CURRICULUM VITAE

                                           ________________________________
                            ...
Professor, Departments of Pediatrics, Neurology and Radiology
Director, Positron Emission Tomography Center
Director, Pedi...
4.    Best abstract: XIII International Symposium on Cerebral Blood Flow and
      Metabolism. Montreal, June 1987.

5.   ...
22.    Invited by Senator Patricia Birkholz to address the 2003 Michigan Legislative Children’s
       Caucus Meeting, Lan...
(Washington, DC)                           7/77-6/78

Neurology Resident          Georgetown University Hospital
         ...
PI: H.T. Chugani
      $258,750.

8.    NIH Grant 2 P01 NS 15654-09S1 (Supplement)
      "Metabolic Maturation of the Brai...
March 1995 to February 1998         $100,000
      PI: Harry T. Chugani

16.   Pheasant Ring Community
      $12,500 year ...
12/1/96 to 11/30/99          $180,525
      Funded for period 9/15/00 to 8/31/05; Total award:
      9/15/00 to 8/31/01   ...
January 1, 2004 to December 31, 2007, Total award $925,000 direct costs


CURRENT RESEARCH SUPPORT

30.   NIH Grant: R01 N...
36.      Project SOFIA
         Sponsor: Neuropharm
         PI: Harry T. Chugani
         Funded period 01/30/08 – 11/29/...
6.   Grant reviewer for March of Dimes
     National Institutes of Health Special Study Section
     National Institutes o...
Chairman, Professional Advisory Board, October 2005-present. The Sturge-Weber
         Foundation
         Executive Board...
2.    Pediatric Neurology Clinic: one afternoon each week (1981-1993). UCLA

3.    Pediatric Neurology Clinic: Olive View ...
In Gastric Hydrogen Ion Secretion Marcel-Dekker, 187-211, 1976.

2.    Chugani HT, Rosemblat AM, Lavenstein BL, Palumbo FM...
synaptic density. J. Theor Biol. 142: 149-161, 1990.

15.   Chugani HT, Shewmon DA, Shields WD, Peacock WJ, Phelps ME: Ped...
27.   Rintahaka PJ, Chugani HT, Messa C, Phelps ME: Hemimegalencephaly:
      Evaluation with positron emission tomography...
S82-S88, 1994.

40.   Gaily E, Rantala H, Rintahaka P, Shewmon DA, Chugani HT, Peacock WJ,
      Shields WD, Alle kaksivuo...
children. Brain & Development 18: 347-356, 1996.

52.   Awaad Y, Shamoto H, Chugani H: Hemidystonia improved by baclofen a...
epileptic foci in children using positron emission tomography. Epilepsia, 38:
      1198-1208, 1997.

64.   Moore GJ, Slov...
75.   Nimura K, Chugani DC, Muzik O, Chugani HT: Cerebellar reorganization
      following cortical injury is age-dependen...
Brain organization for language in children, adolescents, and adults with left
      hemisphere lesion: A PET study. Prog....
Relationship of flumazenil and glucose PET abnormalities to neocortical epilepsy surgery
       outcome. Neurology 2001; 5...
109.   Chander S, Ergun EL, Chugani HT, Chugani DC, Juhasz C, Shields AF, Weaver DW.
       High 2-deoxy-2-[18F]fluoro-D-g...
121.Chugani HT. Fine-tuning the baby brain. Cerebrum 2004;6:33-48.

122.Kagawa K, Chugani DC, Asano E, Juhász C, Muzik O, ...
133.Luat AF, Bernardi B, Chugani HT. Congenital perisylvian syndrome: MRI and glucose
    PET correlations. Pediatr Neurol...
146.Chugani HT, Juhasz C, Behen ME, Ondersma R, Muzik O. Autism with facial port-wine
    stain: a new syndrome? Pediatr N...
159.Sundaram SK, Sivaswamy L, Makki MI, Behen ME, Chugani HT. Absence of arcuate
    fasciculus in children with global de...
171.Vossler DG, Conry JA, Murphy JV; ZNS-502/505 Progressive Myoclonic Epilepsy Study
    Group. Zonisamide for the treatm...
Menkes JH: Textbook of Child Neurology. 3rd edition, Lea & Febiger, Philadelphia, pp.
      720-763, 1985.

5.    Chugani ...
Theodore W, Laxer K: Chronic focal encephalitis of Rasmussen: Functional
        neuroimaging studies with positron emissi...
28.   Chugani HT: The use of positron emission tomography in the clinical assessment
      of epilepsy. Sem Nucl Med 22: 2...
pediatric epilepsy. In Adelson PD, Black PM (eds): Surgical management of
      pediatric epilepsy. Neurosurgery Clin Nort...
Press, New York, 947-968, 1997.

54.     Chugani, H.T. Tomografía por emisión de positrones. In: Fejerman, N,
        Fern...
clinical picture and relation to neuroimaging. Engel J, Schwartzkrkoin PA,
         Moshe Sl, Lowenstein DH (eds): Brain P...
76. Fitz CR, Byrd SE, Vezina G, Muzik O, Chugani HT. Part IV: The Brain, Chapter 2:
    Imaging Modalities. In Kuhn JP, Sl...
89. Luat AF, Makki M, Chugani HT. Neuroimaging in tuberous sclerosis complex. Current
    Opinions in Neurology 2007;20:14...
6.    Chugani HT, Ackerman RF, Chugani DC, Engel J Jr.: Autoradiographic studies
      of opiate-mediated epileptogenic ph...
2-fluorodeoxyglucose in the Sturge-Weber syndrome. American Academy of
      Neurology, Dallas, April-May 1985.

