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The Health Report

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  • 1. The Health Report appeals to both specialist and mainstream audiences by applying a broad definition of health, and seeing health and medicine within social, scientific and political contexts. The Health Report is a valued information source for professionals and students in the medical and health professions, as well as attracting a sizeable audience of general listeners seeking jargon-free, easy-to-understand information and analysis on health and medical matters. Presented by Dr Norman Swan, the program covers wide-ranging topics and issues, among them: cancer, endocrinology, epidemiology, exercise, gastroentorolgy, gynaecology, health education, mental health, nutrition, obstetrics, paediatrics, physiotherapy, and rheumatology. The Health Report is broadcast on Monday at 8.30am, repeated Monday evening at 8.30pm and Tuesday at 1.30am, on Radio National, the Australian Broadcasting Corporation's national radio network of ideas. http://www.abc.net.au/rn/talks/8.30/helthrpt/about.htm Mercury in Fish 8 September 2003 Program Transcript Mercury has been known to be highly toxic. But is mercury in fish as toxic as has been suggested? Researchers have analysed the mercury in fish to see what form it actually takes. Program Transcript Norman Swan: Welcome to the program. Today on The Health Report, why young adult Australians risk being put on the spot; spot checks on unborn Australians; and the hidden problem spots in our diet. Let’s start with the diet. On the one hand we’re exhorted to eat fish frequently, while on the other there are regular scares about the mercury content in some of the corpses on the fishmonger’s slab. It’s a controversy that research just published might lay to rest a little. A group including Dr Hugh Harris from the University of Sydney has analysed the mercury in fish to see what form it actually takes. Hugh Harris: Most of the debate seems to centre on whether low levels that people get from eating fish cause neurological symptoms in unborn children. There’s also some evidence that might be linked to increased risk of heart attack. Norman Swan: And what was the theory you were pursuing? Hugh Harris: Most of the reports and the health advisories just mentioned what they call methylmercury. Now there’s various different types of methylmercury, and the toxic
  • 2. properties of the different chemicals depend upon their form. We wanted to find out exactly what type of methylmercury was present in fish flesh. Norman Swan: Before we get into the esoteric but important detail about the chemical structure of mercury in biological systems, it’s worth putting the story into context. While mercury has been known for centuries to be highly toxic, it was a disaster in Japan, which made the world realise that fish could be the vehicle to get it into our bodies. Environmental mercury is the research interest of Professor Jerry Keeler, of the University of Michigan, Ann Arbor. Jerry Keeler: Yes, the Minamata incident was one of the ones that really elevated our understanding and concern about how bad a problem mercury pollution can be. Norman Swan: Just remind us of that story. Jerry Keeler: Well in the ‘50s, Japan was trying to get their industrial base going and so they started their chemical manufacturing back-up in earnest, and a chemical plant, which was using mercury as part of the process, began dumping mercury into the Minamata Bay, and to save on money they started using seawater in the process rather than fresh water, and the seawater caused the mercury to go into a toxic form, methylmercury, and they started dumping enormous amounts of methylmercury into the Bay, which quickly bio-accumulated up the food chain and all the fish that were in the Minamata Bay became contaminated at very, very high levels. And because the area was rather poor and fish was their main source of food, thousands of people quickly became contaminated with mercury, and now it’s called Minamata Disease. Norman Swan: What did it do to them? Jerry Keeler: Minamata Disease is something that has multiple effects. First of all, people that have very high levels of mercury in their fish for a long period of time actually died. It causes neurological impairment, you get to a point where you can’t walk, your nerves are completely gone. They had cats who got Minamata Disease, and shook from eating the fish, the leftover fish. It causes all kinds of neurological and birth impairments as well. So a whole generation of children whose parents were pregnant at the time of this incident and this tragedy, were born with very, very gross birth defects. Norman Swan: And of course one of the reasons for being so concerned about mercury, is that you don’t get rid of it very easily, it accumulates in your body. Jerry Keeler: That is correct. The organic form, the methyl-mercury form, does accumulate in the body and in the organs, and then builds up. Norman Swan: Professor Jerry Keeler, who has also, with others, shown how mercury circulates in the environment, and it’s not necessarily through water run-off from dirty industries. Atmospheric circulation seems to be a major source. Jerry Keeler: Well the most important industries are related to fossil fuel combustion and waste incineration. Norman Swan: So cars produce mercury? Jerry Keeler: Some of the research that we’ve been doing more recently has shown that in fact motor vehicles do emit mercury and that the amount of mercury emitted is related to the type of fuel that they burn, and also the type of engine. But this is very preliminary at this point.
