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ISyPeM
ISyPeM
ISyPeM
ISyPeM
ISyPeM
ISyPeM
ISyPeM
ISyPeM
ISyPeM
ISyPeM
ISyPeM
ISyPeM
ISyPeM
ISyPeM
ISyPeM
ISyPeM
ISyPeM
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ISyPeM

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  • Our aim is to meet unmet healthcare needs.Medical and pharmaceutical progress is bringing up an increasing number of powerful, life-saving drug agents which must be administered on the long term and are known for important pharmacokinetic variability, thus requiring careful monitoring to avoid both inefficacy and toxicity.The project has the ambition to Target a much wider application spectrum. Platform..Potential medical applications are in HIV treatment, immunosuppression for organ transplant maintenance, anticancer therapy with tyrosine kinase inhibitors, etc. The laboratory and computer work related to the project started swiftly, with the health professionals formalizing conceptually the processes needed for treatment individualization. pharmacokinetic characterization of new drug agents has become mandatory from registration agencies during the last two decadespopulation pharmacokinetic modeling has progressed and is increasingly used in clinical research, the need for dosage individualization is more and more widely acknowledged among experts, especially regarding new critical therapies.
  • RADIO_CSEM: integrated radio chip able to be interfaced to a portable phone. The chip will be ultra-low power and will communicate at 2.4GHz. It would be remotely charged by the phone.MICS (Medical Implant Communication Services) band (400MHz).Ability to talk on Bluetooth Low Energy Extension (BT-LE at 2.4GHz) with the monitoring unit.
  • Lavoranovari partner sullostesso topic
  • Can see receptors.They does not exist and have not been used for surface detection
  • Can see receptors.They does not exist and have not been used for surface detection
  • Transcript

