Iowa MSTP Honors Seven 2010 Graduates:

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  • Should we mention Graduate Institution (U of Wisconsin), she got her MS in Biomed Eng
  • 1, Alford, SK and Hoffman EA. Measurement of Pulmonary Blood Distribution and Vasculature Structure by NMR and 4D X-ray CT. Textbook of Pulmonary Vascular Disease. Springer 2010. (In press). 2. Alford SK , van Beek EJR, McLennan G, Hoffman EA. Heterogeneity of pulmonary perfusion as a mechanistic image-based phenotype in emphysema susceptible smokers. Proceedings of the National Academy of Sciences. 2010; 107:7485-7490. 3. Saha PK, Zhiyun G, Alford SK , Sonka M, Hoffman EA. Topomorphologic Separation of Fused Iso-intensity Objects via Multi-Scale Opening: Separating Arteries and Veins in 3-D Pulmonary CT. IEEE Transactions on Medical Imaging. 2010; 29:840-851. 4. Djamali A, Sadowski EA, Samaniego-Picota M, Fain SB, Muehrer RJ, Alford SK , Grist TM, Becker BN. Noninvasive Assessment of Early Kidney Allograft Dysfunction by Blood Oxygen Level-Dependent Magnetic Resonance Imaging. Transplantation. 2006; 82(5): 621-628. 5. Sadowski EA, Fain SB, Alford SK , Korosec FR, Fine J, Muehrer R, Djamali A, Hofmann RM, Becker BN, Grist TM. Assessment of Acute Renal Transplant Rejection with Blood Oxygen Level-Dependent MR Imaging: Initial Experience. Radiology . 2005; 236: 911-919. 6. Alford SK , Sadowski EA, Unal O, Polzin JA, Consigny DW, Korosec FR, Grist TM. Detection of Acute Renal Ischemia in Swine Using Blood Oxygen Level-Dependent Magnetic Resonance Imaging. J Magn Reson Imaging. 2005; Sep 22(3): 347-53 MENTOR COMMENTS (Eric Hoffman, Radiology, Biomedical Engineering): Sara was is a highly focused and hard working student, well liked by all. Her work in the lab (mentor was Eric Hoffman) has served to validate CT-based measures of regional pulmonary parenchymal perfusion, and she has helped to establish an isolated perfused lung preparation for CT imaging with a goal of evaluating potential donor lungs. A portion of Sara’s thesis was recently published in the Proceedings of the National Academy of Science whereby she and her co-authors demonstrated a new functional imaging phenotype serving to distinguish smokers susceptible to emphysema. The increased heterogeneity of perfusion in this group supports the laboratory’s hypothesis that emphysema may develop as a result of an individual’s inability to block hypoxic pulmonary vasoconstriction in the presence of inflammation, leading to a failure to resolve the inflammation as well as the failure to deliver progenitor cells for tissue repair. Sara’s PNAS paper was highlighted in the American Thoracic Society’s “Morning Minutes” e-mailed to the 20,000 plus membership around the world. The paper was also highlighted in “Aunt Minnie,” the primary web-based source of news for radiologists. Within 3 days of the paper’s appearance it had received over 150 references on web sites around the world. Just this week a commentary was published in PNAS by James Crapo of National Jewish Hospital pointing out the importance of Sara’s paper. (….and she has three more still to get out the door!) As Sara packs up and heads for Pittsburgh where she takes the next step along a plan to specialize in pediatric cardiology she leaves a pair of very large shoes behind which two new MSTP students will attempt to fill this fall.
