AT A GLANCE
DR. JOHN. K.J. THARAKAN- MBBS. MD.DM.FRCP. FAAN.
Gold Medallist and Rank holder for MBBS.
Awarded the prestigious “Commonwealth Fellowship” 1987-88.
Elected Fellow of American Academy of Neurology. 1998
Elected Fellow of Royal College of Physicians of Ireland-2002
Started for the first time in Malaysia’ Advanced Masters In Medicine-Neurology” course.
Established “Epilepsy Surgery Programme “in HUSM.
Started for the first time “Deep Brain Stimulation” for Parkinson’s disease in HUSM
Awarded “ANUGERAH PERKIDMATAN CEMERLANG”USM 2004
29 years of full time teaching experience, at undergraduate and postgraduate level.
Examinership at undergraduate level and postgraduate level
Delivered lectures at several C.M.E. Programs.
Actively participated in various National and International Conferences.
Attended C.M.E. courses offered by International Professional Organizations.
Received the “Best Paper Award” at a National level conference.
Several publications in peer reviewed journals.
Member Board of referees of international journals- J.Ind.Acad.Neurol, J.Ped.Neurol.
Engaged in various Clinical Research Activities and conducted Clinical trials
29 years of experience in clinical Neurology/Neurointensive care/Neurophysiology/ Internal
Experience in organizing and developing Neurology services and training programs in
NAME JOHN THARAKAN. K.J.
DATE OF BIRTH: 01 October 1951
MAILING ADDRESS: Professor & Senior Consultant Neurologist
Department of Neuroscience, School of Medical Sciences,
University Sains Malaysia
16150-Kubang-Kerian, Kelanton, Malaysia
TELEPHONE NUMBER: Office 60-9-7664216
1973 M.B.B.S. Medical College, Kottayam Univ:of Kerala, India
1978 M.D. MEDICINE Medical College, Trivandrum Univ:of Kerala, India
1981 D.M. NEUROLOGY All India Institute of Medical Science, Delhi, India
1998 F.A.A.N. Corresponding Fellow American Academy of Neurology
2002 F.R.C.P. Fellow Royal College of Physicians of Ireland.
AWARDS AND GOLD MEDALS
1. First Rank and Gold Medal for Medicine, University of Kerala
2. First Rank and Gold Medal for Ophthalmology, University of Kerala
3. Third Rank for M.B.B.S., University of Kerala
4. E. Merck Award and Gold Medal for Neurology 1985 for the best scientific
paper presented at the annual conference of -Neurological Society of India.
5. Awarded “ANUGERAH PERKIDMATAN CEMERLANG”USM 2004
1. Neuroimmunology Fellowship. August1987- September 1988.
Awarded Commonwealth Fellowship and had further training in Neurology and
Neuroimmunology under Prof. R.A.C. Hughes, M.D.FRCP and Dr. M.D. O'Brien M.D.
FRCP in the Department of Neurology, Guy's Hospital, London. Undertook both clinical
and research work.
2. Short Course on Practical Statistics for Medical Research. 18-22 January 1988
Attended this training programme on Research Methodologies and Statistical
Applications in Medicine, conducted by the Royal Post-Graduate Medical School, London
3. Workshop on “Effective Postgraduate Teaching and Assessment”. August. 14-15
Conducted by University Sains Malaysia in July 2002. This course offered training in
various teaching and assessment tools, currently used in Postgraduate Medical Education.
4. Short course on “ Good Clinical Practice”. October 6-8. 2002
Attended this short course on GCP guidelines for conducting clinical trials and clinical
research, organized by University Sains Malaysia, in October 2002.
5.Transcranial Doppler Training. October 13-14. 2002.
Organised by the Neurosains Unit of University Sains Malaysia. It was conducted as
a “Hands on” training workshop.
6. Ethics in Medical and Health research. 28-29.July 2004. Two-day workshop
organised by U.S.M. and conducted by Dr Emma Williamson, Univ: Bristol,
CME COURSES ATTENDED.
Sleep Disorders. Half-day course conducted by World Federation of Neurology.
September.1997. Buenos Aires
Immunomodulation in Neurological disorders. Half-day course conducted by World
Federation of Neurology. September 1997. Buenos Aires
Update on Neuromuscular disorders. Half-day course conducted by American
Academy of Neurology, April 1999. Toronto.
Parkinson disease-Therapy. CME course conducted by American Academy of
Neurology, April 1999. Toronto.
Stroke - Therapy. CME course conducted by American Academy of Neurology, April
Epilepsy-Therapy. CME course conducted by American Academy of Neurology, April
Treatment issues-Evidence based Epilepsy treatment.- EUREPA Teaching Seminar.
Neurology Update. 1 and 2 . Full day CME course conducted by American Academy of
Neurology on 30-04-07 and 04-05-07. Boston-USA.
Deep Brain Stimulation for Parkinson’s Disease. CME programme conducted by
American Academy of Neurology on 05-05-07. Boston-USA.
CME LECTURES DELIVERED.
1."Etiological Concepts in M.N.D". At the National Seminar on Recent Advances in
Neurosciences”, Trivandrum 1983.
2."Inflammatory Polyneuropathies" at the Department of Neurology, Johns Hopkins
Medical Institutions, Baltimore, U.S.A. June 1988.
3."Immunology of Acute Inflammatory Polyneuropathy” At the Workshop on
"Neuroimmunology" conducted by the National Institute of Immunology New Delhi,
4.Several lectures on “recent advances in neurology” at the yearly Neurology
Update Seminars organized by Sri Chitra Tirunal Institute for Medical Sciences and
Technology, Trivandrum India between 1984-91.
5.“Plasmapheresis in Neurology". At the International Update Session on
Neurosciences, Muscat, December 1991.
6.“Recent advances in Guillain Barre Syndrome” CME at Nizwa Hospital. Oman
7.“Role of EMG and Nerve Conduction Studies in clinical practice” At Khoula
Hospital, Oman. 1993.
8.“Treatment of Seizure disorders” CME at Emergency Medicine Dept: Royal Hospital
9.“Principles of management of Epilepsy” At Khoula Hospital, Muscat Oman. 1995.