    • 1. Microelectronics Division Nanotechnology & Life-Sciences Division Institute of Bioengineering Institute of Electrical Engineering Division of Clinical Pharmacology Reconfigurable and Embedded and Toxicology Digital SystemsIntelligent Integrated Systems for Personalized MedicineISyPeM ISyPeM 1
    • 2. Long-term/highly critical drug therapiesA Personalized Medicine Approach Life-saving drug agents requiring careful monitoring Medical applications identified in the short term:  HIV therapies  Immunosuppression for organ transplant maintenance  Anticancer therapies with tyrosine kinase inhibitors Development of a platform for computer-assisted real-time dose adjustment ISyPeM 2
    • 3. Long-term/highly critical drug therapies A Personalized Medicine Approach Spread Provide ProvideACTIONS Therapeutic Drug a seamless fully automated Monitoring connection with drug monitoring culture databases and and delivery patient records SHORT TERM MEDIUM TERM LONG TERM Point-of-care Model building and Low power circuitsTECHNOLOGIES pharmacokinetics personalization for sensing and monitoring biotelemetry Localized and remote processing BT_LE MICS SW for dosing adjustment Automated in vivo 3500 3000 2500 delivery 2000 1500 1000 500 0 5:00 8:52 12:44 16:36 20:28 0:20 4:12 8:4 ISyPeM 3
    • 4. Technologies in the framework of ISyPeM Bio and Low power circuits and ICT and algorithms system architectureNanotechnologies WP3 and 5 WP1 and 4 WP2 Miniaturized  Bayesian  Low power CMOSbiosensors for drug algorithms biosensor interfaceand biomarker implemented onconcentration portable platforms  Low power radiomeasurement for WBAN node(STMicroelectronics)  Formal modeling of the therapeutic Distribution and Advanced surface protocol for management offunctionalization correctness computing power on(Arrayon Biotech.) verification embedded platformsDrug delivery bynanoporousmembranes ISyPeM 4
    • 5. Bio and nanotechnologies Biosensing techniques for drug concentration measurements ISyPeM 5
    • 6. Bio and nanotechnologiesQuasi Label-free Analyte Label No drug Drug Drug No signal No signal Signal Analyte Tag-Label Label-based No drug Drug No signal Signal Analyte Label-free No drug Drug No signal ISyPeM Signal 6
    • 7. Bio and nanotechnologies Aptamers that change conformationOligo BindingLibrary to beads AnalytePCR Binding toamplification target,of releaseselected from beads 11/22/2011 ISyPeM Plenary Meeting 7
    • 8. Bio and nanotechnologies Institute of BioengineeringLabel-based sensing on miniaturized electrodes on silicon Temiz, IEEE Sensors, 2010 ISyPeM Guiducci, APCCAS, 2010 8 Guiducci, ISSCC 2010
    • 9. Bio and nanotechnologies Institute of BioengineeringLabel-free sensing on miniaturized electrodes on silicon ISyPeM 9
    • 10. Bio and nanotechnologies Institute of Bioengineering Label-free sensing on miniaturized electrodes on siliconCappi et al, SPP 2011 ISyPeM 10
    • 11. Nanotechnology & Life-SciencesBio and nanotechnologiesNanoporous membrane for controlled delivery Silicon-based materials Biocompatible Electrically driven, integrable with actuation circuitryUltrathin (100 nm) nanoporous SiN membranes areproduced by combining Block-copolymerslithography and standard microfabricationprocesses (photolithography, wet/dry etching) –diffusion through nanopores has beendemonstrated. Popa, Nanotechnology, 2009 ISyPeM 11
    • 12. Nanotechnology & Life-SciencesBio and nanotechnologiesNanoporous membrane for controlled delivery Grafting of poly(NIPAM) brushesinsideSiNnanopores Permeability control by varying T below and above LCST, using pelletier element or electricalactuator.  Surface modification with poly(NIPAM) hydrogel containing gold NPs. Permeability control by external light inducing local heating of gold NPs (optical-to-thermal energy conversion) hydrogel unpublished ISyPeM 12
    • 13. ICT and algorithms Institute of Electrical EngineeringBayesian algorithms for Therapeutic Drug MonitoringOther prediction strategies under investigation: Example-based learning algorithm Imatinib. tyrosine kinase inhibitor Unpublished results ISyPeM 13
    • 14. Low Power Circuits and System ArchitectureReconfigurable low-Power CMOS Biosensor Interface Microelectronics Division Institute of Bioengineering CMOS Interface to the biosensoris:  Reconfigurable (Synchronous and Asynchronous Mode).  Versatile (CyclicVoltammetry, ImpedanceSpectroscopy, Capacitive Sensing). ISyPeM Balasubramanian, ISCAS 2010 14
    • 15. Low Power Circuits and System ArchitectureLow-power Radio for WBAN nodeAbility to communicate on MICS (Medical Microelectronics DivisionImplant Communication Services) band(400MHz)AND Reconfigurable andon Bluetooth Low Energy Extension (BT-LE at Embedded Digital Systems2.4GHz) with the monitoring unit.RF input Sampling RF front-end fc1,fc2 S/H mixer Decimation Prefilter I 0 I fC,1 I LNA S fBB fs fBB To ADC Q Q Q (Antialias) Sampling clock fs Decimation,down conversion 0 I I fC,2 I S fIF fs fBB To ADC Q Q Q Heragu, ISCAS 2010 ISyPeM 15
    • 16. Low Power Circuits and System Architectureicyflex embedded programming Reconfigurable and Embedded Digital Systems Microelectronics Division  Definition of drug management policies  Management of the control loop  Safe and secure transmission of data  Integration and miniaturization ISSCC 2010 ISyPeM 16
    • 17. Industrial contributionSTMicroelectronics Development of a prototype of a point-of-care in vitro drugmeasurement system • fully automated measurement system equipped with sample preparation functionalitiesArrayon Biotechnologies Functionalization of surfaces based on a polysaccharidephotolinkers called Optodex® to overcome the phenomenonof non-specific interactions ISyPeM 17

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