  • 1. Gehrs, K. M., J. R. Jackson, E. N. Brown , R. Allikmets, G. S. Hageman. Complement, age-related macular degeneration and a vision of the future (2010). Archives of Ophthalmology 128, 349{58. 2. Friemann, R., K. Lee, E. N. Brown , D. T. Gibson, H. Eklund, S. Ramaswamy. Structures of the multicomponent Rieske non-heme iron toluene 2,3-dioxygenase enzyme system (2008). ActaCrystallgr D Biol Crystallogr 65, 24{33. 3.Lord, R. L., L. Davis, E. L. Millam, E. N. Brown , C. Oerman, P. Wray, S. M. E. Green. Ab Initio Determinations of Photoelectron Spectra Including Vibronic Features. An Upper-Level Undergraduate Physical Chemistry Laboratory (2008). J Chem Educ 85, 1672{4. 4. Brown, E. N., R. Friemann, A. Karlsson, J. V. Parales, M. M. J. Couture, L. D. Eltis, and S. Ramaswamy. Determining Rieske cluster reduction potentials (2008). J Biol Inorg Chem 13, 1301. 5. Brown, E. N . Removing bias from solvent atoms in electron density maps (2008). J Applied Crystallography 41, 761{7. 6. Brown, E. N . and Ramaswamy, S. Quality of protein crystal structures (2007). Acta Crystallogr DBiol Crystallogr 63, 941{50. 7. Ferraro D. J., E. N. Brown , C. L. Yu, R. E. Parales, D. T. Gibson, and S. Ramaswamy (2007).Structural investigations of the ferredoxin and terminal oxygenase component of the biphenyl 2,3-dioxygenase from Sphingobium yanoikuyae B1. BMC Struct Biol 7, 10. 8. Yu C. L., W. Liu, D. J. Ferraro, E. N. Brown , J. V. Parales, S. Ramaswamy, G. J. Zylstra, D. T. Gib-son, and R. E. Parales (2007). Purication, characterization, and crystallization of the components of a biphenyl dioxygenase system from Sphingobium yanoikuyae B1. J Ind Microbiol Biotechnol 34,311{24. MENTOR COMMENTS: Rams Eric is like a very bright and focused scientist. He is an outstanding quantitative biologist with exceptional computer skills (he built several computers for the lab). He did very exciting and controversial work - ask him why not to pay too much attention to papers in CELL? His work and papers are of high impact and will continue to have significant contribution. He was a fun guy to have in the lab. He wants to be an ophthalmologist and he will be a great one - at least in theory :-)
  • 1. Lu Y, Allen M, Halt AR, Weisenhaus M, Dallapiazza RF , Hall DD, Usachev YM, McKnight GS, Hell JW. Age-dependent requirement of AKAP150-anchored PKA and GluR2-lacking AMPA receptors in LTP. EMBO J. 2007 Nov 1; 26(23):4879-90. PMID: 17972919 MENTOR COMMENTS (Johannes Hell and Donna Hammond): Hell: Attached is a ppt with 2 slides I selected from my intro for Robert before his defense. One shows him with Amy Halt, his closest collaborator on his project on the physiological function of CaMKII binding to the NMDAR. Amy’s task was it to define the interactions on a molecular and cellular level and Robert’s goal was to test the physiological significance by highly sophisticated electrophysiological recordings (synaptic responses and synaptic plasticity) and in learning in mutant mice in which sing residue mutations in the NMDAR genes aboraged CaMKII binding. I mention Amy because she was also an MSTP student of course but you can cut her part. out. Robert deserves credit for introducing fear into our lab-fear conditioning to be more precise and that was in close collaboration with John Wemmie.  In fact Robert actually identified mice with less fear-fearless as he might himself be now choosing a career path in neurosurgery... The other picture shows Robert with one of the largest deer ever shot in Iowa-certainly the largest in that season (I think 2008) Hunting is an important part in Robert’s life... The two jpg files show Robert with his German style academic hat with symbols of his accomplishments. Especially remarkable was a situation in which he was quick to use the fire extinquisher to contain a fire another student had caused by first sterilizing a terminally anesthetized mother rat with alcohol and then using a flame to sterilize his blade-the rat caught fire and Robert immediately used the extinquisher to save the rat (and nearly ruined our $ 20,000 equipment for making brain slices just on the other side of the bench but luckily he missed the equipment so he earned a toy  fire truck on  his hat). The football reflects his success in the imaginary football league that was an important part of our lab in Iowa... Hammond: It has been a real pleasure to mentor Robert during his professional and personal development while in the MSTP. He’s faced challenges head-on, maintained a thoughtful state of mind no matter what event presented itself unexpectedly, and succeeded. While there was some initial interest in Psychiatry and a passing dalliance with Anesthesia, in the end it was Neurosurgery that engaged his heart and mind. And, I am confident that he will be a star in that firmament in the future.