10.“Treatment of refractory epilepsy” At the Neurology update seminar. Royal Hospital,
11.“General principles of management of Stroke.” CME Nizwa Hospital, Oman.
12.“Modern trends in Stroke management” CME at Sohar Hospital Oman. 2000.
13.“Stroke-Current concepts of management” and “Treatment of refractory epilepsy”
At the 2 day course on “Neurology for the General Practitioners” July 2002.
Organized this course at University Sains Malaysia.
14.“GBS-What is new?” And “Recent Advances in Disorders of Neuromuscular
Junction” At the National Postgraduate Neurology Update Seminar, University
Kebagsan Malaysia. Kuala Lumpur. July 16-19.2002.
15.“Diagnostic approach to Peripheral Neuropathy” and Mitochondrial Myopathy”. At
the National Post Graduate course-Neurology Update-2003. February15-
16Organized this course at University Sains Malaysia and also conducted the
clinical interactive sessions during this course
16. National conference on “Neurocritical care” – University Sains Malaysia. 4-5
September 2004. Gave 2 lectures- “Approach to unconscious patient” and “Acute
17. Stroke in the context of Interventional Radiologist. Lecture delivered at the 3rd
Neurointerventional Seminar – USM. 09-08-2005
18. Stroke- An Evidence based Treatment. Invited talk at MMA-Kelantan meeting.
19. Approach to headache in Emergency department. Lecture given at the 2nd
Congress of Emergency Medicine. USM Malaysia. 26-11-2006.
20. Ischaemic Stroke- Advances in the past decade and what is in store for the future.
Lecture delivered at the First Scientific Meeting of Surgical neurology trainees of
Malaysia- Johor- 25-11-2006.
MEMBERSHIP IN PROFESSIONAL ORGANIZATIONS
1. Association of Physicians of India
2. Neurological Society of India
3 American Academy of Neurology.
4 Royal College of Physicians of Ireland
5 Malaysian Society of Neurosciences
1. Travancore Cochin Medical Council. Trivandrum, Kerala- (State Medical Council
under the Indian Medical Council)- Registration Number-6913-Dated 5th
2. Malaysian Medical Council (Ministry of Health, Kula Lumpur, Malaysia).
Registration Number-37637 dated 4th
3. Limited Registration with General Medical Council (153 Cleveland St; London
W1P6DE). Registration Number-87/0788.dated 8th
Year Position Field of Work Place of Work
Aug1974 -Aug 75
Feb.1976 - March 1978
Jan.1980 – Jan 1982
July.1985 – Jan.1986
Aug.1987 - Sept. 1988
Jan.1986 - Sept. 1991
Sept.1991 - April.2002
May.2002 – April 2008
May 2008- till date
AIIMS, New Delhi, India
Med: Coll: Hosp: Trivandrum
AIIMS, New Delhi, India
Sri Chitra Tirunal Institute for
Medical Sciences and Technology
SCTIMST, Trivandrum, India
Guy’s Hospital. London
SCTIMST, Trivandrum, India
S.Q.University, Muscat, Oman
Sri Chitra Tirunal Institute for Medical Science and Technology. Trivandrum. India
February 1979 – September 1991.
S.C.T.I.M.S.T. is a tertiary level referral centre, catering to a population of 25 million, and it is
declared as a University and an Institute of National Importance by an act of Indian Parliament. I
joined this institute as a full time faculty member in February 1979 and worked there till
September 1991. I was second in position in the hierarchy of neurology department.
Neurology services have 50 inpatient beds with an ICU dedicated exclusively for their patients.
This is complemented by the Neurosurgery department having similar bed strength and ICU
facilities, and supported by a Neuroradiology division with facilities for CT scanning, MRI
scanning, Digital Subtraction Angiography and Myelography, a Neuropathology division having
facilities for all types of histopathological, immunopathological and electron microscopic studies
and a neurochemistry division offering various neurochemical assays. The Neurophysiology
laboratory has facilities for digital EEG and brain mapping, 24-hour EEG video monitoring;
multimodality evoked potential studies, EMG and nerve conduction studies.
The department conducts 5 neurology clinics and 3 special clinics for epilepsy, headache and
neuromuscular disorders in a week and offered advanced treatment facilities for all types of
neurological problems. Twenty-five new cases are scheduled in a single neurology clinic, and an
average of 850-900 new cases are admitted annually to neurology wards. I conducted 2 general
neurology clinics and one neuromuscular clinic in a week. In addition to the routine clinical
neurological activities, I was in charge of Neurology ICU and 1065 patients were treated in
NICU between 1st
January 1981 and 31st
December 1990. Plasmapheresis, critical care
neurology, interventional neuroradiology for vascular malformations of brain and surgery for
epilepsy and movement disorders, are some of the specialized clinical services offered by this
centre. I was in charge of Plasmapheresis programme, which was offered to Acute GBS and in
selected indications of Myasthenia patients. Our department was one of the early centres in India
offering Thymectomy for Myasthenia Gravis and I was instrumental in starting this way back in
I have gained extensive experience in performing and reporting Neurophysiological
investigations. On an average 1400-1500 EEGs, 300-350 NCS/EMG studies and 400-450 EP
studies were performed annually in the Neurophysiology labs and 2 – 3 Neurologists shared this
workload. Consultants took on call duty once in 3 days for most part of my stay and at times
once in 2 days.
There are weekly Neuroradiological conferences on every Saturday morning and
Neuropathology meeting /brain cutting sessions every Saturday afternoon.
I was member of the Library Committee and Junior Staff Selection Committee during varying
periods of my tenure.
Sultan Qaboos University, College of Medicine, Muscat, Oman (www.squ.edu.om/)
September 1991- April 2002.
This is the only medical school in this country and the University hospital is the apex referral
centre here. I joined the division of Neurology - Department of Medicine, from the very
beginning of the department in September 1991,and was actively involved in the organization
and development of neurology services and training in that country. The neurology division has
all modern facilities and offers tertiary level service to the entire country. Neurophysiology
Laboratory facilities include EMG and nerve conduction studies, digital EEG and video
monitoring, 24-hour EEG recording, polysomnography and electronystagmography.
