UCL Institute of Neurology
UCL Institute of Neurology
The Institute of Neurology is a specialist postgraduate institute of UCL. The Institute is closely
associated in its work with the National Hospital for Neurology & Neurosurgery, University
College London Hospitals' NHS Foundation Trust, and in combination they form a national and
international centre at Queen Square for teaching, training and research in neurology and allied
clinical and basic neurosciences.
The Institute website is at: http://www.ion.ucl.ac.uk/.
The Institute of Neurology is a member of the newly formed Faculty of Biomedical Sciences at
UCL, and has nine academic departments. Seven encompass clinical and basic research within
each theme: Neurodegenerative Disease; Molecular Neuroscience; Clinical and Experimental
Epilepsy; Motor Neuroscience and Movement Disorders; Imaging Neuroscience; Brain Repair and
Rehabilitation; and Neuroinflammation. The remaining two are the Reta Lila Weston Institute of
Neurological Studies and the Department of Clinical Neuroscience, Royal Free Campus, both of
which are now fully merged with the Institute. In parallel there are currently six divisions
representing professional affiliations: Clinical Neurology; Neurosurgery; Neurophysiology;
Neuropathology; Neuropsychiatry and Neuropsychology; and Neuroradiology and Neurophysics.
The Institute employs a total of around 425 staff, occupies some 6,451 sq m of laboratory and
office space in five buildings, and has a current annual turnover of £30m.
The Institute receives over £19.1m per annum in grants for research from the principal medical
charities concerned with neurological diseases, and from government agencies such as the Medical
Research Council. Approximately 19% of the Institute's funding is obtained from the Higher
Education Funding Council for England which has awarded high ratings for the Institute in each of
the national Research Assessment Exercises since 1986. The Institute currently holds over 250
active grants, supporting research into the causes and treatment of a wide range of neurological
diseases, including movement disorders, multiple sclerosis, epilepsy, brain cancer, stroke and brain
injury, muscle and nerve disorders, cognitive dysfunction and dementia, and the work of the
Institute's clinical academic staff is closely integrated with the Hospital's care of patients.
Generous support for research at the Institute of Neurology is provided by the medical charities and
especially by the charity, The Brain Research Trust http://www.brt.org.uk
The Institute was awarded a Grade 5*A rating (the highest possible rating) in the 2001 Exercise, a
measure of its national and international standing. In the calendar year 2005 Institute staff
published 584 peer-reviewed papers, 74 chapters and 10 books. Thirty-six papers were published
in the top 50 of all scientific journals, including Science, Nature, Neuron, Cell and New England
Journal of Medicine. Eight of the thirty most highly cited UK neuroscientists are at the Institute of
Neurology, and there are seven Fellows of the Royal Society at Queen Square.
A number of important research centres are based at the Institute of Neurology. These include:
• Wellcome Centre for Neuroimaging http://www.fil.ion.ucl.ac.uk/
• MRC Prion Unit
• MRC Centre for Neuromuscular Disease http://www.ucl.ac.uk/neuromuscular/
• Dementia Research Centre http://www.dementia.ion.ucl.ac.uk/
• Department of Health Dementias and Neurodegenerative Diseases Research Network
We share many research programmes with the Institute of Cognitive Neuroscience, the Gatsby
Computational Neuroscience Unit, the Reta Lila Weston Institute, the Royal Free Department of
Clinical Neuroscience, the High Field Imaging Laboratory (Department of Engineering and
Medical Physics), and also the neuroscience research groups based in our sister Institutes (Institute
of Child Health and Institute of Ophthalmology).
The Institute of Neurology plays a major role in postgraduate teaching and training. There are over
125 graduate students at Queen Square. The Institute runs a number of graduate teaching
programmes, including Master’s degrees in Clinical Neuroscience, Clinical Neurology and
Advanced Neuroimaging. It is also making a major contribution to the new London-Paris MSc in
Mind and Brain. We attract excellent graduate students of the highest quality through UCL-wide
PhD programmes, including the Wellcome 4-year PhD in Neuroscience
http://www.physiol.ucl.ac.uk/neurosciencephd/. Institute staff contribute to undergraduate teaching
of clinical neurology for the Medical School.
