What will the individual manifest as the disease progresses?
How is the disease diagnosed?
↑ dopaminergic activity in corpus striatum
↓ excessive influence of cholinergic neurons on extrapyramidal tracts
Acts on neurotransmitter pathways
Deep brain stimulation
Enhancing self-care activities
Improving bowel elimination
Encouraging use of assistive devices
Supporting coping abilities
Amyotropic Lateral Sclerosis (ALS)
Degenerative disease of unknown cause
Loss of motor neurons in anterior horns of spinal cord and the motor nuclei of the lower brain stem
Atropic changes seen in muscle fibers supplied by dying motor neuron cells
Can occur in both upper and lower motor neuron systems
What will manifestations depend upon?
Progressive muscle weakness
Assessments and Diagnostics
How is ALS diagnosed?
What diagnostic tests would you expect?
What would be the goal of supportive therapy?
Durg Therapy: riluzole (Rilutek)
Give some examples of medications for spasticity.
What is the expected outcome of this disease?
What care measures would you anticipate?
Degenerative Disk Disease
Herniated (Ruptured) intervertebral disk:
“ rupture of the soft tissue that separates two vertebral bones into the spinal canal or adjacent spinal nerve roots. Herniation of intervertebral disks can cause back pain and, occasionally, loss of neurological function in the distribution of the affected nerves”