Neuroradiology facilities include CT scanner, MRI, digital subtraction angiography and
myelography. There were 3 Neurologists in the Unit.
The neurology unit conducts 3 outpatient clinics in a week and the average booking for a day
was 25-30 patients. Neurology clinics were conducted at two regional hospitals in Nizwa and
Sohar once a month. Annual neurological admissions ranged between 250-300 patients. I did on
call rota with general physicians on a 1 in 6 scale and also gave on call cover for emergency
neurology admissions once in 3 days. Neurology consultation service was provided to other
departments on a regular basis. On an average 1200-400 EEGs were performed annually.
Statistics for other Neurophysiological procedures are tabulated below.
I was a member of the Medical records Committee during 1995-98.
TEST NCS EMG
1993 436 84
1994 503 122
1995 565 126
1996 524 82
1997 592 72
1998 701 66
1999 618 33
2000 637 34
Total 5283 619 5902
Test BAEP VEP SSEP
1990 49 34 13
1991 205 27 2
1992 482 73 34
1993 336 189 111
1994 340 149 109
1995 353 126 129
1996 257 97 125
1997 74 48 51
1998 212 137 127
1999 240 153 76
2000 255 152 95
Total 2803 1185 872 4860
Department of Neurosciences- School of Medical Sciences-University Sains Malaysia
www:medic.usm.my/dept/neuroscience Since May 2002
The Unit of Neurosciences at the University Sains Malaysia is comprised of Neurology,
Neurosurgery and allied supporting specialties like Neuroradiology, Neuropathology etc: and I
am the Chief Neurologist in the Unit. This is a tertiary level referral centre for neurological
disorders in the eastern part of peninsular Malaysia, equipped with all modern facilities. There is
a 6-bedded dedicated ICU for Neurosciences. Neurophysiology Laboratory facilities include
EMG and nerve conduction studies, digital EEG and video monitoring, 24-hour EEG recording,
polysomnography and electronystagmography. Neuroradiology facilities include CT scanner,
MRI, digital subtraction angiography and SPECT.
There are 2 general neurology clinics in a week and the average booking per clinic is 40-50
patients. Yearly neurology admissions are in the region of 230-250 patients. Neurology
consultation service is provided to other departments on a regular basis. The volumes of
Neurophysiological testes are 900-1000 EEGs, 100-125 NCS/EMG and 150-200 EP’s annually.
There are weekly neuroradiology conferences and monthly neuropathology meetings. I drew up
the protocol for Thrombolysis in Stroke and this treatment is offered at this unit since 2003. I
also drafted the Epilepsy Surgery Protocol and we have started Epilepsy surgery programme
here since July 2004. In 2006 we started D.B.S. for movement disorders for the first time in
PRACTICALS-CLINICAL (PER YEAR)
Institution. SCTIMST (78-91). SQU Muscat (91-02). USM (02)
1. Outpatients 3500/year 1500/year 1500-2000/yr
2. Inpatients 800-900/Yr 300-350/Yr 300-350/yr
3.Critical care 150-75/Yr 50-70/Yr 100-125/yr
4.EEG, VEEG. 1200/Yr 1200/Yr 900-1000/Yr
5.NCS/EMG 350-400/Yr 450-500/Yr 100-125/Yr
6.Evo.Poten: 400-425/Yr 400-450/Yr 150-200/Yr
CLINICAL PROTOCOLS DEVELOPED.
1. HUSM guidelines for “Thrombolytic therapy in acute stroke”
2. Protocol for “Evaluation of refractory epilepsy patients and Surgical treatment for Epilepsy”
3. Protocol for “Deep Brain Stimulation for Movement Disorders “
4. Protocol for “Management of Hypertensive Intracranial haemorrhage”
5. Protocol for “Treatment of spasticity with Baclofen Pump “
SRI CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCE AND TECHNOLOGY.
INDIA (http://www.sctimst.ac.in) February 1979 – September 1991.
The department conducts Neurology Residency Program of 3 years duration, leading to
Doctorate in Medicine (D.M.) in Neurology. I was actively involved with the organization and
running of this residency program from the very beginning. The entry requirement is Masters
degree in Internal Medicine, Psychiatry or Paediatrics. Candidates were selected based on their
performance at the entrance examination and interview.
The residents undertook supervised clinical responsibilities with more autonomy in decision
making as they progressed through their training. There are dedicated teaching activities in the
form of bedside teaching rounds, PG case discussions, Journal clubs, Seminars /Tutorials,
Clinical Neurophysiology training sessions, weekly Neuroradiology and Neuropathology
conferences and few didactic lectures on basic neuroscience topics. The residents also gained
experience in clinical research when they undertook at least one research project during their
training period. I regularly conducted all of the teaching activities listed above and supervised
resident’s research projects.
There are periodic internal assessments as well as two examinations-one at the end of year 1 for
basic neurosciences and the other at the end of year 3, consisting of written, clinical and viva
components. 22 neurology residents were trained during my tenure. Their list can be found at
Neurology training was also offered to Internal Medicine, Paediatrics and Psychiatry residents
who rotated through our department as part of their residency program. Continuing Medical
Education Courses in Neurology were also conducted periodically, targeting the general
practitioners and internists in the state.
SULTAN QABOOS UNIVERSITY, COLLEGE OF MEDICINE, MUSCAT, OMAN
(http://www.squ.edu.om/) September 1991- April 2002.
The division of neurology is actively involved in both undergraduate and postgraduate training
programs. Undergraduate training is mainly in the form of bedside clinical teaching, problem-
based teaching of major neurological problems and integrated lecture series covering all the
As the Coordinator of
1. Junior rotation of medical students in the Department of Medicine. I was responsible
for their overall posting in Medicine, timetabling, conducting the end of rotation
examination, verification of log books and evaluation of training programme.