  • 3. Norman Swan: So coal-fire power stations produce mercury? Jerry Keeler: Yes, the largest source of mercury to the environment in the world today is coal-fired power plants. And today, China, with its increased use of coal, is becoming the No.l country in the world emitting mercury. Norman Swan: So where does the mercury go? It goes into the air, in particulate form, or gaseous form, what is it? Jerry Keeler: Yes, well that’s an excellent question. Mercury is emitted in multiple forms and this is one of the problems we’ve had in terms of understanding what to do about it. Mercury is emitted in various gaseous forms: in an elemental form like what we have in a thermometer; but it’s also emitted in a form which we call divalent mercury, or mercuric chloride, and it’s this form that rapidly deposits around plants and facilities, gets taken in the clouds and deposits, and then that’s the form that actually is methylated in the environment. So sources like medical waste incinerators and municipal waste incinerators emit almost entirely in this mercuric chloride form. And so those sources are more severe in terms of their impact than say, other fossil fuel-burning sources, or sources that put out just elemental mercury. Norman Swan: OK. So it goes into the air and it just drops down with gravity, or washed out with rain? Jerry Keeler: Well the mercuric chloride form is a very water-soluble form, so most of the mercury contamination is related to mercury that’s engulfed in the clouds. It gets into the cloud droplets and then comes out in the rain. So one of the things that our Swedish colleagues found years ago was that the acid deposition problem with lower pHs and so forth, was also related to high mercury problems, and so the same areas that were getting hit with high levels of acid deposition also had very high levels of mercury. Norman Swan: Air to water, so it lands in the sea? Or it lands in lakes, or what’s the story here now? What happens when it comes back to earth? Jerry Keeler: Well here again, this is one of the things that’s really difficult. The plumes are emitted in multiple forms. I already mentioned about the gas phase forms, but they also do come out as particulates, and these forms then get engulfed in the clouds, they come to the surface and what happens to the mercury once it hits the surface is it changes forms and then comes back up again. So that it’s a continual cycle, it’s like a grasshopper: it goes up, comes down, goes up, comes down. Norman Swan: Well how can it go back up? So you’re saying it lands on a field and goes back up again somehow? Jerry Keeler: Yes. Sunlight basically transforms it into a form that it likes to be in the gas phase, and it comes back off of the surface. So it’s a problem that allows for a very wide contamination, so pollutants that are emitted in one spot can be transformed and continue to be transported all around the globe, and that’s why it’s really a global problem. Norman Swan: And in terms of human beings, we presumably inhale that, but there presumably is a food chain problem too? Jerry Keeler: Yes, the greatest health risk due to mercury is in the ingestion of food. So it’s through eating fish and other food products that are contaminated with mercury.