Full details of the Institute’s research and teaching activity can be found on the Institute of
Neurology website at http://www.ion.ucl.ac.uk
MRC Centre for Neuromuscular Disease,
Research Department of Molecular Neuroscience
UCL Institute of Neurology &
The National Hospital for Neurology and Neurosurgery
Post: Clinical Research Associate
Line Manager: Dr Mary Reilly
Head of Department: Professor Nick Wood
Overview of the Post:
The post is a maternity leave locum based in the MRC Centre for Neuromuscular Disease, Research
Department of Molecular Neuroscience at UCL Institute of Neurology, Queen Square.
The research portfolio of the DMN is based on multiple and interacting groups that engage in basic
and clinical science research on the genetic and molecular pathology of neurological diseases. The
Department has strong links to important IoN and NHNN centres, including the Sobell Department
of Motor Neuroscience & Movement Disorders.
The Centre for Neuromuscular Disease (Director: Professor Michael Hanna) is the largest clinical and
research centre in the UK for patients with muscle wasting diseases such as muscular dystrophy and
peripheral neuropathy. The Centre has major support from the Department of Health for two of its
specialist services in muscle channel diseases and mitochondrial diseases. This direct funding now
amounts to £1.5 million per annum. In addition the Centre has recently been awarded a major MRC
grant to establish an MRC translational research centre as part of the clinical centre.
The clinical aspects of the study on which the postholder will be engaged will be conducted at the
National Hospital for Neurology and Neurosurgery. The key elements of this post are:
• The research will include running a clinical trial of ascorbic acid treatment in Charcot-Marie-
Tooth disease type 1A.
• The Clinical Research Associate will actively participate in the educational and research
activities of the research group and the MRC Centre.
• For the clinical aspects of the study, the Clinical Research Associate will work under the
direction of Dr Mary Reilly (the principal investigator and grant holder for the study).
• The postholder will provide support and information to the MRC when required.
1.1To assess patients with Charcot-Marie-Tooth disease and perform the clinical scales on patients
enrolled in the trial.
1.2To perform neurophysiological assessments on patients enrolled in the trial.
1.3To ensure clinical trials run according to GCP.
2. Teaching and R&D
2.1 To maintain study folders in line with guidance from R&D Department.
2.2 To acquire the knowledge and skills essential for effective research governance.
3. Quality Assurance
3.1To establish a database for recording all relevant trial data and to ensure that it is updated and
maintained to the highest levels of accuracy throughout.
3.2 To provide information required for the purposes of safety and data monitoring during
studies, as specified by protocols or when required by the Data and Safety Monitoring
4.1 To act as an independent agent in setting up appointments, dealing with referrals and
telephone calls and in the general co-ordination of arrangements for patients/carers.
4.2 To ensure the highest standard of record keeping, maintaining accurate and appropriate patient
records, including the strict confidentiality of all records.
4.3 To attend Departmental and other meetings as appropriate.
5.1 To act at all times in accordance with the highest professional standards, and to ensure that
these are maintained in the delivery of all aspects of patient care.
5.2 To ensure that he/she is covered, at all times, by appropriate medical indemnity.
6.1 As duties and responsibilities change, the job description will be reviewed and amended in
consultation with the post holder.
6.2 The post holder will carry out any other duties as are within the scope, spirit and purpose
The job as requested by the line manager.