2. “Introductory week in Clinical Medicine”. Students start their clinical rotations from
year5 onwards. During this week they are introduced to etiquettes of clinical medicine,
history taking and proper techniques
of performing a thorough clinical examination of different systems. I was
responsible for running this programme
Specific Teaching activities.
Bedside clinical teaching of Year 5 and 7 students
Direct supervised training of 7th
year (final year) students posted to the unit
Problem based teaching of 7th
Data interpretation session with year 5 students
Problem based teaching –year 5 students- Neurology, Cardiology, Respiratory medicine
and Infectious diseases.
Neurophysiology teaching –year 7 students- during their interdisciplinary week posting in
Clinical physiology laboratories
Post Graduate Teaching.
Residents from Medicine, Psychiatry, Family Medicine and Ophthalmology have their
rotation in Neurology
Postgraduate training included case discussion, seminars, journal clubs, clinicopathological
meetings and other interdisciplinary meetings.
On an average 20 hours were spent in teaching per week.
I was also an Examiner for various in course assessments as well as for the final
DEPT: OF NEUROSCIENCES- SCHOOL OF MEDICAL SCIENCES-UNIVERSITY
SAINS MALAYSIA. (http://www.medic.usm.my/dept/neuroscience/) Since May 2002
Neuroscience unit is responsible for providing Neurology input to both undergraduate and
postgraduate training programme. Undergraduate programme at U.S.M follows the Problem
Oriented Learning module. Postgraduate programme offers 4-year M.Med degree. At present,
residents from Medicine, Emergency Medicine, Psychiatry, Family Medicine and
Ophthalmology have their rotation in Neurology. Our unit has started the M.Med Neurosurgery
course in 2001, the only centre to offer this programme in Malaysia. Similarly, for the first time
in Malaysia, Advanced Masters Degree course in Neurology was started in our department in
June 2007. I was responsible for drafting the course objectives and curriculum and piloting it
through various university bodies.
Member of the PPSP MD Curriculum revision work shop held at Cameroon Highlands from 9-
11 March 2006.
Member of the Task Force on “Delivery of Teaching and Learning”
Bedside clinical teaching 4th and 5th
(final) year students
Tutorials for 4th
(final) year students
Problem based Learning- Nervous System Block
Coordinates Nervous system block.
Lectures for interdisciplinary week
Moderate student seminars.
Advanced Masters in Neurology
For the first time in Malaysia, a well structured sub-specialty training programme
in Neurology is started at USM, in the academic year 2007-08. I am in charge of
conducting this course.
Coordinator for Phase I Neurosurgery Masters programme
Organize the Phase I Neurosurgery teaching schedules, rotations, conduct internal
assessment and Phase I examination.
Supervising training of masters students from Psychiatry, Ophthalmology, Emergency
Medicine and Surgery rotating through Neurosciences Department.
Conduct clinical teaching and moderate seminars, tutorials, journal clubs for P.G.
Supervise thesis work
1 Dr Masnun Mahmood M Med Radiology. “Correlation of CT perfusion
parameters with Stroke severity in acute Ischaemic Stroke patients”- Co
supervisor- completed May 2005
2 Dr Abdul Rahman Izaini Ghani. M Med Neurosurgery. “Survival probability
and functional outcome at 6 months in surgical treatment of Spontaneous
Supratentorial Intracerebral Haemorrhage”- Co investigator. Completed in
3 .Dr Zulkifli Zaki Abdul Ghani. M Med Radiology. “ Preliminary study of CT
perfusion of Penumbra in patients with Hypertensive Intracranial
Haemorrhage”. Co Investigator.Completed May 2005.
4. Dr Sani Sanuti. M Med Neurosurgery. “Surgery for refractory epilepsy A pilot
study”. Main supervisor. Completed in 2006
6. Dr Siti Suhaila Bt Ismail. M Med Radiology. “ Hippocampal Volumetric
studies in patients with refractory Epilepsy”. Co investigator. Completing in
7. Dr Chan. M.Med Neurosurgery. Study of Post traumatic seizures- predictors of
seizure development and role of prophylactic antiepileptic drugs. Completing in
1. Master’s Thesis- 2002-03. “MRI in Epilepsy. Correlation study with EEG”. USM
2. Master’s Thesis- 2003-2004.” A Pilot study-Prevalence of negative plain CT
Scan and positive CT perfusion study in cases of acute stroke.” USM
3 Masters thesis- 2005.CT Brain study to determine the site of predilection of
intracranial lesions in HIV/AIDS patients and its association with neurological
symptoms and CD4 count.
4. Masters thesis- 2007.Comparison between FLAIR and Complete sequence MRI
brain in patients with headache and no neurological deficits.
Supervisor of MSc students.
Mohd.Harizal working on “Effects of treatment with Mitragina speciosa korth extract
on psychoactivity of rat hippocampus: in vitro and in vivo study”. Supported by USM
short term grant held by me.
Mazira working on “APOE-e in Haemorrhagic stroke” and the study is in progress.
Short Course on Practical Statistics for Medical Research
Attended this training programme on Research Methodologies and Statistical
Applications in Medicine, conducted by the Royal Post-Graduate Medical School,
London. 18-22.January 1988.
Short course on “ Good Clinical Practice”. October 6-8. 2002
Attended this 3-day course on GCP guidelines for conducting clinical trials and clinical
research, organized by University Sains Malaysia, in October 2002.
Ethics in Medical and Health research. 28-29.July 2004.
Two-day workshop organised by U.S.M. and conducted by Dr Emma
Williamson, Univ: Bristol, U.K.
Research work undertaken./ ongoing
1. Immune mediated Polyneuropathies.
Most of my early research work was centred on Guillain Barre Syndrome and Chronic
Inflammatory Demyelinating Polyneuropathies. It involved prospective study of the
natural history, outcome prediction, role of Plasmapheresis, Clinicopathological and
Immunological studies and cost effective studies. Most of these works are published.
2. Myasthenia gravis.
Large experience with MG and Thymectomy. Results of Thymectomy in
Asian population and the Experiences in Oman are already published.
3. Multiple Sclerosis.
Clinical epidemiological studies in MS patients.
