PACKAGING MATERIALS
PLASTICS
DODDA DINESH KUMAR
IST YEAR M.PHARMACY
GITAM INSITUTE OF PHARMACY
CONTENTS:-
 Classification
 Advantages
 Disadvantages
 Drug plastics consideration
 Moulding processes
 Testing of p...
Packaging:-
Packaging is best described as a coordinated system of
preparing goods for transport, distribution, storage,
r...
PLASTICS
Plastics are group of substances either natural or synthetic origins, consisting
chiefly of polymers of high mole...
 Advantages of Plastics
 Light weight.
 Reduced volume, (these two result in significant savings in warehousing
and dis...
 Disadvantages of Plastics
 No plastic is totally impermeable to moisture, gases, etc.
 May be permeable to, or subject...
 Guides offered by the FDA have identified the need for the following information when a
plastic is used for parenterals ...
DRUG PLASTIC CONSIDERATIONS
 Permeation
 Leaching
 Sorption
 Chemical Reaction
PERMEATION
Transmission of gases, vapours or liquids
through packing material.
Permeation of oxygen and water vapour
may...
LEACHING
Migration of contents of the container to the
drug product.
Problems will be with colouring agents
used in plas...
SORPTION
Removal of constituents of the drug product
by packing material.
This may cause serious problem like loss of
po...
CHEMICAL REACTION
Some ingredients of plastic containers may
chemically react with drug product or vise
versa.
MOULDING PROCESS:-
• EXTRUSION MOULDING
COMPRESSION MOULDING/COMPRESSION
TRANSFER MOULDING
•
• THERMOFORMING BY
PRESSURE, VACUUM, MECHANICAL
FORMING OR COMBINATIONS
ROTATIONAL MOULDING
REACTION INJECTION MOULDING (RIM)
SOFT MOULDING
DIP MOULDING
TESTING OF PLASTICS
General tests on plastics for pharmaceutical
purposes include
 Extractive and biological tests,
 Che...
STANDARD TEST PROCEDURES APPLIED TO
PLASTICS.
 Density
 Melt flow index (MFI)
Appearance—optical properties
 Gloss, Haz...
APPLICATIONS
Based on the utility of plastics they can be
categorized as
1. Rigid material plastics
2. Flexible material p...
Rigid material plastics
 These are the phenolic resines with various
inert filters these are used in the fabrication
of a...
Flexible material plastics
 These are thermo plastic materials these
materials can be rigid or flexible depending
upon th...
Metallic surface plastics
 Plastics of polyethylene or poly vinyl chloride
types are used along with plasticizer for the
...
Plastic cements
 These are used for spaces between acid
resistance tiles and bricks.
References…
1. Packaging of pharmaceutical dosage forms
by. Thomas J Ambrosio
2. Pharmaceutical engineer
by. C.V.S. Subrah...
THANK YOU
PACKAGING PLASTIC MANUFACTURE
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PACKAGING PLASTIC MANUFACTURE

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Packaging is best described as a coordinated system of
preparing goods for transport, distribution, storage,
retailing, and use of the goods. Contains, Types, Procedure of manufacturing the plastics, Advantages & Disadvantages.

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PACKAGING PLASTIC MANUFACTURE

