Hsv Tvrao

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Human Herpes simplex infection are a grwoing concern to Medical Profession Need effective prevention Diagnosis and treatment. HSV are more Important in the era of AIDS

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  • This is real take it serious, who will believe that a herb can cure herpes, i navel believe that this will work i have spend a lot when getting drugs from the hospital to keep me healthy, what i was waiting for is death because i was broke, one day i hard about this great man who is well know of HIV and cancer cure, i decided to email him, unknowingly to me that this will be the end of the herpes in my body, he prepare the herb for me, and give me instruction on how to take it, at the end of the one month, he told me to go to the hospital for a check up, and i went, surprisingly after the test the doctor confirm me negative, i thought it was a joke, i went to other hospital was also negative, then i took my friend who was also herpes positive to the Dr Agumagu, after the treatment she was also confirm negative . He also have the herb to cure cancer. please i want every one with this virus to be free, that is why am dropping his email address, agumaguspelltemple@outlook.com or agumaguspelltemple@gmail.com do email him he is a great man. the government is also interested in this DR, thank you for saving my life, and I promise I will always testify for your good work call his number +233200116937
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  • More and more people have herpes. Share this with Herpes singles at STDromance.com
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Hsv Tvrao

  1. 1. HERPES SIMPLEX INFECTIONS Dr.T.V.Rao. MD
  2. 2. Human Herpes viruses <ul><li>A big family of viruses </li></ul><ul><li>Most Important viral infections </li></ul><ul><li>Outstanding character – Produce life long infections. </li></ul><ul><li>Assosicated with maligencies </li></ul><ul><li>1 Epstein Barr virus ( EBV ) causes </li></ul><ul><li>Burkett's lymphoma </li></ul><ul><li>Nasopharyngeal carcinoma </li></ul><ul><li>2 HHV 8 with primary effusion, Lymphoma and Kaposi’s sarcoma </li></ul>
  3. 3. Human Herpes viruses Identified types <ul><li>1 Herpes simplex 1 ( type 1 ) </li></ul><ul><li>2 Herpes simplex 2 ( type 2 ) </li></ul><ul><li>3 Varicella zoster ( type 3 ) </li></ul><ul><li>4 Epstein- Barr - Infectious mononucleosis </li></ul><ul><li>type 4 </li></ul><ul><li>5 Cytomegalovirus ( type 5 ) </li></ul><ul><li>HHV – 6 causes Roseola subitum </li></ul><ul><li>HHV - 7 Human infections ? </li></ul><ul><li>HHV - 8 - Linked to Kaposi's Sarcoma </li></ul>
  4. 4. Herpes simplex-1,2
  5. 5. Herpes simplex virus <ul><li>Virion - Spherical in shape. </li></ul><ul><li>Size is 150 – 200 nm </li></ul><ul><li>( Icosahedral ) </li></ul><ul><li>More than 35 proteins are present. </li></ul><ul><li>Contains Viral glycoprotein's </li></ul>
  6. 6. Herpes simplex-1,2 <ul><li>Herpes virus 1 affect mainly oral cavity </li></ul><ul><li>Herpes virus 2 affect Genital tract. </li></ul><ul><li>Herpes 2 infections have increased with sexual activity </li></ul><ul><li>Recent findings - Even HSV 1 has increased association with urogenital infections in USA and Israel > 65 – 70% </li></ul>
  7. 7. Long persistence <ul><li>Herpes viruses produce both Primary and Reactivations of disease </li></ul><ul><li>In advanced HIV infection HSV infections reactivate more rapidly </li></ul>
  8. 8. Clinical features HSV 1 <ul><li>HSV1 associated with Mucocutaneous lesions involving mouth and oral cavity </li></ul>
  9. 9. Herpes simplex 1 <ul><li>HSV1 mainly produce moist ulcers and lesions get epithelized in 1 – 2 weeks Recurent eruptions but heal faster </li></ul><ul><li>Stress, fever,infections, </li></ul><ul><li>sunlight.chemotherpay </li></ul><ul><li>Many non specific condtions predispose to eruptions </li></ul>
  10. 10. Sites of HSV 2 predisposition
  11. 11. Herpes simplex-2 Genital lesions.
  12. 12. Herpes simplex 2 <ul><li>HSV 2 infections are mainly associated with Genital regions </li></ul><ul><li>More in the Developing world </li></ul><ul><li>Virus have presacral latency </li></ul><ul><li>Present with multiple painful small vesicles May manifest with pelvic pain </li></ul><ul><li>Aseptic meningitis. </li></ul>
  13. 13. Herpes simplex 2 <ul><li>Risk factors include </li></ul><ul><li>Female sex, </li></ul><ul><li>Black race </li></ul><ul><li>Sexaulually traanmitted infections in the partners </li></ul><ul><li>Contact with sex workers </li></ul><ul><li>Lower economic status </li></ul><ul><li>Sexaully acitivity at yonger age </li></ul>