  • 1. Fineberg SK , Kosik KS, Davdison B. microRNAs potentiate neural development. Neuron. 2009 Nov 12;64(3):303-9. 2.Caldwell JC, Fineberg SK , Eberl DF. Reduced ocelli Encodes the Leucine Rich Repeat Protein Pray for Elves in Drosophila melanogaster. Fly. 2007 May-Jun;1(3):146-52. 3.Harper SQ, Staber PD, Beck CR, Fineberg SK , Stein C, Ochoa D, Davidson BL. Optimization of FIV vectors for RNA interference. Journal of Virology. 2006 Oct;80(19):9371-80. MENTOR COMMENTS (Bev Davidson, Internal Medicine, Mol Physiology & Biophysics, etc): One of the characteristics that distinguished Sarah from other students was her desire to train. She took on two undergraduates during her itime in the lab, and held mini-journal clubs for all that were interested, with the journal articles relevant to her project. An example: One of her students has since graduated from Iowa, and while working with Sarah was given an undergraduate research fellowship, won a poster award, and is now in the combined neuroscience program at Brown University and the NIH. Watching Sarah during these early days, its clear she will be a superb teacher and mentor.
  • 1.Tahirov TH, Babayeva ND, Varzavand K, Cooper JJ, Sedore SC , Price DH. Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature , 2010. In Press. 2. Sedore SC , Byers SA, Biglione S, Price JP, Maury WJ, Price DH. Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR. Nuc. Acid Res. , 2007. 35(13):4347-58. 3. Michels AA, Fraldi A, Li Q, Adamson TE, Bonnet F, Nguyen VT, Sedore SC , Price JP, Price DH, Lania L, Bensaude O. Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor. EMBO J . 2004.23:2608-19. MENTOR COMMENTS (David Price, Biochemistry): Stanley was chosen as the top student in Medical Biochemistry and enjoyed being the TA in a difficult course taught by Bryce Plapp. He made a discovery that changed the way people viewed HIV-Tat function. This led to the idea that it might be possible to purify a Tat/P-TEFb complex. Stanley worked with technicians in the lab to produce large amounts of the complex and now a paper describing the crystal structure of the complex is in press at Nature. This structure may allow novel HIV therapeutics to be discovered. David
  • Wang SY , Veeramani S, Dahle CE, Cagley J, Fritzinger DC, Vogel CW, St. John W, Weiner GJ. 2009. Depletion of the C3 component of complement enhances the ability of rituximab-coated target cells to activate human NK cells and improves the efficacy of monoclonal antibody therapy in an in vivo model. Blood 114(26):5322-30. *Wang SY , Weiner GJ. 2008. Complement and cellular cytotoxicity in antibody therapy of cancer. Expert Opin Biol Ther 8(6):759-68. *Wang SY , Racila E, Taylor RP, Weiner GJ. 2008. NK-cell activation and antibody-dependent cellular cytotoxicity induced by rituximab-coated target cells is inhibited by the C3b component of complement. Blood 111(3):1456-63. *Bowles JA, Wang SY , Link BK, Allan B, Beuerlein G, Campbell MA, Marquis D, Ondek B, Wooldridge JE, Smith BJ, Breitmeyer JB, Weiner GJ. 2006. Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab. Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab. Blood 108(8):2648-54. MENTOR COMMENTS: George Weiner Some graduate students function better when they work on one thing at a time and can get overwhelmed if they have too many things on their plate. Siao was the opposite. We both learned early on that he was more productive when his inbox was overflowing and he felt the pressure was on. So… we always made sure we talked about experiments 2 or 3 steps ahead, or had parallel experiments on the docket so he knew there was enough work in the pipeline to keep him busy for the next couple of months. This kept him motivated and busy…
