Invest in Kids Andrea McGuire, MD, MBA Chief Medical Officer American Republic Insurance Company Iowa Early Care, Health a...
Why talk about Brain Research? <ul><li>Data Driven </li></ul><ul><li>Evidence Based </li></ul><ul><li>Findings relate to A...
Early Childhood Brain Research <ul><li>Brain Anatomy,Cellular function and neuropathways </li></ul><ul><li>Brain Research ...
NeuroAnatomy
 
NeuroAnatomy
NeuroAnatomy <ul><li>Synapse </li></ul>
Positron Emission Tomography
Newborn Brain Pet Scans*  * Harry T. Chugani -  Biological Basis of Emotions: Brain Systems and Brain Development -  Pedia...
2-3 months* * Harry T. Chugani -  Biological Basis of Emotions: Brain Systems and Brain Development -  Pediatrics, Nov 199...
8 months* * Harry T. Chugani -  Biological Basis of Emotions: Brain Systems and Brain Development -  Pediatrics, Nov 1998;...
Scott Grafton, M.D. - Dept. of Neurology and Dept. of Radiology - University of Southern California  John Mazziotta, M.D.,...
Scott Grafton, M.D. - Dept. of Neurology and Dept. of Radiology - University of Southern California  John Mazziotta, M.D.,...
Synapse production & pruning # synapses age in years 20 40 60 80 4 8 12 16 0 frontal lobe visual cortex
Plasticity Note: The listed factors are not intended to be exhaustive. Chronic stress Social interaction Methyl mercury Ac...
Resting Scott Grafton, M.D. - Dept. of Neurology and Dept. of Radiology - University of Southern California  John Mazziott...
Hearing Scott Grafton, M.D. - Dept. of Neurology and Dept. of Radiology - University of Southern California  John Mazziott...
Visual Scott Grafton, M.D. - Dept. of Neurology and Dept. of Radiology - University of Southern California  John Mazziotta...
Thinking task Scott Grafton, M.D. - Dept. of Neurology and Dept. of Radiology - University of Southern California  John Ma...
Later Recall Scott Grafton, M.D. - Dept. of Neurology and Dept. of Radiology - University of Southern California  John Maz...
 
Florida State University, Center for Educational Enhancement & Development, Wil Bechman, M.D., 1998.
The Child Development and Public Expenditures chart source is researchers at the RAND Corporation (see  Investing in our C...
Conclusions <ul><li>Window of Opportunity </li></ul><ul><li>Return on investment </li></ul><ul><li>Nurture and Protect our...
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    1. 1. Invest in Kids Andrea McGuire, MD, MBA Chief Medical Officer American Republic Insurance Company Iowa Early Care, Health and Education Day on the Hill Feb 2007
    2. 2. Why talk about Brain Research? <ul><li>Data Driven </li></ul><ul><li>Evidence Based </li></ul><ul><li>Findings relate to Actions </li></ul>
    3. 3. Early Childhood Brain Research <ul><li>Brain Anatomy,Cellular function and neuropathways </li></ul><ul><li>Brain Research Studies of Early Childhood </li></ul><ul><li>Conclusions </li></ul>
    4. 4. NeuroAnatomy
    5. 6. NeuroAnatomy
    6. 7. NeuroAnatomy <ul><li>Synapse </li></ul>
    7. 8. Positron Emission Tomography
    8. 9. Newborn Brain Pet Scans* * Harry T. Chugani - Biological Basis of Emotions: Brain Systems and Brain Development - Pediatrics, Nov 1998; 102: 1225.
    9. 10. 2-3 months* * Harry T. Chugani - Biological Basis of Emotions: Brain Systems and Brain Development - Pediatrics, Nov 1998; 102: 1225.
    10. 11. 8 months* * Harry T. Chugani - Biological Basis of Emotions: Brain Systems and Brain Development - Pediatrics, Nov 1998; 102: 1225.
    11. 12. Scott Grafton, M.D. - Dept. of Neurology and Dept. of Radiology - University of Southern California John Mazziotta, M.D., Ph.D. - Dept. of Molecular and Medical Pharmacology and Dept. of Neurology - UCLA School of Medicine
    12. 13. Scott Grafton, M.D. - Dept. of Neurology and Dept. of Radiology - University of Southern California John Mazziotta, M.D., Ph.D. - Dept. of Molecular and Medical Pharmacology and Dept. of Neurology - UCLA School of Medicine
    13. 14. Synapse production & pruning # synapses age in years 20 40 60 80 4 8 12 16 0 frontal lobe visual cortex
    14. 15. Plasticity Note: The listed factors are not intended to be exhaustive. Chronic stress Social interaction Methyl mercury Activity Aluminum Sensory stimulation Metabolic abnormalities (excess phenylalanine, ammonia) Essential fatty acids Cocaine Folic acid Ionizing radiation Thyroid hormone Polychlorinated biphenyls (PCBs) Iodine Prenatal infections Adequate gestation Tobacco Micronutrients, such as iron and zinc Lead Adequate protein and energy Alcohol Oxygen Detrimental or Toxic Needed for Normal Brain Development
    15. 16. Resting Scott Grafton, M.D. - Dept. of Neurology and Dept. of Radiology - University of Southern California John Mazziotta, M.D., Ph.D. - Dept. of Molecular and Medical Pharmacology and Dept. of Neurology - UCLA School of Medicine
    16. 17. Hearing Scott Grafton, M.D. - Dept. of Neurology and Dept. of Radiology - University of Southern California John Mazziotta, M.D., Ph.D. - Dept. of Molecular and Medical Pharmacology and Dept. of Neurology - UCLA School of Medicine
    17. 18. Visual Scott Grafton, M.D. - Dept. of Neurology and Dept. of Radiology - University of Southern California John Mazziotta, M.D., Ph.D. - Dept. of Molecular and Medical Pharmacology and Dept. of Neurology - UCLA School of Medicine
    18. 19. Thinking task Scott Grafton, M.D. - Dept. of Neurology and Dept. of Radiology - University of Southern California John Mazziotta, M.D., Ph.D. - Dept. of Molecular and Medical Pharmacology and Dept. of Neurology - UCLA School of Medicine
    19. 20. Later Recall Scott Grafton, M.D. - Dept. of Neurology and Dept. of Radiology - University of Southern California John Mazziotta, M.D., Ph.D. - Dept. of Molecular and Medical Pharmacology and Dept. of Neurology - UCLA School of Medicine
    20. 22. Florida State University, Center for Educational Enhancement & Development, Wil Bechman, M.D., 1998.
    21. 23. The Child Development and Public Expenditures chart source is researchers at the RAND Corporation (see Investing in our Children in section 4). Brain development curve Figure 2.4 in D. Purves, Body and Brain , Harvard University Press, 1988. Public spending on children from Table 1 in R. Haverman and B. Wolfe, &quot;Determinants of Children's Attainments: A Review of Methods and Findings,&quot; Journal of Economic Literature , Vol. 33, December 1995
    22. 24. Conclusions <ul><li>Window of Opportunity </li></ul><ul><li>Return on investment </li></ul><ul><li>Nurture and Protect our Children </li></ul>
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