19.   Chu...
30.   Hovda DA, Chugani HT, Badie B, Phelps ME, Villablanca JR: Cerebral
      maturation of oxidative metabolism in the c...
42.   Chugani HT, Shewmon DA, Phelps ME: Infantile spasms: lenticular nuclei
      hypermetabolism identified with positro...
54.   Watkins JM, Chugani HT, Elliott TK, Messa C, Lippe B, Phelps ME: Positron
      emission tomography and neuropsychol...
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  1. 1. CURRICULUM VITAE ________________________________ Signature ________________________________ Date HARRY T. CHUGANI, M.D. OFFICE ADDRESS: Children's Hospital of Michigan Pediatric Neurology / PET Center 3901 Beaubien Blvd Detroit, Michigan 48201-2196 (313) 993-2605 (Office) (313) 745-0955 (Fax) (248) 932-5249 (Home) E-Mail: hchugani@pet.wayne.edu DATE OF BIRTH: October 6, 1948 PLACE OF BIRTH: Hong Kong CITIZENSHIP: United States FACULTY PROFESSIONAL EXPERIENCE: Los Angeles: Assistant Professor, Departments of Neurology and Pediatrics, UCLA School of Medicine July 1981 - June 1988 Associate Professor with Tenure (accelerated promotion), Departments of Neurology and Pediatrics, UCLA School of Medicine July 1988 - July 1993 Consultant in Pediatric Neurology, Olive View Medical Center, Los Angeles 1981 - 1991 Faculty of the Brain Research Institute, UCLA 1987 – 1993 Instructor, Division of Nuclear Medicine and Biophysics, UCLA, 1990-1992 Associate Professor, Division of Nuclear Medicine and Biophysics, UCLA, 1992-1993 Detroit: 1
  2. 2. Professor, Departments of Pediatrics, Neurology and Radiology Director, Positron Emission Tomography Center Director, Pediatric Epilepsy Surgery Program Children's Hospital of Michigan, Wayne State University July 1993 – Present Chief, Division of Pediatric Neurology, Children’s Hospital of Michigan January 1999 – Present Rosalie and Bruce Rosen Chair in Neurology, November 2002 Professor, Department of Pharmacology, September 2006 - present SPECIALTY BOARD CERTIFICATION Neurology: Diplomat, American Board of Psychiatry and Neurology (1982), with Special Competency in Child Neurology Pediatrics: American Board of Pediatrics (board-eligible). Nuclear Medicine: Board-eligible - July 1992 SOCIETIES 1. Alpha Epsilon Delta 2. American Academy of Neurology 3. Child Neurology Society 4. Society for Neuroscience 5. International Child Neurology Association (Executive Board Member 2006 – present) 6. American Epilepsy Society HONORS AND AWARDS 1. UCLA Pediatrics Faculty Scholar Award (1986-1987) 2. Young Investigator Award (1986-1987) - Association of Indian Neuroscientists (USA) 3. Acknowledgment in the President's A Report to the Regents of the University of California, March 21, 1986. 2
  3. 3. 4. Best abstract: XIII International Symposium on Cerebral Blood Flow and Metabolism. Montreal, June 1987. 5. Certificate of Merit: Scientific Exhibit Award. Radiological Society of North American, Chicago, November-December, 1987. 6. Distinguished Scientist Award (1992): Crump Institute, UCLA 7. Killam Honorary Lecturer. Montreal Neurological Institute, McGill University, Montreal, May 1997. 8. Appeared before the United States Senate Subcommittee on Children and Families as an invited expert to testify on research progress in child brain development. Washington, D.C., June 1997 9. White House conference on Brain Development; invited by President and Mrs. Clinton. Washington, D.C., April 1997, The White House. 10. Niilo Hallman Award for Outstanding Research in Pediatrics. Awarded by the University of Helsinki. Helsinki, Finland. September 1997. 11. Milestone Award (MIRA) Mental Illness Research Association 1997 Recognition for contribution to the understanding of autism. 12. Holroyd Award. Recognition award for a distinguished graduate in the health care profession. La Salle University, Philadelphia, PA., April 1998. 13. 1st Annual Sunny Days Award, Sesame Street Parent Magazine, June 1998. 14. Invited to become member of the Dana Alliance for Brain Initiatives, November 1998. 15. Robert Dow Lecture. Legacy Portland Hospitals. Portland, OR, December 1998. 16. Michigan Council for Maternal and Child Health’s Outstanding Achievement Award, May 1999. 17. Named as one of the “top docs” in Michigan: Hour Magazine survey. October 2000. 18. Invited to become member of the Professional Advisory Committee of the Epilepsy Foundation of Michigan. October 2000. 19. Richmond Paine Lecturer, Children’s National Medical Center, Washington, DC, March 14, 2001. 20. Lifetime Achievement Award: from the Epilepsy Foundation of Michigan, August 2001. 21. Ring of Hope Award from the Pheasant Ring Foundation (November 2001) 3
  4. 4. 22. Invited by Senator Patricia Birkholz to address the 2003 Michigan Legislative Children’s Caucus Meeting, Lansing, June 4, 2003 (joint House and Senate members) 23. Distinguished Lecturer, Human Biology Program, Stanford University, Palo Alto, CA, May 8, 2003 24. The Harry T. Chugani Scientific Scholar of Merit Award. Established by the Sturge- Weber Foundation in 2004. “This award is presented to an individual who displays the degree of commitment, curiosity, and collaboration that is the hallmark of Dr. Chugani’s professional career.” 25. Visiting Professor. Boston Children’s Hospital, Harvard University, Department of Nuclear Medicine, May 9-11, 2005. Two formal lectures, teaching session with neurology and nuclear medicine residents, informal discussions. 26. Named Lecture. The Alavi Lecture, University of Pennsylvania, “PET scanning in pediatric neurological disorders”, Philadelphia, September 13, 2005. 27. Invited Lecture. American Academy of Pediatrics National Conference 2005, Washington , DC. Section on Adoption and Foster Care October 10, 2005, “Neuroimaging, plasticity and early childhood experience” [Note: lecture covered by the press and referred to in USA Today on October 11, 2005]. 28. Invited Guest and Lecturer. Invitation by Her Royal Highness Professor Doctor Princess Chulabhorn to celebrate her 48th birthday, October 22-24, Bangkok, Thailand. EDUCATION: High School St. Joseph's College, Hong Kong (1964-1968) Baccalaureate La Salle College, Philadelphia, PA (1968-1972) B.A. (Magna Cum Laude) Doctorate Georgetown University School of Medicine, Washington, D.C. (1972-1976) M.D. POSTGRADUATE TRAINING: Pediatric Intern Children's Memorial Hospital (Chicago) 7/76-6/77 Pediatric Resident Georgetown University Hospital 4
  5. 5. (Washington, DC) 7/77-6/78 Neurology Resident Georgetown University Hospital (Washington, DC) 7/78-6/80 Pediatric Neurology Georgetown University Hospital Fellow (Washington, DC) 7/80-6/81 Nuclear Medicine UCLA Medical Center 7/90-6/92 Fellow* *NOTE: this was achieved while being tenured faculty at the same time PREVIOUS RESEARCH SUPPORT 1. USPHS Grant #DA02518 "Neurophysiological and Developmental Studies on Opiates." PI: J.R. Villablanca. Funded from September 30, 1981 to February 28, 1985 Co-investigator 2. Neuropsychiatric Institute BRSG award "Naloxone-induced Seizures: Autoradiographic Mapping and Pharmacological Studies" PI: H.T. Chugani. Funded from February 1, 19983 to January 31, 1984. $4,860. 3. NIH Grant Po1 NS156454 "Neuroscience Research with Positron Emission Tomography." PI: M.E. Phelps. Funded from September 1, 1984 to August 31, 1989. $4,572,420. Co-investigator. 4. Epilepsy Foundation of American Award AP840123 "Uncoupling of Hippocampal Blood Flow from Metabolism during Kindled Seizures in the Rat." PI: H.T. Chugani. March 1, 1984 to February 28, 1985. $14,908. 5. NINCDS Teacher Investigator Development Award 1 K07 NS00886. July 1, 1984 to June 30, 1989. PI: H.T. Chugani $218,000. 6. NIH Grant NS 02808 "A Clinical Research Program for the Partial Epilepsies." January 1, 1985 to December 31, 1989. PI: J. Engel, Jr. $3,325,680. Co-investigator 7. United Cerebral Palsy Association R-368-86 "Positron Emission Tomography with 2-deoxy-2[18F] fluoro-D-glucose in children with cerebral palsy." November 1, 1986 to October 31, 1989 5
  6. 6. PI: H.T. Chugani $258,750. 8. NIH Grant 2 P01 NS 15654-09S1 (Supplement) "Metabolic Maturation of the Brain". PI: H.T. Chugani Program Project Director: M.E. Phelps May 1, 1988 to August 31, 1989 $301,932. 9. NIH Grant 2 P01 NS 15654 (years 11 to 15) Program Project: "Neuroscience Research with PET" Project II: "Metabolic Maturation of the Brain" PI: H.T. Chugani Budget for Project II: $960,856 Program Project Director: M.E. Phelps Total Budget: $7,942,549 September 1, 1989 to August 31, 1994 10. Siemens Corporation PET Research in Children PI: H.T. Chugani January 1, 1994 to December 31, 1996 Total Budget: $225,000 11. Leukemia Research Life, Inc. Brain Tumor Metabolism PI: H.T. Chugani November 1, 1994 to October 31, 1995 Total Budget: $45,000. 12. Mental Illness Research Association PET Studies in Autism PI: H.T. Chugani November 1, 1994 to October 31, 1995 Total Budget: $30,000. 13. MIRA-Mental Illness Research Association $30,000 per year for years 1995, 1996, and 1997 for PET Studies of Autism $25,000 year ongoing commitment beginning July 1997 for "Autism Research Clinic" awarded to Harry T. Chugani and Diane C. Chugani 14. International Foundation for Alternating Hemiplegia 7/1/95 - 6/30/96 $17,000 1/1/97 - 12/31/97 $30,000 PI: Harry T. Chugani 15. Japanese Epilepsy Association Grant "Functional PET Studies of Television-induced Epilepsy" 6
  7. 7. March 1995 to February 1998 $100,000 PI: Harry T. Chugani 16. Pheasant Ring Community $12,500 year ongoing commitment beginning July 1997 for “Autism Research Clinic” Awarded to Harry T. Chugani and Diane C. Chugani 17. NIH Grant: 1 R13 NS38447-01 Sturge Weber Syndrome Consensus Conference PI: Harry T. ChuganiCo-PI: Diane C. Chugani Funded for period 4/1/99 – 3/31/00: Total award $45,000 18. Parke-Davis – Warner Lambert Company Gabapentin in Partial Epilepsy in Infancy PI: Harry T. Chugani Funded for period 6/8/99 – 1/7/00 17. NIH Grant 1 R01 HD34942 Brain serotonin synthesis in autism PI: Diane C. Chugani Co-PI: Harry T. Chugani Funded for period 12/15/98 to 11/30/01; Total award: $758,181 12/15/98 to 11/30/99 $251,578 12/1/99 to 11/30/00 $245,265 12/1/00 to 11/30/01 $251,641 20. NIH Grant: 1 R01 NS38324 Imaging tryptophan metabolism in tuberous sclerosis PI: Diane C. Chugani Co-PI: Harry T. Chugani Funded for period 2/1/99 to 1/31/04; Total award $973,273 2/1/99 to 1/31/00 $194,213 2/1/00 to 1/31/01 $187,170 2/1/01 to 1/31/02 $192,511 2/1/02 to 1/31/03 $197,249 2/1/03 to 1/31/04 $202,130 21. NIH grant R01 HD40007 Ontogeny of human GABA-A receptor complex measured with PET PI: Otto Muzik Co-PI: Harry T. Chugani Funded for period 9/29/00 – 9/28/03, Total award $550,000 direct costs 22. NIH Grant: R01 NS 34488 "Localization of Epileptic Foci with PET in Children" Principal Investigator: Harry T. Chugani Co-Principal Investigator: Diane C. Chugani Funded for period December 1, 1996 to November 30, 1999 Total Award: $559,279. 12/1/96 to 11/30/99 $198,000 12/1/96 to 11/30/99 $179,985 7
  8. 8. 12/1/96 to 11/30/99 $180,525 Funded for period 9/15/00 to 8/31/05; Total award: 9/15/00 to 8/31/01 $277,471 9/01/01 to 8/31/02 $272,916 9/01/02 to 8/31/03 $281,102 9/01/03 to 8/31/04 $289,535 23. R21 DA015919-01 (Muzik) Software tools for pediatric neuroimaging PI: Otto Muzik Co-Investigator: Harry T. Chugani Funded for period 10/01/02-9/30/04 Total award $300,000 direct costs 18. Topiramate pharmacokinetics and tolerability in infants with seizures. Johnson & Johnson Pharmaceutical Research & Development. PI: Harry T. Chugani 1-21-03 to 12-31-03 $142,000 25. Johnson & Johnson Pharmaceutical Inc. Topiramate pharmacokinetics and tolerability in infants with seizures. PI: Harry T. Chugani Amount: $142,000 Duration of study: 2/1/03 – 1/31/04 (1 year) 26. Johnson & Johnson Pharmaceutical Inc. Topiramate in human newborn PI: Harry T. Chugani Amount: $40,000 Duration of study: 5/1/03 – 4/30/04 27. Johnson & Johnson Pharmaceutical Inc. Topiramate in infantile spasms PI: Harry T. Chugani Amount: $40,000 Duration of study: 5/1/03 – 4/30/04 28. U01 HD37261-04S2 Pediatric Pharmacology Research Unit PI: Jacob Aranda Subproject title: Early pharmacotherapy aimed at neuroplasticity in autism Subproject PI: Diane C. Chugani Co-Investigator: Harry T. Chugani Funded for period 9/30/02 to 12/31/05 Total award $120,000 direct costs 29. NIH R01 NS 45151 Tryptophan metabolism in children with epilepsy PI: Diane Chugani Co-PI: Harry T. Chugani 8
