85-88. 6. Mallick, B. N., S. Kaur, S. K. Jha and Siegel, J. M., Possible role of GABA in regulation of REM sleep with special reference to REM-off neurons. In : Rapid Eye Movement Sleep, eds. B. N. Mallick and S. Inoue, Marcel Dekker (and also by Narosa Publishing House, New Delhi), pp. 153 - 166, 1999. 7. Mallick, B. N., Adya, A. and Thankachan. S. REM sleep deprivation alters factors affecting neuronal excitability : Role of norepinephrine and its mechanism of action. In : Rapid Eye Movement Sleep, eds. B. N. Mallick and S. Inoue, Marcel Dekker (and also by Narosa Publishing House, New Delhi) pp. 338 - 354, 1999. 8. Mallick, B. N., Kaur, S., Thankachan, S. and Jha, S. K. Use of bio-physical correlates to elucidate neural regulation of some physiological phenomena. In : Biophysical process in Living Systems. Oxford University Press & IBH Publishers, New Delhi, ed. P. Parda Saradhi, pp. 327-342, 2001. 9. Mallick, B. N. and Thankachan, S., Role of sleep and wake areas of the brain stem in the regulation of REM Sleep, In : Trends in Physiological Sciences: Cells to Systems, Vallabhbhai Patel Chest Institute, Univ of Delhi, Delhi, ed. Md. Fahim, pp. 299-316, 2002. 10. Mallick, B. N., Madan, V. and Faisal, Mohd. Biochemical Changes. In : Sleep Deprivation : Basic Science, Physiology and Behavior, Ed : C. A. Kushida, Marcel Dekker, Inc, USA, 2005, pp. 339-357. 11. Mallick, B. N., Kaur, S., Thankachan, S. and Pal, D. Role of Wakefulness Area in the Brainstem Reticular Formation in Regulating Rapid Eye Movement Sleep. In : Sleep and Sleep Disorders : A Neuropsychopharmacological Approach (vol.1 & II), Eds. Lader M., Cardinali D. P. and Pandi-Perumal, S. R., Landes Bioscience Publisher, George Town, Texas, USA, 2004. 12. Mallick, B. N., Jha, S. K. and Madan V. Role of Norepinephrine in Thermoregulation during Rapid Eye Movement Sleep and its Deprivation. In : "Molecular and cellular Biology" Eds. M. K. Thakur, Narosa, New Delhi, 2005 (in press). 13. Mallick, B. N., Madan V. and Pal, D. Locus coeruleus and adrenergic modulation of rapid eye movement sleep. In : Neuroendocrine Correlates of Sleep/Wakefulness, eds. D. Cardinali and S. R. Pandi-Perumal Springer Science+Business Media, Inc., New York, USA, pp. 163-178, 2006. 14. Mallick B. N., Madan, V. Pal, D. and Baskey, G. C. Rapid eye movement (REM) sleep physiology and effects of its deprivation, Proceedings of the Sleep Medicine in the 21st Century, Dept of Neurology, AIIMS, New Delhi, Feb 11-12, 2005. 15. Rapid Eye Movement sleep regulation by modulation of noradrenergic system. In : The Neurochemistry of Sleep and Wakefulness, eds. M. Monti, C. Sinton, S. R. Pandi
  • 16. Perumal, Cambridge University Press, (submitted). C. Books edited/written : 1. Mallick, B. N. and Singh, R. (1994) Environment and Physiology, New Delhi. Narosa Publishing House, 278 p. 2. Mallick, B. N., and Inoue, S. (1999) Rapid Eye Movement Sleep, Marcel Dekker Inc, USA, 419 p. (Also published by Narosa Publishing House, New Delhi). 3. Mallick, B. N., (2001) Sleep-Wakefulness, National Book Trust, India. D. Deposited in the data bank : 'Homology Modeling of Alpha1A-Adrenoreceptor ' RCSB ID : rcsb 035534 PDB ID : code 2F75 Vijayan, R., Subbarao, N. and Mallick B. N. Summary of Research Contributions A) Mechanism of Rapid eye movement sleep generation : i) Wake inducing area keeps Locus Coeruleus noradrenergic REM-OFF neurons active, which keep the cholinergic REM-ON neurons inactive ; ii) During slow sleep the REM-OFF neurons are disinhibited ; iii) At a depth of sleep the brain stem sleep inducing area stimulates REM-ON neurons; iv) REM-OFF neurons must cease firing during REM sleep generation ; v) This cessation is triggered by activation of cholinergic REM-ON neurons which execute its action through GABA ; vi) The REM-OFF neurons receive GABA from local interneurons and from prepossitus hypoglossi. B) Mallick's hypothesis : "One of the functions of REM sleep is to Maintain Brain Excitability" i) REM Sleep deprivation alters neuronal firing rate when challenged with the stimulus to which the respective neuron was responsive to; ii) The REM Sleep deprivation alters neuronal excitability by affecting Na-K ATPase, one of the primary factors responsible for maintenance of neuronal excitability; iii) This deprivation induced increase in Na-K ATPase activity is mediated by norepinephrine acting on α-1A adrenoceptor;
  • 17. iv) The norepinephrine action on α-1A adrenoceptor is mediated through phospholipase C pathway causing release of calcium from the membrane. This calcium then dephosphorylates the Na-K ATPase. v) Also, the REMS deprivation may be affecting the neuronal responsiveness through changes in membrane fluidity and membrane lipid peroxidation. C) Sleep-wakefulness and relation to thermoregulation : i) The preoptic area regulates sleep-wakefulness and body temperature simultaneously, however, the medial preoptic area is more effective than the lateral; ii) the preoptic area has independent parallel pathways to regulate those functions. The regulation of those two functions may be dissociated, however, they go hand in hand to maintain the body temperature within physiological limit i.e. one of the functions of sleep is to maintain the body temperature; iii) Norepinephrine, acting on the medial preoptic area, alters sleep, wakefulness and body temperature by acting on α-2, β and α-1 adrenoceptors, respectively; iv) The cholinergic and adrenergic systems have parallel inputs (and not in series) into the preoptic area where they are integrated and the output is an algebraic sum of those inputs. D) Marker for REM Sleep deprivation : We have identified a blood protein (~200 KDa) which decreases after REM sleep deprivation. Its physiological importance is under study. E) Changes in Cellular Morphology after REM sleep deprivation : REM sleep deprivation alters the neuronal morphology. Its physiological significance and cellular mechanism of action are under investigation. The findings have been schematically represented in the Figs 1 & 2. The findings mentioned above have been cited by others in several reviews including Annu. Rev. Psychol., Curr. Opinion Neurobiol., Prog. Brain Res., and in several journals including Acta Neurol., Am. J. Physiol., Arch. Ital. Biol., Brain Research, Brain Res. Bull., EEG Clin.Neurophysiol., J. Comp. Neurol., Neuroscience, Neurosci. Res., Psychopharmacology, Science, Sleep, Sleep Res Online, etc., to name a few. Fig 1
  • 18. DECREASED MAO REM SLEEP LOSS INCREASED TH INCREASED NE LC REM-OFF NEURONS CONTINUE FIRING ACTIVATION OF LC-NEURONS CHEMICAL ELECTRICAL ALTERED BEHAVIOR DISEASE DECREASED MEMBRANE FLUIDITY α-1A receptor INCREASED Na-K ATPase ACTIVITY INCREASED IP3 MEMBRANE CALCIUM CAM Ca++ Calcineurin activation INCREASED NEURONAL EXCITABILITY INTRACELLULAR Cell Membrane Fig 2