Les moments les plus                                                                                propices pour Baillerf...
Any place is good to ya especially if boring                          (16-21 days, only 18% sleep % controls)             ...
melatonin                                                                                                          melaton...
MEL                                                                                        ⇓ -20%                         ...
thyroxine thyro-         ⇑              +61%  xine ⇓  -74% cortisolACTH                        5
What did he taketo sleep so well ?                     6
figure :                      REM sleep during 23 h – 01 h                                                                ...
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3. sleep & hormones short

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Dr. Dalal Akoury the founder of AWAREmed Health and Wellness Resource Center describes the relationship between hormonal imbalances and sleep disorders.

Published in: Self Improvement
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3. sleep & hormones short

  1. 1. Les moments les plus propices pour Baillerfigure : animals that are seldom attacked sleep a great deal. There is a relationship across species between metabolic rate and sleep pattern:↑ metabolic rate ⇒↑ slow wave sleep ⇒ ↑ (longer) sleep (Shapiro et al BMJ Feb 1993 , volume 306 :383-385) to preserve & restore energy 1
  2. 2. Any place is good to ya especially if boring (16-21 days, only 18% sleep % controls) 2
  3. 3. melatonin melatonin maximum exercise lowerBright light → ↓↓ plasma melatonin levels Physical stress →no effect on figure: variations of the total antioxidants levels during a whole plasma melatonin but ↑cortisol day matches significantly the levels of melatonin. Melatonin figure : measurement of plasma melatonin and cortisol levels in 7 healthy biosynthesis requires tryptophan as a single substract (one of the most reactive men (25- 34 yea.) in resting, before and after exercise performed at 23:40- aa -ROTS. Melatonin (sedative effect) acts as antioxidant and glutamate 24:00, 30 min after exposition to bright light (2500lx). Human pineal gland is (neuroexcitatory) act as pro-oxidant. The level of plasmatic tryptophan and its oxidability seems to be a critical factor in biosynthesis of melatonin ( Olinescu R et not responsive to sympathic ativation induced by physical stress even in the middle of al Rev Roum Biocim 1995 32 , 1-2,57-66) the dark phase. (Monteleone P et al Neuroendocrinol 1992, 55:367-371) 3
  4. 4. MEL ⇓ -20% MEL MEL ⇓ ⇓ -31% -14% Total Light sleep sleep 534 479 (stages 1 + 2) (+ 53 ‘) 8h REM SLEEP corrected within the 368 first 390 min sleep (+ 2 h) (delta) (the shortest total (stages 3 + 4) sleep time in 246 controls) 4h 98 74 94 72 (1 h 38) (- 24 ‘) (1 h 34)(- 22’) Figure: growth hormone-deficient young adults have ↓ deep & REM sleep (study with 60 patients). (Aström C et Lindholm J, Neuroendocrinology, 1990; 51: 82-84) (- 39’) LIGHT SLEEP 0 518 (- 41’) 0 309 (+ 27’) hormone (+ 15’ ) 0 111 138 64 79Figure: improvement of sleep efficiency after 6 months of growth hormone treatment (2 IU/M2/day) of growth hormone-deficient young adults. (Aström C et Lindholm J, Neuroendocrinology, 1990; 33: 495-500) 4
  5. 5. thyroxine thyro- ⇑ +61% xine ⇓ -74% cortisolACTH 5
  6. 6. What did he taketo sleep so well ? 6
  7. 7. figure : REM sleep during 23 h – 01 h a single dose of 500 mg DHEA increases sigma EEG activity REM sleep during 01 h – 03 h1 during REM sleep during the first 2 h.- period in 10 healthy REM sleep during 03 h – 05 h young volunteers (age 21-30 yrs; mean age of 24.9figure : 500 mg oral DHEA ↑ duration of REM sleep & EEG activity yr). REM sleep during 05 h – 07 h in the sigma frequency range activity during REM sleep in (Friers E et al, Am J the first 2 h. sleep period in 10 healthy young men (mean age of 24.9 yrs (21-30)). Physiol. 1995, 268 (1 (Frien E et al, Am J Physiol. 1995; 268 (1 Rt 1) : 107-13) Rt 1) : E 107-13) Delta Theta Alpha Sigma Beta CE ⇑ ⇑ CE +25’ CE ⇓ 12’ +25’ -16’ 7
  8. 8. 8

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