  9. 9. January 1, 2004 to December 31, 2007, Total award $925,000 direct costs CURRENT RESEARCH SUPPORT 30. NIH Grant: R01 NS 34488 "Localization of Epileptic Foci with PET in Children" Principal Investigator: Harry T. Chugani Funded for period 9/1/05 to 8/31/10; Total award $1,948,541 31. NIH Grant R01 NS045911 CHMC 367 Childhood absence epilepsy Rx PK-PD pharmacogenetics PI: Tracy Glauser Subcontract PI: Harry T. Chugani Funded period 9/30/03 – 10/31/08 Total award $17,336,053 Subcontract for 9/30/05 – 10/31/06: $45,816 Subcontract for 9/30/07 - 10/31/08: $65,773 Currently at no cost extension 32. RO1 NS41922 Longitudinal neuroimaging in Sturge-Weber syndrome PI: C. Juhasz Co-investigator: H.T. Chugani July 1, 2008 to April 30, 2013 Total award: $990,000 direct costs 33. RO1 CA123451 Tryptophan metabolism in human brain tumors Agency: NIH/National Cancer Institute PI: C. Juhasz Co-Investigator: H.T. Chugani December 1, 2007 to November 30, 2012 Total award: $1,095,000 direct costs 34. “Structural and Functional neural correlates of early postnatal deprivation” PI: Michael E. Behen, PhD Mentor: Harry T. Chugani NIH 1K08MH079176 9/3/07 - 7/31/12 Total Award: $733,409. 35. "Early pharmacotherapy guided by biomarkers in autism" Principal Investigator: DC Chugani PhD. Co-Investigator: Harry T. Chugani Agency: NINDS Type U01 NS61264 Period: 2/1/08 - 1/31/13 Total award $5,800,000 9
  10. 10. 36. Project SOFIA Sponsor: Neuropharm PI: Harry T. Chugani Funded period 01/30/08 – 11/29/08 Total Award $59,142 37. Project EMMA Sponsor: Neuropharm PI: Harry T. Chugani Funded period 09/15/08– 12/31/09 Total Award $39,671 Pending grant: 1. "Epilepsy in Tuberous Sclerosis Complex" Start/End Date: 7/1/07 - 6/30/12 Direct cost: $1,512,784 Total cost: $2,216,388 SERVICES PERFORMED 1. Grant reviewer for the National Science Foundation 2. Ad Hoc Reviewer for various journals (Annals of Neurology, Proceedings National Academy of Sciences, Journal of Neuroscience, Journal of Neuroendocrinology, Pediatric Research, Journal of Experimental Neurology, Neurology, New England Journal of Medicine, Journal of Cerebral Blood Flow and Metabolism, Epilepsia, Journal of Nuclear Medicine, Journal of the Neurological Sciences, NeuroImage, Archives of Neurology, Brain, Biological Psychiatry). 3. Symposium chairman: Neuroimaging in pediatrics, Child Neurology Society Boston 1986. 4. Invited member of Joint Committee on Research in Pediatric Neurology (sponsored by Child Neurology Society). 5. Thesis Committee for Ph.D degree of the following students: Randall A. Hawkins (Radiological Sciences, UCLA) Magnus Dahlbom (Medical Physics, UCLA) Fernando Gomez-Pinilla (Anatomy, UCLA) Guido Germano (Radiological Sciences, UCLA) Ronald See (Psychology, UCLA) Daniel Valentino (Radiological Sciences, UCLA) 10
  11. 11. 6. Grant reviewer for March of Dimes National Institutes of Health Special Study Section National Institutes of Health Neurology A Study Section (Ad Hoc 1997-1998) National Institutes of Health BDCN-5 Study Section Standing Member CHAIRMAN of NIH Study section BDCN-5 (1999-2002) CHAIRMAN of NIH Study section Developmental Brain Disorders (DBD) (2003-2005) Board of Scientific Counsel of NINDS (Ad Hoc reviewer of intramural research program, 2005) Ad hoc reviewer February 2006 for Motor Function, Speech and Rehabilitation study (MFSR) section Ad hoc reviewer for the National Research Council (UK) Ad hoc reviewer for the Austrian Research Council NIH special Study Section for Clinical Translational Science Awards (CTSA) (2006) 7. Nominations Committee (Child Neurology Society) 1988-1989 Research Committee (Child Neurology Society) 1989 Scientific Selection Committee (Child Neurology Society) 1989-1990 Scientific Selection Committee (American Academy of Neurology) 1989-1990, 1990-1991. Scientific Selection Committee (International Society of Cerebral Blood Flow and Metabolism) 1991 Organizing Committee: International Workshop on Infantile Spasms, Paris, May 1991 Scientific Selection Committee (International Symposium on Cerebral Blood Flow and Metabolism) 1993 Invited Member of the Scientific Committee of the International School of Neurological Sciences, Italy Editorial Board: Journal of Child Neurology (1991-present) Editorial Board: Brain and Development (1994-present) Editorial Board: Pediatric Neurology (1994-present) Editorial Board: Journal of Developmental Disabilities (1997) Editorial Board: Journal of Pediatric Neurology (2003-present) Editorial Board: Neurology (January 2004-December 2005) Childhood Epilepsy Committee (American Epilepsy Society) 1994-1996 Professional Advisory Board: Sturge-Weber Foundation (Executive Committee) Scientific Selection Committee (Child Neurology Society) 1994-1996 President, Medical Board of the Alternating Hemiplegia Foundation, 1995-2003 Member, National Tuberous Sclerosis Association Professional Advisory Board May 25, 1995 to present Member, Scientific Program Committee, American Epilepsy Society, February 1997 Scientific Program Committee, International Child Neurology Association, 1998 Member, Professional Advisory Committee of the Epilepsy Foundation of Michigan Member, Professional Advisory Board for the Pheasant Ring Foundation Member of Scientific Committee, Child Neurology Section, International School of Neurological Sciences, Venice, Italy (2003-2006) Member, Research Committee, Child Neurology Education and Research Foundation (2002-present) 11
  12. 12. Chairman, Professional Advisory Board, October 2005-present. The Sturge-Weber Foundation Executive Board Member, International Child Neurology Association, 2006 - present 8. External Advisor on Center Grant Proposal (P50) entitled "Fetal Drug Exposure: Risks, Interventions and Outcomes", submitted to the National Institute on Drug Abuse by Massachusetts General Hospital, Harvard Medical School, September 1996 9. Consultant on the Advisory Committee to the FDA’s Peripheral and Central Nervous System Committee action on the anticonvulsant drug vigabatrin. January 7-8, 2009, Washington, DC. UNIVERSITY COMMITTEES 1. Pediatrics Quality Assurance Committee, UCLA (1987) 2. Grand Rounds Committee, Neurology Department, UCLA (1988) 3. Hospital Utilization Committee, UCLA (1990-1993) 4. Research Committee, Children's Hospital of Michigan (1993-1995; 199-2001) 5. Research Advisory Committee, Children's Hospital of Michigan (1993-1996) 6. Internal Review Board, Children's Hospital of Michigan (1996-1998). 7. Member, Internal Review Committee for Department of Neurology (1997) 8. Member, Search Committee for Chief of Pediatric Neurosurgery (2001-2002) 9. Member, Wayne State University Imaging Research Oversight Committee (2001 to present) 10, Member, Internal Review Committee for Department of Neurology (2002) 11. Member, Promotion and Tenure Committee, Department of Neurology 12. Co-Chair, Search Committee for CHM CRCM Director (2005-2006) TEACHING ACTIVITIES (for residents, fellows and medical students) 1. Ward attending in pediatric neurology; 3 months each year, consists of daily teaching rounds lasting 2 hours (1981-1993). UCLA 12
  13. 13. 2. Pediatric Neurology Clinic: one afternoon each week (1981-1993). UCLA 3. Pediatric Neurology Clinic: Olive View Medical Center, 2 mornings each month (July 1981-June 1987). Los Angeles 4. Pediatric admission residents' conference (Intake Conference): 2 times per week for 3 months of the year. (1981-1993). UCLA 5. Pediatric Neurology Residents' Clinic: 1 afternoon each month (1981-1983). UCLA 6. Neurology Clerkship NE-011: 4 students, 2 weeks each year, 2 hours each day (1981-1988). UCLA 7. Fundamentals of Clinical Medicine: Instruction in the neurological examination, 2nd year medical students, 2 afternoons each year (1981-1993). UCLA 8. Pediatric Core Lectures (Pediatric Neurology): one each 2 months (1981-1993). UCLA 9. Instruction in interpreting pediatric evoked potentials recordings: 1 hour each week (1981-1991). UCLA 10. Pediatric Neurology Journal Club: 1 hour each month (1983-1986). UCLA 11. Pediatric Neurology Research Conference: 1 hour each month (1984-1991). UCLA 12. Pediatric Neurology Clinic Review Conference: 1-2 hours each week (1984-1991). UCLA 13. Miscellaneous invited lectures at UCLA and other institutions. (List available upon request). 14. Ward attending in pediatric neurology: 1 month each year, consists of daily teaching rounds lasting 3-4 hours (1994-1999). 2-3 months each year of ward attending Children's Hospital of Michigan Wayne State University. (1999-Present) 15. Epilepsy Surgery Conference: 1 hour each week (1994-Present). 16. Pediatric Neurology Conference (1999-Present). PUBLICATIONS RESEARCH PAPERS (refereed publications) 1. Kasbekar DK, Chugani H: Role of calcium ion in 'in vitro' gastric acid secretion. 13
  14. 14. In Gastric Hydrogen Ion Secretion Marcel-Dekker, 187-211, 1976. 2. Chugani HT, Rosemblat AM, Lavenstein BL, Palumbo FM, Luessenhop AJ, Manz HJ: Childhood medulloblastoma presenting with hemorrhage. Child's Brain 11:135-140, 1984. 3. Chugani HT, Akermann RF, Chugani DC, Engel J Jr: Opioid-induced epileptogenic phenomena in rats: anatomical, behavioral, and electroencephalographic studies. Ann Neurol 15: 361-368, 1984. 4. Phelps ME, Barrio JR, Huang S-C, Keen RE, Chugani Chugani HT, Mazziotta JC: Criteria for the tracer kinetic measurement of cerebral protein synthesis in humans with positron emission tomography. Ann Neurol 15 (suppl): S192-S202, 1984. 5. Shields WD, Lake JL, Chugani HT: Amantadine in the treatment of refractory epilepsy in childhood: Report of an open trial in 10 patients. Neurology 35: 579-581, 1985. 6. Furman JM, Baloh RW, Chugani HT, Waluch V, Bradley WG: Infantile cerebellar atrophy. Ann Neurol 17: 399-402, 1985. 7. Chugani HT, Phelps ME: Maturational changes of cerebral function in the infant determined by FDG positron emission tomography. Science 231: 840-843, 1986. 8. Chugani HT, Mazziotta JC, Engel J Jr., Phelps ME: Lennox-Gastaut syndrome: Metabolic subtypes determined by 18FDG positron emission tomography. Ann Neurol 21: 4-13, 1987. 9. Chugani HT, Phelps ME, Mazziotta JC: Positron emission tomography study of human brain functional development. Ann Neurol 22: 487-497, 1987. 10. Chugani HT, Shewmon DA, Peacock WJ, Shields WD, Mazziotta JC, Phelps ME: Surgical treatment of intractable neonatal-onset seizures: The role of positron emission tomography. Neurology 38: 1178-1188, 1988. 11. Chugani HT, Phelps ME: PET in children with seizures. Applied Radiology 17: 37-49, 1988. 12. Chugani HT, Mazziotta JC, Phelps ME: Sturge-Weber syndrome: A study of cerebral glucose utilization with positron emission tomography. J. Pediatrics 114: 244-253, 1989. 13. Olson DM, Chugani HT, Shewmon DA, Phelps ME, Peacock WJ: Electrocorticographic confirmation of focal positron emission tomographic abnormalities in children with intractable epilepsy. Epilepsia 31: 731-739, 1990. 14. Feinberg I, Thode HC, Chugani HT, March JD: Gamma distribution model describes maturational curves for delta wave amplitude, cortical metabolic rate and 14
  15. 15. synaptic density. J. Theor Biol. 142: 149-161, 1990. 15. Chugani HT, Shewmon DA, Shields WD, Peacock WJ, Phelps ME: Pediatric Epilepsy surgery: Pre-and post-operative evaluation with PET. J. Epilepsy 3 (suppl): 141-155, 1990. 16. Shewmon DA, Shields WD, Chugani HT, Peacock WJ: Contrasts between pediatric and adult epilepsy surgery: Rationale and strategy for focal resection. J. Epilepsy 3 (Suppl): 141-155, 1990. 17. Shields WD, Shewmon DA, Chugani HT, Peacock WJ: The role of surgery in the treatment of infantile spasms. J. Epilepsy 3 (Suppl): 321-324, 1990. 18. Chugani HT, Shields WD, Shewmon DA, Olson DM, Phelps ME, Peacock WJ: Infantile spasms: I. PET identifies focal cortical dysgenesis in cryptogenic cases for surgical treatment. Ann Neurol, 27: 406-413, 1990. 19. Chugani HT, Hovda DA, Villablanca JR, Phelps ME, Xu WF: Metabolic maturation of the brain: A study of local cerebral glucose utilization in the cat. J. Cereb Blood Flow Metab, 11: 35-47, 1991. 20. Kerrigan JF, Chugani HT, Phelps ME: Regional cerebral glucose metabolism in clinical subtypes of cerebral palsy. Pediatric Neurol, 7:415-425, 1991. 21. Dietrich RB, El Saden S, Chugani HT, Bentson J, Peacock WJ: Resective surgery for intractable epilepsy in children: Radiologic evaluation. Am J. Neuroradiol 12: 1149-1158, 1991. 22. Hovda DA, Chugani HT, Villablanca JR, Badie B, Sutton RL: Maturation of cerebral oxidative metabolism in the cat: A cytochrome oxidase histochemistry study. J Cereb Blood Flow Metab 12: 1039-1048, 1992. 23. Chugani HT, Shewmon DA, Sankar R, Chen BC, Phelps ME: Infantile spasms: II. Lenticular nuclei and brainstem activation on positron emission tomography. Ann Neurol 31: 212-219, 1992. 24. Gorman DG, Shields WD, Shewmon DA, Chugani HT, Finkel R, Comair YG, Peacock WJ: Neurosurgical treatment of refractory status epilepticus. Epilepsia 33: 546-549, 1992. 25. Caplan R, Comair Y, Shewmon DA, Jackson L, Chugani HT, Peacock WJ: Intractable seizures, compulsions, and coprolalia: A pediatric case study. J. Neuropsychiat Clin Neurosci 4: 315-319, 1992. 26. Jacobs B, Harris GC, Allada V, Chugani HT, Pollack DB, Raleigh MJ: Midazolam as an effective intravenous adjuvant to prolonged ketamine sedation in young rhesus (Macaca Mulatta) and vervet (Cercopithecus aethiops sabeaus) monkeys: a preliminary report. Am J Primat 29: 291-298, 1993. 15
