C.V. David Labbé, M.Sc., agr., chm.

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C.V. David Labbé, M.Sc., agr., chm.

  1. 1. DAVID LABBÉ, M.Sc., agr., chm. EMail: david.labbe@mail.mcgill.ca LinkedIn: ca.linkedin.com/in/labbedavid EXPERIMENTAL MEDICINE Ph.D. CANDIDATE Deeply involved student with great marks who have also proven able to carry on, publish and communicate research projects in multiple fields. Very active student who’s passionate for research and has a deep faith in the multidisciplinary approach. Worked in a number of laboratories since the beginning of undergraduate studies. Has proven able to carry out research projects and produce publications of high quality in the Cancer and Food Sciences research fields. Demonstrated abilities to communicate scientific issues in collaboration with the only magazine aimed at the Québec food industry in French, l’Actualité Alimentaire. Obtained international experience during undergraduate studies. Possesses good basis in management.EDUCATIONExperimental Medicine (Ph.D.) 2008-presentMcGill University, Goodman Cancer Research Center, Montréal Ph.D. thesis: Protein tyrosine phosphatase 1B (PTP1B) gene regulation and role in prostate cancer Supervisor, Dr Michel L. TremblayChemistry, specialization in biochemistry (M.Sc.) 2008Université du Québec à Montréal/Hôpital Sainte-Justine, Montréal Master thesis: Les flavonoïdes d’origine alimentaire et le cancer – Inhibition de l’angiogenèse tumorale et du potentiel invasif des médulloblastômes Supervisor, Dr Richard Béliveau • Master’s thesis accepted with an ”excellent” rating • Degree obtained with honoursAdministration (certificate) 2007Université Laval, Québec • Specialization in managementFood Sciences, experience abroad (B.Sc.A.) 2006Université Laval, Québec • Semester at the ”Polytech’Montpellier”, France • Specialization in chemistryBILINGUAL: French and EnglishPROFESSIONAL ORDERS: • Agrologist, member of the “Ordre des agronomes du Québec”. • Chemist, member of the “Ordre des chimistes du Québec”.
  2. 2. DAVID LABBÉ, agr., chm., M.Sc. Page 2 / 10AWARDS AND PRIZESResearch awardsAward name Organization Amount DateRolande and Marcel Gosselin Graduate Studentship McGill University 11,000 2011-2012McGill Integrated Cancer Research Training Program CIHR/FRSQ 12,000 2011-2012Frederick Banting and Charles Best doctoral research award CIHR 105,000 2008-2011Doctoral research award (declined) FRSQ 60,000 2008-2011Master research award FQRNT 15,000 2007Canada Graduate Scholarship – Master’s NSERC 17,500 2006Undergraduate Student Research Award NSERC 5,625 2006Internship award “Excellence” Ordre des chimistes du Québec 5,000 2005Undergraduate Student Research Award NSERC 5,625 2004Undergraduate Student Research Award NSERC 5,625 2003PrizesAward name Organization Amount DateGraduate Research Enhancement & Travel (GREAT) Award McGill University 1,500 2012Travel award McGill Integrated Cancer 1,000 2011(Europhosphatase 2011, Vienna, Austria) Research Training ProgramTravel award Canderel 500 2010(FASEB meeting, Steamboat Springs, CO)Phil Gold Scientist in Training Award MISAM 100 2009(3rd best poster presentation)National Student Research Poster Competition CIHR (declined) - 2009(Winnipeg, Manitoba)Travel award Canderel 500 2009(Cold Spring Harbor meeting, Cold Spring Harbor, NY)Best poster presentation CHU Sainte-Justine 150 2007(Centre de recherche du CHU Sainte-Justine, Montréal)Second rank Can. Inst. Food. Sci. and Tech. - 2006(Student Challenge opposing 7 canadian universities)Second best poster presentation FAV Health 2005 100 2005Academic awardsAward