  1. 1. PACKAGING MATERIALS PLASTICS DODDA DINESH KUMAR IST YEAR M.PHARMACY GITAM INSITUTE OF PHARMACY
  2. 2. CONTENTS:-  Classification  Advantages  Disadvantages  Drug plastics consideration  Moulding processes  Testing of plastics  Application
  3. 3. Packaging:- Packaging is best described as a coordinated system of preparing goods for transport, distribution, storage, retailing, and use of the goods.
  4. 4. PLASTICS Plastics are group of substances either natural or synthetic origins, consisting chiefly of polymers of high molecular weight, that can be moulded into a shape or form by heat and pressure Different Types of Plastics: LDPE HDPE Polystyrene Polycarbonate Poly propylene PVC PET
  5. 5.  Advantages of Plastics  Light weight.  Reduced volume, (these two result in significant savings in warehousing and distribution costs plus advantages to the consumer).  No corrosion problems.  Good resistance to mould and bacteria.  Generally inert chemically, but be wary of ‘solvents’.  Usually have good impact strength; difficult to break, if breakage occurs fragments tend to be less hazardous than glass.  Wide design and decorative possibilities.  Offer a wide range of moulding processes.
  6. 6.  Disadvantages of Plastics  No plastic is totally impermeable to moisture, gases, etc.  May be permeable to, or subject to attack by, organic substances, particularly solvents.  Subject to adsorption and absorption according to formulation ingredients.  Fully effective closing systems are sometimes difficult to achieve.
  7. 7.  Guides offered by the FDA have identified the need for the following information when a plastic is used for parenterals (now similarly covered by EN 9090/III). 1. Name of manufacturer. 2. Type of plastic. 3. Composition, method of manufacture of the resin and the finished container, plus a full description of the analytical controls. 4. Physical characteristics (size, dimensions, whether flame treated, etc.). 5. Defect classifications (weight, seams, seals, wall thickness, pin holes, etc.). 6 .Light transmission test, USP (particularly if product is photosensitive). 7. Tests (USP): • biological • physico-chemical • permeation. 8. Vapour transmission test (if appropriate). 9 .Toxicity studies not included in USP: • sub-acute on extracts • cell culture. 10 .Tests for leaching and migration. 11. Compatibility. 12. Sampling plan. 13. Acceptance specifications.
  8. 8. DRUG PLASTIC CONSIDERATIONS  Permeation  Leaching  Sorption  Chemical Reaction
  9. 9. PERMEATION Transmission of gases, vapours or liquids through packing material. Permeation of oxygen and water vapour may cause oxidation or hydrolysis of sensitive drugs. Increase in temperature and humidity will make the condition still worst.
  10. 10. LEACHING Migration of contents of the container to the drug product. Problems will be with colouring agents used in plastics.
  11. 11. SORPTION Removal of constituents of the drug product by packing material. This may cause serious problem like loss of potency of drug. A common problem is loss of preservatives. Factors influencing: Chemical structure, pH. Solvent system, temperature, length and area of contact
  12. 12. CHEMICAL REACTION Some ingredients of plastic containers may chemically react with drug product or vise versa.
  13. 13. MOULDING PROCESS:- • EXTRUSION MOULDING
  14. 14. COMPRESSION MOULDING/COMPRESSION TRANSFER MOULDING •
  15. 15. • THERMOFORMING BY PRESSURE, VACUUM, MECHANICAL FORMING OR COMBINATIONS
  16. 16. ROTATIONAL MOULDING
  17. 17. REACTION INJECTION MOULDING (RIM)
  18. 18. SOFT MOULDING
  19. 19. DIP MOULDING
  20. 20. TESTING OF PLASTICS General tests on plastics for pharmaceutical purposes include  Extractive and biological tests,  Chemical tests,  Physical tests and  Toxicity tests.
  21. 21. STANDARD TEST PROCEDURES APPLIED TO PLASTICS.  Density  Melt flow index (MFI) Appearance—optical properties  Gloss, Haze and transmittance (Clarity), Refractive index, Fastness to light General physical properties  Tensile properties  Resistance to stress and flexing  Compression, Torsion, Shear, Stress  Impact strength  Tear properties (tear propagation resistance)  Hardness  Abrasion resistance (wear resistance) Temperature and heat sensitive evaluations (thermal properties)  Heat distortion temperature (or heat deflection temperature)  Melting point (Tm or crystalline melting point)  Vicat softening point  Brittleness temperature  Thermal conductivity  Flammability Electrical properties
  22. 22. APPLICATIONS Based on the utility of plastics they can be categorized as 1. Rigid material plastics 2. Flexible material plastics 3. Metallic surface plastics 4. Plastic cements
  23. 23. Rigid material plastics  These are the phenolic resines with various inert filters these are used in the fabrication of a number of items and it is light in weight such as gears, pipes, valves, filter press, pumps, etc…
  24. 24. Flexible material plastics  These are thermo plastic materials these materials can be rigid or flexible depending upon the amount of plasticizer added these are used in the fabrication of tanks,funnels,buckets,etc…
  25. 25. Metallic surface plastics  Plastics of polyethylene or poly vinyl chloride types are used along with plasticizer for the coating of metallic surface these are used to protect the metals from corrosion. These linings are applied on tanks, vessels, bottle caps etc..
  26. 26. Plastic cements  These are used for spaces between acid resistance tiles and bricks.
  27. 27. References… 1. Packaging of pharmaceutical dosage forms by. Thomas J Ambrosio 2. Pharmaceutical engineer by. C.V.S. Subrahmanyam 3. www.google.com
  28. 28. THANK YOU
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