  • 4. Norman Swan: Jerry Keeler is Associate Professor of Environment Health Sciences in the School of Public Health at the University of Michigan, Ann Arbor. So after having the bejesus out of you, let’s go back to low-level mercury exposure and Dr Hugh Harris, who decided with colleagues at Stanford University in California to look more closely at what form mercury takes once it gets into fish flesh. And the massive machine they used to do the work is called a synchrotron. Hugh Harris: A synchrotron generates very bright x-rays and you can tune the energy of those x-rays. Norman Swan: In a sense you’re illuminating an object with x-rays instead of visible light? Hugh Harris: Yes. Norman Swan: And hope to be able to see through it and see its structure? Hugh Harris: Unlike a standard x-ray that you might get at the doctor, which is just one energy of x-rays, you actually illuminate the sample with a range of different energies, and you look at the response. Norman Swan: And the advantage of a synchrotron, because we’re building one at great expense here in Victoria, what is the advantage of a synchrotron? It can describe molecular structure? Hugh Harris: Those bright x-rays can be used for a range of different techniques, which you really can’t perform anywhere else. One of them which is what I did, was called x- ray absorption spectroscopy. Norman Swan: So you took swordfish, orange roughy, these are American fish. Hugh Harris: Yes, well swordfish and orange roughy are commonly available in Australia. The other one is sand sole which I suppose is equivalent to a flounder here. Norman Swan: And what do you do with the fish? Mash them up? Hugh Harris: Essentially just cut a piece of the flesh out and freeze them down to 10 Kelvin. Norman Swan: Very, very cold. Hugh Harris: To reduce the effect of the x-ray. Norman Swan: And there was potentially good news. It seems the form that methyl- mercury takes in at least the fish they studied might be less biologically available. Hugh Harris: We found that in all of the fish there’s certainly mercury, but the main finding is that the methyl-mercury is bound to another molecule which has sulphur atom bound directly. Previously, toxicological modelling for mercury has been based on methylmercury chloride, which seems to be a fair bit more toxic than methylmercury cysteine. Norman Swan: Cysteine being the chemical indication that sulphur is there somewhere. So what you’re saying is, that when people have said, ‘Look, mercury is toxic’, they’ve taken a form of mercury which is, if you like, a free form of mercury in the environment, this methylmercury chloride, whereas what you found is that in these fish, it seems bound to sulphur and therefore more stable, less likely to get into the rest of the system?
  • 5. Hugh Harris: It’s possible. There’s an interesting study recently published about fish- eating habits in the Seychelles. The study there was where people actually ate the fish, so they’re getting the real form where they’re actually getting methylmercury cysteine in that study. Norman Swan: And? Hugh Harris: Well they don’t see any link between increased levels of mercury and neurological problems in children whose mothers have eaten fish. Norman Swan: So as is the usual refrain: more research is needed, but meantime the odd swordfish steak won’t write you off.
  • 6. Dr Hugh Harris is Australian Synchrotron Research Fellow at the University of Sydney. Harris H et al. The Chemical Form of Mercury in Fish. Science 29 August 2003;301;5637:1203 Rea A.W.et al. Assessment of dry deposition of foliar leaching of mercury and selected trace elements based on washed foliar and surrogate surfaces. Env Sci Technol. 34:2505-2509 Dvonch J.T. et al. Utilization of elemental tracers to source apportion mercury in South Florida Precipitation. Env Sci Technol. 33:4522-4527 Vincent J.H. et al. Application of recent advances in aerosol sampling Science towards the development of improved sampling devices: the way ahead. Env Monitoring. 1:285-292 Clark N.M. et al. Childhood Asthma. Env Hlth Perspectives. 107: 421-429 Albalak R. et al. Assessment of PM10 concentrations from domestic biomass fuel combustion in two rural Bolivian highland villages. Env Sci Technol. 33: 2505-2509 Albalak R. et al. Domestic biomass fuel combustion and chronic bronchitis in two rural Bolivian villages. Thorax. 54: 1104-1108 Scherbatskoy T. et al. Factors controlling mercury transport in an upland forested catchment. Water, Air and Soil Pollution. 105: 427-438 Guests on this program: Dr Hugh Harris ASRP Postdoctoral Fellow School of Chemistry University of Sydney New South Wales 2006 Dr Gerald Keeler Professor of Environmental Health Sciences School of Public Health University of Michigan 109 South Observatory, 1530 SPH l, Ann Arbor, MI 48109-2029 Presenter: Norman Swan Producer: Brigitte Seega

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