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Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
Sliding filament theory   muscle contraction
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Sliding filament theory muscle contraction

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  • 1. Sliding Filament Theory Lloyd Dean How Muscles Contract
  • 2. Structure of Skeletal Muscle: Microstructure
    • Sarcolemma
      • Muscle cell membrane
    • Myofibrils
      • Threadlike strands within muscle fibers
      • Actin (thin filament)
        • Troponin
        • Tropomyosin
      • Myosin (thick filament)
    • Further divisions of
    • Myofibrils
      • Z-line
      • A-band
      • I-band
    • Sarcoplasm
      • Sarcoplasmic reticulum
        • Storage sites for calcium
        • Surrounds myofibrils
      • Transverse tubules
  • 3.  
  • 4.  
  • 5.  
  • 6. Muscular Contraction
    • The sliding filament model
      • Muscle shortening occurs due to the movement of the actin filament over the myosin filament
      • Reduction in the distance between Z-lines of the Sarcomere
      • Lets see a preview before the play………..
  • 7. Sliding Filament Theory: A Love Story
    • Winner of 2 Golden Globes and 3 Oscar’s.
    • Directed by Lloyd Dean and his award winning students
    • The background
    • Actin and Myosin are in deeply in love and wish to live a happy life together and stay in full muscle contraction.
    • The nasty Tropomyosin has other idea’s…….
    • Let’s see the cast……..
  • 8. Cast
    • Actin – The thin protein that needs some HELP to join with Myosin
    • Myosin - The thick protein
    • Acetylcholine – A helping hormone
    • Troponin – Will assist in removing the horrid tropomyosin from actin
    • Tropomyosin – Doesn’t want actin and myosin to become attached
    • ATP – Energetic friend
    • Calcium – Will it win it’s battle against tropomyosin ?
    • Nervous Impulse - Messenger
    • Now to the chapters of this story.........
  • 9. Chapters
    • A Milky Message
    • Two Forces Join
    • A T iresome P ull
    • Powering Through
    • A Milky Removal
  • 10. A Milky Message
    • Nerve Impulse sent to neuromuscular junction (Place where the brain and muscle communicate)
    • Hormone (Acetylcholine) diffuses
    • This causes calcium ions to be released in the sarcoplasmic reticulum (Surrounds myofibrils)
  • 11.  
  • 12. Two Forces Join
    • Calcium ions join with troponin
    • Causes tropomyosin to be removed from actin
    • Actin and myosin join together
  • 13. A T iresome P ull
    • Actin and myosin are now joined
    • Myosin pulls actin inwards slightly
    • ATP enables quick detachment of actin and myosin in preparation for power stroke
  • 14. Powering Through
    • ATP is broken down
    • This enables Myosin to powerfully pull actin inwards
    • Sarcomere and distance between Z discs shortens
    • This process continues at a high rate and as long as there are calcium ions present
  • 15. A Milky Removal
    • Once impulse stops....
    • Calcium Ions are sent back to sarcoplasmic reticulum
    • Tropomyosin rejoins actin
    • Sarcomere and Z disc distance increase
    • Muscle is relaxed
  • 16. All or None Law
    • Fiber contracts completely or not at all
  • 17.  
  • 18.  
  • 19.  

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