  16. 16. 27. Rintahaka PJ, Chugani HT, Messa C, Phelps ME: Hemimegalencephaly: Evaluation with positron emission tomography. Pediatr Neurol 9: 21-28, 1993. 28. Rocha L, Ackermann RF, Nassir Y, Chugani HT, Engel J Jr.: Characterization of mu opioid receptor binding during amygdala kindling in rats and effects of chronic naloxone pretreatment: an autoradiographic study. Epilepsy Res 14: 195-208, 1993. 29. Chugani HT, Shewmon DA, Khanna S, Phelps ME: Interictal and postictal focal hypermetabolism on positron emission tomography. Pediatr Neurol 9: 10-15, 1993. 30. Chugani HT, Shewmon DA, Shields WD, Sankar R, Comair Y, Vinters HV, Peacock WJ: Surgery for intractable infantile spasms: neuroimaging perspectives. Epilepsia 34: 764-771, 1993. 31. Rocha L, Tatsukawa K, Chugani HT, Engel J Jr.: Benzodiazepine receptor binding following chronic treatment with naloxone, morphine and met-enkephalin in normal rats. Brain Res 612: 247-252, 1993. 32. Caplan R, Chugani HT, Messa C, Guthrie D, Sigman M, de Traversay J, Mundy P: Hemispherectomy for intractable seizures: Presurgical cerebral glucose metabolism and postsurgical non-verbal communication. Dev Med Child Neurol 35: 582-592, 1993. 33. Kornblum HI, Chugani HT, Tatsukawa K, Gall CM: Cerebral hemidecortication alters expression of transforming growth factor alpha mRNA in the neostriatum of developing rats. Mol Brain Res 21: 107-114, 1994. 34. Rocha L, Ackermann RF, Chugani HT, Engel J Jr.: Chronic pretreatment with naloxone modifies benzodiazepine receptor binding in amygdaloid kindled rats. Epilepsy Res 21: 107-114, 1994. 35. Chugani HT, Rintahaka PJ, Shewmon DA: Ictal patterns of cerebral glucose utilization in children with epilepsy. Epilepsia 35: 813-822, 1994. 36. Chugani HT, Jacobs B: Metabolic recovery in caudate nucleus of children following cerebral hemispherectomy. Ann Neurol 36: 794-797, 1994. 37. Khanna S, Chugani HT, Messa C, Curran JG: Corpus callosum agenesis and epilepsy: PET findings. Pediatr Neurol 10: 221-227, 1994. 38. Philippart M, Messa C, Chugani HT: Spielmeyer-Vogt (Batten, Spielmeyer- Sjogren) disease: Distinctive patterns of cerebral glucose utilization. Brain 117: 1085-1092, 1994. 39. Chugani HT: The role of PET in childhood epilepsy. J Child Neurol 9 (Suppl) 16
  17. 17. S82-S88, 1994. 40. Gaily E, Rantala H, Rintahaka P, Shewmon DA, Chugani HT, Peacock WJ, Shields WD, Alle kaksivuotiaan lapsen vaikea epilepsia: onko leikkauksesta apua? Duodecim, 110: 44-51, 1994. 41. Jacobs B, Chugani HT, Allada V, Chen S, Phelps ME, Pollack DB, Raleigh MJ: Developmental changes in brain metabolism in sedated rhesus macaques and vervet monkeys revealed by positron emission tomography. Cerebral Cortex, 3: 222-233; 1047-3211, 1995. 42. Shamoto H, Chugani DC, Chugani HT: Glucose metabolism in the human cerebellum: anatomical-functional correlations. J Child Neurol, 11: 451-457, 1996. 43. Gaily EK, Shewmon DA, Chugani HT, Curran JG: Asymmetric and asynchronous infantile spasms. Epilepsia 36: 873-882, 1995. 44. Chakraborty P, Mangner T, Chugani DC, Muzik O, Chugani HT: A high-yield and simplified procedure for the synthesis of alpha-[11C]methyl-L-tryptophan. Nuc Med & Bio, 23: 1005-1008, 1996. 45. Philippart M, Chugani HT, Bateman JB: New Spielmeyer-Vogt variant with granular inclusions and early brain atrophy. Am J Med Genet 57: 160-164, 1995. 46. Rintahaka PJ, Chugani HT, Sankar R: Landau-Kleffner syndrome with continuous spikes and waves during slow-wave sleep. J Child Neurol, 10: 127-133, 1995. 47. Chugani HT, Conti JR: Etiological classification of infantile spasms in 140 cases: Role of positron emission tomography. J. Child Neurol 11: 44-48, 1996. 48. Caplan R, Curtiss S, Chugani HT, Vinters HV: Pediatric Rasmussen encephalitis: social communication, language, PET, and pathology before and after hemispherectomy. Brain and Cognition 32: 45-46, 1996. 49. Chugani HT, da Silva EA, Chugani DC: Infantile spasms: III. Prognostic implications of bitemporal hypometabolism on positron emission tomography. Ann Neurol 39: 643-649, 1996. 50. Hovda DA, Villablanca JR, Chugani HT, Phelps ME: Cerebral metabolism following neonatal or adult hemineodecortication in cats: I. Effects on glucose metabolism using [14C]2-deoxy-D-glucose autoradiography. J Cereb Blood Flow Metab, 16: 1, 134-146, 1996. 51. Chugani HT, Muller R-A, Chugani DC: Functional brain reorganization in 17
  18. 18. children. Brain & Development 18: 347-356, 1996. 52. Awaad Y, Shamoto H, Chugani H: Hemidystonia improved by baclofen and PET scan findings in a patient with glutaric aciduria type I. J Child Neurol 11: 167-169, 1996. 53. Shamoto H, Chugani DC, Chugani HT: Glucose metabolism in the human cerebellum: anatomical-functional correlations. J Child Neurol 11: 451-457, 1996. 54. Elliott TK, Watkins JM, Messa C, Lippe B, Chugani HT: Positron emission tomography and neuropsychological correlations in Turner Syndrome children. Developmental Neuropsych 12: 365-386, 1996. 55. Rintahaka P, Chugani HT: Clinical role of positron emission tomography in children with tuberous sclerosis complex. J Child Neurol, 12: 42-52, 1997. 56. Muzik O, Chugani DC, Chakraborty P, Mangner T, Chugani HT: Analysis of [11C]alpha-methyl-tryptophan kinetics for the estimation of serotonin synthesis rate in vivo. J Cereb Blood Flow Metab, 17: 659-669. 1997. 57. Chugani DC, Muzik O, Rothermel R, Behen M. Chakraborty P, Mangner T, da Silva EA, Chugani HT: Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys. Ann Neurol, 42 4: 666-669, 1997. 58. Phillipart M, da Silva EA, Chugani HT: The value of positron emission tomography in the diagnosis and monitoring of late infantile and juvenile lipopigment storage disorders. Neuropediatrics, 28: 74-76, 1997. 59. Muller R-A, Chugani HT, Muzik O, Chakraborty PK, Language and motor function activate calcified hemisphere in patients with Sturge-Weber syndrome: a PET study. J Child Neurol, 12: 431-437, 1997. 60. Muller, R-A, Rothermel RD, Behen ME, Muzik O, Chakraborty PK, Chugani HT: Plasticity of motor organization in children and adults. NeuroReport 8: 3103-3108, 1997. 61. Shamoto H, Chugani HT: Glucose metabolism in the human cerebellum: an analysis of crossed cerebellar disachisis in children with unilateral cerebral injury. J Child Neurol 12: 407-417, 1997. 62. da Silva EA, Chugani HT, Chugani DC: Landau-Kleffner syndrome: Metabolic abnormalities in temporal lobe is a common feature. J Child Neurol, 12: 489-495, 1997. 63. da Silva EA, Chugani DC, Muzik O, Chugani HT: Identification of frontal lobe 18
  19. 19. epileptic foci in children using positron emission tomography. Epilepsia, 38: 1198-1208, 1997. 64. Moore GJ, Slovis TL, Chugani HT: Proton magnetic resonance spectroscopy in children with Surge-Weber Syndrome. J Child Neurol 13: 332-335, 1998. 65. Loopvijt LD, Hovda DA, Ebrahim A, Villablanca JR , Chugani HT: Increase in D2 dopamine receptor binding in the neostriatum of neonatal compared to adult hemidecorticated cats. Dev Brain Research, 107: 113-122, 1998. 66. Muller RA, Rothermel RD, Behen ME, Muzik O, Mangner TJ, Chugani HT: Receptive and expressive language activations for sentences: a PET study. NeuroReport 8: 3767-3770, 1997. 67. Vinas FC, Zamorano L, Muller R-A, Zhaowei J, Chugani HT, Fuerst D, Muzik O, Mangner T, Diaz FG: [150]-water PET and localization of eloquent cortex. Neurol Research 19: 601-608, 1997. 68. Muller R-A, Chugani HT, Muzik O, Mangner TJ: Brain organization of motor and language functions following hemispherectomy: A [150]-water PET study. J Child Neurol, 13: 16-22, 1998. 69. Chugani DC, Muzik O, Chakraborty PK, Mangner T, Chugani HT: Human brain serotonin synthesis capacity measured in vivo with alpha-[C-11]methyl-L- troptophan. Synapse 28: 33-43, 1998. 70. Chugani DC, Chugani HT, Muzik O, Shah JR, Shah AK, Canady AL, Mangner TJ, Chakraborty PK: Imaging epileptogenic tubers in children with tuberous sclerosis complex using alpha[11C]-methyl-L-tryptophan PET. Ann Neurol, 44: 858-866, 1998. 71. Muller RA, Chugani DC, Behen ME, Rothermel RD, Muzik O, Chakraborty PK, Chugani HT: Impairment of dentatothalamocortical pathway in autism: Language activation data from PET. Neurosci Letters 245, 1-4, 1998. 72. Muller RA, Watson CE, Muzik O, Chakraborty PK, Chugani, HT: Motor organization after early middle cerebral artery stroke: A PET Study. Pediatr Neurol, 19:4, 294-298, 1998. 73. Muller RA, Behen ME, Rothermel RD, Chugani DC, Muzik O, Mangner TJ, Chugani HT: Brain mapping of language and auditory perception in high- functioning autistic adults: a PET study. J Autism Dev. Disorders 29: 19-31, 1999. 74. Chugani DC, Muzik O, Behen ME, Rothermel RD, Lee J, Chugani HT: Developmental changes in brain serotonin synthesis capacity in autistic and non-autistic children. Ann Neurol 45: 287-295, 1999. 19
  20. 20. 75. Nimura K, Chugani DC, Muzik O, Chugani HT: Cerebellar reorganization following cortical injury is age-dependent in humans: effects of lesion size and age. Neurology 52: 792-797, 1999. 76. Chugani HT: A critical period of brain development: studies of cerebral glucose utilization with PET. Preventive Medicine 26: 184-188, 1998. 77. da Silva EA, Muller RA, Chugani DC, Shah J, Shah A, Watson C, Chugani HT: Brain activation during intermittent photic stimulation: A [150]-water PET study on photosensitive epilepsy. Epilepsia 40, 17-22, 1999. 78. Muller RA, Rothermel RD, Behen ME, Muzik O, Mangner TJ, Chakraborty PK, Chugani HT: Brain organization of language after early unilateral lesion: A PET Study. Brain and Language 62, 422-451, 1998. 79. Muller RA, Rothermel RD, Muzik O, Becker C, Fuerst DR, Behen ME, Mangner TJ, Chugani HT: Determination of language dominance by [150]-water PET in children and adolescents: A comparison with the wada test. J. Epilepsy 11: 152-161, 1998. 80. Muller RA, Behen ME, Muzik O, Rothermel RD, Downey RA, Mangner TJ, Chugani HT: Task-related activations in heterotopic brain malformations: a PET study. NeuroReport 9, 2527-2533, 1998. 81. Muzik, O, Chugani DC, Chenggang S, da Silva EA, Shah J, Shah A, Canady A, Watson C, Chugani HT: Objective method of localization of cortical asymmetries using positron emission tomography to aid surgical resection of epileptic foci. Computer Aided Surgery 3: 74-82, 1998 82. Philippart M, da Silva, EA, Bateman JB, Chugani HT: Late-onset grod (ICNL) variant: similarties and differences with Spielmeyer-Vogt Disease. (Submitted) 83. Muller RA, Rothermel RD, Behen ME, Muzik O, Mangner TJ, Chugani HT: Developmental changes of cortical and cerebellar motor control: a clinical positron emission tomography study with children and adults. J Child Neurol 13:11, 550-556, 1998. 84. Muller RA., Rothermel RD, Behen ME, Muzik O, Chakraborty PK, Chugani HT: Language organization in patients with early and late left-hemisphere lesion: A PET study. Neuropsychologia 37, 545-557, 1999. 85. Muzik O, Janisse J, Ager J, Shen C, Chugani DC, Chugani HT: A mathematical model for the analysis of cross-sectional brain glucose metabolism data in children. Prog. Neuro-Psychopharmacol & Biol Psychiat., 23, 589-600, 1999. 86. Muller RA, Behen ME, Rothermel RD, Muzik O, Chakraborty PK, Chugani HT: 20