Studies on the Clinical radiological correlations in acute stroke,
Role of Mitral Valve Prolapse Syndrome in Young stroke
Original description of “MUCOID VASCULOPATHY” a new entity of non
atherosclerotic disease of blood vessels causing stroke.
Correlation of CT perfusion parameters with severity in acute ischemic stroke patients.
Survival probability and functional outcome at 6 months in surgically treated
spontaneous intracerebral haemorrhage.
Preliminary study of CT perfusion of Penumbra in patients with Hypertensive
APOE ε in Haemorrhagic Stroke.
Surgery for Epilepsy- A pilot study
Refractory seizures- Clinical-Radiological and Neuropsychological evaluation
CLINICAL TRIALS UNDERTAKEN
1. Valproate in Partial Epilepsy. Principal investigator of this multinational clinical trial
at University Sains Malaysia. The trial worth US$ 6,000 was successfully completed in
July 2004. Results are pending analysis
2. PROFESS- Principal investigator at USM for this multinational clinical trial
evaluating secondary stroke prevention. This trial brings in revenue of US$ 220,000.00
to the University. Trial will be completed in March 2008
3. PERFORM- Principal investigator for this International Multicentric clinical trial.
Evaluating secondary stroke Prophylaxis. Revenue of Euro.120,000.to the University.
Trial is expected to be completed in 2010.
4. ENOS. Principal investigator for this investigator initiated multicentric study
evaluating the role of B.P. management in acute stroke.
1 J.Tharakan. National Seminar on "Infections of Nervous System", New
2 J.Tharakan. National Seminar on "Recent Advances in Neurosciences”,
Trivandrum 1983. Read a paper on "Etiological Concepts in M.N.D".
3 J.Tharakan Annual Conference of Neurological Society of India, Madurai
1983. Read a paper on "Plasmapheresis in Acute Polyneuritis".
4 J.Tharakan. Annual Conference of Neurological Society of India. Patna 1985.
Read a paper on "Immunohistological Studies in Acute Inflammatory
5 J.Tharakan. W.H.O. sponsored workshop on "National Curriculum for
Neurosciences", Bangalore 1986.
6 J.Tharakan. Annual Conference of Neurological Society of India, Delhi 1986.
Read a paper on "Painful Ophthalmoplegia - Sinister Variety".
7 J.Tharakan. Conference of the "Association of British Neurologists",
8 J.Tharakan. Gave a short research seminar on "Inflammatory
Polyneuropathies" at the Department of Neurology, Johns Hopkins Medical
Institutions, Baltimore, U.S.A. (June 1988).
9 J.Tharakan. XIVth World Congress of Neurology, New Delhi, 1989. Read a
paper on "ClinicoPathological Study of Seven Patients with Guillain Barre
10 J.Tharakan. Workshop on "Neuroimmunology" conducted by the National
Institute of Immunology New Delhi, February 1990. Gave a lecture on
"Immunology of Acute Inflammatory Polyneuropathy"
11 J.Tharakan. Annual Conference of Neurological Society of India, Indore 1990.
Read a paper on "Prognostic Factors in GBS Prospective Study of 100
12 J.Tharakan. IXth Asian Ocean Congress of Neurology Tokyo, September
1991. Read a paper on "Mucoid Vasculopathy - A New Entity of Non-
atherosclerotic stroke in the young - A Preliminary Clinico-Pathological
13 J.Tharakan. International Update Session on Neurosciences, Muscat,
December 1991. Gave a lecture on “Plasmapheresis in Neurology".
14 J.Tharakan. Annual Conference of Neurological Society of India: 1993 -
Symposium on Guillain Barre Syndrome - Gave an invited lecture on "Recent
advances in the management of G.B.S."
15 J.Tharakan. XVI World Congress of Neurology, September 1997. Buenos
Aires, Argentina. Presented a paper on Multiple Sclerosis in Oman: A
16 J.Tharakan. Neurology Update Seminar- 1997. Ministry of Health Muscat.
Invited lecture on “Treatment of refractory Epilepsy”
17 J.Tharakan. Recent advances in Rheumatology. January 1999. Sultan Qaboos
18 J.Tharakan. 51st
Annual Conference of American Academy of Neurology.
April 1999, Toronto. Canada
19. J.Tharakan. The 8th
Pan Arab Neurological Sciences Conference and 2nd
Arab Epilepsy Conference. April. 2000, Beirut.
20 J.Tharakan. Second GCC conference of Neurology, November.2001 Muscat.
Read a paper on “Multiple Sclerosis in Oman”
21 J.Tharakan. Neurology for the General Practitioners- July 2002. University
Sains Malaysia. Organized this 2-day conference. Gave 2 lectures on Stroke
Current concepts of management and Treatment of Refractory epilepsy
22. J.Tharakan. National Postgraduate Neurology Update Seminar, July 16-
19.2002. University Kebagsan Malaysia. Kuala Lumpur. Gave 2 lectures- “GBS-
What is new?” And “Recent Advances in Disorders of Neuromuscular
23 J.Tharakan. Neurology Update-2003. February-15-16.Organized this national
level Post Graduate course at University Sains Malaysia and gave two lectures-
“Diagnostic approach to Peripheral Neuropathy” and “Mitochondrial
Myopathy”. Also conducted the clinical interactive sessions during this course.
24 J.Tharakan. Malaysian Society of Neurosciences. - Annual conference April
4-5.2003. Member of the expert panel on “Neuromuscular disorders –Clinico
25 J.Tharakan. Paediatric Genetics Seminar. April 9.2003. University Sains
Malaysia. Kota Bharu.
26 J.Tharakan. Neuropsychiatry workshop. 30th
27 J.Tharakan. Parkinson’s Disease an Update. 14th
July 2003. University Sains
28 J.Tharakan. FORUMS-on MS- “Improving the management of MS in Asia”
August 2003 Perth. Australia.
29 J.Tharakan. ASEAN Neurological Associations conference-ASNA. Nov29-
Dec2. 2003. Cebu- Philippines.