name Organization Amount DateGraduate Excellence Fellowship McGill University 1,500 2012Principal’s Graduate Fellowship McGill University 2,500 2009-2010Provost’s Graduate Fellowship McGill University 5,500 2008-2009Junior/Senior Scholarship Institute of Food Technologist (USA) 1,000 2006Excellence award Canadian Inst. of Food Science and Tech. 1,000 2005Award Fondation de technologie laitière du Québec inc. 500 2005Junior/Senior Scholarship Institute of Food Technologist (USA) 1,000 2005Excellence award Canadian Inst. of Food Science and Tech. (Québec) 800 2005Studentship studies abroad, France Université Laval 3,000 2004Excellence award Canadian Inst. of Food Science and Tech. 1,000 2004Excellence award Promotion Agronomie 1965, Université Laval 1,500 2004Excellence award Canadian Inst. of Food Science and Tech. (Québec) 800 2004Excellence award Canadian Inst. of Food Science and Tech. (Québec) 800 2003Excellence award Faculty (FSAA), Université Laval 1,000 2002Summer English language program Minister of Canadian Heritage 1,625 2002
  3. 3. DAVID LABBÉ, agr., chm., M.Sc. Page 3 / 10RESEARCH EXPERIENCEDevelopment of a preconcentration method for green tea catechins 2006 • Research internship (NSERC), Université Laval, Québec Dr Laurent BazinetOptimisation of an electrodialysis method for green tea catechins separation 2005 • Research collaboration, Institut européen des membranes (IEM), Montpellier, France Dr Philippe Sistat and Dr Laurent BazinetNutritional impact of chitosan on rats under a cholesterol and saturated fat-rich diet 2005 • Exploratory study, Polytech’Montpellier, Université de Montpellier II, France Dr Jean-Max Rouanet and Dr Bernard PossompesGreen tea polyphenols electromigration with ultrafiltration membranes 2004 • Research internship (NSERC), Université Laval, Québec Dr Laurent BazinetStudy on the maturation of cheese 2004 • Industrial research internship, Les Fromages de l’isle d’Orléans, Québec Dr Jacques GouletStudy on the green tea polyphenols electromigration potential 2003 • Research internship (NSERC), Université Laval, Québec Dr Laurent BazinetProduction of emulsifier molecules by enzymatic means 2003 • Research internship, Université Laval, Québec Dr Jean-Christophe VuillemardSKILLS AND TECHNIQUES Food sciences Biochemistry Experimental Medicine•Bioactive molecule extraction •Tissue culture •Transgenic mouse models•Electrodialysis •Cellular biology •Murine prostate cancer model•HPLC •Biochemical assays •Xenograft assays•Green tea •Gene regulation studies •Clinical studies •Microarrays •Immunohistochemistry
  4. 4. DAVID LABBÉ, agr., chm., M.Sc. Page 4 / 10SCIENTIFIC PUBLICATIONSARTICLES1. *Labbé, DP.; *Lessard, L.; Deblois, G.; Bégin, LR.; Hardy, S.; Mess-Masson, AM.; Saad, F.; Trotman,LC.; Giguère, V.; Tremblay, ML. PTP1B is an androgen receptor-regulated phosphatase thatpromotes the progression of prostate cancer, Cancer Research, epub ahead of print (2012) January 26th.*Contributed equally to the work Top Story: Prostate Cell News, 3.03, January 27, 2012 Publication of the Month: Goodman Cancer Research Centre, January 20122. Provençal, M.; Berger-Thibault, N.; Labbé, D.; Veitch, R.; Boivin, D.; Rivard, G-É.; Gingras, D.;Béliveau, R. Tissue factor mediates the HGF/MET-induces anti-apoptotic pathway inmedulloblastoma cells, Journal of Neuro-Oncology, 97(3) (2010) 365-372.3. Provençal, M.; Labbé, D.; Veitch, R.; Boivin, D.; Rivard, G-É.; Gingras, D.; Béliveau, R. c-Metactivation in meduloblastoma induces tissue factor expression and activity: effects cell migration,Carcinogenesis, 30(7) (2009) 