  21. 21. Brain organization for language in children, adolescents, and adults with left hemisphere lesion: A PET study. Prog. Neuro-Psychopharmacol & Biol Psychiat., 23, 657-668, 1999. 87. Nagy F, Chugani DC, Juhasz C, da Silva EA, Muzik O, Kupsky W, Canady A, Watson C, Shah J, Chugani HT: Altered in vitro and in vivo flumazenil binding in human epileptogenic neocortex. J Cereb Blood Flow Metab 19: 939-947, 1999. 88. Chugani DC, Niimura K, Chaturvedi S, Muzik O, Fakhouri M, Lee ML, Chugani HT: Increased brain serotonin synthesis in migraine. Neurology 53: 1473-1479, 1999. 89. Muzik, O, da Silva EA, Juhasz C, Chugani DC, Shah J, Nagy F, Canady A, von Stockhausen H.-M, Herholz K, Gates J, Frost M, Ritter F, Watson C, Chugani HT: Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy. Neurology 54: 171-179, 2000. 90. Juhasz C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT: Relationship between EEG and positron emission tomography abnormalities in clinical epilepsy. J of Clinical Neurophysiology 17, 29-42, 2000. 91. Pfund Z, Chugani DC, Juhasz C, Muzik O, Chugani HT, Wilds I, Seraji-Bozorgzad N, Moore GJ: Evidence for coupling between glucose metabolism and glutamate cycling using FDG PET and 1H magnetic resonance spectroscopy in patients with epilepsy. J Cereb Blood Flow Metab 20: 871-878, 2000. 92. Pfund Z, Chugani HT, Juhasz C, Muzik O, Behen MA, Chugani DC, Nigro MA, Trock GL, Squires LA: Lissencephaly: Fetal pattern of glucose metabolism on positron emission tomography? Neurology 55, 1683-1688, 2000. 93. Juhasz C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT: Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy. Neurology 55, 825-834, 2000. 94. Juhasz C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT: Is epileptogenic cortex truly hypometabolic on interictal positron emission tomography? Ann of Neurol 48, 88-96, 2000. 95. Asano E, Chugani DC, Muzik O, Shen C, Juhasz C, Janisse J, Ager J, Canady A, Shah JR, Shah AK, Watson CE, Chugani HT: Multimodality imaging for improved detection of epileptogenic lesions in tuberous sclerosis complex. Neurology 54: 1976-1984, 2000. 96. Muzik O, Chugani DC, Juhasz C, Shen C, Chugani HT: Statistical parametric mapping: assessment of application in children. NeuroImage 12, 538-549, 2000. 97. Juhasz C, Chugani DC, Muzik O, Shah A, Shah J, Watson C, Canady A, Chugani HT: 21
  22. 22. Relationship of flumazenil and glucose PET abnormalities to neocortical epilepsy surgery outcome. Neurology 2001; 56:1650-1658. 98. Lee Js, Asano E, Muzik O, Chugani DC, Juhasz C, Pfund Z, Philip S, Behen M, Chugani HT: Sturge-Weber syndrome: Correlation between clinical course and FDG PET findings. Neurology 57: 189-195, 2001. 99. Chugani DC, Muzik O, Juhasz C, Janisse JJ, Ager J, Chugani HT: Postnatal maturation of human GABAA receptors measured with positron emission tomography. Annals of Neurology 49: 618-626, 2001. 100. Chugani HT, Behen ME, Muzik O, Nagy F, Juhasz C, Chugani DC: Local brain functional activity following early social deprivation: A study of post-institutionalized Romanian orphans. NeuroImage 14:1290-1301, 2001. 101.Asano E, Chugani DC, Juhasza C, Muzik O, Chugani HT. Surgical treatment of West syndrome. Brain Dev 23: 668-676, 2001. 102.Juhasz C, Chugani HT, Muzik O, Chugani DC. Neuroradiological assessment of brain structure and function and its implication in the pathogenesis of West syndrome. Brain Dev 23:488-495, 2001. 103.Juhász C, Behen ME, Muzik O, Chugani DC, Chugani HT. Bilateral Prefrontal and Temporal Neocortical Hypometabolism in Children with Epilepsy and Aggression. Epilepsia 42:991-1001, 2001. 104.Asano E, Chugani DC, Muzik O, Behen M, Janisse J, Rothermel R, Mangner TJ, Chakraborty PK, Chugani HT. Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction. Neurology 57:1269-1277, 2001. 105.Juhász C, Muzik O, Chugani DC, Shen C, Janisse J, Chugani HT. Prolonged vigabatrin treatment modifies developmental changes of GABAA receptor binding in young children with epilepsy. Epilepsia 42:1320-1326, 2001. 106.Lee JS, Juhasz C, Kaddurah AK, Chugani HT: Patterns of cerebral glucose metabolism in early and late stages of Rasmussen’s syndrome. J Child Neurol 2001;16:798-805. 107.Pfund Z, Chugani DC, Muzik O, Juhasz C, Behen ME, Lee J, Chakraborty P, Mangner T, Chugani HT. α[C-11]methyl-L-tryptophan PET in patients with alternating hemiplegia of childhood. J Child Neurol 2002;17:253-60. 108.Lee JS, Pfund Z, Juhasz C, Behen ME, Muzik O, Chugani DC, Nigro MA, Chugani HT. Altered regional brain glucose metabolism in Duchenne muscular dystrophy: A PET study. Muscle & Nerve 2002; 26:506-512. 22
  23. 23. 109. Chander S, Ergun EL, Chugani HT, Chugani DC, Juhasz C, Shields AF, Weaver DW. High 2-deoxy-2-[18F]fluoro-D-glucose accumulation in a case of retroperitoneal fibrosis following resection of carcinoid tumor. Molecular Imaging and Biology 2002;4:363-368. 110. Juhasz C, Chugani DC, Muzik O, Shah A, Asano E, Mangner TJ, Chakraborty PK, Sood S, Chugani HT. Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology 2003;60:960-968. 111.Asano E, Muzik O, Shah A, Juhász C, Chugani DC, Sood S, Janisse J, Ergun EL, Ahn- Ewing J, Shen C, Gotman J, Chugani HT. Quantitative interictal subdural EEG analyses in children with neocortical epilepsy. Epilepsia 2003;44:425-434. 112.Shah JR, Juhasz C, Kupsky WJ, Asano E, Sood S, Fain D, Chugani HT. Rasmussen encephalitis associated with Parry-Romberg syndrome. Neurology 2003;61:395-397. 113. Chugani DC, Chugani HT. Does serotonin have trophic effects in temporal lobe epilepsy? (invited peer-reviewed editorial). Neurology 2003;60:736-737. 114.Pfund Z, Kagawa K, Juhasz C, Shen C, Lee JS, Chugani DC, Muzik O, Chugani HT. Quantitative analysis of gray and white matter volumes and glucose metabolism in the Sturge-Weber Syndrome. J Child Neurol 2003;18:119-126. 115.D’Agostino MD, Bastos A, Piras C, Bernasconi A, Grisar T, Gross Tsur V, Snipes J, Juhasz C, Chugani H, Guerrini R, Cross H, Andermann E, Dubeau F, Montes J, Olivier A, Andermann F. Posterior quadrantic dysplasia or hemi-hemimegalencephaly: a characteristic brain malformation. Neurology 2004;62:2214-2220. 116.Juhász C, Chugani DC, Padhye UN, Muzik O, Shah A, Asano E, Mangner TJ, Chakraborty PK, Sood S, Chugani HT. Evaluation with α[11C]methyl-L-tryptophan PET for reoperation  after failed epilepsy surgery. Epilepsia 2004;45:124-30 117.Asano E, Muzik O, Shah A, Juhasz C, Chugani DC, Kagawa K, Benedek K, Sood S, Gotman J, Chugani HT. Clinical Neurophysiology 2004;115:2718-2727. 118.Benedek K, Juhasz C, Muzik O, Chugani DC, Chugani HT. Metabolic changes of subcortical structures in intractable focal epilepsy. Epilepsia 2004;45:1100-1105. 119.Asano E, Benedek K, Shah A, Juhasz C, Shah J, Chugani DC, Muzik O, Sood S, Chugani HT. Is intraoperative electrocorticography reliable in children with intractable neocortical epilepsy? Epilepsia 2004;45:1091-1099. 120.Chandana SR, Behen ME, Juhasz C, Muzik O, Rothermel RD, Mangner TJ, Chakraborty PK, Chugani HT, Chugani DC. Significance of abnormalities in developmental trajectory and asymmetry of cortical serotonin synthesis in autism. Int J Devl Neuroscience 2005;23:171-182. 23
  24. 24. 121.Chugani HT. Fine-tuning the baby brain. Cerebrum 2004;6:33-48. 122.Kagawa K, Chugani DC, Asano E, Juhász C, Muzik O, Shah A, Shah J, Sood S, Kupsky WJ, Mangner TJ, Chakraborty PK, Chugani HT. Epilepsy surgery outcome in children with tuberous sclerosis studied with alpha[11C]methyl-L-tryptophan PET. J Child Neurol 2005;20:429-38. [Note: Editorial on this article by E. S. Roach, M.D., p.399 same issue]. 123.Maiti DK, Chakraborty PK, Chugani DC, Muzik O, Mangner TJ, Chugani HT. Synthesis procedure for routine production of [carbonyl-11C]desmethyl-WAY-100635. Appl Radiat Isot. 2005 May;62(5):721-7. 124.Asano E, Juhász C, Shah A, Muzik O, Chugani DC, Shah J, Sood S, Chugani HT. Origin and propagation of epileptic spasms delineated on electrocorticography. Epilepsia 2005;46:1086-1097. 125.Rackhade SN, Yao B, Ahmed S, Asano E, Beaumont TL, Shah AK, Draghici S, Krauss R, Chugani HT, Sood S, Loeb JA. A common pattern of persistent gene activation in human neocortical epileptic foci. Ann Neurol 2005;58:736-747. 126.Asano E, Pawlak C, Shah A, Shah J, Luat AF, Ahn-Ewing J, Chugani HT. The diagnostic value of initial video-EEG monitoring in children---review of 1000 cases. Epilepsy Research 2005;66:129-135. 127.Juhasz C, Chugani DC, Muzik O, Wu D, Sloan AE, Barger G, Watson C, Shah AK, Sood S, Ergun EL, Mangner TJ, Chakraborty PK, Kupsky WJ, Chugani HT. In vivo uptake and metabolism of alpha-[(11)C]methyl-L-tryptophan in human brain tumors. J Cereb Blood Flow Metab. 2005 Aug 3; [Epub ahead of print] 128.Kimiwada T, Juhasz C, Makki M, Muzik O, Chugani DC, Asano E, Chugani HT. Hippocampal and thalamic diffusion abnormalities in children with temporal lobe epilepsy. Epilepsia. 2006 Jan;47(1):167-75. 129.Benedek K, Juhasz C, Chugani DC, Muzik O, Janisse J, Chugani HT. Longitudinal changes of cortical glucose hypometabolism in children with intractable epilepsy. J Child Neurol 2006; 21:26-31. 130.Eluvathingal T, Chugani HT, Behen M, Juhasz C, Muzik O, Chugani DC, Makki M, Maqbool M. Abnormal brain connectivity in children following early severe socio- emotional deprivation: A diffusion tensor imaging study. Pediatrics 2006; 117:2093-2100. 131.Luat AF, Chugani HT, Asano E, Juhász C, Trock G, Rothermel R. Episodic receptive aphasia in a child with Landau-Kleffner syndrome: PET correlates. Brain & Development 2006; 28:592-596. 132.Edwards DJ, Chugani DC, Chugani HT, Chelab J, Malian M, Aranda JV. Pharmacokinetics of buspirone in autistic children. J Clin Pharmacol 2006; 46:508-514. 24
  25. 25. 133.Luat AF, Bernardi B, Chugani HT. Congenital perisylvian syndrome: MRI and glucose PET correlations. Pediatr Neurol 2006; 35:21-29. 134.Lin F-Y, Gascon GG, Hyland K, Chugani H, Chugani D. Transient non-ketotic hyperglycinemia and defective serotonin metabolism in a child with neonatal seizures. J Child Neurol 2006; 21:900-903. 135.Hovda DA, Villblanca JR, Chugani HT, Barrio JR. Metabolic maturation of the brain: a study of local cerebral protein synthesis in the developing cat. Brain Res 2006; 1113:54-63. 136.Luat AF, Asano E, Juhasz C, Chandana SR, Shah A, Sood S, Chugani HT. Relationship between brain glucose metabolism positron emission tomography (PET) and electroencephalography (EEG) in children with continuous spike-and-wave activity during slow-wave sleep. J Child Neurol 2006; 20:682-690. 137.Sood S, Asano E, Chugani HT. Significance of preserving the vein of Labbé in epilepsy surgery involving temporal lobe resection. J Neurosurg: Pediatrics 2006; 105:210-213. 138.Wakamoto H, Eluvathingal TJ, Makki M, Juhász C, Chugani HT. Diffusion tensor imaging of the corticospinal tract following cerebral hemispherectomy. J Child Neurol 2006; 21:566-571. 139.Eluvathingal TJ, Behen ME, Chugani HT, Janisse J, Bernardi B, Chakraborty P, Juhász C, Muzik O, Chugani DC. Cerebellar lesions in tuberous sclerosis complex: neurobehavioral and neuroimaging correlates. J Child Neurol 2006; 21:846-851. 140.Juhasz C, Chugani HT. An almost missed leptomenigeal angioma in Sturge-Weber syndrome. Neurology 2007;68:243. 141.Batista CEA, Chugani HT, Juhasz C, Behen ME, Shankaran S. Transient hypermetabolism of the basal ganglia following perinatal hypoxia. Pediatr Neurol 2007; 36:330-333. 142.Holmes GL, Stafstrom CE, and the Tuberous Sclerosis Study Group. Tuberous sclerosis complex and epilepsy: recent developments and future challenges. Epilepsia 2007;48:617-630. 143.Juhasz C, Batista CEA, Chugani DC, Muzik O, Chugani HT. Evolution of cortical metabolic abnormalities and their clinical correlates in Sturge-Weber syndrome. Eur J Paediatr Neurol 2007;11:277-284. 144.Asano E, Mihaylova T, Juhasz C, Sood S, Chugani HT. Effect of sleep on interictal spikes and distribution of sleep spindles on electrocorticography in children with focal epilepsy. Clin Neurophysiol 2007;118:1360-8. 145.Luat AF, Asano E, Chugani HT. Paroxysmal tonic upgaze of childhood with co-existent absence epilepsy. Epileptic Disord 2007;9:332-6. 25