30 J.Tharakan. Asia Pacific Regional meeting of International Working Group on
“Harmonisation of dementia drug guidelines”. 23rd
31 J.Tharakan. Symposium on Epilepsy in the Women –20-21st
Singapore. Conducted by Prof Martha J Morrell USA.
32 J.Tharakan. Multiple Sclerosis Symposium2004. Changing Malaysia’s
May 2004 Kuala Lumpur. Malaysia.
33. J.Tharakan Workshop on “ Ethics in Medical Research”University Sains
Malaysia. 28- 29th
34. J.Tharakan. 5th
Asian Oceanian Epilepsy Congress- Bangkok. 28-31
35. J.Tharakan. National conference on “Neurocritical care” – University Sains
Malaysia. 4-5 September 2004. Gave 2 lectures- “Approach to unconscious
patient” and “Acute flaccid Paralysis”
36. Attended the Annual conference of American Academy of Neurology -28th
37. Neurology update-1 . AAN full day course. 30-April 2007
38. Neurology Update-2. AAN full day course. -4-Mayl 2007
39. Deep Brain Stimulation for Parkinson Disease” AAN half day course-5 may 2007
40. Chaired the session on “Parkinsons Disease-new treatment options” organized by the
Neurosciences Department June 2007.
41. Chaired the session “Update on treatment of Parkinson’s Disease” organized by
42. Chaired the session on “Epilepsy Recent advances “ organized by the Neurosciences
Department August 2007.
43. Ist Asian and Oceanian Parkinsons Disease and Movement disorders Congress.
Singapore. 20-22 October 2007.
44. Invited to chair the scientific session at the Annual conference of Neurological Society
of India . Agra 14-17 December 2007
RESEARCH EXPERIENCE- PUBLICATIONS
1. Tharakan, JKJ(80%). Bhatia R.: Continuous Hemifacial Spasm in Cerebello
Pontine angle Tumors. Neurol.India 1981. 29 (3): 112-115
2. Tharakan, JKJ.(80%) Ahuja, G.K.; Manchanda, S.C.; Asha Khanna: Mitral Valve
Prolapse and Cerebrovascular Accident in the Young. Acta. Neurol. Scandinav. 1982.
3. Tharakan, JKJ.(80%) Tandon M.; Maheswary, M.C.; Plasmapheresis in Acute
Inflammatory Polyneuropathy. A Case Report. J. Assoc. Physicians, India 1982.
4. Ahuja, G.K.; Tharakan, JKJ(80%). Ipsilateral Seizures. Epilepsia 1982. 23 (5):.
5. Tharakan, JKJ.(70%); Mohanta A.; Maheswary M.C.; Goulati R.K.: Clinical and CT
Correlation in Cases of Cerebro Vascular Accident. Neurol. India 1984. 32 (4): 21-26.
6. Tharakan,(60%) JKJ; R.E. Ferner; R.A.C. Hughes; J. Winer; M. Barnett; E.R. Brown; G.
Smith: Plasma Exchange for Guillain Barre Syndrome. J. Royal Society of Medicine.
1989. 82: 458-461.
7. Mohan. P.K.; J. Shanmugan; Ashalatha Nair; Tharakan, JKJ(50%). Fatal Outcome of
Group G. Streptococcal Meningitis. A Case Report. J. Postgraduate Med. 1989. 35
8 Sandhyamoni S, Radhakrishnan VV, Tharakan, JKJ,(50%) Nair MD.
Nonatherosclerotic cerebral vascular disease. A histopathological report on 2 cases.
D. Rout. Proceedings of International Symposium on vascular lesions of the brain, 1989;
9. Tharakan, JKJ.(70%); Jayaprakash P.A.; Padmanabhaiyer V.: Small Volume Plasma
Exchange in Guillain Barre Syndrome. Experience in 25 patients. J. Assoc.
Physicians, India. 1990. 38 (8): 550-553.
10. Honaver M., Tharakan, JKJ;(70%) R.A.C. Hughes; S. Leibowitz; J.B. Winer: Clinico-
Pathological Study of Guillain Barre Syndrome. Nine Cases and Literature Review.
Brain 1991. 114: 1245-1269.
11. Tharakan, JKJ,(60%) Sandhyamoni S, Nair MD, Radhakrishnan VV. Mucoid
vasculopathy - A new entity of non-atherosclerotic stroke in the young. A preliminary
clinicopathological study. Abstracts - 8th Asian Ocean Congress of Neurology 1991;
12. Tharakan, JKJ,(70%) J. Mathai, A. Mathai, P.V.Sulochana: Immune complex levels and
Plasmapheresis in Guillain - Barre Syndrome. Acta. Neurol 1993. 15:138-141
13. Pratap Chand R, Tharakan JKJ(50%), Dilip Kumar S: Juvenile onset O.P.C.A.
Canadian J. Neurol Sci: 1993. 20 ( Suppl 4) 120
14. C. Sarada, Tharakan.JKJ(70%), M. Nair: Guillain Barre Syndrome. A prospective
clinical study in 25 children and comparison with adults. Ann. Trop. Paed: 1994, 14.
281 - 286.
15. Pratap Chand R, Guru Raj AK, Tharakan.JKJ(40%), Dilip Kumar S: Enlargement of
foramen of Magendie in childhood O.P.C.A. Neurol INDIA 1995; 43:124-125
16. Jacob PC, Tharakan JKJ(50%). Hypomelanosis of Ito - A rare neurocutaneous
syndrome. Neurol India 1995; 43:177-178
17. Tharakan JKJ, (70%)Jacob PC. Lesson learned. Elevated ESR in an elderly stroke
patient. J. Family Practice 1995; 41(5): 512-513.
18. Jacob PC, Pratap Chand R, Tharakan JKJ,(40%) Koul RL. Clinical profile of Dystonic
syndromes in an Oman University Hospital. Saudi Med. J 1996; 17(4): 461-465.
19. Pratap Chand R, Tharakan JKJ(40%) , Koul RL, Dilip Kumar S. Clinical and
Radiological features of juvenile onset olivopontocerebellar atrophy. Clinical Neurol
Neurosurg 1996; 98: 152-156.