1089-1096.4. Boivin, D.; Labbé, D.; Fontaine, N.; Lamy, S.; Beaulieu, É.; Gingras, D.; Béliveau, R. The stem cellmarker CD133 (prominin-1) is phosphorylated on cytoplasmic tyrosine-828 and tyrosine-852 by Srcand Fyn tyrosine kinase, Biochemistry, 48(18) (2009) 3998-4007.5. Labbé, D.; Provençal, M.; Lamy, S.; Boivin, D.; Gingras, D.; Béliveau, R. The flavonols quercetin,kaempferol and myricetin inhibit hepatocyte growth factor-induced medulloblastoma cell migration,The Journal of Nutrition, 139(4) (2009) 646-652.6. Lamy, S.; Bédard, V.; Labbé, D.; Sartelet, H.; Barthomeuf, C.; Gingras, D.; Béliveau, R. The dietaryflavones apigenin and luteolin impair smooth muscle cell migration and VEGF expression throughinhibition of PDGFR-! phosphorylation, Cancer Prevention Research 1(6) (2008) 452-459.7. Lamy, S.; Beaulieu, É.; Labbé, D.; Bédard, V.; Moghrabi, A.; Barette, S.; Gingras, D.; Béliveau, R.Delphinidin, a dietary anthocyanidin, inhibits platelet derived growth factor ligand/receptor(PDGF/PDGFR) signaling, Carcinogenesis, 29(5) (2008) 1033-1041.8. Labbé, D.; Têtu, B.; Trudel, D.; Bazinet, L. Catechin stability of EGC- and EGCG-enriched teadrinks produced by a two-step extraction procedure, Food Chemistry, 111 (2008) 139-143.9. Bazinet, L.; Labbé, D.; Tremblay A. Production of green tea EGC- and EGCG-enriched fractions bya two-step extraction procedure, Separation and Purification Technology, 56 (2007) 53-56.10. Labbé, D.; Bazinet, L. Effect of membrane type on cation migration during green teaelectromigration and equivalent mass transported calculation, Journal of Membrane Science, 275 (2006)220-228.
  5. 5. DAVID LABBÉ, agr., chm., M.Sc. Page 5 / 1011. Labbé, D.; Tremblay, A.; Bazinet, L. Effect of brewing temperature and duration on green teacatechin solubilization: basis for production of EGC and EGCG-enriched fractions, Separation andPurification Technology, 49 (2006) 1-9.12. Labbé, D.; Araya-Farias, M.; Tremblay, A.; Bazinet, L. Electromigration feasability of green teacatechins, Journal of Membrane Science, 254 (2005) 101-109.REVIEWTrudel, D.; Labbé, DP.; Bairati, I.; Fradet, V.; Bazinet, L.; Têtu, B. Green tea for ovarian cancerprevention and treatment: A systematic review of the in vitro, in vivo and epidemiological studies,Gynecologic Oncology, submited #GYN-12-116.BOOK CHAPTERLabbé, DP.; Hardy, S.; Tremblay, ML. Protein tyrosine phosphatases in cancer: Friends and Foes!, inProtein Phosphorylation and Health and Disease an issue of Progress in Molecular Biology and TranslationalScience (Shenolikar, S. ed.), Academic Press. 106 (2012) 253-306.BROAD INTEREST PUBLICATIONS1. Labbé, D. Inflammation et cancer : Quand le système immunitaire se retourne contre soi, Sciencesexpress (UQÀM), 2008, vol. 7, n° 9.2. Labbé, D. Être à l’affût : un défi de pointe, L’Actualité alimentaire, 2006, vol. 3, n° 3, p. 46-49.3. Labbé, D. S’afficher sans allergènes, L’Actualité alimentaire, 2006, vol. 3, n° 2, p. 52-55.4. Labbé, D. La modélisation au service de l’optimisation, L’Actualité alimentaire, 2005, vol. 2, no 6, p.42-44.5. Labbé, D. L’extraction de molécules bioactives, L’Actualité alimentaire, 2005, vol. 2, no 5, p. 44-47.6. Labbé, D. Les technologies membranaires flirtent avec les nutraceutiques, L’Actualité alimentaire,2005, vol. 2, no 1, p. 46-48.7. Labbé, D. Produire sans lait, sans œufs ou sans gluten : Un casse-tête nécessaire, L’Actualitéalimentaire, 2004, vol. 1, no 6, p. 44.8. Labbé, D. Transformer bio, un noble défi! L’Actualité alimentaire, 2004, vol. 1, no 6, p. 42-43.9. Labbé, D. L’aspirine, un remède aux allergies alimentaires? Le Ligand, mars 2003, vol. 14, no 1, p. 3.