6.3 The post holder will actively follow UCL policies including Equal Opportunities policies.
6.4 The post holder will maintain an awareness and observation of Fire and Health & Safety
7. Person Specification
* Registered Medical Practitioner
* Completed general medical training
* Have experience in Neurology at SPR or equivalent level
* Have MRCP or equivalent
* Experience of peripheral nerve and/or muscle disease
* Experience of neurophysiology
* Resourceful and able to act on own initiative
* Excellent organizational skills
* Good inter-personal skills with an ability to work co-operatively in a multidisciplinary setting
* A very high level of consideration and care for patients and research subjects
* Interested in research and a commitment to quality in the research process
* Experience of computing (database, word processing, email)
* Experience of laboratory work
* Interest in neuromuscular disorders or genetics
* Understanding of research methodology
* Experience of statistics
The post, which is available from 17 November 2008, is funded by the Muscular Dystrophy
Campaign for a period of 18 weeks in the first instance or until the return of the permanent
postholder (whichever is sooner). It will be offered subject to satisfactory references, satisfactory
completion of a probationary period of nine months in principle, and satisfactory health clearance
by the Occupational Health Department.
Starting salary will be in the range £30,231 - £38,336 pa on the CL7 scale), plus London
Allowance of £2,649 pa. The post is superannuable under the Universities’ Superannuation
Scheme (USS) or, subject to eligibility, the National Health Service Superannuation Scheme
Annual Leave: 33 days per annum pro rata
Hours of Work: 36.5 per week
Interest-free season ticket loan available (after a qualifying period).
Applications (2 copies of CV plus 1 copy of the declaration (see below) and names of 3 referees)
should be sent to:
Miss E Bertram
Institute of Neurology
The National Hospital for Neurology & Neurosurgery
London WC1N 3BG
Fax: 020 7278 5069
Email: personnel @ion.ucl.ac.uk
Closing date: 19 September 2008
It is anticipated that interviews will be held on 6 October 2008.
Please note: Where applicants are shortlisted for formal interview, references will normally be
taken up prior to interview. Applicants who do not wish any referees to be so contacted should
make this explicitly clear beside the referees’ contact details.
We are unfortunately unable to reply to those applicants who have not been shortlisted and invited
for interview. However, we would like to thank all candidates for their applications and for their
interest in the Institute of Neurology. Please contact us on 7676 2191 if you wish to check the
progress of your individual application.
Brief outline of research
The post is to cover the examining neurologist running a trial of ascorbic acid treatment in Charcot-
Marie-Tooth disease type 1 A.
This is a placebo controlled double blind study designed to assess the efficacy and safety of
treatment with Ascorbic Acid (AA) in patients with Charcot-Marie-Tooth disease type 1A. 50
subjects have been randomized to one of two groups: placebo (25 patients) or AA 1500 mg/daily
(25 patients). Participants will receive study medication for 2 years. The recruitment has been
completed in September 2007. During the treatment trial patients will be seen at screening, day 0
(Baseline) and months 6, 12, 18, 24. Patients are also followed up every 3 months to assess
compliance with treatment. Patients enrolled have now completed the 12-month follow-up.
Study subjects must meet all of the following criteria:
1. Clinical diagnosis of CMT1A;
2. Genetic confirmation of CMT1A diagnosis, based on presence of the 17p11.2 duplication;
3. CMT Neuropathy Score (CMTNS) between 1 (excluding the electrophysiological
component) and 35 (including the electrophysiological component) (Shy 2005);
4. Age 18-70 years;
5. Ability to accomplish the primary outcome measures;
6. Women of child-bearing age only if they are not pregnant or breast feeding at the inclusion
into the study and agree not to become pregnant during the study*;
