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Cancer immunotherapy

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types of cancer immunotherapy

types of cancer immunotherapy

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  • 1. Immunoth erapy B.Devada tha
  • 2. What is immunotherapy? • Treatment that uses certain parts of the immune system to fight diseases such as cancer • Stimulating your own immune system to work harder or smarter to attack cancer cells • Giving you immune system components, such as man-made immune system proteins • Dr William Coley used Coley's Toxins in the late 1800s as crude immunotherapy with some success. • first therapeutic monoclonal antibodies rituximab (Rituxan) and trastuzumab (Herceptin) were approved during the late 1990s to treat lymphoma and breast cancer
  • 3. Immune Response to Tumors
  • 4. Types of immunotherapy • Passive immunotherapy: • Adminstration of monoclonal antibodies which target either tumour-specific or over-expressed antigens. • Active immunotherapies: • Cytokines- IL-2 / IFNs / TNFα • Cancer vaccines • Cell-based therapies • tumour-specific CTL • tumour-derived APC • DC priming
  • 5. Monoclonal antibody therapy • monoclonal antibodies that bind only to cancer cell-specific antigens and induce an immunological response against the target cancer cell. • Naked mAbs :antibodies that work by themselves. boost a person’s immune response against cancer cells. • blocking specific proteins that help cancer cells grow. Eg. Trastuzumab-HER2 • Conjugated mAbs: are those joined to a chemotherapy drug, radioactive particle, or a toxin • Radiolabelled: Ibritumomab tiuxetan and tositumomab –CD20Ag • Chemolabeled: brentuximab vedotin -CD30 antigen • Immunotoxins: denileukin diftitox
  • 6. Monoclonal antibodies for cancer. ADEPT, antibody directed enzyme pro drug therapy; ADCC, antibody dependent cell-mediated cytotoxicity; CDC, complement dependent cytotoxicity; MAb, monoclonal antibody; scFv single-chain Fv fragment
  • 7. Cancer vaccines • Tumor cell vaccines: made from actual cancer cells that have been removed during surgery. • Antigen vaccines: These vaccines boost the immune system by using only one antigen rather than whole tumor cells • Dendritic cell vaccines: special immune cells in the body that help the immune system recognize cancer cells • DNA vaccines: Vectors can be given bits of DNA that code for protein antigens. • When the vectors are then injected into the body, this DNA might be taken up by cells and can instruct them to make specific antigens
  • 8. Mechanism of action of Sipuleucel-T
  • 9. Adoptive immunotherapy for cancer vemurafenib
  • 10. Dendritic Cell based Immunotherapy
  • 11. cytokine based cancer therapy
  • 12. Other drugs that boost the immune system • Thalidomide: • treatment for multiple myeloma • Lenalidomide: • Newer drug , treatment for multiple myeloma • Bacille Calmette-Guérin: • treatment of superficial forms of bladder cancer • Colorectal cancer • Lung cancer • Melanoma • Medicinal mushrooms: • Agaricus subrufescens -anticancer properties
  • 13. Reference • Kantoff PW, Schuetz TJ, Blumenstein BA, et al. Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer. J Clin Oncol. 2010;28:1099-1105. • Recent Advances and Current Challenges inTumor Immunology and Immunotherapy • Text books: • The biology of Cancer:R.A Weinberg 2nd ed • Kuby Immunology 8th ed • Ivan roitt Essential Immunology 12th ed
  • 14. Thank u for your attention

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