  26. 26. 146.Chugani HT, Juhasz C, Behen ME, Ondersma R, Muzik O. Autism with facial port-wine stain: a new syndrome? Pediatr Neurol 2007;37:192-199. 147.Peng F, Juhasz C, Bhambhani K, Wu D, Chugani DC, Chugani HT. Assessment of progression and treatment response of optic pathway glioma with positron emission tomography using alpha-[(11)C]methyl-L-tryptophan. Mol Imaging Biol 2007;9:106-9. 148.Juhasz C, Lai C, Behen ME, Muzik O, Helder EJ, Chugani DC, Chugani HT. White matter volume as a major predictor of cognitive function in Sturge-Weber syndrome. Arch Neurol 2007;64:1169-1174. 149.Shah AK, Fuerst D, Sood S, Asano E, Ahn-Ewing J, Pawlak C, Chugani HT. Seizures lead to elevation of intracranial pressure in children undergoing invasive EEG monitoring. Epilepsia 2007;48:1097-1103. 150.Juhasz C, Haacke EM, Hu J, Xuan Y, Makki M, Behen ME, Maqbool M, Muzik O, Chugani DC, Chugani HT. Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome. Am J Neuroradiol 2007;28:900-906. 151.Batista CE, Juhasz C, Muzik O, Chugani DC, Chugani HT. Increased visual cortex glucose metabolism contralateral to angioma in children with Sturge-Weber syndrome. Dev Med Child Neurol 2007;49:567-73. 152.Makki MI, Chugani DC, Janisse J, Chugani HT. Characteristics of abnormal diffusivity in normal-appearing white matter investigated with diffusion tensor MR imaging in tuberous sclerosis complex. Am J Neuroradiol 2007;28:1662-1667. 153.Behen M, Chugani HT, Juhasz C, Helder E, Ho A, Maqbool M, Rothermel RD, Perry J, Muzik O. Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome. Mov Disord 2007;22:2256-62. 154.Muzik O, Chugani DC, Zou G, Hua J, Lu Y, Lu S, Asano E, Chugani HT. Multimodality data integration in epilepsy. Int J Biomed Imaging 2007;13963. 155.Haseeb A, Asano E, Juhasz C, Shah A, Sood S, Chugani HT. Young patients with focal seizures may have the primary motor area for the hand in the postcentral gyrus. Epilepsy Res 2007;76:131-9. 156.Luat AF, Asano E, Rothermel R, Sood S, Chugani HT. Psychosis as a manifestation of frontal lobe epilepsy. Epilepsy & Behavior 2008; 200-204. 157.Chugani HT, Juhasz C, Chugani DC, Lawrenson L, Muzik O, Chakraborty PK, Sood S. Increased striatal serotonin synthesis following cortical resection in children with intractable epilepsy. Epilepsy Res 2008; 78:124-130. 158.Govindan RM, Chugani HT, Makki MI, Behen ME, Dornbush J, Sood S. Diffusion tensor imaging of brain plasticity after occipital lobectomy. Pediatr Neurol 2008; 38:27-33. 26
  27. 27. 159.Sundaram SK, Sivaswamy L, Makki MI, Behen ME, Chugani HT. Absence of arcuate fasciculus in children with global developmental delay of unknown etiology: a diffusion tensor imaging study. J Pediatr 2008; 152:250-255. 160.Sood S, Asano E, Chugani HT. Role of external ventriculostomy in the management of fever after hemispherectomy. J Neurosurg Pediatrics 2008; 2:427-429. 161.Kumar A, Chugani HT, Luat A, Asano E, Sood S. Epilepsy surgery in a case of encephalitis: use of 11C-PK11195 positron emission tomography. Pediatr Neurol 2008; 38:439-442. 162.Govindan RM, Makki MI, Sundaram SK, Juhasz C, Chugani HT. Diffusion tensor analysis of temporal and extra-temporal lobe tracts in temporal lobe epilepsy. Epilepsy Res 2008; 80:30-41. 163.Batista CE, Chugani HT, Hu J, Haacke EM, Behen ME, Helder EJ, Juhasz C. Magnetic resonance spectroscopic imaging detects abnormalities in normal-appearing frontal lobe iof patients with Sturge-Weber syndrome. J Neuroimaging 2008; 18:306-13. 164.Makki MI, Behen M, Bhatt A, Wilson B, Chugani HT. Microstructural abnormalities of striatum and thalamus in children with Tourette syndrome. Mov Disord 2008; 23:2349-56. 165.Wakamoto H, Chugani DC, Juhasz C, Muzik O, Kupsky WJ, Chugani HT. Alpha-methyl- L-tryptophan positron emission tomography in epilepsy with cortical developmental malformations. Pediatr Neurol 2008; 39:181-8. 166.Behen ME, Helder E, Rothermel R, Solomon K, Chugani HT. Incidence of specific absolute neurocognitive impairment in globally intact children with histories of early severe deprivation. Child Neuropsychol 2008; 453-69. 167.Hu J, Yu Y, Juhasz C, Kou Z, Xuan Y, Latif Z, Kudo K, Chugani HT, Haacke EM. MR susceptibility weighted imaging (SWI) complements conventional contrast enhanced T1 weighted MRI in characterizing brain abnormalities of Sturge-Weber syndrome. J Magn Reson Imaging 2008; 28:300-7. 168.Nishida M, Juhasz C, Sood S, Chugani HT, Asano E. Cortical glucose metabolism positively correlates with gamma-oscillations in nonlesional focal epilepsy. Neuroimage 2008; 42:1275-84. 169.Fukuda M, Nishida M, Juhasz C, Muzik O, Sood S, Chugani HT, Asano E. Short-latency median-nerve somatosensory-evoked potentials and induced gamma-oscillations in humans. Brain 2008; 131:1793-805. 170.Brown EC, Rothermel R, Nishida M, Juhasz C, Muzik O, Hoechstetter K, Sood S, Chugani HT, Asano E. In vivo animation of auditory-language-induced gamma-oscillations in children with intractable focal epilepsy. Neuroimage 2008; 41:1120-31. 27
  28. 28. 171.Vossler DG, Conry JA, Murphy JV; ZNS-502/505 Progressive Myoclonic Epilepsy Study Group. Zonisamide for the treatment of myoclonic seizures in progressive myoclonic epilepsy: an open-label study. Epileptic Disord 2008: 10:31-4. 172.Sundaram SK, Kumar A, Makki MI, Behen ME, Chugani HT, Chugani DC. Diffusion tensor imaging of frontal lobe in autism spectrum disorder. Cerebral Cortex 2008; 18: 2659-65. 173.Sivaswamy L, Rajamani K, Juhasz C, Maqbool M, Makki M, Chugani HT. The corticospinal tract in Sturge-Weber syndrome: a diffusion tensor tractography study. Brain Dev 2008; 30:447-53. 174.Nishida M, Asano E, Juhasz C, Muzik O, Sood S, Chugani HT. Cortical glucose metabolism correlates negatively with delta-slowing and spike-frequency in epilepsy associated with tuberous sclerosis. Hum Brain Mapp 2008; 29:1255-64. 175.Juhasz C, Asano E, Shah A, Chugani DC, Batista CE, Muzik O, Sood S, Chugani HT. Focal decreases of cortical GABAA receptor binding remote from the primary seizure focus: what do they indicate? Epilepsia, 2009, in press 176.Asano E, Juhász C, Shah A, Sood S, Chugani HT. Role of subdural electrocorticography in prediction of long-term seizure outcome in epilepsy surgery. Brain (in press, 2009). INVITED CHAPTERS AND REVIEWS 1. Engel J Jr., Ackermann RF, Caldecott-Hazard S, Chugani HT: Do altered opioid mechanisms play a role in human epilepsy? In Fariello RG, Engel J Jr., Morselli PL, Quesney LF (eds): Neurotransmitters in Seizures and Epilepsy II. Raven Press, New York, pp 263-274, 1984. 2. Chugani HT, Ackermann RF, Chugani DC, Engel J Jr.: Autoradiographic studies of opioid-mediated epileptogenic phenomena in rats. In Fariello RG, Engel J Jr., Morselli PL, Quesney LF (eds): Neurotransmitters in Seizures and Epilepsy II. Raven Press, New York, pp. 315-325, 1984. 3. Engel J Jr., Caldecott-Hazard S, Chugani HT, Ackermann RF: Neuropeptides, seizures and epilepsy. In Porter RJ, Mattson RH, Ward AA Jr., Dam M (eds): Advances in Epileptology: XVth Epilepsy International Symposium. Raven Press, New York, pp. 25-30, 1984. 4. Chugani HT, Menkes JH: Neurological manifestations of systemic disease. In 28
  29. 29. Menkes JH: Textbook of Child Neurology. 3rd edition, Lea & Febiger, Philadelphia, pp. 720-763, 1985. 5. Chugani HT, Olsen RW: Benzodiazepine/GABA receptor binding in vitro and in vivo in analysis of clinical disorders. In: Olsen RW, Venter JC (eds): Benzodiazepine/GABA Receptors and Chloride Channels. AR Liss, New York, pp. 315-335, 1986. 6. Chugani HT, Engel J Jr.: PET in intractable epilepsy. In Schmidt D, Morselli PL (eds): Intractable epilepsy: Experimental and clinical aspects. Raven Press, New York, pp. 119-128, 1986. 7. Ackermann RF, Chugani HT, Handforth A, et al.: Autoradiographic studies of cerebral metabolism and blood flow in rat amygdala kindling. In Wada JA (ed.): Kindling III. Raven Press, New York, pp. 73-90, 1986. 8. Chugani HT, Babb TL, Baumgartner F. Capacchione JF: Binding of "inhibitory" receptors by 3H-muscimol and 3H-flunitrazepam in human epileptic hippocampus. In Nistico G, Morselli PL, Lloyd KG, Fariello RG, Engel J Jr. (eds.): Neurotransmitters, Seizures, and Epilepsy III, Raven Press, New York, pp. 319-330, 1986. 9. Chugani HT: Positron emission tomography: Principles and applications in pediatrics. Mead Johnson Symposium in Perinatal and Developmental Medicine, 1987. 10. Chugani HT, Phelps ME, Barnes D: PET in normal and abnormal brain development. In Messer A, Swann JW (eds): Disorders of the Developing Nervous System: Changing Views on their Origins, Diagnoses and Treatments. AR Liss, New York, pp. 51-67, 1988. 11. Phelps ME, Barrio JR, Huang SC, Keen RE, Chugani HT, Mazziotta JC: Model, assumptions and preliminary results. In Greitz T, Ingvar DH, Widen L (eds): The Metabolism of the Human Brain Studied with Positron Emission Tomography. Raven Press, New York, pp. 215-232, 1989. 12. Chugani HT, Phelps ME, Mazziotta JC: Metabolic assessment of functional maturation and neuronal plasticity in the human brain. In: Von Euler C, Forssberg H: Neurobiology of Early Infant Behavior. MacMillan press, pp. 323-330, 1989. 13. Chugani HT, Phelps ME, Shewmon DA: Cerebral glucose utilization in intractable neonatal epilepsy and in the developing brain. In: Vert P, Wasterlain C (eds.): Neonatal Seizures. Raven Press, New York, pp. 169-179, 1990. 14. Crandall PH, Risinger MW, Suterling WW, Chugani H, Peacock W, Levesque M: Surgical treatment of the partial epilepsies. In: Dam M, Gram L. Comprehensive Epileptology. Raven Press, New York, pp. 683-714, 1990. 15. Hwang P, Gilday DL, Spire JP, Hosny H, Chugani HT, Garnett ES, 29
  30. 30. Theodore W, Laxer K: Chronic focal encephalitis of Rasmussen: Functional neuroimaging studies with positron emission tomography and single-photon emission computed tomography scanning. In: Andermann F. Chronic Encephalitis and Epilepsy (Rasmussen's Syndrome). Butterworth-Heinemann, Stoneham, MA, pp. 61-72, 1991. 16. Chugani HT, Phelps ME: Editorial: Imaging human brain development with positron emission tomography. J. Nucl Med 32: 23-26, 1991. 17. Chugani HT: Childhood Epilepsy: Anatomical and functional neuroimaging. In: Ohtahara S, Roger J: New Trends in Pediatric Epileptology. Okayama Med Press, pp. 17-28, 1991. 18. Phelps ME, Barrio JR, Hoffman EJ, Huang SC, Chugani HT: PET: A biochemical image of the brain at work. In: Lassen NA, Ingvar DH, Raichle ME, Friberg L: Brain Work and Mental Activity. Munksgaard, Copenhagen, pp. 32-49, 1991. 19. Chugani HT, Shields WD, Shewmon DA, Peacock WJ: (letter) Reply to: Surgical treatment for infantile spasms? Ann Neurol 29: 111-112, 1991. 20. Engel J Jr., Henry TR, Risinger MW, Sutherling WW, Chugani HT: PET in relation to intracranial electrode evaluations. In: Theodore WH (ed): Epilepsy Research, Surgical treatment of epilepsy. Elsevier Science BV, pp 111-120, 1992. 21. Chugani HT, Dietrich RB: Sturge-Weber Syndrome: Recent developments in neuroimaging and surgical considerations. In: Fetal and Perinatal Neurology. Fukuyama Y, Suzuki Y, Kamoshita S, Casaer P (eds): Karger, Basel, pp. 187-196, 1992. 22. Chugani HT: Functional brain imaging in pediatrics. Ped Clinics North America 39: 777-799, 1992. 23. Chugani HT, Dietrich RB: Pediatric Disorders. In: Mazziotta JC, Gilman S: Clinical Brain Imaging: Principles and Applications. F.A. Davis, Philadelphia, pp. 411-457, 1992. 24. Chugani HT: Functional maturation of the brain. International Pediatr 7: 111-117, 1992. 25. Chugani HT: The role of positron emission tomography in childhood epilepsy. International Pediatr 7: 260-265, 1992. 26. Peacock WJ, Comair YG, Chugani HT, Shewmon DA, Shields WD: Epilepsy surgery in childhood. In: Luders H (ed). Epilepsy Surgery, Raven Press, New York, pp. 589-598, 1992. 27. Shields WD, Shewmon DA, Chugani HT, Peacock WJ: Treatment of infantile spasms: medical or surgical? Epilepsia 33 (suppl. 4): S26-S31, 1992. 30
  31. 31. 28. Chugani HT: The use of positron emission tomography in the clinical assessment of epilepsy. Sem Nucl Med 22: 247-253, 1992. 29. Sankar R, Chugani HT: Strategies for diagnosis and treatment of childhood epilepsy. Current Opinion in Neurology and Neurosurgery 6: 398-402, 1993. 30. Chugani HT: The application of PET and SPECT imaging in pediatric neurology. In Fejerman N. Chamoles NA (eds.): New Trends in Pediatric Neurology. Elsevier Publishers, Amsterdam, pp. 13-21, 1993. 31. Chugani HT: Positron emission tomography scanning: Applications in newborns. Clinics in Perinatology 20: 395-409, 1993. 32. Chugani HT: Editorial: PET in preoperative evaluation of intractable epilepsy. Pediatr Neurol 9: 411-413, 1993. 33. Henry TR, Chugani HT, Abou-Khalil BW, Theodore WH, Swartz BE: Positron emission tomography. In Engel J Jr (ed): Surgical Treatment of the Epilepsies, 2nd ed. New York, Raven Press, pp. 211-243, 1993. 34. Roach ES, Riela AR, Chugani HT, Shinnar S, Bodensteiner JB, Freeman J: Sturge-Weber syndrome: recommendations for surgery. J. Child Neurol 9: 190-192, 1994. 35. Chugani HT: Positron emission tomography (PET) in childhood. Rev Neurol (Barcelona) 22: 217-220, 1994. 36. O’Tuama LA, Bjornson B, Chugani H, Treves ST: Chapter 6: Brain. In Treves ST (ed): Pediatric Nuclear Medicine, 2nd Edition. Springer-Verlag, New York, pp. 88-108. 37. Chugani HT: Development of regional brain glucose metabolism in relation to behavior and plasticity. In Dawson G, Fischer KW (eds.): Human Behavior and the Developing Brain. Guilford, New York, pp. 153-175, 1994. 38. Gupta R, Chugani HT: Infantile spasms. In: Burg FD, Ingelfinger JR, Wald ER, Polin RA (eds.): Gellis and Kagan's Current Pediatric Therapy, 15th edition. Saunders, Philadelphia, pp. 106-107, 1996. 39. Chugani HT: Imaging: Anatomical and functional. In Wallace SJ (ed): Epilepsy in Children. Chapman & Hall, London, 483-506, 1996. 40. Chugani HT, Kupsky WJ, Chugani DC: Cortical dysplasia: Surgical treatment and neuropathological findings in infants and children. In Guerrini R, Andermann F, Canapicchi R, Roger J, Zifkin BG, Pfanner P (eds): Dysplasias of Cerebral Cortex and Epilepsy, 427-433, Lippincott-Raven, Philadelphia, 1996. 41. Cummings TJ, Chugani DC, Chugani HT: Positron emission tomography in 31
