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Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
Celebration of science final
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Celebration of science final

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FUSF Presentation giving at the Celebration of Science conference.

FUSF Presentation giving at the Celebration of Science conference.

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Transcript

  • 1. Focused Ultrasound
  • 2. DisclosureInSightec board member and shareholder
  • 3. 3 Focused UltrasoundNew, revolutionary, noninvasive therapeutic technologyAlternative or adjunct  Surgery  Radiation therapy  Drug deliveryEarly stage, MR 25 years ago, additional R&DAs important to therapy as MR is to diagnosesTransform treatment of a variety of serious medical disorders  Benign and malignant tumors  Metastatic cancer  Parkinson’s disease & epilepsy  Back pain, hypertensionReal today, infancy
  • 4. Essential Tremor
  • 5. Essential Tremor
  • 6. Essential Tremor
  • 7. Essential Tremor
  • 8. Functional Testing Before Procedure After Procedure
  • 9. Thalamic Lesion Created to Treat Essential Tremor
  • 10. Uterine Fibroid Treatment Pre-treatment MR scan of fibroid
  • 11. Uterine Fibroid Treatment ComparisonHysterectomy Focused UltrasoundMajor surgery Noninvasive, no incisionGeneral anesthesia Conscious sedationPainful Minimal discomfortHospitalization Outpatient6 weeks recovery 1 day recoverySide effects No side effectsNo more children Preserved fertility
  • 12. Uterine Fibroid Treatment Pre-treatment 9 months post-treatment Nine months after treatment, the fibroid has been absorbed
  • 13. Breast CancerPre treatment 2 weeks post treatment
  • 14. What is Focused Ultrasound?
  • 15. Marriage of Two Breakthrough TechnologiesFocused Ultrasound: therapy Treat tissue deep in body • Noninvasively • Accurately and preciselyMagnetic Resonance (MR) or Ultrasound (US) Imaging Identify and target tissue to be treated Guide and control treatment in real time Immediate confirmation of effectiveness
  • 16. Focused UltrasoundAnalogous to a magnifying glass focusing rays of the sun…
  • 17. Focused UltrasoundMultiple intersectingbeams of ultrasound  Focused with extreme accuracy  Point: 1 mm diameter  Deep in bodyIndividual beams pass harmlessly through tissuePoint of convergence: profound effectAdjacent tissue unaffected
  • 18. Effects at Focal PointDestroy tissue: thermal ablation, cavitationDeliver drugsDissolve clots: sonothrombolysisRadiation sensitizationDrug activity enhancementCoagulate blood vesselsAmplification of cancer biomarkersImmunomodulationNeuromodulationVasodilation Variety of effects, variety of disorders Abundant research opportunities
  • 19. Destroy Tissue: Thermal AblationHeating any tissue to 130 F (56 C) for one secondDestroys any tissue, normal or abnormal.
  • 20. Focal Drug DeliveryDeliver drugs in high concentrations Precisely where needed Minimizing systemic toxicityDrugs Chermotherapeutic agents Antibotics Genes Growth factors
  • 21. Drugs contained in microbubbles released by ultrasoundonly at the target 1/5
  • 22. Drugs contained in microbubbles released by ultrasoundonly at the target 2/5
  • 23. Drugs contained in microbubbles released by ultrasoundonly at the target 3/5
  • 24. Drugs contained in microbubbles released by ultrasoundonly at the target 4/5
  • 25. Drugs contained in microbubbles released by ultrasoundonly at the target 5/5
  • 26. Focused Ultrasound ProcedureSteps in procedure Targeting Planning Treating Confirming
  • 27. Procedure: Targeting Structures to be avoided Region to be treated
  • 28. Procedure: Planning Automatic planning
  • 29. Procedure: Treatment Real time guidance Temperature measurement
  • 30. FUS Advantages vs Radiation  Single treatment  Immediate and verifiable effect  Greater precision and accuracy  Real time localization  No cumulative dose  No limitations on lesion size  No limitations on number of treatments  No secondary tumors  100% cell death  Sharp margins
  • 31. Global Development Landscape
  • 32. Imagine the Future: 2020Advances in technology  Imaging  Focused ultrasound  Focal drug deliveryUndreamed-of applications
  • 33. SNAKE OIL: CURE-ALL33
  • 34. Limitations: Cannot be used for all conditions Scoliosis Leukemia Traumatic Injuries Lung Tumors
  • 35. Potential Impact, Urgent NeedTechnology widely available  Delay = unnecessary death, disability, suffering  Countless individuals: friends, family, you!Focused Ultrasound Foundation  Shorten time to wide-spread use  Saving time, saving lives
  • 36. Focused UltrasoundFoundation It’s all about the patients

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