20. Narayan SK, Sarada C, Radhakrishnan K, Nair MD, Kartha CC, Neelakandhan KS,
Tharakan JKJ.(60%) Response to thymectomy in South Indian patients with
myasthenia gravis. Acta Neurol Scand 1996; 94:63-66
21. Scrimgeour EM, Koul RL, Chand RP, Tharakan JKJ.(30%) Juvenile onset
Huntington’s Disease in an Omani child with asymptomatic, at risk parents. J. Med.
Genet 1997; 34:701.
22 Tharakan JKJ,(60%) Chand P, Jacob PC. Multiple Sclerosis in Oman: Clinical and
epidemiological study. J. Neurol. Sciences. 1997; 150 (suppl): 188.
23 Jacob.PC, Chand.P, Tharakan.JKJ(40%) Cerebral cortical lesions leading to dystonia.
Neurosciences. 1998; 3:208-210.
24 Bulusu.S, Chand.RP, Jacob.PC, Tharakan.JKJ.(40%) The Sympathetic Skin Response in
Carpal Tunnel Syndrome. Autonomic Neuroscience;Basic and Clinical.2000; 84: 119-
25 Jacob.PC, Chand.RP, Bulusu.S, Tharakan.JKJ.(40%) Clinical profile of Carpal Tunnel
Syndrome in Oman. Neurosciences. 2000; 5(4): 223-225.
26 Jacob.PC, Tharakan.JKJ(70%), Chand.RP, Koul.RL, Alexander.PC Clinical profile of
Myasthenia Gravis in the Sultanate of Oman. Neurosciences.2003;8(3) 171-172.
27. Rao. TV, Tharakan.JKJ(60%), Jacob. PC. Systemic lupus erythematosus presenting as
amyotrophic lateral sclerosis. Clinical neuropathology. 2004; 23:99-101
28 Zamzuri Idris, J.Abdullah, J.P. George, J.Tharakan KJ(20%), A.Prasad, S.Sayuthi,
A.Rahman Izaini Ghani, M.Saufi Awang, M.Rusli Abdullah, A.Rahman Mohd. Ariff,
G.Ghazali, M.Mohamad Ghazali and I.Roberts. 2002. The MRC CRASH Trial
Pilot Phase in Malaysia, International Conference on Recent Advances in
Neurotraumatology, Bali (Indonesia), pg 143-147.
29. A.R.I. Ghani, J.M. Abdullah, P.J.George, A.M. Hussin, K.J.J.Tharakan(10%), A.Prasad.
2004. A Simple Intraoperative Chart for Stereotactic Surgery for Movement
Disorders in Developing Nation. Acta Neurochirurgica. Vol 146. pg 925.
30. K.Man, M.M. Abdul Kareem, N.A. Ahmad Alias, I.L.Shuaib, J.Tharakan,(20%)
A.Prasad, A.M. Hussin, J.M. Abdullah. 2004. Outcome and cost effectiveness of
urgent perfusion CT scan services in a rural based Malaysia University Hospital
for stroke patients. 5th
World Stroke Congress, Vancouver B.C., Canada. pg 142.
31. J Abdullah, Y Mohamed, NN Alias, IL Shuaib, J Tharakan.(20%) 2004. Cross sectional
study of aetiology, clinical and electroencephalographic correlation of rural North
East Malaysian patients with intractable epilepsy : Is there a high incidence of
traumatic head injury causing epilepsy? 7th
International Neurotrauma Symposium.
Adelaide .2004. pg 129
32. T Ahamed, J.Abdullah, F Zakaria, F.Mustapha, J.Tharakan(10%), AMH Zabidi-Hussin.
Nonlinear Dynamic Modeling of Epilepsy sufferers after Head Injury. 7th
International Neurotrauma Symposium. Adelaide 2004. pg 61-64.
33. Jafri Malin Abdullah, Ahmad Munnawir Hussin, John Tharakan, Mohamed Rusli
Abdullah, Ramli Saad, Zaidun Kamari, Zabidi Azhar Mohd Hussin and Dzulkifli Abdul
Razak..National response to neurological diseases in Malaysia:planning for the future.
The Southeast Asian J.of Tropical Medicine and Public Health. July 2006;Vol 37: (4).
34. Man K, Kareem AM, Ahmad Alias NA, Shuaib IL, Tharakan J, Abdullah JM, Prasad A,
Hussin AM, Naing NN. Computed tomography perfusion study of ischaemic stroke
patients in a rural Malaysian tertiary referral centre. Singapore Med J. 2006
35. Mohamad Ghazali Mazira, Tharakan John, Abdullah Jafri Malin, Ghani Abdul
RahmanIzaini, Abdul Rashid Faridah, Abdullah Mohamed Rusli. Preminilary study on
apolipoprotein E epsilon 4 in hemorrhagic stroke.Presented at the 3rd
International Neuroscience Conference, 23-24 May 2006 : 28.
36. J.M.Abdullah, Z.Z Abdul Ghani, N.A. Ahmad Alias, S.Jalaluddin, J.Tharakan,
N.N.Naing, A.R.I Ghani. Computer tomography perfusion of penumbra versus
outcome in hypertensive intracranial haemorrhage undergoing conservative versus
surgical management: a prospective study. Journal of Neurology; Vol.253 :II/65.
37. J.M.Abdullah, J.Tharakan, A.R.I Ghani, Z.Idris, S.Sayuthi, S.Awang, N.Abdul
Wahab,M.Mohamad Ghazali, N.Murshid, F.Abdul Rashid. Survival analysis and
functional outcome at 6 months in surgical treatment of spontaneous supratentorial
intracerebral haemorrhage. Journal of Neurology; Vol.253 :II/65.
38. Jafri Malin Abdullah, Ahmad Munnawir Hussin, John Tharakan, Mohamed Rusli
Abdullah, Ramli Saad, Zaidun Kamari, Zabidi Azhar Mohd Hussin and Dzulkifli Abdul
Razak. National response to neurological diseases in Malaysia : planning for the
future. The Southeast Asian Journal of Tropical Medicine and Public Health. July
2006;Vol 37: (4).
