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The Science and Ethics of  Life Extension Third Meeting, Winter Quarter Stanford Transhumanism Association January 28, 2005 Michael Jin
Senescence: a fatal disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Part I – Should we seek life extension? Part I S HOULD  W E  S EEK  L IFE  E XTENSION ? “ If we are to be destroyed, I am now convinced that it will not be a neutral or malevolent force that will do us in, but one that is benevolent in the extreme, one whose only motivation is to improve us and better our civilization” – Sherwin Nylund
Aubrey de Grey, Cambridge bio-gerontologist, addressing his critics  ,[object Object],[object Object]
Defeating aging is a matter of morality, not practicality ,[object Object]
De Grey addresses practical arguments anyway ,[object Object],[object Object],[object Object],[object Object],[object Object]
The Human Dignity Argument ,[object Object]
Rebutting Kass’ Human Dignity ,[object Object],[object Object]
The Human Virtue Argument ,[object Object]
Rebutting the virtue argument ,[object Object],[object Object],[object Object],[object Object]
The Laundry List Argument ,[object Object]
Rebutting the Laundry List Argument: What is man?  ,[object Object]
Unamuno: What man is not ,[object Object]
Unamuno: What man wants (In three words: To live forever) ,[object Object],[object Object]
Part II – Can we seek life extension? Part II C AN  W E  S EEK  L IFE  E XTENSION ? “ Those who hope for no other life are dead even for this” – Johann Wolfgang Von Goethe
Evidence from Calorie Restriction ,[object Object]
CR Mechanism?
CR Theory, “ Caloric Restriction: Explaining the Enigma of Aging ” ,[object Object]
Another Idea (Note: Speculation here, not science.) ,[object Object],[object Object]
CR in Humans? (Fontana et al., 4/19/04, Proc. Natl. Acad. Sci.) Abstract Excerpt:  “The CR group were markedly leaner than the comparison group  (BMI, 19.6 � 1.9 vs. 25.9 � 3.2; % body fat, 8.7 � 7% vs. 24 � 8%). Total serum cholesterol (Tchol), LDL-cholesterol, Tchol/HDLChol ratio, triglycerides, fasting glucose, fasting insulin, hsCRP, PDFG-AB, systolic and diastolic BP were all markedly lower, while HDL-Chol was higher, in the CR, than in the American diet group… Based on measurements of a range of risk factors, it appears that long-term CR has a powerful protective effect against atherosclerosis.” 30 months on CR, 123lbs, BMI 18.5
The Search for a CR Mimetic: “Have Your Cake…” ,[object Object],[object Object]
Aubrey de Grey’s 7 Point Plan ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Aubrey’s Predictions: Milestones ,[object Object],[object Object]
Mainstream Response to de Grey ,[object Object],[object Object]
Living after 2100 graphic
Part III – What can I do today? Part III W HAT CAN W E  DO TODAY? First they ignore you, then they laugh at you, then they fight you, then you win. – Mohandas Gandhi
How much, how fast ,[object Object]
Kick-starting the War on Aging ,[object Object],[object Object]
Diet, Exercise, Supplementation ,[object Object],[object Object],[object Object],[object Object]
Cryonics: Extreme Life Extension ,[object Object],[object Object],[object Object],[object Object]
Michael Shermer on Cryonics: A Secular Pascal’s Wager? ,[object Object]
Why the critics may be wrong ,[object Object],[object Object],[object Object]
The Coming Future ,[object Object]
My Personal Predictions ,[object Object],[object Object],[object Object],[object Object],[object Object]

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The Science and Ethics of Life Extension

  • 1. The Science and Ethics of Life Extension Third Meeting, Winter Quarter Stanford Transhumanism Association January 28, 2005 Michael Jin
  • 2.
  • 3. Part I – Should we seek life extension? Part I S HOULD W E S EEK L IFE E XTENSION ? “ If we are to be destroyed, I am now convinced that it will not be a neutral or malevolent force that will do us in, but one that is benevolent in the extreme, one whose only motivation is to improve us and better our civilization” – Sherwin Nylund
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15. Part II – Can we seek life extension? Part II C AN W E S EEK L IFE E XTENSION ? “ Those who hope for no other life are dead even for this” – Johann Wolfgang Von Goethe
  • 16.
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  • 20. CR in Humans? (Fontana et al., 4/19/04, Proc. Natl. Acad. Sci.) Abstract Excerpt: “The CR group were markedly leaner than the comparison group (BMI, 19.6 � 1.9 vs. 25.9 � 3.2; % body fat, 8.7 � 7% vs. 24 � 8%). Total serum cholesterol (Tchol), LDL-cholesterol, Tchol/HDLChol ratio, triglycerides, fasting glucose, fasting insulin, hsCRP, PDFG-AB, systolic and diastolic BP were all markedly lower, while HDL-Chol was higher, in the CR, than in the American diet group… Based on measurements of a range of risk factors, it appears that long-term CR has a powerful protective effect against atherosclerosis.” 30 months on CR, 123lbs, BMI 18.5
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  • 26. Part III – What can I do today? Part III W HAT CAN W E DO TODAY? First they ignore you, then they laugh at you, then they fight you, then you win. – Mohandas Gandhi
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