  • 1. Chai Y, Shao J, Miller VM, Williams A , Paulson HL (2002) Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis. Proc Natl Acad Sci U S A 99: 9310-9315. 2. Powell JA, Molgo J, Adams DS, Colasante C, Williams A , Bohlen M, Jaimovich E (2003) IP3 receptors and associated Ca2+ signals localize to satellite cells and to components of the neuromuscular junction in skeletal muscle. J. Neurosci. 23: 8185-8192. 3. Miller VM, Nelson RF, Gouvion CM, Williams A , Rodriguez-Lebron E, Harper SQ, Davidson BL, Rebagliati MR, Paulson HL (2005) CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo. J. Neurosci . 25: 9152-9161. 4. Marden JJ, Harraz MM, Williams AJ , Nelson K, Luo M, Paulson H and Engelhardt JF (2007) Redox modifier genes in amyotrophic lateral sclerosis in mice. J Clin Invest 117: 2913-2919. 5. Harraz MM, Marden JJ, Zhou W, Zhang Y, Williams A , Sharov VS, Nelson K, Luo M, Paulson H, Schöneich C, Engelhardt JF (2008) SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. J Clin Invest. 118: 659-670. 6. Winborn BJ, Travis SM, Todi SV, Scaglione KM, Xu P, Williams AJ , Cohen RE, Peng J, Paulson HL. (2008) The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63-linkages in mixed linkage ubiquitin chains. J. Biol. Chem . 283: 26436-26443. 7. Williams AJ , Knutson TM, Colomer Gould VF, Paulson HL. (2009) In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70 interacting protein (CHIP) supports an aggregation model of pathogenesis. Neurobiol . Dis. 33: 342-353. 1. Todi SV, Williams AJ , Paulson HL (2007). Polyglutamine Repeat Disorders, including Huntington’s Disease. Molecular Neurology; edited by Stephen G. Waxman: 257-76. Academic Press. 2. Williams AJ and Paulson HL. (2008) Polyglutamine neurodegeneration: protein refolding revisited. Trends Neurosci. 31:521-528 MENTOR COMMENTS (Hank Paulson, Neurology, Neuroscience, Genetics): it is painful for a student to cope with a PI's transition to a new institution in the midst of her training.... inevitable downtime, separation from friends and colleagues... but that's what Aislinn dealt with, and did so without complaints and with plenty of buck-up enthusiasm. Of course, it didn't hurt that the transition brought her back home to Michigan, to which I am thrilled to she will return, again, for residency (even if it is psychiatry rather than neurology). It will be a pleasure to have Aislinn as a colleague and co-wolverine (as well as a co-closeted Hawkeye!) I don't think I ever told Aislinn fully how much I appreciated her taking a lead in kicking off our new lab in the right way - thanks Aislinn! I wish I could be there on this very special day! Everyone in the lab sends congratulations! We will take it as an occasion/excuse to order and consume a cake in honor of our former lab cakemeister... 2007 Gordon Research Conference Travel Award 2007 Parkinson’s Disease and Other Movement Disorders Symposium Travel Award 2007 Society of Neuroscience Travel Award
  • Iowa MSTP Honors Seven 2010 Graduates:

    1. 1. 2010 Graduating Class May 14, 2010 26 Manuscripts- 10 First Author 2 Individual NRSA Fellowships 8 semesters of TA in CCOM and Graduate College 7 Travel Awards 1 Patent
    2. 2. Sara K. Alford Hometown: Excelsior, MN Undergraduate Institution: University of Wisconsin Pediatrics University of Pittsburgh