  6. 6. DAVID LABBÉ, agr., chm., M.Sc. Page 6 / 10PATENTS1. Bazinet, L.; Labbé, D.; Tremblay, A. Method for selectively and sequentially extracting catechinsfrom plant product. North American # US2005176939.2. Bazinet, L.; Amiot, J.; Poulin, J.-F; Tremblay, A.; Labbé, D. Process and system for separation oforganic charged compounds. Worldwide #WO2005082495.Reviewer (peer-reviewed journal)Current Oncology 2010-PRESENTATIONSORAL PRESENTATIONS1. *Labbé, DP.; *Lessard, L.; Deblois, G.; Bégin, LR.; Hardy, S.; Mess-Masson, AM.; Saad, F.; Trotman,LC.; Giguère, V.; Tremblay, ML. PTP1B is an androgen receptor-regulated phosphatase associatedwith tumor-promoting functions in prostate cancer. 12th Annual McGill Biomedical GraduateConference, Montréal (Québec), February 16th 2012.*Contributed equally to the work2. *Labbé, DP.; *Lessard, L.; Deblois, G.; Bégin, LR.; Hardy, S.; Mess-Masson, AM.; Saad, F.; Trotman,LC.; Giguère, V.; Tremblay, ML. PTP1B is an androgen receptor-regulated phosphatase associatedwith tumor-promoting functions in prostate cancer. Phosphatases in Human Disease, Melbourne,Australia, February 3rd-4th 2012.*Contributed equally to the work3. *Labbé, D.; *Lessard, L.; Deblois, G.; Hardy, S.; Bégin, LR.; Filion, M.; Saad, F.; Mes-Masson, A-M.;Giguère, V.; and Tremblay, ML. Protein tyrosine phosphatase 1B is regulated by the androgenreceptor and plays a tumor-promoting role in prostate cancer. Europhosphatase 2011 (EMBOConference Series); Protein Phosphatases: From Molecules to Networks, Vienna, Austria, July 18th-23rd 2011.*Contributed equally to the work4. Labbé, D. PTP1B is regulated by the androgen receptor and plays a tumor-promoting role inprostate cancer. Work In Progress (WIP) talk, Goodman Cancer Research Centre, McGill University,Montréal (Québec) January 18th 2011.5. Labbé, D. Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of theamino-terminus domain of the androgen receptor. Journal Club, Goodman Cancer Research Centre,McGill University, Montréal (Québec), November 26th 2010.
  7. 7. DAVID LABBÉ, agr., chm., M.Sc. Page 7 / 106. Provençal, M.; Labbé, D.; Gingras, D.; Béliveau, R. Le facteur de croissance hépatocytaire induit lasurexpression du facteur tissulaire dans les médulloblastomes. 4th annual meeting of the “Centre deRecherches Biomédicales (BioMed)”, Université du Québec à Montréal, Montréal (Québec), April 30th2008.7. Labbé, D. Sciences et médias : Information ou désinformation? 2nd “Colloque des chercheursétudiants et postdoctoraux de l’Institut des nutraceutiques et des aliments fonctionnels (INAF)”,Château Bromont, Bromont (Québec), November 1-2 2007.8. Trudel, D.; Bairati, I.; Bazinet, L.; Labbé, D.; Plante, M.; Bachvarov, D.; Overall, C.; Jones, T. Greentea intake for maintenance of complete remission in women with advanced stage ovarian cancer. 45th“Journée scientifique annuelle Carlton-Auger”, Québec (Québec), October 12-13 2007. Published abstract: Annales de pathologie 28(1) (2008) 71-75.9. Labbé, D. Serions-nous tous mal nourris? Invited panelist at the “Forum des jeunes en sciences”,Collège Montmorency, Laval (Québec), November 6th 2006.10. Labbé D.; Araya-Farias, M.; Tremblay A.; Bazinet L. Effet du type de membrane sur la migrationdes cations au cours de l’électromigration de thé vert et le calcul des équivalents-masses transportés.“Journée d’information scientifique et technique en génie agroalimentaire”, Saint-Hyacinthe(Québec), March 23rd 2005.11. Bazinet, L.; Labbé, D.; Tremblay, A. Production d’une fraction enrichie en EGCG du thé vert parune procédure d’extraction en deux étapes. 72nd “Congrès de l’ACFAS, discipline chimie-physique,inorganique et des surfaces”, UQAM, Montréal (Québec), May 13th 2004.12. Bazinet, L.; Labbé, D.; Tremblay, A. Effect of temperature and brewing duration on solubilizationof green tea catechins. First Natural Health Product Research Conference organized by the NaturalHealth Product Research Society of Canada, Montréal (Québec), February 20-22 2004.POSTER PRESENTATIONS1. *Labbé, DP.; *Lessard, L.; Deblois, G.; Bégin, LR.; Hardy, S.; Mess-Masson, AM.; Saad, F.; Trotman,LC.; Giguère, V.; Tremblay, ML. PTP1B is an androgen receptor-regulated phosphatase thatpromotes the progression of prostate cancer. Poster presented at the PTEN Pathways & Targets, ColdSpring Harbor, New York (USA), March 13-16 2012.*Contributed equally to the work2. Hardy, S.; Wong, NN.; Labbé, D.; Aubry, I.; Lessard, L.; Bégin, LR.; Saad, F.; Mes-Masson, A-M.;Kerr, R.; Tremblay, ML. Regulation of phosphatase of regenerating liver-2 (PRL-2) in cancer. Posterpresented at the Europhosphatase 2011 (EMBO Conference Series); Protein Phosphatases: FromMolecules to Networks, Vienna, Austria, July 18-23 2011.