  32. 32. pediatric epilepsy. In Adelson PD, Black PM (eds): Surgical management of pediatric epilepsy. Neurosurgery Clin North America, 465-472, 1995. 42. Chugani HT: Infantile spasms. Current Opinion in Neurology 8:139-144, 1995. 43. Functional imaging in cortical dysplasias: positron emission tomography. In Guerrini R, Andermann F, Canapicchi R, Roger J, Zifkin BG, Pfanner P (eds): Dysplasias of Cerebral Cortex and Epilepsy, 169-174, Lippincott-Raven, Philadelphia, 1996. 44. Moore GJ, Chugani HT: Cerebral metabolic imaging in Sturge-Weber syndrome. In: Gobbi G, Andermann F, Naccarato S, Banchini G. Epilepsy and Other Neurological Disorders in Coeliac Disease, 195-201, 1996. 45. Chugani HT: Neuroimaging of developmental nonlinearity and developmental pathologies. In Thatcher RW, Lyon GR, Rumsey J, Krasnegor (Eds): Developmental Neuroimaging: Mapping the Development of Brain and Behavior, Academic Press, San Diego, 197-195, 1996. 46. Watson C, Moore GJ, Chugani HT: Neuroimaging in epilepsy. The Neurologist, 2: 96-118, 1996. 47. Chugani HT, Muller RA: Plasticity associated with cerebral resections. Shorvon S, Chauvel P, (eds): In: Advances in Neurology: Plasticity in Epilepsy: Dynamic Aspects of Brain Function 81, 241-250, Lippincott Williams & Wilkins, 1999. 48. Chugani HT: Positron emission tomography (PET) in substance-abuse exposed infants: a preliminary report. In: Konkol RJ, Olsen GD, (eds): Prenatal Cocaine Exposure. Boca Raton: CRC Press 1, 183-186, 1996. 49. Chugani HT: Pathophysiology of Infantile Spasms. In: Burnham WM, Carlen PL, Hwang PA, (eds): Intractable Seizures: Diagnosis and Therapy. New York: Plenum Publishing Corporation, 1997, pp. 111-121. 50. Chugani HT: Positron emission tomography. In: Berg, BO (ed): Principles of Child Neurology. New York: McGraw Hill, 113-128, 1996. 51. Chugani HT: The Developing Brain. In: Wagner HN, Szabo Z, Buchanan JW, (eds): Principles of Nuclear Medicine, 2nd Edition. Philadelphia: W.B. Saunders, 483-491, 1995. 52. Koo B, Chugani HT: Neonatal seizures and infantile spasms. In: Johnson RT, Griffin JW (eds), Current Therapy in Neurologic Disease, 5th Ed. St. Louis: Mosby Year Book, Inc., 25-29, 1997. 53. Henry TR, Chugani HT: Positron Emission Tomography in the Epilepsies. In: Epilepsy: A Comprehensive Textbook, Engel J. Jr, Pedley TA, (eds), Raven 32
  33. 33. Press, New York, 947-968, 1997. 54. Chugani, H.T. Tomografía por emisión de positrones. In: Fejerman, N, Fernández Alvarez, E, editors. Neurología Pediátrica, 2a edición. Buenos Aires: Panamerica, 1997: 86-96 55. Chugani HT: Neuroimaging II: Functional Imaging. In: Textbook of Pediatric Neuropsychiatry, Coffey CE, Brumback RA, (eds), American Psychiatric Press, Inc., Washington, D.C., London, England, 289-314, 1998. 56. Chugani HT, da Silva EA, Chugani DC, Mueller R-A: PET in the diagnostic evaluation of children with focal epilepsy, In: Tuxhorn I, Holthausen H, (eds). Pediatric Epilepsy Syndromes and their Surgical Treatment, London: John Libbey: 592-606, 1997. 57. Chugani HT: Role of PET in detection of cerebral dysgenesis. In: Kotagal P, Luders H (eds): The Epilepsies: Etiology and Prevention. Academic press, San Diego, pp. 29-36, 1998. 58. Chugani HT: The ontogeny of cerebral glucose metabolism. In: Garreau B, (ed). Neuroimaging in Child Neuropsychiatric Disorders, Springer Publications: 89-96, 1998. 59. Chugani HT: Positron emission tomography in mitochondrial diseases. BioFactors. IOS Press: 255-257, 1998. 60. da Silva EA, Chugani DC, Chugani HT: PET – Tomografia por Emissao de Positrons: Principios Basicos e Aplicacoes Clinicas em Epilepsia, Costa da Costa J, Palmini A, Yacubian EMT, Cavalheiro EA, (eds). In: Fundamentos Neurobiologicos das Epilepsias, 687-703, 1998. 61. Chugani HT: Metabolic imaging: A window on brain development and plasticity. Neuroscientist, 5: 29-40, 1999. 62. Chugani HT: Biological basis of emotions: Brain systems and brain development.. In: Warhol JG (ed). New Perspectives in Early Emotional Development. 1998 Johnson & Johnson Round Table, 5-16, 1998. 63. Juhasz C, Chugani DC, Chugani HT: A PET a normalis agy fejlodesenek es gyermekkori neuropszichiatriai korkepeknek a vizsgalataban. Rudolph C (ed). In: Magyar Tudomany: A Pozitron Emisszios Tomografia (PET) A Vilagban es Magyarorszagon. Oktober/Kulonszam, 1999. 64. Shah JR, Chugani DC, Chugani HT: Diagnostic positron emission tomography. Oxbury J, Polkey C, Duchowny M (eds): Intractable Focal Epilepsy. WB Saunders., pp. 311-321, 2000. 65... Chugani HT, Chugani DC: Abnormal development and catastrophic epilepsies: the 33
  34. 34. clinical picture and relation to neuroimaging. Engel J, Schwartzkrkoin PA, Moshe Sl, Lowenstein DH (eds): Brain Plasticity and Epilepsy. Academic Press, pp. 141-155, 2000. 66. Juhász C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT: Relationship between EEG and positron emission tomography abnormalities in clinical epilepsy. J Clin Neurophysiol 2000;17:29-42. 67. Muzik O, Chugani DC, Shen C, Juhasz C, Von Stockhausen HM, Chugani HT: Assessment of the performance of FDG and FMZ PET imaging against the gold standard of invasive EEG monitoring for the detection of extratemporal lobe epileptic foci in children. Physiological Imaging of the Brain with PET. Academic Press, pp 381-387, 2001. 68. Chugani DC, Chugani HT: New directions in PET neuroimaging for neocortical epilepsy. In Neocortical Epilepsies, eds, Williamson PD, Siegel AM, Roberts DW, Thadani VM, Gazzaniga MS. Adv Neurol 84: 447-456, 2000. 69. Chugani DC, Chugani HT: Mapping of serotonin synthesis. In Functional Imaging in the Epilepsies, eds Henry TR, Duncan JS, Berkovic SF. Adv Neurol 83:165-171, 2000. 70. Chugani HT, Chugani DC: Ancillary Investigations, Section 2: Studies with Positron Emission Tomography. In: Movement Disorders in Children, editors Fernandez-Alvarez E, Aicardi J. International review of Child Neurology Series, 2001, MacKeith Press, London, pp. 235-249. 71. Asano E, Juhasz C, Chugani DC, Muzik O, Chugani HT. Positron emission tomography: Localization for epilepsy surgery. In Reisin RC, Nuwer MR, Hallett M, Medina C (eds.), Advances in Clinical Neurophysiology, Supplements to Clinical Neurophysiology, vol. 54, Elsevier,, 2002, chapter 53, pp. 351-8. 72. Juhász C, Chugani HT, Muzik O, Chugani DC: Hypotheses from functional neuroimaging studies. In Schwartzkroin PA, Rho JM (eds.): Epilepsy, Infantile Spasms, and Developmental Encephalopathy. Int. Rev. Neurobiology 2002; 49:37-55. 73. Chugani DC, Chugani HT: Positron emission tomography (PET) and single photon emission computed tomography (SPECT) in developmental disorders. In Segalowitz SJ and Rapin I (eds.): Handbook of Neuropsychology, 2nd Edition, Vol. 8, Part 1, Elsevier Science, 2002, Chapter 8, pp. 195-215. 74. Juhasz C, Chugani HT. Imaging the epileptic brain with positron emission tomography. Neuroimag Clin N Am 2003;13:705-716 75. Asano E, Chugani DC, Chugani HT. Positron emission tomography. In Curatolo P (Ed.): Tuberous sclerosis complex: from basic science to clinical phenotypes. International Review of Child Neurology series, Mac Keith Press, London, pp. 124-135, Chapter 8, 2003. 34
  35. 35. 76. Fitz CR, Byrd SE, Vezina G, Muzik O, Chugani HT. Part IV: The Brain, Chapter 2: Imaging Modalities. In Kuhn JP, Slovis TL, Haller JO (eds.): Caffey’s Pediatric Diagnostic Imaging,, Tenth edition, Mosby Press, pp. 482-506, 2004. 77. Juhasz C, Chugani HT. Functional imaging. In Wallace S and Farrell K (eds): Epilepsy in Children. Arnold Press, London, 2004, pp. 342-351, chapter 19B. 78. Chugani HT. Fine-tuning the baby brain. Cerebrum 2004;6(3):33-48 79. Juhász C, Chugani DC, Muzik O, Chugani HT. Positron emission tomography in epilepsy. In Kuzniecky RI and Jackson GD (eds): Magnetic Resonance in Epilepsy---Neuroimaging Techniques, 2nd edition. Elsevier Press, Burlington, MA, 2005, pp. 395-411, Chapter 15. 80. Lehr VT, Chugani HT, Aranda JV. Anticonvulsants. In Yaffe SJ, Aranda JV (eds): Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice, 3rd edition. Lippincott, Williams &Wilkins, Philadelphia, 2005, pp. 504-519, Chapter 35. 81. Jagadeesan BD, Juhasz C, Chugani DC, Chugani HT. Pediatric cortical dysplasia: positron emission tomography studies. In: Bioimaging in Neurodegeneration, Broderick PA, Rahni DN, Kolodny EH (eds.), Humana Press, Totowa, NJ, 2005, pp. 131-140. 82. Chugani HT, Chugani DC. Imaging of serotonin mechanisms in epilepsy. Epilepsy Curr. 2005 Nov-Dec;5(6):201-6. 83. Asano E, Chugani HT. Temporal lobe epilepsy and cognition: what do we learn from PET studies in children? In Arzimanoglou et al. (Eds): Cognitive Dysfunction in Children with Temporal Lobe Epilepsy, John Libbey, Paris, 2005, pp. 127-140. 84. Sundaram SK, Chugani HT, Chugani DC. Positron emission tomography methods with potential for increased understanding of mental retardation and developmental disabilities. Ment Retard Dev Disabil Res Rev. 2005;11(4):325-30. 85. Chugani HT, Juhasz C: Functional imaging of the developing human brain. In: Pediatric Neuropsychiatry, Coffey CE, Brumback RA, (eds), Lippincott Williams &Wilkins, Philadelphia, 2006, Chapter 6, pp. 109-133. 86. Sood S, Chugani HT. Functional neuroimaging in the preoperative evaluation of children with drug-resistant epilepsy. Childs Nerv Syst 2006; 22:810-820. 87. Chugani HT. Editorial: What can we learn from functional neuroimaging in children? Indian Pediatrics 2006; 43:203-206. 88. Treves ST, Chugani HT, Bourgeois BFD: Chapter 2: Central Nervous System. Part 1: Brain. In Treves ST (ed): Pediatric Nuclear Medicine/PET, 3rd Edition. Springer, New York, 2007, pp. 16-39. 35
  36. 36. 89. Luat AF, Makki M, Chugani HT. Neuroimaging in tuberous sclerosis complex. Current Opinions in Neurology 2007;20:142-150. 90. Chugani HT, Asano E, Sood S. Surgical treatment of West syndrome. In: Guzzetta F, Dalla Bernardina B, Guerrini R (eds): Progress in Epileptic Spasms and West Syndrome. John Libbey, Montrouge, France, 2007, pp. 143-151. 91. Chugani HT. Tomografia por emision de positrones. In: Fejerman N and Fernandez Alvarez E (Eds.): Neurologia Pediatrica, 3rd Edition, Buenos Aires, Medica Panamericana, 2007, pp. 87-105. 92. Faerber EN, Bulas DI, Cecil KM, Muzik O, Chugani HT. Section III Neuroradiology: Brain - Imaging modalities, pp 623-652. In Caffey's Pediatric Diagnostic Imaging, 11th Ed. (Slovis TL and Frush DP, Editors) Elsevier, Philadelphia 2007 93. Henry TR, Chugani HT. Positron emission tomography (Chapter 80). In: Engel J Jr. and Pedley TA (Eds.), Epilepsy: A comprehensive textbook, 2nd edition, Lippincott, Williams & Wilkins, Philadelphia, 2008, pp. 945-964. 94. Luat AF, Chugani HT. Molecular and diffusion tensor imaging of epileptic networks. In: Noebels JL (Ed.) Mapping Epileptic Circuitry. Proceedings from the 26th Annual Merritt- Putnam Symposium. Epilepsia 2008; 49(suppl. 3):15-22. ABSTRACTS 1. Chugani HT, Chugani DC: Altered energy metabolism in manganese toxicity. Presented at the 34th Annual Meeting of the American Academy of Neurology, Washington, D.C., April 1982. 2. Lavenstein B, Chugani HT, Woo S, Sinks L: Effectiveness of the brainstem auditory evoked response to monitor clinical course and response to chemotherapy in children with brainstem tumors. Presented at the 34th Annual Meeting of the American Academy of Neurology, Washington, D.C., April 1982. 3. Chugani HT, Ackermann RF, Chugani DC, Engel J Jr.: Local cerebral glucose utilization and electroencephalographic alterations in enkephalin induced seizures. Ann Neurol 12: 93, 1982. 4. Chugani HT, Dwyer BE, DeRay M, Shields WD: Effects of valproic acid on local brain protein synthesis in newborn rats. Ann Neurol 12: 208, 1982. 5. Shields WD, Chugani HT: Amantadine HC1 in the treatment of children with refractory epilepsy. Presented at the 35th Annual Meeting of the American Academy of Neurology, San Diego, April 1983. 36
