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An overview of PNA: structure and applications Chandan Sona NISER National Institue Of Science Education And Research
Orientation of the talk ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
A bit of History ,[object Object],[object Object]
Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Interaction with DNA
Applications ,[object Object],[object Object],[object Object],[object Object]
Structures of PNA and DNA
Structure of PNA molecule attached to DNA.
Synthesis and Purification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Differences between the two brothers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Comparison of PNA-DNA Duplexes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PNA-DNA Chimera ,[object Object],[object Object],[object Object],[object Object]
To check the geometry ,[object Object],[object Object],[object Object]
Differentiating PNA
PNA-DNA-PNA  triplexes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Triple bond formation
Binding DNA ,[object Object],[object Object],[object Object]
PNA-DNA-PNA triplex ,[object Object],[object Object],[object Object],[object Object]
Strand invasion structures
Antigene and antisense application ,[object Object],[object Object],[object Object],[object Object]
Differentiating antisense and antigene
Antigene strategy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Gene regulation
Antisense strategy   ,[object Object],[object Object],[object Object],[object Object]
Antisense strategy ,[object Object],[object Object],[object Object],[object Object],[object Object]
Antisense strategy ,[object Object],[object Object],[object Object],[object Object]
Blocking translation
Inhibiting replication ,[object Object],[object Object],[object Object],[object Object]
Artificial life ,[object Object],[object Object],[object Object],[object Object]
Artificial life continues ,[object Object],[object Object],[object Object],[object Object]
Diagrammatic representation of artificial life .
Problems in artificial life ,[object Object],[object Object]
PNA WORLD/Pre-RNA WORLD
Origin of life (PNA world/Pre RNA world) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Supporting Pre RNA world ,[object Object],[object Object],[object Object],[object Object]
Still a Problem ,[object Object],[object Object],[object Object]
My project proposal ,[object Object],[object Object],[object Object],[object Object]
Conclusion ,[object Object]
Acknowledgement ,[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object]
THANK YOU THANK YOU

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