  8. 8. DAVID LABBÉ, agr., chm., M.Sc. Page 8 / 103. *Labbé, D.; *Lessard, L.; Hardy, S.; Deblois, G.; Bégin, LR.; Filion, M.; Saad, F.; Mes-Masson, A-M.;Giguère, V.; and Tremblay, ML. PTP1B is regulated by the androgen receptor and promotestumorigenesis in prostate cancer. Poster presented at the Montréal International Symposium onAngiogenesis and Metastasis (MISAM 2011), Montréal (Québec), June 15-17 2011.*Contributed equally to the work4. Tremblay, ML.; *Labbé, D.; *Lessard, L.; Bégin, LR.; Filion, M.; Leloy, A.; Filion, M.; Saad, F.; Mes-Masson, A-M. Inhibition of PTP1B attenuates the tumorigenic properties of prostate cancer cells.Poster presented at the Innovative Minds in Prostate Cancer Today (IMPaCT) Conference, Orlando,Florida (USA), March 9-12, 2011.*Contributed equally to the work5. *Labbé, D.; *Lessard, L.; Hardy, S.; Deblois, G.; Bégin, LR.; Filion, M.; Saad, F.; Mes-Masson, A-M.;Giguère, V.; and Tremblay, ML. PTP1B is regulated by the androgen receptor and promotestumorigenesis in prostate cancer. Poster presented at the 9th Conference on Signaling in Normal andCancer Cells, Banff (Alberta), March 6-10 2011.*Contributed equally to the work6. *Labbé, D.; *Lessard, L.; Deblois, G.; Filion, M.; Giguère, V.; Tremblay, ML. Androgen-dependentregulation of PTP1B expression and activity. Poster presented at the FASEB Summer ResearchConferences “Protein Phosphatases”, Steamboat Springs, Colorado (USA), July 18-23 2010.*Contributed equally to the work7. *Labbé, D.; *Lessard, L.; Bégin, LR.; Leloy, A.; Filion, M.; Saad, F.; Mes-Masson, A-M.; Tremblay,ML. Inhibition of PTP1B attenuates the tumorigenic properties of prostate cancer cells. Posterpresented at the FASEB Summer Research Conferences “Protein Phosphatases”, Steamboat Springs,Colorado (USA), July 18-23 2010.*Contributed equally to the work8. Labbé, D.; Provençal, M.; Veitch, R.; Boivin, D.; Rivard, G-E.; Sartelet, H.; Robitaille, Y.; Gingras,D.; Béliveau, R. c-Met activation in medulloblastoma induces tissue factor expression and activity:Effects on cell migration. Poster presented at the Montréal International Symposium on Angiogenesisand Metastasis (MISAM 2009), Montréal (Québec), June 11-12 2009.9. Labbé, D.; Provençal, M.; Veitch, R.; Boivin, D.; Rivard, G-E.; Sartelet, H.; Robitaille, Y.; Gingras,D.; Béliveau, R. c-Met activation in medulloblastoma induces tissue factor expression and activity:Effects on cell migration. Poster presented at Phosphorylation, signaling & disease, Cold SpringHarbor, New York (USA), May 12-16 2009.10. Labbé, D.; Provençal, M.; Lamy, S.; Gingras, D.; Béliveau, R. Les flavonols d’origine alimentaire,de nouveaux inhibiteurs du récepteur au facteur de croissance hépatocytaire. Poster presented at the“XXIIIe Congrès annuel de la recherche des étudiants gradués et post-gradués du Centre derecherche du CHU Sainte-Justine”, Montréal (Québec), June 12th 2008.