  37. 37. 6. Chugani HT, Ackerman RF, Chugani DC, Engel J Jr.: Autoradiographic studies of opiate-mediated epileptogenic phenomena in rats. International Symposium on Cerebral Blood Flow, Metabolism and Epilepsy, Montpellier (France), June 1983. 7. Ackermann RF, Chugani HT, Finch DM, Babb TL, Lear JL, Engel J Jr.: Autoradiographic studies of stimulation-induced changes in rat hippocampal metabolism and blood flow. J Cereb Blood Flow Metab 3: S238-S239, 1983. 8. Barrio JR, Keen R, Chugani H, Ackermann R, Chugani DC, Phelps ME: L-(1-C-11) phenylalanine for the determination of cerebral protein synthesis rates in man with positron emission tomography. Society of Nuclear Medicine, St. Louis, June 1983. 9. Chugani HT, Ackermann RF, Engel J Jr.: Uncoupling of rat hippocampal blood flow and metabolism by enkephalins. Ann Neurol 14: 127-128, 1983. 10. Ackermann RF, Chugani HT, Yan HJ, Lear JL, Engel J Jr.: Autoradiographic studies of uncoupling between blood flow and metabolism in rat hippocampus during amygdala-kindled seizures. 15th Epilepsy International Symposium and American Epilepsy Society Meeting, Washington, D.C., September 1983. 11. Chugani HT, Engel J Jr., Mazziotta JC, Phelps ME: 18F-2-Fluorodeoxyglucose positron emission tomography in medically refractory childhood epilepsy. Presented at the 36th Annual Meeting of the American Academy of Neurology, Boston, April 1984. 12. Chugani HT, Mazziotta JC, Engel J Jr., Phelps ME: Positron emission tomography with 18F-2-fluorodeoxyglucose in infantile spasms. Ann Neurol 16: 376-377, 1984. 13. Ackermann RF, Chugani HT, Caldecott-Hazard S, Engel J Jr.: Postictal cerebral metabolism-blood flow mismatches observed in hippocampus and substantia nigra of amygdala-kindled rats. Soc Neurosci Abstr 10: 3, 1984. 14. Chugani HT, Villablanca JR, Harris CM, Burgess JW: Effects of a single, small dose of morphine on local cerebral glucose utilization (LCGU) in cats. Soc Neurosci Abstr 10: 3, 1984. 15. Furman JM, Chugani HT, Baloh RW: Familial cerebellar hypoplasia with upbeating nystagmus. Ann Neurol 16: 135, 1984. 16. Chugani HT: Positron emission tomography in pediatric seizure disorders. Western Society for Pediatric Research (Plenary Session), Carmel, February 1985. 17. Chugani HT, Phelps ME: Maturational changes of glucose metabolic patterns in the human infant determined by 18F-2-fluorodeoxyglucose positron emission tomography. American Academy of Neurology, Dallas, April-May 1985. 18. Chugani HT, Mazziotta JC, Phelps ME: Positron emission tomography with 18F- 37
  38. 38. 2-fluorodeoxyglucose in the Sturge-Weber syndrome. American Academy of Neurology, Dallas, April-May 1985. 19. Chugani HT, Mazziotta JC, Phelps ME, Engel J Jr.: Structural lesions detected by 18F-2-Flurodeoxyglucose positron emission tomography in childhood epilepsy. American Academy of Neurology, Dallas, April - May, 1985. 20. Chugani HT, Phelps ME: Maturational changes of glucose metabolic patterns in the human infant determined by 18F-2-fluorodeoxyglucose positron emission tomography. Soc Neurosci Abstr 11: 1125, 1985. 21. Chugani HT, Phelps ME, Mazziotta JC: Local cerebral metabolic rates for glucose during brain development. American Academy of Neurology, New Orleans, April - May, 1986. 22. Chugani HT, Phelps ME, Mazziotta JC: Patterns of local cerebral metabolic rates for glucose in children with psychomotor retardation determined with positron emission tomography. Ann Neurol 20: 425, 1986. 23. Ackermann RF, Chugani HT: Relative hypoperfusion in hippocampus and substantia nigra immediately following rat amygdala kindled seizures. J Cereb Blood Flow Metab 7 (Suppl 1): S436, 1987. 24. Chugani HT, Shewmon DA, Phelps ME, Mazziotta JC: Refractory neonatal seizures: Determination of local cerebral metabolic rates for glucose (LCMRglc) with 2-deoxy-2[18]fluoro-D-glucose (FDG) and positron emission Tomography (PET). J Cereb Blood Flow Metab 7 (Suppl 1): S437, 1987. 25. Chugani HT, Phelps ME, Mazziotta JC: Human brain functional development: A study of local cerebral metabolic rates for glucose (LCMRglc) with positron emission tomography (PET). J. Cereb Blood Flow Metab 7 (Suppl 1): S523, 1987. 26. Chugani HT, Phelps ME, Light RK, Mazziotta JC: Metabolic correlates of mental retardation in children determined with FDG positron emission tomography (PET). J. Cerebral Blood Flow Metabol 7 (Suppl 1): S523, 1987. 27. Chugani HT, Hovda DA, Phelps ME, Villablanca JR: Metabolic maturation of the brain: A study of local cerebral glucose utilization in the cat. Soc Neurosci Abst 13, 1987. 28. Chugani HT, Phelps ME, Mazziotta JC: Local cerebral metabolic rates for glucose (1CMRG1c) following cerebral hemisphrectomy. American Academy of Neurology, Cincinnati, Ohio, April 1988. 29. Chugani HT, Babb TL, Kupfer WR, Pretorius JK: Anatomic-pharmacologic analysis of benzodiazepine receptor binding in human epileptic hippocampus. Soc Neurosci Abstr 14, 1988. 38
  39. 39. 30. Hovda DA, Chugani HT, Badie B, Phelps ME, Villablanca JR: Cerebral maturation of oxidative metabolism in the cat. Soc Neurosci Abstr 14: 48, 1988. 31. Chugani HT, Phelps ME, Mazziotta JC: Positron emission tomography evidence of brain plasticity in children following large cerebral resections. J Cereb Blood Flow Metab 9: 2-30, 1989. 32. Olson DM, Chugani HT, Shewmon DA, Peacock WJ, Mazziotta JC, Phelps ME: Electrocorticography in children with intractable seizures and focal abnormalities on positron emission tomography. J Cereb Blood Flow Metab 9: S-213, 1989. 33. Kerrigan JF, Chugani HT, Mazziotta JC, Phelps ME: Cerebral palsy subtypes: a study of cerebral glucose utilization using PET. J Cereb Blood Flow Metab 9: S709, 1989. 34. Hovda DA, Chugani HT, Badie B, Villablanca JR: Metabolic maturation of the brain: A study of oxidative metabolism utilizing cytochrome oxidase histochemistry in cat. J Cereb Blood Flow Metab 9: S-27, 1989. 35. Shewmon DA, Olson DM, Peacock WJ, Chugani HT: Nonepileptiform abnormalities in electrocorticography: Utility in pediatric epilepsy surgery. Presented in EEG Society Meeting, 1989. 36. Sutton RL, Hovda DA, Chugani HT: Time course of local cerebral glucose utilization (LCGU) alterations after motor cortex ablation in the rat. Soc Neurosci Abstr 15: 128, 1989. 37. Chugani HT, Phelps ME, Mazziotta JC: Metabolic evidence of brain plasticity in children following large cerebral resections. Soc Neurosci Abstr 15: 448, 1989. 38. Kerrigan JF, Chugani HT, Hovda DA, Villablanca JR, Huang S-C, Barrio J, Phelps ME: Local cerebral protein synthesis in the cat during normal development. Soc Neurosci Abstr 15: 854, 1989. 39. Shewmon DA, Shields WD, Olson DM, Peacock WJ, Chugani HT: Multifocal independent epileptogenicity in children treated by focal cortical resection. Epilepsia 30: 660, 1989. 40. Chugani HT, Shields WD, Shewmon DA, Peacock WJ, Phelps ME: Infantile spasms: surgical treatment of focal cortical dysgenesis detected by positron emission tomography. Epilepsia 30: 691-692, 1989. 41. Okonek A, Light R, Chugani H, Phelps M: Neuropsychological correlates of FDG positron emission tomography (PET) in children. Presented at the 18th Annual Meeting of the International Neuropsychological Society, February, 1990. 39
  40. 40. 42. Chugani HT, Shewmon DA, Phelps ME: Infantile spasms: lenticular nuclei hypermetabolism identified with positron emission tomography (PET). Neurology 40 (Suppl 1): 407, 1990. 43. Sankar R, Chugani HT, Lubens P, Philippart M, Phelps ME: Heterogeneity in the patterns of cerebral glucose utilization in children with Landau-Kleffner syndrome. Neurology 40 (Suppl 1): 257, 1990. 44. Altman KD, Chugani HT, Phelps ME: Agenesis of the corpus callosum: associated abnormalities detected by positron emission tomography. Neurology 40 (Suppl. 1): 358, 1990. 45. Chugani HT, Shewmon DA, Phelps ME: Ictal patterns of cerebral glucose utilization in children with epilepsy. American Epilepsy Society 1990, Epilepsia 3: 626, 1990. 46. Kunchandy J, Chugani HT, Nassir Y: Hemidecortication in newborn rat: effects on local cerebral metabolic rates for glucose in adulthood. Child Neurology Society 1990, Ann Neurol 28: 412, 1990. 47. Peacock WJ, Shields WD, Shewmon DA, Chugani HT: Surgery for intractable infantile spasms. International Society for Pediatric Neurosurgery/ 18th Annual Scientific Meeting, Paris, September 1990. 48. Philippart M, Chugani HT, Phelps ME: Spielmeyer-Vogt ("Batten") disease: distinctive patterns of cerebral glucose utilization. Neurology 41 (suppl.1): 333, 1991. 49. Chugani HT, Shewmon DA, Peacock WJ, Vinters H, Phelps ME, Comair Y, Shields D: Functional imaging with PET in children undergoing epilepsy surgery. J Cereb Blood Flow Metab 11 (Suppl 2): S416, 1991. 50. Tatsukawa K, Chugani HT, Brown D, Nassir Y: Chronic cerebral glucose metabolic rates in hemidecorticated rats are dependent on age-at-lesion. J Cereb Blood Flow Metab 11 (Suppl 2): S794, 1991. 51. Rocha L, Engel J Jr., Nassir Y, Chugani HT: Effect of upregulation of opioid receptors on amygdaloid kindling in rats and its association with 'mu' opioid receptor levels. Eplepsia 32(suppl): 33, 1991. 52. Engel J Jr., Rocha L, Ackermann RF, Chugani HT: Molecular substrates of interictal behavioral disturbances. Workshop on Neuotransmitters in Epilepsy, Brazil, 1991. 53. Ashwal S, Nadi NS, Huang Y, Chugani HT: Paroxysmal kinesigenic choreoathetosis: Cerebrospinal fluid neurochemistry and positron emission tomography. Ann Neurol 30: 503, 1991. 40
  41. 41. 54. Watkins JM, Chugani HT, Elliott TK, Messa C, Lippe B, Phelps ME: Positron emission tomography and neuropsychological correlations in Turner syndrome. Ann Neurol 30: 454, 1991. 55. Elliott TK, Chugani HT, Messa C, Phelps ME: Developmental dysphasia studied with positron emission tomography. Ann Neurol 30: 483, 1991. 56. Chugani HT, Shewmon DA, Shields WD, Peacock WJ, Comair Y, Vinters H, Phelps ME: Positron emission tomographic scanning in pediatric epilepsy operations: UCLA experience in 84 patients. Ann Neurol 30: 483, 1991. 57. Chugani HT, Shewmon DA, Phelps ME: Interictal and postictal focal hypermetabolism on positron emission tomography. Epilepsia 32 (suppl 3): 80, 1991. 58. Caplan R, Chugani HT, Messa C, Mundy P, Sigman M, Phelps ME: Surgery for early onset intractable seizures: Presurgical PET patterns and postsurgical communication skills. Epilepsia 32 (suppl 3): 38, 1991. 59. Brown D, Chen S, Tatsukawa K, Nassir Y, Hovda D, Villablanca J, Chugani HT: Muscarinic cholinergic receptor binding following neonatal or adult hemispherectomy in the cat. Epilepsia 32 (suppl l3): 37, 1991. 60. Farrell MA, Vinters HV, Curran J, Chugani HT: Correlation between neuropathological and positron emission tomography findings in refractory childhood focal epilepsy. Epilepsia 32 (suppl 3): 104, 1991. 61. Rocha L, Engel J. Jr., Chugani HT, Tatsukawa K, Ackermann RF: Effect of chronic naloxone treatment on benzodiazepine receptor levels in normal and kindled rats. Soc Neurosci Abstr 17: 512, 1991. 62. Hovda DA, Chugani HT, Villablanca JR: Lack of asymmetry in cerebral glucose metabolism in neonatal as compared to adult cerebral hemispherectomized cats. Soc Neurosci Abstr 17: 894, 1991. 63. Nassir Y, Tatsukawa K, Brown D, Ebrahim A, Chen S, Hovda D, Villablanca J, Chugani HT: Increased 3H-flunitrazepam binding in visual structures of adult cerebral hemispherectomized compared to neonatally hemispherectomized cats. Soc Neurosci Abstr 17: 984, 1991. 64. Loopuijt LD, Ebrahim A, Hovda DA, Villablanca JR, Chugani HT: D2 receptor densities of striatum in adult- and neonatal-hemispherectomized cats. 7th International Catecholamine Symposium, Amsterdam, June 1992. 65. Pascual-Leone A, Chugani HT, Cohen LG, Brasil-Neto JP, Wasserman EM, Valls-Sole J, Fuhr P, Hallett M: Reorganization of human motor pathways following hemispherectomy. Ann Neurol 32: 261, 1992. 41

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