    3. 3. Sara K. Alford PhD in Biomedical Engineering Mentor: Eric Hoffman, PhD Thesis Title: Quantification of Regional Pulmonary Blood Flow Parameters via Multidetector-row CT: Evaluation of Vascular-based Phenotypes of COPD Awards and Publications: 2009 Outstanding Graduate Student, Iowa Institute for Biomedical Imaging 2 Publications/1 First Author 1 Book Chapter Pediatrics University of Pittsburgh
    4. 4. Eric N. Brown Ophthalmology University of Missouri Hometown: Blaine, MN Undergraduate Institution: St. Olaf College
    5. 5. Eric N. Brown PhD in Biochemistry Mentor: S. Ramaswamy, PhD Thesis Title: Rieske Business: Rieske Metal Clusters in Rieske Ferredoxins and Rieske Dioxygenases Awards and Publications: 2008 Subramanian Award for Best Thesis in Dept. of Biochemistry 7 Publications/3 First Author Ophthalmology University of Missouri-Kansas City
    6. 6. Robert Dallapiazza Neurological Surgery University of Virginia <ul><li>Hometown: </li></ul><ul><li>Florence, WI </li></ul><ul><li>Undergraduate Institution: </li></ul><ul><li>University of Wisconsin </li></ul><ul><li>MSTP: </li></ul><ul><ul><li>Retreat Committee (08/09) </li></ul></ul>
    7. 7. Robert Dallapiazza PhD in Pharmacology Mentor: Johannes Hell, PhD Thesis Title: The role of CaMKII binding NMDA Receptors in synaptic plasticity and memory Awards and Publications: 2007 Individual F31 NRSA 1 Publication Neurological Surgery University of Virginia
    8. 8. Sarah K. Fineberg Psychiatry Yale-New Haven Medical Center Hometown: Galesburg, IL Undergraduate Institution: Oberlin College MSTP: Social Coordinator and Literary Group Founder (06-07) CCOM: Co-founder and Chair Mobile Clinic (02-05)
    9. 9. Sarah K. Fineberg PhD in Molecular Physiology and Biophysics Mentor: Beverly Davidson, PhD Thesis Title: MicroRNA's Role in Brain Development and Disease Awards and Publications: 2008 North American and Latin American Societies for Developmental Biology Short Course Invitee 1 Travel Award 2008 CCOM Research Day Poster Award 3 Publications/1 First Author Psychiatry Yale-New Haven Medical Center
    10. 10. Stanley C. Sedore Pediatrics Yale-New Haven Medical Center Hometown: Ottumwa, IA Undergraduate Institution: Yale University CCOM: Outstanding Performance in Medical Biochemistry Award
    11. 11. Stanley C. Sedore PhD in Biochemistry Mentor: David Price, PhD Thesis Title: Gene-specific control of P-TEFb by HIV Awards and Publications: 2009 Subramanian Award for Best Thesis in Dept of Biochemistry 2008 Sandra H. Barkan Outstanding Graduate Student Mentor Award 3 Publications/1 First Author Pediatrics Yale-New Haven Medical Center
    12. 12. Siao-Yi Wang Postdoctoral Research Fellowship University of California-San Francisco Hometown: Sacramento, CA Undergraduate Institution: University of California-Berkeley CCOM: Nathan Alcock Award in Urology
    13. 13. Siao-Yi Wang PhD in Immunology Mentor: George Weiner, MD Thesis Title: Interactions Between Complement And Cellular Mediated Mechanisms In Antibody Therapy Of Cancer Awards and Publications: 2 Travel Awards 4 Publications/3 First Author Postdoctoral Research Fellowship University of California-San Francisco
    14. 14. Aislinn J. Williams Psychiatry University of Michigan Hometown: Three Lakes, WI and Ann Arbor, MI Undergraduate Institution: Smith College MSTP: Journal Club Committee (05-06) Speaker Committee (05-07)
    15. 15. Aislinn J. Williams PhD in Neuroscience Mentor: Hank Paulson, MD, PhD Thesis Title: Toxic Intermediates and Protein Quality Control in the Polyglutamine Disease, SCA3 Awards and Publications: 2007 Individual F31 NRSA 3 Travel awards to National meetings 6 Publications/ 1 First Author 1 Book Chapter Psychiatry University of Michigan

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