7. Signed informed patient consent.
The presence of any of the following excludes subject participation in the study:
1. Clinical or echographic diagnosis of nephrolithiasis;
2. Positive history of recurrent renal colic;
3. One or more episodes of renal colic during the 6 months prior to the enrolment;
4. Deficit of Glucose-6P-Dehydrogenase (G6PD) (Non spherocytic Hemolytic anemia due to
5. Acquired or hereditary haemochromatosis; thalassemia major; sideroblastic anaemia;
6. Treatment with ramified chain amino-acids or other drugs considered as potential
therapeutic agents for CMT1A during the three months prior to screening;
7. AA treatment in the three months prior to screening;
8. Other causes of neuropathy (e.g. diabetes, monoclonal gammopathy, cryoglobulinaemia,
neoplasms, B12 deficiency, HCV-related liver disease);
9. Presence of other neurological disorders (such as multiple sclerosis, cerebrovascular
diseases, movement disorders), or major comorbidities (e.g., definite cognitive impairment,
psychiatric disease, heart or lung failure, orthopaedic or rheumatological disorders);
10. Limb surgery during the six months prior to screening (or planned before final assessment).
Screening and Informed Consent: At the screening visit, potential research participants will be
informed about study procedures and then will sign an informed consent form. The
inclusion/exclusion criteria will be reviewed and a medical history and full physical and
neurological examination completed. The potential research participant will be given a
neurological examination. Vital signs, weight and concomitant medications will be recorded.
Safety laboratory tests will be performed including a complete blood count (CBC) with differential,
electrolytes (including glucose), thyroid function, vit. B12, immunofixation, ALT, AST, serum
creatinine and uerea, Hep C antibodies, iron, ferritin, iron binding capacity, uric acid, a full
urinalysis with oxalate/creatinine ratio. The principal investigator will review all inclusion and
exclusion criteria and safety laboratory tests prior to randomization. If the subject passes all
screening procedures and is confirmed as eligible, the randomization is performed and the baseline
visit can be scheduled.
Baseline: Baseline evaluations will include vital signs and weight check, concomitant medication
review, assessment of muscle strength with a myometer (MVIC), performing of Charcot-Marie-
Tooth neuropathy score (CMTNS), 10-metre timed walking, Overall Neuropathy Limitation scale
(ONLS), 9-hole peg test (9-HPT), pain and SF-36 questionnaires, nerve conduction study, CHEPs
and thermal threshold. A blood sample will be also taken for AA assay.
Follow-up Visits: At month 6 and 18 blood and urine tests, CMTNS, MVIC, ONLS, 9-HPT, 10m
timed walking, nerve conduction study will be performed. At month 12 blood and urine, CMTNS,
MVIC, ONLS, SF-36, 9-HPT, 10m timed walking, nerve conduction study will be performed. At
month 24 blood and urine tests, CMTNS, MVIC, ONLS, 9-HPT, 10m timed walking, nerve
conduction study, CHEPs, thermal thresholds, pain and SA-36 questionnaires will be performed.
At every study visit participants will be seen for assessment of adverse experiences. Every 3-month
patients will come to the Hospital to collect study drug supply and to be assessed for compliance.
To be completed by all those submitting a CV in application for a post with UCL. Our equal
opportunities policy includes the provision that in recruitment, the only consideration must be that
the individual meets or is likely to meet the genuine requirements of the job. No one will be
discriminated against on the basis of gender, age, race, colour, ethnic origin, physical disability,
marital status, sexual orientation, caring or parental responsibilities, or belief on any matters
including religion and politics. Please complete this form in black ink/biro or by typing or an
Application for the position of:
Department: Institute of Neurology Ref No or Job Code:
Other Name(s): Preferred Forename:
Address: Telephone numbers and email address at
which we may contact you
Do you require permission/a work permit to take up employment in the UK? Yes/No
(Immigration and Asylum Act 1996 – see attached sheet)
I confirm that I will provide the relevant documentation should I be invited to interview.
Do you need to register under the Home Office EU Accession State Worker Registration
Scheme? (For further information, see:
Have you ever been convicted in a Court of Law? Yes/No
(Declaration subject to the Rehabilitation of Offenders Act 1974 and the (Exceptions)
(Amendment) order 1986 – see attached sheet)
If yes, please give details:
How many days sick leave have you had in the last 12 months?
Are you are 64 or over? Yes/No
It is UCL policy that staff normally retire on the 31st July following their 65th birthday. In line with
this UCL will not normally employ someone who is within six months of that date.