39. Man K, Kareem AM, Ahmad Alias NA, Shuaib IL, Tharakan J, Abdullah JM,
PrasadA,Hussin AM, Naing NN. Computed tomography perfusion, study of
ischaemic stroke patients in a rural Malaysian tertiary referral centre. Singapore
Med J. 2006 Mar;47(3):194-7.
40. Y.Mohammed, NN Alias, IL Shuaib, J.Tharakan., J Abdullah, AH Munawir and NN
Naig. Referral of epileptic patients in north east coast of west – an area with poor
MRI coverage. An analysis.. Southeast Asian j Trop. Med. Pub. Health.2006; 37(6):
41. Hussin A.M, A.Prasad, J.Tharakan(60%), J.Malin, Abdul Rahman. 2003. Recombinant
tissue plasminogen activator(rt-PA) in acute stroke – USM experience. MJMS.
42. Saufi A, Abdullah J, George Jain P, Tahir A, Abdullah MR, Tharakan J,(50%) Prasad A,
Munawwir H, Salmi R. 2003. Nerve conduction study of the upper limb and lower
limb in healthy subjects. A comparison between sexes. Preliminary results. MJMS.
43. S.Sayuthi, J.Abdullah, J.Tharakan,(10%) George Jain P, A.Prasad, Tahir A, S.S. Hassan,
Z.Idris, ARI Ghani, S.Awang, K.Salleh, R.Yaacob, Z.Hussin. 2003. Smart balancing for
vestibular rehabilitation. MJMS. 2003; 10:156-157.
44. Adnan T, Saufi A, Abdullah J, Idris Z, Ghani ARI, Sayuthi S, Wahab N, Ali D,
Rasalingam K, Tharakan J(10%), Prasad A, Munawwir H, Salmi R. 2003. Magnetic
stimulation of the central and peripheral nervous system – our experience in
Neurosciences Unit. . MJMS. 2003; 10: pg 157.
45. Ghani ARI, Tharakan J(70%), Prasad A, Hussain AM, J.Abdullah,George Jain P. Spinal
multiple sclerosis : a case report. . MJMS. 2003; 10:170.
46. Sayuthi, J.Abdullah, J.Tharakan(10%), J.George, A.Prasad, A.R.Ariff, NA Wahab,
A.Rahman, S.Awang, Z.Idris. Case report of rare spontaneous caroticoca venous
fistula (CCF) associated with two arteriovenous malformations (AVM). MJMS.
47. ARI Ghani, J.Abdullah, J.George, P.R.Gollapudi, AM Hussin, J. Tharakan (10%)and
A.Prasad. A simple intraoperative chart for stereotactic surgery for movement
disorders in developing nation. MJMS. 2004; 9th
National Conference on Medical
Sciences. pg 160.
48. Idris Z, Ghani ARI, Sayuthi S, Awang MS, George J, Prakash RG, Tharakan J (60%)and
Abdullah JM. 2004. Multiple sclerosis or intracranial tumour ?: A proper clinical
evaluation, radiological images and steroids trial therapy could differentiate them.
National Conference on Medical Sciences. pg 163.
49. Saufi A, Abdullah J, John T(20%), Atul P, Munawwir H, George J, Sayuthi S, Tahir A,
Abdullah MR and Salmi A.R. Nerve conduction study among healthy Kelantanese.
The influence of age, sex, height and weight on nerve velocities. 9th
Conference on Medical Sciences. pg 178.
50 Shafie A, Zamzuri I, Jafri MA, Tharakan J, Abdul Rahman IG, Mohamed Saufi A, Sani
S, Murshid N.A rare case of multiple intracerebral haemorrhage in a female with
abnormal platelet aggregation test and right middle cerebral artery aneurysm. The
Malaysian Journal of Medical Sciences, 2005; Vol 12,Suppl 1; 228.
51. Abdul Rahman IG, Murshid N, Jafri MA, Tharakan J. Neurochemical monitoring
using intracerebral microdialysis in patients with spontaneous supratentorial
intracerebral hemorrhage (ICH). The Malaysian Journal of Medical Sciences,
2005; Vol 12,Suppl 1; 230.
52 Sani S, Tharakan J, Jafri MA, George J, Salma W, Soccoro M, Madhavan M, Awang S,
Abdul Rahman IG, Toh CJ, Tahir A.Pre-operative evaluation for refractory epilepsy:
Universiti Sains Malaysia Programme. The Malaysian Journal of Medical Sciences,
2005; Vol 12,Suppl 1; 231.
53 Abdul Rahman IG, Jafri MA, John Tharakan, Zamzuri I, Sani S, Mohamed Saufi A,
Naseer AW, Mazira MG, Nur-Leem Murshid, Faridah AR.Survival analysis and
functional outcome at 6 months in surgical treatment of spontaneous supratentorial
intracerebral hemorrhage (ICH). The Malaysian Journal of Medical Sciences, Volume
13 (Suppl 1) 2006; 152.
54. Maria SP, Rahida MS, John Tharakan, Jafri MA, Sani S. The impact of epilepsy
surgery on the quality of life of patients: Preliminary results. The Malaysian Journal
of Medical Sciences, Volume 13 (Suppl 1) 2006; 156.
55. Mazira MG, John T, Jafri MA, Abdul Rahman IG, Faridah AR, Mohamed Rusli A.
Preminilary study on apolipoprotein E epsilon 4 in hemorrhagic stroke. The
Malaysian Journal of Medical Sciences, Volume 13 (Suppl 1) 2006; 191.
56 Harizal SN, Mordi MN, Mansor SM, Hilman S, Khoo KH, Azim P, Nasir MN, Mohd
Ghazali M, Rammes G, Hasnan J, Tharakan J KJ, Zulkifli M, Abdullah J. Detection of
Mitragynine from mitragyna speciosa korth crude extract by using gas
chromatography mass spectrometry (GC-MS) for learning and memory process :
preliminary result. ). The Malaysian Journal of Medical Sciences, Volume 13 (Suppl 1)