Development of nano-scale technologies for food safety protection

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  • Cross-contamination from other processing industries (water supply, environmental cross-contamination). Direct addition (encapsulates, microemulsions, antioxidants, antimicrobials, etc.) Food manufacture (Coatings, packaging)
  • Development of nano-scale technologies for food safety protection

    1. 1. Improving Life through Science and Technology. Development of nano-scale technologies for food safety protection Matthew Taylor, Ph.D. Department of Animal Science, Texas AgriLife Research September 14, 2011
    2. 2. Nanotechnology Significance <ul><li>“ Nanotechnology holds great promise for the development of new treatments and diagnostics.” </li></ul><ul><li>Andrew Von Eschenbach, MD </li></ul><ul><li>FDA Commissioner, 2007 </li></ul>FDA Nanotechnology Task Force Report, 2007
    3. 3. Global Nanotechnology Research Funding Adapted from Bugusu (2010). Food Technology (www.ift.org)
    4. 4. Nano-materials in Foods <ul><li>Naturally occurring </li></ul><ul><ul><li>Food macro-, micro-components & nutrients </li></ul></ul><ul><ul><li>DNA, RNA </li></ul></ul><ul><ul><li>Casein micelles </li></ul></ul><ul><li>Synthetic systems </li></ul><ul><ul><li>Encapsulates </li></ul></ul><ul><ul><li>Nano-wires </li></ul></ul><ul><ul><li>Biosensors </li></ul></ul>
    5. 5. Nano-materials entry into foods Magnuson et al. 2011. J. Food Sci. 76:R126.
    6. 6. Food Safety Applications of Nanotechnology <ul><li>Antimicrobial encapsulation/delivery strategies </li></ul><ul><ul><li>Encapsulates </li></ul></ul><ul><ul><li>Nano-wires </li></ul></ul><ul><li>Active packaging/antimicrobial-bearing films </li></ul><ul><li>Pathogen detection/diagnostics </li></ul><ul><ul><li>Biosensors </li></ul></ul>
    7. 7. Nanotechnologies: Regulatory Concerns <ul><li>Definition of nano and engineered versus naturally occurring </li></ul><ul><li>Purpose(s) of engineered nanotechnology use in foods </li></ul><ul><li>Detection of nanomaterial presence in foods </li></ul><ul><li>Characterization of interactions with food components </li></ul><ul><li>Safety and toxicity of nanomaterials </li></ul>
    8. 8. Antimicrobial Encapsulations <ul><li>Liposomes, Micelles </li></ul><ul><ul><li>Self-directed formation </li></ul></ul><ul><ul><li>Entrapment rate can be high </li></ul></ul><ul><ul><li>Formed from lipids dispersed in aqueous systems </li></ul></ul><ul><ul><li>Not long-term stable without post-formation modifications </li></ul></ul>
    9. 9. Liposomal Formulations Taylor et al. 2006. Crit. Rev. Food Sci. Nutr. 45:587.
    10. 10. L. monocytogenes Inhibition in Milk with Liposomal Nisin (50 IU/ml) at 20°C Schmidt et al. 2009. Probiotics Antimicrob. Prot. 1:152-8.
    11. 11. E. coli O157:H7 Inhibition in 2% Milk with 0.5% Eugenol Microemulsions Gaysinsky et al. 2007. J. Food Protect . 70: 2631-7. Assay Detection Limit
    12. 12. Polymeric Encapsulate Research <ul><li>Β -Cyclodextrins </li></ul><ul><li>Antimicrobials (Essential Oils) </li></ul><ul><ul><li>Carvacrol </li></ul></ul><ul><ul><li>Thymol </li></ul></ul>
    13. 13. Texas A&M Nanotechnology Research in Food Safety <ul><li>Dairy (Fluid Milk): Liposomes with entrapped nisin inhibit Listeria monocytogenes (Schmidt et al. 2009) </li></ul><ul><li>Fresh Produce (Pre-, Post-Harvest) </li></ul><ul><ul><li>Micellar organic acids, essential oils </li></ul></ul><ul><ul><li>Field application, packing house </li></ul></ul><ul><ul><li>Pathogen inhibition </li></ul></ul><ul><ul><li>USDA Funding: NIFSI, AFRI </li></ul></ul><ul><li>Processed/RTE poultry: Incorporated pre-lethality for L. monocytogenes control post-processing </li></ul><ul><ul><li>Corporately sponsored </li></ul></ul><ul><ul><li>Validation of antimicrobial activity </li></ul></ul>
    14. 14. Forced nano-particle/pathogen interaction on produce surfaces
    15. 15. Collaborators (TAMU) <ul><li>Investigators: </li></ul><ul><ul><li>Elsa Murano </li></ul></ul><ul><ul><li>Alex Castillo </li></ul></ul><ul><ul><li>Luis Cisneros-Zevallos </li></ul></ul><ul><ul><li>Carmen Gomes </li></ul></ul><ul><ul><li>Christine Alvarado </li></ul></ul><ul><li>Graduates: </li></ul><ul><ul><li>Laura Hill (PhD) </li></ul></ul><ul><ul><li>Keila Perez (PhD) </li></ul></ul><ul><ul><li>Songsirin Ruengvisesh (PhD) </li></ul></ul><ul><ul><li>Shannon Schmidt (MS) </li></ul></ul>
    16. 16. T. Matthew Taylor, PhD <ul><li>310 Kleberg Animal and Food Sciences Center, College Station, TX, 77843-2471 </li></ul><ul><li>P: 979.862.7678; F: 979.862.3475 </li></ul><ul><li>Email: matt_taylor@tamu.edu </li></ul><ul><li>http://animalscience.tamu.edu/facultystaff/faculty/taylor.htm </li></ul>
    17. 17. <ul><li>Thank you! </li></ul>

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