(See http://www.ucl.ac.uk/hr/docs/retirement.php for more information)
Do you have a Personal Relationship with any member of staff/student at UCL? Yes/No
(See http://www.ucl.ac.uk/hr/docs/personal_relationships.php for more details)
If so, please give details:
To the best of my knowledge the answers given to the questions contained above and all
statements made are true and accurate. I understand that any falsification may be considered
sufficient cause for rejection or, if employed, dismissal.
I give my consent to UCL to process sensitive data for the purposes of personnel administration.
My consent is conditional upon UCL complying with the obligations and duties under the Data
Protection Act 1998.
Signature of applicant: Date:
IMMIGRATION AND ASYLUM ACT 1996
Under Section 8 of the Asylum and Immigration Act 1996 it is a criminal offence to employ
someone who does not have permission to be in, or to work in, the United Kingdom. The Act
does provide a defence against a potential charge of employing an illegal worker if we can show
that the person produced an "official document" when they commenced employment. You are
asked to provide one of the following “official documents”.
Passport from an EEA country or visa stamp showing permission to work (for further advice,
contact Human Resources)
• Birth certificate from an EEA country
Please note that a National Insurance number does not automatically indicate that the individual is
eligible to work, and is not sufficient evidence.
REHABILITATION OF OFFENDERS ACT 1974
The Rehabilitation of Offenders Act 1974 is intended to ensure that a person convicted of a
criminal offence (whether in Great Britain or abroad), not involving a sentence of more than 2.5
years’ imprisonment who has not since re-offended for a specified period of time (a rehabilitation
period) related to the severity of their sentence is treated as if the offence, conviction and
sentence had never occurred. Sentences of more than 2.5 years put an individual concerned
outside the scope of the Act. Such convictions can never therefore become spent.
(Exceptions) (Amendment) order 1986
Exempted professions NOT covered by The Rehabilitation of Offenders Act 1974 are:-
• Medical practitioner
• Barrister (in England and Wales), advocate (in Scotland), solicitor
• Chartered accountant, certified accountant
• Dentist, dental hygienist, dental auxiliary
• Veterinary surgeon
• Nurse, midwife
• Ophthalmic optician, dispensing optician
• Pharmaceutical chemist
• Registered teacher (in Scotland)
• Any profession to which the Professions Supplementary to Medicine Act 1960 applies and
which is undertaken following registration under the Act.
STAFF EQUAL OPPORTUNITIES CLASSIFICATION FORM
Surname: First Name(s):
Date of Birth:
University College London has a commitment to ensuring that staff are appointed and promoted on the basis
of merit, regardless of ethnic origin, sex or disability, sexual orientation, race, colour, nationality (within
current legislation), marital status, caring or parental responsibilities, age, or beliefs on matters such as
religion and politics. Monitoring enables us to see what is happening in practice, to assess the impact of our
equal opportunities policy and its implementation, and to set any targets for improvements, and measure
progress. To enable us to do this, and to make the exercise successful, we rely on all staff to supply the
following details, which will be treated in the strictest confidence. Thank you for your co-operation.
Choose the appropriate box
White – British
White – Irish
White – Other
Mixed Race - White & Black Caribbean
Mixed Race - White & Black African
Mixed Race - White & Asian
Mixed Race - Other
Sex Male Female
Are you disabled or do you have any condition that may require adjustments to your work or working
environment? (Examples of a ‘condition’ may include impairment of senses, co-ordination, memory,
mobility, learning, health or wellbeing.)
(If you have ticked yes, you will be contacted by UCL’s Occupational Health Service to assess your
requirements and to advise your manager of any reasonable adjustments that are needed)
I do consider myself to have a disability, but I do not wish this information to be shared with anyone else.
(If you have ticked yes, but require reasonable adjustments in the future, it is your responsibility to inform
UCL through your manager)