  14. 14. Risk of HSV infection <ul><li>Shedding of the virus can spread the transmission in the vicinity of the infected. </li></ul><ul><li>HSV 2 increases the risk of HIV acquisition. </li></ul><ul><li>Control of HSV 2 carries top priority in reducing the Incidence of HIV infection </li></ul>
  15. 15. HSV – Ocular infections <ul><li>Keratitis </li></ul><ul><li>Blepharitis </li></ul><ul><li>Kerato conjunctivitis </li></ul><ul><li>Predisposes to recurrences </li></ul><ul><li>Difficult to diffentiate from Adenovirus infections. </li></ul>
  16. 16. HSV – Neonatal and congenital infections <ul><li>Can lead to congenital malformations </li></ul><ul><li>Organomegaly </li></ul><ul><li>Bleeding tendencies </li></ul><ul><li>CNS abnormalities </li></ul><ul><li>Neonatal transmision common during delivery than intrauterine infection </li></ul><ul><li>Vacum / Forceps use during delivery increases the neonatal infections. </li></ul>
  17. 17. HSV – Encepalitis and Meningitis <ul><li>May present as Flu like illness </li></ul><ul><li>Temporal seizures </li></ul><ul><li>CSF present with pleocytosis with presence of Red blood cells. </li></ul><ul><li>Prompt Diagnosis reduces Morbidity and Mortality. </li></ul><ul><li>Diagnosis </li></ul><ul><li>MRI scans are more useful in diagnosis </li></ul><ul><li>HSV – PCR – DNA are emerging technologies carreis good Sensitivity and specificity </li></ul><ul><li>Antibodies can be detected in the CSF - affordable investigation in Devloping world. </li></ul><ul><li>Patients may present with recurrent lymphocytic meingitis </li></ul>
  18. 18. HSV – Disseminated Infections <ul><li>Can produce life threatening conditions In </li></ul><ul><li>Immunosupressed On higher / prolonged use of cortosteriods </li></ul>
  19. 19. HSV – Other manifestations <ul><li>Bells palsy </li></ul><ul><li>Esophagitis </li></ul><ul><li>Erythema Multiformis </li></ul>
  20. 20. Health care workers and HSV <ul><li>Health care workers, Doctors, Nurses and Dentists can present with Whitlows. </li></ul><ul><li>Precautions in handling infected patients and material is a priority. </li></ul>
  21. 21. Diagnosis of HSV infections <ul><li>PCR technology a growing tool for specific diagnosis. </li></ul><ul><li>Specimens can be obtained from </li></ul><ul><li>Throat washings, CSF, and Stool </li></ul><ul><li>Viral cultures and use of Neutralization protocols </li></ul><ul><li>Direct fluorescent Microscopy helpful </li></ul><ul><li>Tzanck preparation with scrapings from material – is simple and practicable methods in resource poor settings. </li></ul>
  22. 22. Serological diagnosis - HSV <ul><li>Serology is simple affordable in resource poor countries </li></ul><ul><li>Antibodies develop as early as 4 -7 days </li></ul><ul><li>peak titers appears in 2 – 4 weeks </li></ul><ul><li>Use of HSV type specific antibodies clinches the Diagnosis </li></ul>
  23. 23. Treatment and Prevention <ul><li>Antiviral agents </li></ul><ul><li>1 Acyclovir </li></ul><ul><li>2 Famciclovir </li></ul><ul><li>3 Foscarnet </li></ul><ul><li>( Used In Immunosupressed ) </li></ul><ul><li>4 Val acyclovir </li></ul><ul><li>5 Idoxuridine for Topical applications </li></ul><ul><li>6 Interferon alfa – 2b </li></ul>
  24. 24. HSV and AIDS <ul><li>It is important to HIV infected should be assayed for HSV 2 antibodies </li></ul><ul><li>Use of HAART ( In AIDS ) reduces the associated lesions of HSV 2 infections and reduces the complication and lesions. </li></ul>
  25. 25. Why HSV 2 Important in AIDS <ul><li>Control, prevention and treatment of HSV2 reduces the incidence of HIV infections </li></ul>
  26. 26. Prevention of HSV 2 infections. <ul><li>Barrier precautions during sexaul intercourse </li></ul><ul><li>Hand washing in the working environment by Health care workers when dealing with HSV patients. </li></ul><ul><li>Gloves and Gowning to be practiced </li></ul>
  27. 27. Counseling in HSV infections. <ul><li>Needs counseling at Prenatal clinics,HIV,and Sexaully transmitted Infection centers, with </li></ul><ul><li>1 Uncertain clinical History </li></ul><ul><li>2 High risk behaviour </li></ul><ul><li>3 Increaed number of sex partners. </li></ul>
  28. 28. Vaccine for HSV ? <ul><li>Yet there is no successful vaccine to the universal use </li></ul><ul><li>A glycoprotein vaccine for HSV 2 for women with negative serology, on record with success </li></ul>
  29. 29. Created for Medical and Health care workers in Developing World Dr.T.V.Rao MD Email [email_address]

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