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3. sleep & hormones short
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3. sleep & hormones short

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Dr. Dalal Akoury the founder of AWAREmed Health and Wellness Resource Center describes the relationship between hormonal imbalances and sleep disorders.

Dr. Dalal Akoury the founder of AWAREmed Health and Wellness Resource Center describes the relationship between hormonal imbalances and sleep disorders.

Published in Self Improvement
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  • 1. Les moments les plus propices pour Baillerfigure : animals that are seldom attacked sleep a great deal. There is a relationship across species between metabolic rate and sleep pattern:↑ metabolic rate ⇒↑ slow wave sleep ⇒ ↑ (longer) sleep (Shapiro et al BMJ Feb 1993 , volume 306 :383-385) to preserve & restore energy 1
  • 2. Any place is good to ya especially if boring (16-21 days, only 18% sleep % controls) 2
  • 3. melatonin melatonin maximum exercise lowerBright light → ↓↓ plasma melatonin levels Physical stress →no effect on figure: variations of the total antioxidants levels during a whole plasma melatonin but ↑cortisol day matches significantly the levels of melatonin. Melatonin figure : measurement of plasma melatonin and cortisol levels in 7 healthy biosynthesis requires tryptophan as a single substract (one of the most reactive men (25- 34 yea.) in resting, before and after exercise performed at 23:40- aa -ROTS. Melatonin (sedative effect) acts as antioxidant and glutamate 24:00, 30 min after exposition to bright light (2500lx). Human pineal gland is (neuroexcitatory) act as pro-oxidant. The level of plasmatic tryptophan and its oxidability seems to be a critical factor in biosynthesis of melatonin ( Olinescu R et not responsive to sympathic ativation induced by physical stress even in the middle of al Rev Roum Biocim 1995 32 , 1-2,57-66) the dark phase. (Monteleone P et al Neuroendocrinol 1992, 55:367-371) 3
  • 4. MEL ⇓ -20% MEL MEL ⇓ ⇓ -31% -14% Total Light sleep sleep 534 479 (stages 1 + 2) (+ 53 ‘) 8h REM SLEEP corrected within the 368 first 390 min sleep (+ 2 h) (delta) (the shortest total (stages 3 + 4) sleep time in 246 controls) 4h 98 74 94 72 (1 h 38) (- 24 ‘) (1 h 34)(- 22’) Figure: growth hormone-deficient young adults have ↓ deep & REM sleep (study with 60 patients). (Aström C et Lindholm J, Neuroendocrinology, 1990; 51: 82-84) (- 39’) LIGHT SLEEP 0 518 (- 41’) 0 309 (+ 27’) hormone (+ 15’ ) 0 111 138 64 79Figure: improvement of sleep efficiency after 6 months of growth hormone treatment (2 IU/M2/day) of growth hormone-deficient young adults. (Aström C et Lindholm J, Neuroendocrinology, 1990; 33: 495-500) 4
  • 5. thyroxine thyro- ⇑ +61% xine ⇓ -74% cortisolACTH 5
  • 6. What did he taketo sleep so well ? 6
  • 7. figure : REM sleep during 23 h – 01 h a single dose of 500 mg DHEA increases sigma EEG activity REM sleep during 01 h – 03 h1 during REM sleep during the first 2 h.- period in 10 healthy REM sleep during 03 h – 05 h young volunteers (age 21-30 yrs; mean age of 24.9figure : 500 mg oral DHEA ↑ duration of REM sleep & EEG activity yr). REM sleep during 05 h – 07 h in the sigma frequency range activity during REM sleep in (Friers E et al, Am J the first 2 h. sleep period in 10 healthy young men (mean age of 24.9 yrs (21-30)). Physiol. 1995, 268 (1 (Frien E et al, Am J Physiol. 1995; 268 (1 Rt 1) : 107-13) Rt 1) : E 107-13) Delta Theta Alpha Sigma Beta CE ⇑ ⇑ CE +25’ CE ⇓ 12’ +25’ -16’ 7
  • 8. 8