  9. 9. DAVID LABBÉ, agr., chm., M.Sc. Page 9 / 1011. Labbé, D.; Provençal, M.; Lamy, S.; Gingras, D.; Béliveau, R. Les flavonols d’origine alimentaire,de nouveaux inhibiteurs du récepteur au facteur de croissance hépatocytaire. Poster presented at the4th “Colloque annuel du Centre de Recherches Biomédicales (BioMed) de l’Université du Québec àMontréal”, Montréal (Québec), April 30th 2008.12. Provençal, M.; Labbé, D.; Gingras, D.; Béliveau, R. Le facteur de croissance hépatocytaire induit lasurexpression du facteur tissulaire dans les médulloblastomes. Poster presented at the 4th “Colloqueannuel du Centre de Recherches Biomédicales (BioMed)” UQAM, Montréal (Québec), April 30th2008.13. Labbé, D.; Lamy, S.; Beaulieu, E.; Bédard, V.; Béliveau, R. La delphinidine, un polyphénold’origine alimentaire, inhibe l’angiogenèse in vitro et in vivo. Poster presented at the XXIInd“Congrès annuel de la recherche des étudiants gradués du Centre de recherche du CHU Sainte-Justine”, Montréal (Québec), May 15-16 2007.14. Labbé, D.; Lamy, S.; Beaulieu, E.; Bédard, V.; Béliveau, R. La delphinidine, un polyphénold’origine alimentaire, inhibe l’angiogenèse in vitro et in vivo. Poster presented at the 3rd “Colloqueannuel Biomed”, UQAM, Montréal (Québec), May 2nd 2007.15. Labbé, D.; Tremblay, A.; Bazinet, L. Electromigration feasability of green tea catechins. Posterpresented at the “International Congress on Membranes and Membrane Processes (ICOM 2005)”,Seoul (South Korea), August 21-25 2005.16. Labbé, D.; Vignal, E.; Sistat, P.; Bazinet, L. Separation of green tea catechins by electrodialysiswith ultrafiltration membranes. Poster presented at the “International Symposium on HumanHealth : effects of fruits and vegetables (FAV Health 2005)”, Québec (Québec), August 17-20 2005. Published abstract: Acta Hort. (ISHS) 744 (2007) 369-376.17. Labbé, D.; Tremblay, A.; Araya-Farias, M.; Bazinet, L. Séparation et purification des catéchinesd’une infusion de thé vert par électromigration. Poster presented at the “Alimentation fonctionnelleet nutraceutiques : approches innovatrices en santé” meeting co-organized by the CQVB / INAFduring the 72nd “Congrès de l’ACFAS”, UQAM, Montréal (Québec), May 13th 2004.
  10. 10. DAVID LABBÉ, agr., chm., M.Sc. Page 10 / 10AFFILIATIONSAlumni association, Université Laval 2006-Association of scientific communicators of Québec 2005-Canadian Institute of Food Science and Technology 2003-Institute of Food Technologists (USA) 2003-EXTRACURRICULAR INVOLVEMENTRepresentative • Academic council of the Faculty of Sciences, Université du Québec à Montréal 2008 • Faculty council of the Faculty of Agricultural Sciences and Food, Université Laval 2004 • Linking commitee with the “Ordre des agronomes du Québec” 2003-2004Food Science student association • President and VP of the external affairs 2003-2006 • President of the organizing comitee “15 e Colloque STA” (more than 160 food 2003 science professionals participate at this meeting). • President of organizing comittee for first year welcoming events (Food Science) 2003 • Organizer of the “Food Science wine and cheese” 2003Volunteer • Défi Canderel 2009, 2010 • Salon de l’agriculture, de l’alimentation et de la consommation (SAAC) 2003, 04, 06 • Mathematics tutor 2001

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